Publications (Department Neurogenetics)

Wilke, J. B. H.; Ntolkeras, A.; Daguano Gastaldi, V.; Borowski, K.; Teegen, B.; Stöcker, W.; Lühder, F.; Nave, K.-A.; Ehrenreich, H.: Acute neuronal cell death and neuroinflammation per se do not trigger secondary autoimmune encephalitis in mice. Scientific Reports 15, 20337 (2025)

Schoknecht, K.; Baeza-Lehnert, F.; Hirrlinger, J.; Dreier, J. P.; Eilers, J.: Spreading depolarizations exhaust neuronal ATP in a model of cerebral ischemia. Proceedings of the National Academy of Sciences of the United States of America 122 (19), e2415358122 (2025)

Heneka, M. T.; van der Flier, W. M.; Jessen, F.; Hoozemanns, J.; Thal, D. R.; Boche, D.; Brosseron, F.; Teunissen, C.; Zetterberg, H.; Jacobs, A. H. et al.; Edison, P.; Ramirez, A.; Cruchaga, C.; Lambert, J.-C.; Laza, A. R.; Sanchez-Mut, J. V.; Fischer, A.; Castro-Gomez, S.; Stein, T. D.; Kleineidam, L.; Wagner, M.; Neher, J. J.; Cunningham, C.; Singhrao, S. K.; Prinz, M.; Glass, C. K.; Schlachetzki, J. C. M.; Butovsky, O.; Kleemann, K.; De Jaeger, P. L.; Scheiblich, H.; Brown, G. C.; Landreth, G.; Moutinho, M.; Grutzendler, J.; Gomez-Nicola, D.; McManus, R. M.; Andreasson, K.; Ising, C.; Karabag, D.; Baker, D. J.; Liddelow, S. A.; Verkhratsky, A.; Tansey, M.; Monsonego, A.; Aigner, L.; Dorothée, G.; Nave, K.-A.; Simons, M.; Constantin, G.; Rosenzweig, N.; Pascual, A.; Petzold, G. C.; Kipnis, J.; Venegas, C.; Colonna, M.; Walter, J.; Tenner, A. J.; O’Banion, M. K.; Steinert, J. R.; Feinstein, D. L.; Sastre, M.; Bhaskar, K.; Hong, S.; Schafer, D. P.; Golde, T.; Ransohoff, R. M.; Morgan, D.; Breitner, J.; Mancuso, R.; Riechers, S.-P.: Neuroinflammation in Alzheimer disease. Nature Reviews Immunology 25, pp. 321 - 352 (2025)

Schneeberger, S.; Kim, S. J.; Geesdorf, M. N.; Friebel, E.; Eede, P.; Jendrach, M.; Boltengagen, A.; Braeuning, C.; Ruhwedel, T.; Hülsmeier, A. J. et al.; Gimber, N.; Foerster, M.; Obst, J.; Andreadou, M.; Mundt, S.; Schmoranzer, J.; Prokop, S.; Kessler, W.; Kuhlmann, T.; Möbius, W.; Nave, K.-A.; Hornemann, T.; Becher, B.; Edgar, J. M.; Karaiskos, N.; Kocks, C.; Rajewsky, N.; Heppner, F. L.: Interleukin-12 signaling drives Alzheimer’s disease pathology through disrupting neuronal and oligodendrocyte homeostasis. Nature aging 5, pp. 622 - 641 (2025)

Garg, V.; Möbius, W.; Heinrich, R.; Ruhwedel, T.; Perera, R. P.; Scholz, P.; Ischebeck, T.; Salinas, G.; Dullin, C.; Göpfert, M. C. et al.; Engelmann, J.; Dosch, R.; Geurten, B. R. H.: Patient-specific mutation of a contact site protein Tomm70 causes neurodegeneration in a zebrafish model. Disease Models & Mechanisms 18 (4), dmm052029 (2025)

Daguano Gastaldi, V.; Hindermann, M.; Wilke, J. B. H.; Ronnenberg, A.; Arinrad, S.; Kraus, S.; Wildenburg, A.-F.; Ntolkeras, A.; Provost, M. J.; Ye, L. et al.; Curto, Y.; Cortés-Silva, J.-A.; Butt, U. J.; Nave, K.-A.; Miskowiak, K. W.; Ehrenreich, H.: A comprehensive and standardized pipeline for automated profiling of higher cognition in mice. Cell Reports Methods 5 (3), 101011 (2025)

