Publications (Department Neurogenetics)

Kaji, S.; Berghoff, S. A.; Spieth, L.; Schlaphoff, L.; Sasmita, A. O.; Vitale, S.; Büschgens, L.; Kedia, S.; Zirngibl, M.; Nazarenko, T. et al.; Damkou, A.; Hosang, L.; Depp, C.; Kamp, F.; Scholz, P.; Ewers, D.; Giera, M.; Ischebeck, T.; Wurst, W.; Wefers, B.; Schifferer, M.; Willem, M.; Nave, K.-A.; Haass, C.; Arzberger, T.; Jäkel, S.; Wirths, O.; Saher, G.; Simons, M.: Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis. Immunity 57 (11), pp. 2651 - 2668.e12 (2024)

Garg, V.; André, S.; Heyer, L.; Kracht, G.; Ruhwedel, T.; Scholz, P.; Ischebeck, T.; Werner, H. B.; Dullin, C.; Engelmann, J. et al.; Möbius, W.; Göpfert, M. C.; Dosch, R.; Geurten, B. R. H.: Axon demyelination and degeneration in a zebrafish spastizin model of hereditary spastic paraplegia. Open Biology 14 (11), 240100 (2024)

Notter, S.; Choezom, D.; Griebel, T.; Ramos Gomes, F.; Möbius, W.; De Oliveira, T.; Conradi, L.-C.; Alves, F.; Feldmann, C.: High-Load Core@Shell Nanocarriers with Irinotecan and 5-Fluorouracil for Combination Chemotherapy in Colorectal Cancer. Small Science 4 (11), 2400196 (2024)

Dibaj, P.; Safavi-Abbasi, S.; Asadollahi, E.: In vivo spectrally unmixed multi-photon imaging of longitudinal axon-glia changes in injured spinal white matter. Neuroscience Letters 841, 137959 (2024)

Curto, Y.; Carceller, H.; Klimczak, P.; Perez-Rando, M.; Wang, Q.; Grewe, K.; Kawaguchi, R.; Rizzoli, S.; Geschwind, D.; Nave, K.-A. et al.; Teruel-Marti, V.; Singh, M.; Ehrenreich, H.; Nácher, J.: Erythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus. Molecular Psychiatry 29, pp. 2979 - 2996 (2024)

da Silva Correia, A.; Schmitz, M.; Fischer, A.; da Silva Correia, S.; Simonetti, F. L.; Saher, G.; Goya‐Maldonado, R.; Arora, A. S.; Fischer, A.; Outeiro, T. F. et al.; Zerr, I.: Cellular prion protein acts as mediator of amyloid beta uptake by caveolin‐1 causing cellular dysfunctions in vitro and in vivo. Alzheimer's & Dementia 20 (10), pp. 6776 - 6792 (2024)

Asadollahi, E.; Nave, K.-A.: Myelin lipid metabolism can provide energy for starved axons. Nature Neuroscience 27, pp. 1862 - 1863 (2024)

Asadollahi, E.; Trevisiol, A.; Saab, A. S.; Looser, Z. J.; Dibaj, P.; Ebrahimi, R.; Kusch, K.; Ruhwedel, T.; Möbius, W.; Jahn, O. et al.; Lee, J. Y.; Don, A. S.; Khalil, M.-A.; Hiller, K.; Baes, M.; Weber, B.; Abel, E. D.; Ballabio, A.; Popko, B.; Kassmann, C. M.; Ehrenreich, H.; Hirrlinger, J.; Nave, K.-A.: Oligodendroglial fatty acid metabolism as a central nervous system energy reserve. Nature Neuroscience 27, pp. 1934 - 1944 (2024)

Gargareta, V.-I.; Berghoff, S. A.; Krauter, D.; Hümmert, S.; Marshall‐Phelps, K. L. H.; Möbius, W.; Nave, K.-A.; Fledrich, R.; Werner, H. B.; Eichel-Vogel, M. A.: Myelinated peripheral axons are more vulnerable to mechanical trauma in a model of enlarged axonal diameters. Glia 72 (9), pp. 1572 - 1589 (2024)

