Journal Article (294)

101.
Journal Article
Fonseca-Ornelas, L.; Schmidt, C. D.; Camacho-Zarco, A. R.; Fernandez, C. O.; Becker, S.; Zweckstetter, M.: Small molecule-induced soluble oligomers of α-synuclein with helical structure. Chemistry. A European Journal 23 (53), pp. 13010 - 13014 (2017)
102.
Journal Article
Miotto, M. C.; Pavese, M. D.; Quintanar, L.; Zweckstetter, M.; Griesinger, C.; Fernández, C. O.: Bioinorganic chemistry of Parkinson's disease: Affinity and structural features of Cu(I) binding to the full-length β-synuclein protein. Inorganic Chemistry 56 (17), pp. 10387 - 10395 (2017)
103.
Journal Article
Rahban, M.; Salehi, N.; Saboury, A. A.; Hosseinkhani, S.; Karimi-Jafari, M. H.; Firouzi, R.; Rezaei-Ghaleh, N.; Moosavi-Movahedi, A. A.: Histidine substitution in the most flexible fragments of firefly luciferase modifies its thermal stability. Archives of Biochemistry and Biophysics 629, pp. 8 - 18 (2017)
104.
Journal Article
Ambadipudi, S.; Biernat, J.; Riedel, D.; Mandelkow, E.; Zweckstetter, M.: Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau. Nature Communications 8, 275 (2017)
105.
Journal Article
Rezaei-Ghaleh, N.; Bakhtiari, D.; Rashidi, A.: Reverse allostasis in biological systems: Minimal conditions and implications. Journal of Theoretical Biology 426, pp. 134 - 139 (2017)
106.
Journal Article
Baker, J. D.; Shelton, L. B.; Zheng, D. L.; Favretto, F.; Nordhues, B. A.; Darling, A.; Sullivan, L. E.; Sun, Z. Y.; Solanki, P. K.; Martin, M. D. et al.; Suntharalingam, A.; Sabbagh, J. J.; Becker, S.; Mandelkow, E.; Uversky, V. N.; Zweckstetter, M.; Dickey, C. A.; Koren, J.; Blair, L. J.: Human cyclophilin 40 unravels neurotoxic amyloids. PLoS Biology 15 (6), e2001336 (2017)
107.
Journal Article
Vincente Miranda, H.; Szego, E. M.; Oliveira, L. M.; Breda, C.; Darendelioglu, E.; de Oliveira, R. M.; Ferreira, D. G.; Gomes, M. A.; Rott, R.; Oliveira, M. et al.; Munari, F.; Enguita, F. J.; Simoes, T.; Rodrigues, E. F.; Heinrich, M.; Martins, I. C.; Zamolo, I.; Riess, O.; Cordeiro, C.; Ponces-Freire, A.; Lashuel, H. A.; Santos, N. C.; Lopes, L. V.; Xiang, W.; Jovin, T. M.; Penque, D.; Engelender, S.; Zweckstetter, M.; Klucken, J.; Giorgini, F.; Quintas, A.; Outeiro, T. F.: Glycation potentiates alpha-synuclein-associated neurodegeneration in synucleinopathies. Brain 140 (5), pp. 1399 - 1419 (2017)
108.
Journal Article
Zweckstetter, M.; Requena, J. R.; Wille, H.: Elucidating the structure of an infectious protein. PLoS Pathogens 13 (4), e1006229 (2017)
109.
Journal Article
Oroz, J.; Kim, J. H.; Chang, B. J.; Zweckstetter, M.: Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90. Nature Structural and Molecular Biology 24 (4), pp. 407 - 413 (2017)
110.
Journal Article
de Oliveira, R. M.; Miranda, H. V.; Francelle, L.; Pinho, R.; Szegö, E. M.; Martinho, R.; Munari, F.; Lázaro, D. F.; Moniot, S.; Guerreiro, P. et al.; Fonseca, L.; Marijanovic, Z.; Antas, P.; Gerhardt, E.; Enguita, F. J.; Fauvet, B.; Penque, D.; Pais, T. F.; Tong, Q.; Becker, S.; Kügler, S.; Lashuel, H. A.; Steegborn, C.; Zweckstetter, M.; Outeiro, T. F.: The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS Biology 15 (3), e2000374 (2017)
111.
Journal Article
Kim, J. H.; Oroz, J.; Zweckstetter, M.: Structure of monomeric transthyretin carrying the clinically important T119M mutation. Angewandte Chemie International Edition 55 (52), pp. 16168 - 16171 (2016)
112.