Sasmita, A. O.; Ong, E. C.; Nazarenko, T.; Mao, S.; Komarek, L.; Thalmann, M.; Hantakova, V.; Spieth, L.; Berghoff, S. A.; Barr, H. J. et al.; Hingerl, M.; Börensen, F.; Hirrlinger, J.; Simons, M.; Stevens, B.; Depp, C.; Nave, K.-A.: Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease. Neuron 113 (6), pp. 838 - 846.e4 (2025)

Schaeper, J. J.; Kampshoff, C. A.; Wolf, B. J.; Roos, L.; Michanski, S.; Ruhwedel, T.; Eckermann, M.; Meyer, A.; Jeschke, M.; Wichmann, C. et al.; Moser, T.; Salditt, T.: 3D virtual histology of rodent and primate cochleae with multi-scale phase-contrast X-ray tomography. Scientific Reports 15, 7933 (2025)

Furukawa, K.; Ikoma, Y.; Niino, Y.; Hiraoka, Y.; Tanaka, K.; Miyawaki, A.; Hirrlinger, J.; Matsui, K.: Dynamics of Neuronal and Astrocytic Energy Molecules in Epilepsy. Journal of Neurochemistry 169 (3), e70044 (2025)

Lohrberg, M.; Mortensen, L. S.; Thomas, C.; Fries, F.; van der Meer, F.; Götz, A.; Landt, C.; Rhee, H. J.; Rhee, J. S.; Gómez-Varela, D. et al.; Schmidt, M.; Möbius, W.; Ruhwedel, T.; Pardo, L. A.; Remling, L.; Kramann, N.; Wrzos, C.; Bahn, E.; Stadelmann, C.; Barrantes-Freer, A.: Astroglial modulation of synaptic function in the non-demyelinated cerebellar cortex is dependent on MyD88 signaling in a model of toxic demyelination. Journal of Neuroinflammation 22, 47 (2025)

Duque, M.; Chen, A. B.; Hsu, E.; Narayan, S.; Rymbek, A.; Begum, S.; Saher, G.; Cohen, A. E.; Olson, D. E.; Li, Y. et al.; Prober, D. A.; Bergles, D. E.; Fishman, M. C.; Engert, F.; Ahrens, M. B.: Ketamine induces plasticity in a norepinephrine-astroglial circuit to promote behavioral perseverance. Neuron 113 (3), pp. 426 - 443.e5 (2025)

Hochmuth, L.; Hirrlinger, J.: Physiological and Pathological Role of mTOR Signaling in Astrocytes. Neurochemical Research 50, 53 (2025)

Markusson, S.; Raasakka, A.; Schröder, M.; Sograte-Idrissi, S.; Rahimi, A.M.; Asadpour, O.; Körner, H.; Lodygin, D.; Eichel-Vogel, M. A.; Chowdhury, R. et al.; Sutinen, A.; Muruganandam, G.; Iyer, M.; Cooper, M.H.; Weigel, M.K.; Ambiel, N.; Werner, H. B.; Zuchero, J.B.; Opazo, F.; Kursula, P.: Nanobodies against the myelin enzyme CNPase as tools for structural and functional studies. Journal of Neurochemistry 169 (1), e16274 (2025)

Siems, S. B.; Gargareta, V.-I.; Schadt, L. C.; Daguano Gastaldi, V.; Jung, R. B.; Piepkorn, L.; Casaccia, P.; Sun, T.; Jahn, O.; Werner, H. B.: Developmental maturation and regional heterogeneity but no sexual dimorphism of the murine CNS myelin proteome. Glia 73 (1), pp. 38 - 56 (2025)

Wolff, C.; John, D.; Winkler, U.; Hochmuth, L.; Hirrlinger, J.; Köhler, S.: Insulin and leptin acutely modulate the energy metabolism of primary hypothalamic and cortical astrocytes. Journal of Neurochemistry 169 (1), e16211 (2025)