Mennen, S.-S.; Franta, M.; Begemann, M.; Wilke, J. B. H.; Schröder, R.; Butt, U. J.; Cortés‐Silva, J.; Çakır, U.; Güra, M.; de Marées, M. et al.; Daguano Gastaldi, V.; Burtscher, J.; Schanz, J.; Bohn, M.; Burtscher, M.; Fischer, A.; Poustka, L.; Hammermann, P.; Stadler, M.; Lühder, F.; Singh, M.; Nave, K.-A.; Miskowiak, K. W.; Ehrenreich, H.: Tolerability and first hints for potential efficacy of motor‐cognitive training under inspiratory hypoxia in health and neuropsychiatric disorders: A translational viewpoint. Neuroprotection 2 (3), pp. 228 - 242 (2024)

Aich, A.; Boshnakovska, A.; Witte, S.; Gall, T.; Unthan-Fechner, K.; Yousefi, R.; Chowdhury, A.; Dahal, D.; Methi, A.; Kaufmann, S. et al.; Silbern, I.; Prochazka, J.; Nichtova, Z.; Palkova, M.; Raishbrook, M.; Koubkova, G.; Sedlacek, R.; Tröder, S.E.; Zevnik, B.; Riedel, D.; Michanski, S.; Möbius, W.; Ströbel, P.; Lüchtenborg, C.; Giavalisco, P.; Urlaub, H.; Fischer, A.; Brügger, B.; Jakobs, S.; Rehling, P.: Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver. Nature Communications 15, 6914 (2024)

Sasmita, A. O.; Depp, C.; Nazarenko, T.; Sun, T.; Siems, S. B.; Ong, E. C.; Nkeh, Y. B.; Böhler, C.; Yu, X.; Bues, B. et al.; Evangelista, L.; Mao, S.; Morgado, B.; Wu, Z.; Ruhwedel, T.; Subramanian, S.; Börensen, F.; Overhoff, K.; Spieth, L.; Berghoff, S. A.; Sadleir, K. R.; Vassar, R.; Eggert, S.; Goebbels, S.; Saito, T.; Saido, T.; Saher, G.; Möbius, W.; Castelo-Branco, G.; Klafki, H.-W.; Wirths, O.; Wiltfang, J.; Jäkel, S.; Yan, R.; Nave, K.-A.: Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice. Nature Neuroscience 27, pp. 1668 - 1674 (2024)

Foerster, S.; Floriddia, E. M.; van Bruggen, D.; Kukanja, P.; Hervé, B.; Cheng, S.; Kim, E.; Phillips, B. U.; Heath, C. J.; Tripathi, R. B. et al.; Call, C.; Bartels, T.; Ridley, K.; Neumann, B.; López-Cruz, L.; Crawford, A. H.; Lynch, C. J.; Serrano, M.; Saksida, L.; Rowitch, D. H.; Möbius, W.; Nave, K.-A.; Rasband, M. N.; Bergles, D. E.; Kessaris, N.; Richardson, W. D.; Bussey, T. J.; Zhao, C.; Castelo-Branco, G.; Franklin, R. J. M.: Developmental origin of oligodendrocytes determines their function in the adult brain. Nature Neuroscience 27, pp. 1545 - 1554 (2024)

Nkeh, Y. B.; Elgin, R. G.; Saher, G.: From the unknown to spotlight: newly identified hormone adjusts hepatic cholesterol synthesis to dietary uptake. Signal Transduction and Targeted Therapy 9, 165 (2024)