Journal Article
Gray, F.; Cho, H. J.; Shukla, S.; He, S.; Harris, A.; Boytsov, B.; Jaremko, L.; Jaremko, M.; Demeler, B.; Lawlor, E. R. et al.; Grembecka, J.; Cierpicki, T.: BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization. Nature Communications 7, 13343 (2016)
113.
Journal Article
Villar-Piquéa, A.; da Fonsecaa, T. L.; Sant’Annab, R.; Szegöa, E. M.; Fonseca-Ornelas, L.; Pinhoa, R.; Carijac, A.; Gerhardta, E.; Masaracchiaa, C.; Gonzalezf, E. A. et al.; Rossettif, G.; Carlonif, P.; Fernándezi, C. O.; Foguelb, D.; Milosevick, I.; Zweckstetter, M.; Venturac, S.; Outeiro, T. F.: Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. Proceedings of the National Academy of Sciences of the United States of America 113 (42), pp. E6506 - E6515 (2016)
114.
Journal Article
Riechers, B.; Maes, F.; Akoury, E.; Semin, B.; Gruner, P.; Baret, J. C.: Surfactant adsorption kinetics in microfluidics. Proceedings of the National Academy of Sciences of the United States of America 113 (41), pp. 11465 - 11470 (2016)
115.
Journal Article
Villar-Piqué, A.; da Fonseca, T. L.; Sant’Anna, R.; Szegö, E. M.; Fonseca-Ornelas, L.; Pinho, R.; Carija, A.; Gerhardt, E.; Masaracchia, C.; Gonzalezf, E. A. et al.; Rossetti, G.; Carloni, P.; Fernández, C. O.; Foguel, D.; Milosevic, I.; Zweckstetter, M.; Ventura, S.; Outeiro, T. F.: Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. Proceedings of the National Academy of Sciences of the United States of Amerca 113 (42), pp. E6506 - E6515 (2016)
116.
Journal Article
Briones, R.; Weichbrodt, C.; Paltrinieri, L.; Mey, I.; Villinger, S.; Giller, K.; Lange, A.; Zweckstetter, M.; Griesinger, C.; Becker, S. et al.; Steinem, C.; de Groot, B. L.: Voltage dependence of conformational dynamics and subconducting states of VDAC-1. Biophysical Journal 111 (6), pp. 1223 - 1234 (2016)
117.
Journal Article
Oroz, J.; Barrera-Vilarmau, S.; Alfonso, C.; Rivas, G.; de Alba, E.: ASC pyrin domain self-associates and binds NLRP3 protein using equivalent binding interfaces. Journal of Biological Chemistry 291 (37), pp. 19487 - 19501 (2016)
118.
Journal Article
Jaremko, M.; Jaremko, L.; Villinger, S.; Schmidt, C. D.; Griesinger, C.; Becker, S.; Zweckstetter, M.: High-resolution NMR determination of the dynamic structure of membrane proteins. Angewandte Chemie International Edition 55 (35), pp. 101518 - 10521 (2016)
119.
Journal Article
Fonseca-Ornelas, L.; Zweckstetter, M.: The protonation state of histidine 111 regulates the aggregation of the evolutionary most conserved region of the human prion protein. Protein Science 25 (8), pp. 1563 - 1567 (2016)
120.
Journal Article
Rezaei-Ghaleh, N.; Kumar, S.; Walter, J.; Zweckstetter, M.: Phosphorylation interferes with maturation of amyloid-β fibrillar structure in the N terminus. Journal of Biological Chemistry 291 (31), pp. 16059 - 16067 (2016)
121.
Journal Article
Beyer, I.; Rezaei-Ghaleh, N.; Klafki, H. W.; Jahn, O.; Haussmann, U.; Wiltfang, J.; Zweckstetter, M.; Knölker, H. J.: Solid-phase synthesis and characterization of N-terminally elongated A beta(-3-x)-peptides. Chemistry-A European Journal 22 (25), pp. 8685 - 8693 (2016)
122.
Journal Article
Akoury, E.; Mukrasch, M.; Biernat, J.; Tepper, K.; Ozenne, V.; Mandelkow, E.; Blackledge, M.; Zweckstetter, M.: Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer. Protein Science 25 (5), pp. 1010 - 1020 (2016)
123.
Journal Article
Tatenhorst, L.; Eckermann, K.; Dambeck, V.; Fonseca-Ornelas, L.; Walle, H.; da Fonseca, T. L.; Koch, J. C.; Becker, S.; Toenges, L.; Bahr, M. et al.; Outeiro, T. F.; Zweckstetter, M.; Lingor, P.: Fasudil attenuates aggregation of alpha-synuclein in models of Parkinson's disease. Acta Neuropathologica Communications 4, 39 (2016)
124.
