Publications
Journal Article (245)
1.
Journal Article
23 (21), 13185 (2022)
Metal Binding to Sodium Heparin Monitored by Quadrupolar NMR. International Journal of Molecular Sciences 2.
Journal Article
24 (10), pp. 6169 - 6175 (2022)
Dynamical component exchange in a model phase separating system: an NMR-based approach. PhysChemChemPhys 3.
Journal Article
298 (3), 101662 (2022)
The calcium-free form of atorvastatin inhibits amyloid-β(1–42) aggregation in vitro. Journal of Biological Chemistry 4.
Journal Article
159 (3), pp. 554 - 573 (2021)
Brain iron enrichment attenuates α-synuclein spreading after injection of preformed fibrils. Journal of Neurochemistry 5.
Journal Article
7, 65 (2021)
Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease. NPJ Parkinsons Disease 6.
Journal Article
12, 4231 (2021)
Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils. Nature Communications 7.
Journal Article
30 (7), pp. 1294 - 1314 (2021)
Liquid–liquid phase separation of tau: From molecular biophysics to physiology and disease. Protein Science 8.
Journal Article
15, 643391 (2021)
Low-Expressing synucleinopathy mouse models based on oligomer-forming mutations and C-terminal truncation of α-synuclein. Frontiers in Neuroscience 9.
Journal Article
12, 3396 (2021)
Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis. Nature Communications 10.
Journal Article
13, 635760 (2021)
Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity. Frontiers in Aging Neuroscience 11.
Journal Article
50 (2), pp. 107 - 108 (2021)
Special issue: Multicomponent lipid membranes—how molecular organisation leads to function. European Biophysics Journal 12.
Journal Article
78 (5), pp. 2355 - 2370 (2021)
Cooperativity of membrane-protein and protein–protein interactions control membrane remodeling by epsin 1 and affects clathrin-mediated endocytosis. Cellular and Molecular Life Sciences 13.
Journal Article
50 (2), pp. 159 - 172 (2021)
Structure, gating and interactions of the voltage-dependent anion channel. European Biophysics Journal 14.
Journal Article
50 (2), pp. 173 - 180 (2021)
Membrane-embedded TSPO: an NMR view. European Biophysics Journal 15.
Journal Article
A novel SNCA A30G mutation causes familial Parkinsonʼs disease. Movement Disorders, In Press (2021)
16.
Journal Article
125 (5), pp. 1378 - 1391 (2021)
Structural Flexibility of Cyclosporine A Is Mediated by Amide Cis–Trans Isomerization and the Chameleonic Roles of Calcium. Journal of Physical Chemistry B 17.
Journal Article
Interplay between tau and α‐synuclein liquid–liquid phase separation. Protein Science, In Press (2021)
18.
Journal Article
60 (2), pp. 726 - 730 (2021)
Disease‐associated tau phosphorylation hinders tubulin assembly within tau condensates. Angewandte Chemie International Edition 19.
Journal Article
10, 21210 (2020)
Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils. Scientific Reports 20.
Journal Article
29 (12), pp. 2422 - 2432 (2020)
Molecular basis of the interaction of Hsp90 with its co‐chaperone Hop. Protein Science 21.
Journal Article
11, 6046 (2020)
Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war. Nature Communications 22.
Journal Article
11, 6041 (2020)
Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates. Nature Communications 23.
Journal Article
10, 12827 (2020)
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization. Scientific Reports 24.
Journal Article
6 (30), eaba3916 (2020)
Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution. Science Advances 25.
Journal Article
11, 2729 (2020)
A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol. Nature Communications 26.
Journal Article
59 (15), pp. 6172 - 6176 (2020)
Determination of complex small molecule structures using molecular alignment simulation. Angewandte Chemie International Edition 27.
Journal Article
132 (14), pp. 5692 - 5695 (2020)
Molecular basis of the interaction of cyclophilin A with alpha-synuclein. Angewandte Chemie International Edition 28.