Chatterjee, M.; Özdemir, S.; Fritz, C.; Möbius, W.; Kleineidam, L.; Mandelkow, E.; Biernat, J.; Doğdu, C.; Peters, O.; Cosma, N.C. et al.; Wang, X.; Schneider, L.-S.; Priller, J.; Spruth, E.; Kühn, A.A.; Krause, P.; Klockgether, T.; Vogt, I.R.; Kimmich, O.; Spottke, A.; Hoffmann, D.C.; Fliessbach, K.; Miklitz, C.; McCormick, C.; Weydt, P.; Falkenburger, B.; Brandt, M.; Guenther, R.; Dinter, E.; Wiltfang, J.; Hansen, N.; Bähr, M.; Zerr, I.; Flöel, A.; Nestor, P.J.; Düzel, E.; Glanz, W.; Incesoy, E.; Bürger, K.; Janowitz, D.; Perneczky, R.; Rauchmann, B.S.; Hopfner, F.; Wagemann, O.; Levin, J.; Teipel, S.; Kilimann, I.; Goerss, D.; Prudlo, J.; Gasser, T.; Brockmann, K.; Mengel, D.; Zimmermann, M.; Synofzik, M.; Wilke, C.; Selma-González, J.; Turon-Sans, J.; Santos-Santos, M.A.; Alcolea, D.; Rubio-Guerra, S.; Fortea, J.; Carbayo, Á.; Lleó, A.; Rojas-García, R.; Illán-Gala, I.; Wagner, M.; Frommann, I.; Roeske, S.; Bertram, L.; Heneka, M.T.; Brosseron, F.; Ramirez, A.; Schmid, M.; Beschorner, R.; Halle, A.; Herms, J.; Neumann, M.; Barthélemy, N.R.; Bateman, R.J.; Rizzu, P.; Heutink, P.; Dols-Icardo, O.; Höglinger, G.; Hermann, A.; Schneider, A.: Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS. Nature Medicine 30 (6), pp. 1771 - 1783 (2024)

Reich, M.; Simon, M. J.; Polke, B.; Paris, I.; Werner, G.; Schrader, C.; Spieth, L.; Davis, S. S.; Robinson, S.; de Melo, G. L. et al.; Schlaphoff, L.; Buschmann, K.; Berghoff, S.; Logan, T.; Nuscher, B.; de Weerd, L.; Edbauer, D.; Simons, M.; Suh, J. H.; Sandmann, T.; Kariolis, M. S.; DeVos, S. L.; Lewcock, J. W.; Paquet, D.; Capell, A.; Di Paolo, G.; Haass, C.: Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration. Science translational medicine 16 (750), eadj7308 (2024)

Reiter, S.; Sun, T.; Gärtner, S.; Pöhlmann, S.; Winkler, M.: Development of rhesus macaque astrocyte cell lines supporting infection with a panel of viruses. PLOS ONE 19 (5), e0303059 (2024)

Liu, X.; Xin, D.E.; Zhong, X.; Zhao, C.; Li, Z.; Zhang, L.; Dourson, A.J.; Lee, L.; Mishra, S.; Bayat, A.E. et al.; Nicholson, E.; Seibel, W.L.; Yan, B.; Mason, J.; Turner, B.J.; Gonsalvez, D.G.; Ong, W.; Chew, S.Y.; Ghosh, B.; Yoon, S.O.; Xin, M.; He, Z.; Tchieu, J.; Wegner, M.; Nave, K. A.; Franklin, R.J.M.; Dutta, R.; Trapp, B.D.; Hu, M.; Smith, M.A.; Jankowski, M.P.; Barton, S.K.; He, X.; Lu, Q.R.: Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration. Cell 187 (10), pp. 2465 - 2484.e22 (2024)

Hong, J.; Garfolo, R.; Kabre, S.; Humml, C.; Velanac, V.; Roué, C.; Beck, B.; Jeanette, H.; Haslam, S.; Bach, M. et al.; Arora, S.; Acheta, J.; Nave, K.-A.; Schwab, M. H.; Jourd'heuil, D.; Poitelon, Y.; Belin, S.: PMP2 regulates myelin thickening and ATP production during remyelination. Glia 72 (5), pp. 885 - 895 (2024)