Journal Article
Rezaei-Ghaleh, N.; Amininasab, M.; Kumar, S.; Walter , J.; Zweckstetter, M.: Phosphorylation modifies the molecular stability of beta-amyloid deposits. Nature Communications 7, 11359 (2016)
125.
Journal Article
Ge, L.; Villinger, S.; Mari, S. A.; Giller, K.; Griesinger, C.; Becker, S.; Müller, D. J.; Zweckstetter, M.: Molecular plasticity of the human Voltage-Dependent Anion Channel embedded into a membrane. Structure 24 (4), pp. 585 - 594 (2016)
126.
Journal Article
Oroz, J.; Bruix, M.; Laurents, D. V.; Galera-Prat, A.; Schönfelder, J.; Canada, F. J.; Carrion-Vazquez, M.: The Y9P variant of the titin I27 module: Structural determinants of its revisited nanomechanics. Structure 24 (4), pp. 606 - 616 (2016)
127.
Journal Article
Jaremko, M.; Jaremko, L.; Giller, K.; Becker, S.; Zweckstetter, M.: Backbone and side-chain resonance assignment of the A147T polymorph of mouse TSPO in complex with a high-affinity radioligand. Biomolecular NMR Assignments 10 (1), pp. 79 - 83 (2016)
128.
Journal Article
Kumar, S.; Wirths, O.; Stüber, K.; Wunderlich, P.; Koch, P.; Theil, S.; Rezaei-Ghaleh, N.; Zweckstetter, M.; Bayer, T. A.; Bruestle, O. et al.; Thal, D. R.; Walter, J.: Phosphorylation of the amyloid beta-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity. Acta Neuropathologica 131 (4), pp. 525 - 537 (2016)
129.
Journal Article
Sadowska-Bartosz, I.; Szewczyk, R.; Jaremko, L.; Jaremko, M.; Bartosz, G.: Anticancer agent 3-bromopyruvic acid forms a conjugate with glutathione. Pharmacological Reports 68 (2), pp. 502 - 505 (2016)
130.
Journal Article
Tenreiro, S.; Rosado-Ramos, R.; Gerhardt, E.; Favretto, F.; Magalhães, F.; Popova, B.; Becker, S.; Zweckstetter, M.; Braus, G. H.; Outeiro, T. F.: Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity. Human Molecular Genetics 25 (2), pp. 275 - 290 (2016)
131.
Journal Article
Ambadipudi, S.; Zweckstetter, M.: Targeting intrinsically disordered proteins in rational drug discovery. Expert Opinion on Drug Discocery 11 (1), pp. 65 - 77 (2016)
132.
Journal Article
Wysoczanski, P.; Zweckstetter, M.: Retention and splicing complex (RES) - the importance of cooperativity. RNA Biology 13 (2), pp. 128 - 133 (2016)
133.
Journal Article
Moree, B.; Yin, G.; Lazaro, D. F.; Munari, F.; Strohäker, T.; Giller, K.; Becker, S.; Outeiro, T. F.; Zweckstetter, M.; Salafsky, J.: Small molecules detected by second-harmonic generation modulate the conformation of monomeric α-synuclein and reduce its aggregation in cell. Journal of Biological Chemistry 290 (46), pp. 27582 - 27593 (2015)
134.
Journal Article
Rauscher, S.; Gapsys, V.; Gajda, M. J.; Zweckstetter, M.; de Groot, B. L.; Grubmüller, H.: Structural ensembles of intrinsically disordered proteins depend strongly on force field: A comparison to experiment. Journal of Chemical Theory and Computation 11 (11), pp. 5513 - 5524 (2015)
135.
Journal Article
Jaremko, L.; Jaremko, M.; Giller, K.; Becker, S.; Zweckstetter, M.: Conformational flexibility in the transmembrane protein TSPO. Chemistry-A European Journal 21 (46), pp. 16555 - 16563 (2015)
136.
Journal Article
Gapsys, V.; Narayanan, R. L.; Xiang, S.; de Groot, B. L.; Zweckstetter, M.: Improved validation of IDP ensembles by one-bond Cα-Hα scalar couplings. Journal of Biomolecular NMR 63 (3), pp. 299 - 307 (2015)
137.
Journal Article
Kadavath, H.; Jaremko, M.; Jaremko, L.; Biernat, J.; Mandelkow, E.; Zweckstetter, M.: Folding of the Tau protein on microtubules. Angewandte Chemie International Edition 54 (35), pp. 10347 - 10351 (2015)
138.
