Publications

Journal Article (294)

1.
Journal Article
Putko, P.; Romero, J. A.; Pantoja, C. F.; Zweckstetter, M.; Kazimierczuk, K.; Zawadzka-Kazimierczuk, A.: Using temperature coefficients to support resonance assignment of intrinsically disordered proteins. Journal of Biomolecular NMR 79, pp. 59 - 65 (2025)
2.
Journal Article
Chakraborty, P.; Zweckstetter, M.: Interplay of p23 with FKBP51 and their chaperone complex in regulating tau aggregation. Nature Communications 16, 669 (2025)
3.
Journal Article
Kulvicius, T.; Zhang, D.; Poustka, L.; Bölte, S.; Jahn, L.; Flügge, S.; Kraft, M.; Zweckstetter, M.; Nielsen-Saines, K.; Wörgötter, F. et al.; Marschik, P. B.: Deep learning empowered sensor fusion boosts infant movement classification. Communications Medicine 5, 16 (2025)
4.
Journal Article
Marvian, A.T.; Strauss, T.; Tang, Q.; Tuck, B.J.; Keeling, S.; Rüdiger, D.; Mirzazadeh Dizaji, N.; Mohammad-Beigi, H.; Nuscher, B.; Chakraborty, P. et al.; Sutherland, D.S.; McEwan, W.A.; Köglsperger, T.; Zahler, S.; Zweckstetter, M.; Lichtenthaler, S.F.; Wurst, W.; Schwarz, S.; Höglinger, G.: Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons. Molecular Neurodegeneration 19, 100 (2024)
5.
Journal Article
Chakraborty, P.; Ibáñez de Opakua, A.; Purslow, J. A.; Fromm, S. A.; Chatterjee, D.; Zachrdla, M.; Zhuang, S.; Puri, S.; Wolozin, B.; Zweckstetter, M.: GSK3β phosphorylation catalyzes the aggregation of tau into Alzheimer's disease-like filaments. Proceedings of the National Academy of Sciences of the United States of America 121 (52), e2414176121 (2024)
6.
Journal Article
Ukmar‐Godec, T.; Yu, T.; de Opakua, A. I.; Pantoja, C. F.; Munari, F.; Zweckstetter, M.: Conformational diversity of human HP1α. Protein Science 33 (7), e5079 (2024)
7.
Journal Article
Ibáñez de Opakua, A.; Pantoja, C. F.; Cima-Omori, M.-S.; Dienemann, C.; Zweckstetter, M.: Impact of distinct FG nucleoporin repeats on Nup98 self-association. Nature Communications 15, 3797 (2024)
8.
Journal Article
Antón, R.; Treviño, M.Á.; Pantoja-Uceda, D.; Félix, S.; Babu, M.; Cabrita, E.J.; Zweckstetter, M.; Tinnefeld, P.; Vera, A.M.; Oroz, J.: Alternative low-populated conformations prompt phase transitions in polyalanine repeat expansions. Nature Communications 15 (1), 1925 (2024)
9.
Journal Article
Zhuang, S.; Chakraborty, P.; Zweckstetter, M.: Regulation of tau by peptidyl-prolyl isomerases. Current Opinion in Structural Biology 84, 102739 (2024)
10.
Journal Article
Ukmar-Godec, T.; Cima-Omori, M.-S.; Yerkesh, Z.; Eswara, K.; Yu, T.; Ramesh, R.; Riviere, G.; de Opakua, A.I.; Fischle, W.; Zweckstetter, M.: Multimodal interactions drive chromatin phase separation and compaction. Proceedings of the National Academy of Sciences of the United States of America 120 (50), e2308858120 (2023)
11.
Journal Article
Shen, Z.; Sun, D.; Savastano, A.; Varga, S. J.; Cima-Omori, M.-S.; Becker, S.; Honigmann, A.; Zweckstetter, M.: Multivalent Tau/PSD-95 interactions arrest in vitro condensates and clusters mimicking the postsynaptic density. Nature Communications 14, 6839 (2023)
12.
Journal Article
Chakraborty, P.; Zweckstetter, M.: Role of aberrant phase separation in pathological protein aggregation. Current Opinion in Structural Biology 82, 102678 (2023)
13.
Journal Article
Huang, Y.; Wen, J.; Ramirez, L.-M.; Gümüşdil, E.; Pokhrel, P.; Man, V. H.; Ye, H.; Han, Y.; Liu, Y.; Li, P. et al.; Su, Z.; Wang, J.; Mao, H.; Zweckstetter, M.; Perrett, S.; Wu, S.; Gao, M.: Methylene blue accelerates liquid-to-gel transition of tau condensates impacting tau function and pathology. Nature Communications 14, 5444 (2023)
14.
Journal Article
Zhang, S.; Dauer, K.; Strohäker, T.; Tatenhorst, L.; Gomes, L. C.; Mayer, S.; Jung, B. C.; Kim, W. S. S.; Lee, S.-J.; Becker, S. et al.; