Publikationen (Abteilung Neurogenetik)
Zeitschriftenartikel (720)
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Neuropeptide CRH prevents premature differentiation of OPCs following CNS injury and in early postnatal development. Cell Reports 44 (11), 116474 (2025)
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ATP Metabolism of Astrocytes: Consumption, Regeneration and Restoration. Neurochemical Research 50, 357 (2025)
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Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy. Science Advances 11 (45), eady4344 (2025)
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Cell-specific Eif2b5 mutant mice: novel insights into roles of macroglia in vanishing white matter. Brain 148 (11), S. 4112 - 4126 (2025)
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Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions. Immunity (2025)
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Multiple Antibody-Coated Gold Nanoparticle-Based ExoAssay for Rapid Isolation of CNS-Specific Exosomes From Blood. Journal of Neurochemistry 169 (10), e70263 (2025)
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Forebrain-specific loss of erythropoietin provokes compensatory upregulation of different EPO receptors. Molecular Psychiatry (2025)
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Gtf2i-encoded transcription factor Tfii-i regulates myelination via Sox10 and Mbp regulatory elements. Nature Communications 16, 8518 (2025)
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Transcriptional dynamics of the oligodendrocyte lineage and its regulation by the brain erythropoietin system. Nature Communications 16, 8291 (2025)
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Neuronal THY1 Signaling Maintains Astrocytes in a Quiescent State. Glia (2025)
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Presynaptic ATP Decreases During Physiological-Like Activity in Neurons Tuned for High-Frequency Transmission. Journal of Neurochemistry 169 (9), e70212 (2025)
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The intracellular Ca2+ sensitivity of transmitter release in glutamatergic neocortical boutons. Science 389 (6755), S. 48 - 52 (2025)
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RNF20/RNF40 supports the aggressive behavior in cervical cancer by regulating a peroxisome-based anti-ferroptotic mechanism. Cell Communication and Signaling 23, 304 (2025)
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Acute neuronal cell death and neuroinflammation per se do not trigger secondary autoimmune encephalitis in mice. Scientific Reports 15, 20337 (2025)
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Spreading depolarizations exhaust neuronal ATP in a model of cerebral ischemia. Proceedings of the National Academy of Sciences of the United States of America 122 (19), e2415358122 (2025)
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Neuroinflammation in Alzheimer disease. Nature Reviews Immunology 25, S. 321 - 352 (2025)
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Interleukin-12 signaling drives Alzheimer’s disease pathology through disrupting neuronal and oligodendrocyte homeostasis. Nature aging 5, S. 622 - 641 (2025)
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Patient-specific mutation of a contact site protein Tomm70 causes neurodegeneration in a zebrafish model. Disease Models & Mechanisms 18 (4), dmm052029 (2025)
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A comprehensive and standardized pipeline for automated profiling of higher cognition in mice. Cell Reports Methods 5 (3), 101011 (2025)
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Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease. Neuron 113 (6), S. 838 - 846.e4 (2025)
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3D virtual histology of rodent and primate cochleae with multi-scale phase-contrast X-ray tomography. Scientific Reports 15, 7933 (2025)
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Dynamics of Neuronal and Astrocytic Energy Molecules in Epilepsy. Journal of Neurochemistry 169 (3), e70044 (2025)
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Astroglial modulation of synaptic function in the non-demyelinated cerebellar cortex is dependent on MyD88 signaling in a model of toxic demyelination. Journal of Neuroinflammation 22, 47 (2025)
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Ketamine induces plasticity in a norepinephrine-astroglial circuit to promote behavioral perseverance. Neuron 113 (3), S. 426 - 443.e5 (2025)
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Physiological and Pathological Role of mTOR Signaling in Astrocytes. Neurochemical Research 50, 53 (2025)
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Nanobodies against the myelin enzyme CNPase as tools for structural and functional studies. Journal of Neurochemistry 169 (1), e16274 (2025)
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Developmental maturation and regional heterogeneity but no sexual dimorphism of the murine CNS myelin proteome. Glia 73 (1), S. 38 - 56 (2025)
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Insulin and leptin acutely modulate the energy metabolism of primary hypothalamic and cortical astrocytes. Journal of Neurochemistry 169 (1), e16211 (2025)
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Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis. Immunity 57 (11), S. 2651 - 2668.e12 (2024)
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Axon demyelination and degeneration in a zebrafish spastizin model of hereditary spastic paraplegia. Open Biology 14 (11), 240100 (2024)
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High-Load Core@Shell Nanocarriers with Irinotecan and 5-Fluorouracil for Combination Chemotherapy in Colorectal Cancer. Small Science 4 (11), 2400196 (2024)
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In vivo spectrally unmixed multi-photon imaging of longitudinal axon-glia changes in injured spinal white matter. Neuroscience Letters 841, 137959 (2024)
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Erythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus. Molecular Psychiatry 29, S. 2979 - 2996 (2024)
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Cellular prion protein acts as mediator of amyloid beta uptake by caveolin‐1 causing cellular dysfunctions in vitro and in vivo. Alzheimer's & Dementia 20 (10), S. 6776 - 6792 (2024)
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Myelin lipid metabolism can provide energy for starved axons. Nature Neuroscience 27, S. 1862 - 1863 (2024)
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Oligodendroglial fatty acid metabolism as a central nervous system energy reserve. Nature Neuroscience 27, S. 1934 - 1944 (2024)
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Myelinated peripheral axons are more vulnerable to mechanical trauma in a model of enlarged axonal diameters. Glia 72 (9), S. 1572 - 1589 (2024)
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Tolerability and first hints for potential efficacy of motor‐cognitive training under inspiratory hypoxia in health and neuropsychiatric disorders: A translational viewpoint. Neuroprotection 2 (3), S. 228 - 242 (2024)
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Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver. Nature Communications 15, 6914 (2024)
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Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice. Nature Neuroscience 27, S. 1668 - 1674 (2024)
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Developmental origin of oligodendrocytes determines their function in the adult brain. Nature Neuroscience 27, S. 1545 - 1554 (2024)
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From the unknown to spotlight: newly identified hormone adjusts hepatic cholesterol synthesis to dietary uptake. Signal Transduction and Targeted Therapy 9, 165 (2024)
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Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS. Nature Medicine 30 (6), S. 1771 - 1783 (2024)
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Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration. Science translational medicine 16 (750), eadj7308 (2024)
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Development of rhesus macaque astrocyte cell lines supporting infection with a panel of viruses. PLOS ONE 19 (5), e0303059 (2024)
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Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration. Cell 187 (10), S. 2465 - 2484.e22 (2024)
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PMP2 regulates myelin thickening and ATP production during remyelination. Glia 72 (5), S. 885 - 895 (2024)
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Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons. Glia 72 (8), S. 1374 - 1391 (2024)
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Targeting PI3K/Akt/mTOR signaling in rodent models of PMP22 gene-dosage diseases. Embo Molecular Medicine 16, S. 616 - 640 (2024)
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Oligodendrocyte–axon metabolic coupling is mediated by extracellular K+ and maintains axonal health. Nature Neuroscience 27, S. 433 - 448 (2024)