Journal Article
Schwalbe, M.; Kadavath, H.; Biernat, J.; Ozenne, V.; Blackledge, M.; Mandelkow, E.; Zweckstetter, M.: Structural impact of Tau phosphorylation at threonine 231. Structure 23 (8), pp. 1448 - 1458 (2015)
139.
Journal Article
Jaremko, M.; Jaremko, L.; Jaipuria, G.; Becker, S.; Zweckstetter, M.: Structure of the mammalian TSPO/PBR protein. Biochemical Society Transactions 43 (4), pp. 566 - 571 (2015)
140.
Journal Article
Wysoczanski, P.; Becker, S.; Zweckstetter, M.: Structures of intermediates during RES complex assembly. Scientific Reports 5, 12545 (2015)
141.
Journal Article
Fontaine, S. N.; Martin, M. D.; Akoury, E.; Assimon, V. A.; Borysov, S.; Nordhues, B. A.; Sabbagh, J. J.; Cockman, M.; Gestwicki, J. E.; Zweckstetter, M. et al.; Dickey, C. A.: The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics. Human Molecular Genetics 24 (14), pp. 3971 - 3981 (2015)
142.
Journal Article
Jaremko, M.; Jaremko, L.; Giller, K.; Becker, S.; Zweckstetter, M.: Structural integrity of the A147T polymorph of mammalian TSPO. ChemBioChem 16 (10), pp. 1483 - 1489 (2015)
143.
Journal Article
Gut, P.; Zweckstetter, M.; Banati, R. B.: Lost in translocation: The functions of the 18-kD translocator protein. Trends in Endocrinology and Metabolism 26 (7), pp. 349 - 356 (2015)
144.
Journal Article
Kadavath, H.; Hofele, R. V.; Biernat, J.; Kumar, S.; Tepper, K.; Urlaub, H.; Mandelkow, E.; Zweckstetter, M.: Tau stabilizes microtubules by binding at the interface between tubulin heterodimers. Proceedings of the National Academy of Sciences of the United States of America 112 (24), pp. 7501 - 7506 (2015)
145.
Journal Article
Kunadt, M.; Eckermann, K.; Stuendl, A.; Gong, J.; Russo, B.; Strauss, K.; Rai, S.; Kügler, S.; Falomir Lockhart, L. J.; Schwalbe, M. et al.; Krumova, P.; Oliveira, L. M. A.; Bähr, M.; Möbius, W.; Levin, J.; Giese, A.; Kruse, N.; Mollenhauer, B.; Geiss-Friedlander, R.; Ludolph, A. C.; Freischmidt, A.; Feiler, M. S.; Danzer, K. M.; Zweckstetter, M.; Jovin, T. M.; Simons, M.; Weishaupt, J. H.; Schneider, A.: Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation. Acta Neuropathologica 129 (5), pp. 695 - 713 (2015)
146.
Journal Article
Rezaei-Ghaleh, N.; Klama, F.; Munari, F.; Zweckstetter, M.: HYCUD: A computational tool for prediction of effective rotational correlation time in flexible proteins. Bioinformatics 31 (8), pp. 1319 - 1321 (2015)
147.
Journal Article
Mbefo, M. K.; Fares, M. B.; Paleologou, K.; Oueslati, A.; Yin, G.; Tenreiro, S.; Pinto, M.; Outeiro, T.; Zweckstetter, M.; Masliah, E. et al.; Lashuel, H. A.: Parkinson disease mutant E46K enhances alpha-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo. Journal of Biological Chemistry 290 (15), pp. 9412 - 9427 (2015)
148.
Journal Article
Gattin, Z.; Schneider, R.; Laukat, Y.; Giller, K.; Maier, E.; Zweckstetter, M.; Griesinger, C.; Benz, R.; Becker, S.; Lange, A.: Solid-state NMR, electrophysiology and molecular dynamics characterization of human VDAC2. Journal of Biomolecular NMR 61 (3-4), pp. 311 - 320 (2015)
149.
Journal Article
Camacho-Zarco, A. R.; Munari, F.; Wegstroth, M.; Liu, W. M.; Ubbink, M.; Becker, S.; Zweckstetter, M.: Multiple paramagnetic effects through a tagged reporter protein. Angewandte Chemie International Edition 54 (1), pp. 336 - 339 (2015)
150.
Journal Article
Delshad, M.; Ghanbarian, A.; Rezaei-Ghaleh, N.; Amirshekari, G.; Askari, S.; Azizi, F.: Reliability and validity of the modifiable activity questionnaire for an Iranian urban adolescent population. International Journal of Preventive Medicine 6 (1), 3 (2015)
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