Journal Article
99, pp. 202 - 214 (2020)
Biomolecular condensation of the microtubule-associated protein tau. Seminars in Cell and Developmental Biology 29.
Journal Article
117 (6), pp. 2948 - 2956 (2020)
Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2. Proceedings of the National Academy of Sciences of the United States of America 30.
Journal Article
1868 (1), 140298 (2020)
Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies. Biochimica et Biophysica Acta-Proteins and Proteomics 31.
Journal Article
10, 5535 (2019)
Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts. Nature Communications 32.
Journal Article
269 (8), pp. 973 - 984 (2019)
Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer's disease from bioptic olfactory mucosa. European Archives of Psychiatry and Clinical Neuroscience 33.
Journal Article
107, pp. 3 - 5 (2019)
Towards a consensus on developmental regression. Neuroscience and Biobehavioral Reviews 34.
Journal Article
138 (3), pp. 415 - 441 (2019)
Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models. Acta Neuropathologica 35.
Journal Article
28 (9), pp. 1545 - 1551 (2019)
Dynamic Aha1 co-chaperone binding to human Hsp90. Protein Science 36.
Journal Article
10 (26), pp. 6503 - 6507 (2019)
Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau. Chemical Science 37.
Journal Article
10 (1), 2909 (2019)
Lysine/RNA-interactions drive and regulate biomolecular condensation. Nature Communications 38.
Journal Article
10, pp. 3369 - 3375 (2019)
Reorientational dynamics of amyloid-β from NMR spin relaxation and molecular simulation. Journal of Physical Chemistry Letters 39.
Journal Article
46 (6), pp. 1208 - 1211 (2019)
In response to: The validity of 18F-GE180 as a TSPO imaging agent. European Journal of Nuclear Medicine and Molecular Imaging 40.
Journal Article
39 (19), pp. 3752 - 3769 (2019)
Translocator protein ligand protects against neurodegeneration in the MPTP mouse model of Parkinsonism. Journal of Neuroscience 41.
Journal Article
9 (3), 105 (2019)
Structure and functions of microtubule associated proteins tau and MAP2c: Similarities and differences. Biomolecules 42.
Journal Article
98, pp. 1 - 9 (2019)
Upregulated levels and pathological aggregation of abnormally phosphorylated Tau-Protein in children with neurodevelopmental disorders. Neuroscience and Biobehavioral Reviews 43.
Journal Article
24 (66), pp. 17606 - 17611 (2018)
Insights into cholesterol/membrane protein interactions using paramagnetic solid-state NMR. Chemistry - A European Journal 44.
Journal Article
57 (46), pp. 15262 - 15266 (2018)
Local and global dynamics in intrinsically disordered synuclein. Angewandte Chemie International Edition 45.
Journal Article
9, 4532 (2018)
Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex. Nature Communications 46.
Journal Article
10 (10), pp. 1383 - 1389 (2018)
Interaction of Cu(i) with the Met-X3-Met motif of alpha-synuclein: Binding ligands, affinity and structural features. Metallomics 47.
Journal Article
25 (9), pp. 833 - 840 (2018)
RNA polymerase II clustering through carboxy-terminal domain phase separation. Nature Structural and Molecular Biology 48.
Journal Article
293 (34), pp. 13297 - 13309 (2018)
Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics. Journal of Biological Chemistry 49.
Journal Article
285 (11), pp. 1988 - 2003 (2018)
The solution structure of monomeric CCL5 in complex with a doubly sulfated N-terminal segment of CCR5. FEBS Journal 50.
Journal Article
75 (12), pp. 2137 - 2151 (2018)
Challenges and approaches to understand cholesterol-binding impact on membrane protein function: An NMR view. Cellular and Molecular Life Sciences 51.
Journal Article
10 (19), pp. 9174 - 9185 (2018)
The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease. Nanoscale 52.
Journal Article
25 (5), pp. 384 - 393 (2018)
Mapping interactions with the chaperone network reveals factors that protect against tau aggregation. Nature Structural and Molecular Biology 53.
Journal Article
57 (12), pp. 3246 - 3250 (2018)
The binding mode of a repeat-like Tau sequence with tubulin. Angewandte Chemie International Edition 54.
Journal Article
11, 49 (2018)
Pathophysiological consequences of neuronal alpha-Synuclein overexpression: Impacts on ion homeostasis, stress signaling, mitochondrial integrity, and electrical activity. Frontiers in Molecular Neuroscience 55.
Journal Article
25 (4), pp. 462 - 477 (2018)
Monitoring interactions inside cells by advanced spectroscopies: Overview of copper transporters and cisplatin. Current Medicinal Chemistry 56.
Journal Article
10 (1), pp. 32 - 47 (2018)
The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology. EMBO Molecular Medicine 57.
Journal Article
8, 1981 (2017)
Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau. Nature Communications 58.
Journal Article
21 (8), pp. 2118 - 2133 (2017)
Capture of dense core vesicles at synapses by JNK-dependent phosphorylation of Synaptotagmin-4. Cell Reports 59.
Journal Article
23 (53), pp. 13010 - 13014 (2017)
Small molecule-induced soluble oligomers of α-synuclein with helical structure. Chemistry. A European Journal 60.
Journal Article
56 (17), pp. 10387 - 10395 (2017)
Bioinorganic chemistry of Parkinson's disease: Affinity and structural features of Cu(I) binding to the full-length β-synuclein protein. Inorganic Chemistry 61.
Journal Article
8, 275 (2017)
Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau. Nature Communications 62.
Journal Article
426, pp. 134 - 139 (2017)
Reverse allostasis in biological systems: Minimal conditions and implications. Journal of Theoretical Biology 63.
Journal Article
15 (6), e2001336 (2017)
Human cyclophilin 40 unravels neurotoxic amyloids. PLoS Biology 64.
Journal Article
140 (5), pp. 1399 - 1419 (2017)
Glycation potentiates alpha-synuclein-associated neurodegeneration in synucleinopathies. Brain 65.
Journal Article
13 (4), e1006229 (2017)
Elucidating the structure of an infectious protein. PLoS Pathogens 66.
Journal Article
24 (4), pp. 407 - 413 (2017)
Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90. Nature Structural and Molecular Biology 67.
Journal Article
15 (3), e2000374 (2017)
The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS Biology 68.
Journal Article
55 (52), pp. 16168 - 16171 (2016)
Structure of monomeric transthyretin carrying the clinically important T119M mutation. Angewandte Chemie International Edition 69.
Journal Article
113 (42), pp. E6506 - E6515 (2016)
Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. Proceedings of the National Academy of Sciences of the United States of America 70.
Journal Article
113 (42), pp. E6506 - E6515 (2016)
Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. Proceedings of the National Academy of Sciences of the United States of Amerca 71.
Journal Article
111 (6), pp. 1223 - 1234 (2016)
Voltage dependence of conformational dynamics and subconducting states of VDAC-1. Biophysical Journal 72.
Journal Article
55 (35), pp. 101518 - 10521 (2016)
High-resolution NMR determination of the dynamic structure of membrane proteins. Angewandte Chemie International Edition 73.
Journal Article
25 (8), pp. 1563 - 1567 (2016)
The protonation state of histidine 111 regulates the aggregation of the evolutionary most conserved region of the human prion protein. Protein Science 74.
Journal Article
291 (31), pp. 16059 - 16067 (2016)
Phosphorylation interferes with maturation of amyloid-β fibrillar structure in the N terminus. Journal of Biological Chemistry 75.
Journal Article
22 (25), pp. 8685 - 8693 (2016)
Solid-phase synthesis and characterization of N-terminally elongated A beta(-3-x)-peptides. Chemistry-A European Journal 76.