Späte, E.; Zhou, B.; Sun, T.; Kusch, K.; Asadollahi, E.; Siems, S. B.; Depp, C.; Werner, H. B.; Saher, G.; Hirrlinger, J. et al.; Möbius, W.; Nave, K.-A.; Göbbels, S.: Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons. Glia 72 (8), pp. 1374 - 1391 (2024)

Krauter, D.; Stausberg, D.; Hartmann, T. J.; Volkmann, S.; Kungl, T.; Rasche, D. A.; Saher, G.; Fledrich, R.; Stassart, R.M.; Nave, K.-A. et al.; Göbbels, S.; Ewers, D.; Sereda, M. W.: Targeting PI3K/Akt/mTOR signaling in rodent models of PMP22 gene-dosage diseases. Embo Molecular Medicine 16, pp. 616 - 640 (2024)

Looser, Z.J.; Faik, Z.; Ravotto, L.; Zanker, H.S.; Jung, R. B.; Werner, H. B.; Ruhwedel, T.; Möbius, W.; Bergles, D.E.; Barros, L.F. et al.; Nave, K.-A.; Weber, B.; Saab, A.S.: Oligodendrocyte–axon metabolic coupling is mediated by extracellular K+ and maintains axonal health. Nature Neuroscience 27, pp. 433 - 448 (2024)

Hintze, A.; Lange, F.; Steyer, A. M.; Anstatt, J.; Möbius, W.; Jakobs, S.; Wichmann, C.: Developmental changes of the mitochondria in the murine anteroventral cochlear nucleus. iScience 27 (1), 108700 (2024)

van Belle, G. J.; Zieseniss, A.; Heidenreich, D.; Olmos, M.; Zhuikova, A.; Möbius, W.; Paul, M. W.; Katschinski, D. M.: Cargo-specific effects of hypoxia on clathrin-mediated trafficking. Pflügers Archiv: European Journal of Physiology 476, pp. 1399 - 1410 (2024)

Altas, B.; Rhee, H. J.; Ju, A.; Solis, H. C.; Karaca, S.; Winchenbach, J.; Kaplan-Arabaci, O.; Schwark, M.; Ambrozkiewicz, M.; Lee, C. et al.; Spieth, L.; Wieser, G. L.; Chaugule, V. K.; Majoul, I.; Hassan, M. A.; Goel, R.; Wojcik, S. M.; Koganezawa, N.; Hanamura, K.; Rotin, D.; Pichler, A.; Mitkovski, M.; de Hoz, L.; Poulopoulos, A.; Urlaub, H.; Jahn, O.; Saher, G.; Brose, N.; Rhee, J.; Kawabe, H.: Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity. Journal of Cell Biology 223 (1), e201902050 (2024)

Khish, N. S.; Ghiasizadeh, P.; Rasti, A.; Moghimi, O.; Zadeh, A. Z.; Bahiraee, A.; Ebrahimi, R.: Regulatory Non-coding RNAs Involved in Oxidative Stress and Neuroinflammation: An Intriguing Crosstalk in Parkinson’s Disease. Current Medicinal Chemistry 31 (34), pp. 5576 - 5597 (2024)

Paulke, N. J.; Fleischhacker, C.; Wegener, J. B.; Riedemann, G. C.; Cretu, C.; Mushtaq, M.; Zaremba, N.; Möbius, W.; Zühlke, Y.; Wedemeyer, J. et al.; Liebmann, L.; Gorshkova, A. A.; Kownatzki-Danger, D.; Wagner, E.; Kohl, T.; Wichmann, C.; Jahn, O.; Urlaub, H.; Toischer, K.; Hasenfuß, G.; Moser, T.; Preobraschenski, J.; Lenz, C.; Rog-Zielinska, E. A.; Lehnart, S. E.; Brandenburg, S.: Dysferlin Enables Tubular Membrane Proliferation in Cardiac Hypertrophy. Circulation Research 135 (5), pp. 554 - 574 (2024)

Simons, M.; Gibson, E. M.; Nave, K.-A.: Oligodendrocytes: Myelination, Plasticity, and Axonal Support. Cold Spring Harbor Perspectives in Biology 16, a041359 (2024)