Publications

Moore, S.; Subramanian, S.; Meschkat, M.; Hemesath, J. W.; Ruhwedel, T.; Möbius, W.; Nave, K.-A.; de Hoz, L.: Early Myelination Supports the Establishment of Consistent Handedness. Glia 74 (7), e70161 (2026)

Dyckow-Schubart, J.; Rabitsch, A. M.; Geywitz, C.; Mayer, C.; Lerma-Martin, C.; Ludwig, N.; Smith, M.; Potschka, H.; Calabresi, P. A.; Nave, K.-A. et al.; Friese, M. A.; Möbius, W.; Schirmer, L.: Oligodendrocyte Piezo2 is a regulator of age-dependent myelin integrity and dysregulated in multiple sclerosis. Communications Biology 9, 849 (2026)

Ignatyeva, N.; Cheruiyot, C.; Saleem, H. N.; Wali, R.; Plota, D.; Zhang, W.; Schön, S.; Brandenburg, S.; Yang, Z.; Steyer, A. et al.; Urlaub, H.; Rasmussen, T.; Mogensen, J.; Pronto, J. R. D.; Döring, Y.; Radke, M. H.; Shcherbata, H.; Lehnart, S. E.; Janshoff, A.; Sossalla, S.; Ruhwedel, T.; Möbius, W.; Toischer, K.; Brügger, B.; Haucke, V.; Gotthardt, M.; Voigt, N.; Ebert, A.: Targeting intracellular cholesterol imbalance rescues sarcomere–ER contact site signaling and ER remodeling in dilated cardiomyopathy. Signal Transduction and Targeted Therapy 11, 237 (2026)

Schmitz, M.; Thüne, K.; Fischer, A.; Hermann, P.; Cramm, M.; Kadel, L. S.; Möbius, W.; Matschke, J.; Saleem, T.; Younas, N. et al.; Zafar, S.; Altmeppen, H.; Glatzel, M.; Zerr, I.: Evidence for different seeding activities of misfolded tau in classical and rapidly progressive Alzheimer's disease. Brain Pathology 36 (3), e70054 (2026)

Saleem, T.; Möbius, W.; Schmitz, M.; da Silva Correia, A.; Thomas, C.; Canaslan, S.; Hermann, P.; Göbel, S.; Zafar, S.; Root, E. et al.; Stadelmann, C.; Andreoletti, O.; Hoppert, M.; Fleming Outeiro, T.; Ferrer, I.; Younas, N.; Zerr, I.: A distinct tau oligomer strain defines the molecular and proteomic landscape of rapidly progressive Alzheimer’s disease. Acta Neuropathologica 151, 27 (2026)

Hümmert, S.; de Faria, J. P.; Jahn, O.; Bilgin, E.; Łukasik, N.; Rao, C.; Mitkovski, M.; Benseler, F.; Brose, N.; Siems, S. B. et al.; Goebbels, S.; Möbius, W.; Ewers, H.; Relvas, J. B.; Werner, H. B.: CDC42-Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity. Glia 74 (3), e70134 (2026)

Canaslan, S.; Schmitz, M.; Maass, F.; Hermann, P.; Da Silva Correia, S.; Zhang, S.; Popper, B.; Möbius, W.; van Riesen, C.; Parchi, P. et al.; Lingor, P.; Zerr, I.: Detection of alpha-synuclein seeding activity in tear fluid in patients with Parkinson’s disease. npj Parkinson's Disease 12, 66 (2026)

Dereddi, R. R.; Djannatian, M.; Fiore, F.; Kalita, D.; Verkest, C.; Torres, F. B.; Möbius, W.; Khodaie, B.; Ruhwedel, T.; Alhalaseh, K. et al.; Schifferer, M.; Wirth, A.; Hill, A.; Ottenheijm, R.; Patrizi, A.; Kann, O.; Lechner, S. G.; Freichel, M.; Agarwal, A.: Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry. Neuron 114 (4), pp. 699 - 723.e11 (2026)

Choezom, D.; Notter, S.; Griebel, T.; Ferreira, N.; Gruetz, J.; Kulkarni, A.; Schröter, M.; Lukinavičius, G.; Möbius, W.; Conradi, L.-C. et al.; Feldmann, C.; Alves, F.: Macropinocytic Uptake and pH-Responsive Endolysosomal Processing Drive Sustained Chemotherapeutic Efficacy of High-Load Core@Shell Nanocarriers in Colorectal Cancer. Small Science 6 (1), e202500470 (2026)

Ries, C.; Stark, T.; Boulat, B.; Ruhwedel, T.; Delling, J. P.; Infante, A. M.; von Poblotzki, J. T.; Ulivi, A.; von Mucke-Heim, I.-A.; Chang, S. et al.; Sakimura, K.; Itoi, K.; Nestvogel, D. B.; Attardo, A.; Czisch, M.; Nave, K.-A.; Möbius, W.; Dimou, L.; Deussing, J. M.: Neuropeptide CRH prevents premature differentiation of OPCs following CNS injury and in early postnatal development. Cell Reports 44 (11), 116474 (2025)

Kapoor, R.; Kim, H.; Garlick, E.; Lima, M. A. d. R. B. F.; Esch, K.; Ruhwedel, T.; Möbius, W.; Wolf, F.; Moser, T.: Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy. Science Advances 11 (45), eady4344 (2025)

Fernandez Flores, L. C.; Younas, N.; Goebel, S.; Dittmar, K.; Saleem, T.; Younas, A.; Budde, H.; Legler, T. J.; Möbius, W.; Hermann, P. et al.; Schmitz, M.; Zerr, I.: Multiple Antibody-Coated Gold Nanoparticle-Based ExoAssay for Rapid Isolation of CNS-Specific Exosomes From Blood. Journal of Neurochemistry 169 (10), e70263 (2025)

Ye, L.; Daguano Gastaldi, V.; Curto, Y.; Wildenburg, A.-F.; Yu, X.; Hindermann, M.; Eggert, S.; Ronnenberg, A.; Wang, Q.; Butt, U. J. et al.; Kawaguchi, R.; Geschwind, D.; Möbius, W.; Boretius, S.; Singh, M.; Nave, K. A.; Ehrenreich, H.: Transcriptional dynamics of the oligodendrocyte lineage and its regulation by the brain erythropoietin system. Nature Communications 16, 8291 (2025)

Jansari, S.; Blandau, A.; Prokakis, E.; Grimm, D.; Naßl, A. M.; Küffer, S.; Möbius, W.; Dullin, C.; Ramos Gomes, F.; Schüürhuis, L. et al.; Fritsche, L.; Schridde, L.; Plessner, M.; Bast, C. A.; Gayer, F. A.; Thoms, S.; Gallwas, J.; Wegwitz, F.: RNF20/RNF40 supports the aggressive behavior in cervical cancer by regulating a peroxisome-based anti-ferroptotic mechanism. Cell Communication and Signaling 23, 304 (2025)

Schneeberger, S.; Kim, S. J.; Geesdorf, M. N.; Friebel, E.; Eede, P.; Jendrach, M.; Boltengagen, A.; Braeuning, C.; Ruhwedel, T.; Hülsmeier, A. J. et al.; Gimber, N.; Foerster, M.; Obst, J.; Andreadou, M.; Mundt, S.; Schmoranzer, J.; Prokop, S.; Kessler, W.; Kuhlmann, T.; Möbius, W.; Nave, K.-A.; Hornemann, T.; Becher, B.; Edgar, J. M.; Karaiskos, N.; Kocks, C.; Rajewsky, N.; Heppner, F. L.: Interleukin-12 signaling drives Alzheimer’s disease pathology through disrupting neuronal and oligodendrocyte homeostasis. Nature aging 5, pp. 622 - 641 (2025)

Garg, V.; Möbius, W.; Heinrich, R.; Ruhwedel, T.; Perera, R. P.; Scholz, P.; Ischebeck, T.; Salinas, G.; Dullin, C.; Göpfert, M. C. et al.; Engelmann, J.; Dosch, R.; Geurten, B. R. H.: Patient-specific mutation of a contact site protein Tomm70 causes neurodegeneration in a zebrafish model. Disease Models & Mechanisms 18 (4), dmm052029 (2025)

Lohrberg, M.; Mortensen, L. S.; Thomas, C.; Fries, F.; van der Meer, F.; Götz, A.; Landt, C.; Rhee, H. J.; Rhee, J. S.; Gómez-Varela, D. et al.; Schmidt, M.; Möbius, W.; Ruhwedel, T.; Pardo, L. A.; Remling, L.; Kramann, N.; Wrzos, C.; Bahn, E.; Stadelmann, C.; Barrantes-Freer, A.: Astroglial modulation of synaptic function in the non-demyelinated cerebellar cortex is dependent on MyD88 signaling in a model of toxic demyelination. Journal of Neuroinflammation 22, 47 (2025)

Garg, V.; André, S.; Heyer, L.; Kracht, G.; Ruhwedel, T.; Scholz, P.; Ischebeck, T.; Werner, H. B.; Dullin, C.; Engelmann, J. et al.; Möbius, W.; Göpfert, M. C.; Dosch, R.; Geurten, B. R. H.: Axon demyelination and degeneration in a zebrafish spastizin model of hereditary spastic paraplegia. Open Biology 14 (11), 240100 (2024)

Notter, S.; Choezom, D.; Griebel, T.; Ramos Gomes, F.; Möbius, W.; De Oliveira, T.; Conradi, L.-C.; Alves, F.; Feldmann, C.: High-Load Core@Shell Nanocarriers with Irinotecan and 5-Fluorouracil for Combination Chemotherapy in Colorectal Cancer. Small Science 4 (11), 2400196 (2024)

Asadollahi, E.; Trevisiol, A.; Saab, A. S.; Looser, Z. J.; Dibaj, P.; Ebrahimi, R.; Kusch, K.; Ruhwedel, T.; Möbius, W.; Jahn, O. et al.; Lee, J. Y.; Don, A. S.; Khalil, M.-A.; Hiller, K.; Baes, M.; Weber, B.; Abel, E. D.; Ballabio, A.; Popko, B.; Kassmann, C. M.; Ehrenreich, H.; Hirrlinger, J.; Nave, K.-A.: Oligodendroglial fatty acid metabolism as a central nervous system energy reserve. Nature Neuroscience 27, pp. 1934 - 1944 (2024)