Journal Article
25 (5), pp. 1010 - 1020 (2016)
Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer. Protein Science 77.
Journal Article
4, 39 (2016)
Fasudil attenuates aggregation of alpha-synuclein in models of Parkinson's disease. Acta Neuropathologica Communications 78.
Journal Article
7, 11359 (2016)
Phosphorylation modifies the molecular stability of beta-amyloid deposits. Nature Communications 79.
Journal Article
24 (4), pp. 585 - 594 (2016)
Molecular plasticity of the human Voltage-Dependent Anion Channel embedded into a membrane. Structure 80.
Journal Article
10 (1), pp. 79 - 83 (2016)
Backbone and side-chain resonance assignment of the A147T polymorph of mouse TSPO in complex with a high-affinity radioligand. Biomolecular NMR Assignments 81.
Journal Article
131 (4), pp. 525 - 537 (2016)
Phosphorylation of the amyloid beta-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity. Acta Neuropathologica 82.
Journal Article
25 (2), pp. 275 - 290 (2016)
Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity. Human Molecular Genetics 83.
Journal Article
11 (1), pp. 65 - 77 (2016)
Targeting intrinsically disordered proteins in rational drug discovery. Expert Opinion on Drug Discocery 84.
Journal Article
13 (2), pp. 128 - 133 (2016)
Retention and splicing complex (RES) - the importance of cooperativity. RNA Biology 85.
Journal Article
290 (46), pp. 27582 - 27593 (2015)
Small molecules detected by second-harmonic generation modulate the conformation of monomeric α-synuclein and reduce its aggregation in cell. Journal of Biological Chemistry 86.
Journal Article
11 (11), pp. 5513 - 5524 (2015)
Structural ensembles of intrinsically disordered proteins depend strongly on force field: A comparison to experiment. Journal of Chemical Theory and Computation 87.
Journal Article
21 (46), pp. 16555 - 16563 (2015)
Conformational flexibility in the transmembrane protein TSPO. Chemistry-A European Journal 88.
Journal Article
63 (3), pp. 299 - 307 (2015)
Improved validation of IDP ensembles by one-bond Cα-Hα scalar couplings. Journal of Biomolecular NMR 89.
Journal Article
54 (35), pp. 10347 - 10351 (2015)
Folding of the Tau protein on microtubules. Angewandte Chemie International Edition 90.
Journal Article
23 (8), pp. 1448 - 1458 (2015)
Structural impact of Tau phosphorylation at threonine 231. Structure 91.
Journal Article
43 (4), pp. 566 - 571 (2015)
Structure of the mammalian TSPO/PBR protein. Biochemical Society Transactions 92.
Journal Article
5, 12545 (2015)
Structures of intermediates during RES complex assembly. Scientific Reports 93.
Journal Article
24 (14), pp. 3971 - 3981 (2015)
The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics. Human Molecular Genetics 94.
Journal Article
16 (10), pp. 1483 - 1489 (2015)
Structural integrity of the A147T polymorph of mammalian TSPO. ChemBioChem 95.
Journal Article
26 (7), pp. 349 - 356 (2015)
Lost in translocation: The functions of the 18-kD translocator protein. Trends in Endocrinology and Metabolism 96.
Journal Article
112 (24), pp. 7501 - 7506 (2015)
Tau stabilizes microtubules by binding at the interface between tubulin heterodimers. Proceedings of the National Academy of Sciences of the United States of America 97.
Journal Article
129 (5), pp. 695 - 713 (2015)
Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation. Acta Neuropathologica 98.
Journal Article
31 (8), pp. 1319 - 1321 (2015)
HYCUD: A computational tool for prediction of effective rotational correlation time in flexible proteins. Bioinformatics 99.
Journal Article
290 (15), pp. 9412 - 9427 (2015)
Parkinson disease mutant E46K enhances alpha-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo. Journal of Biological Chemistry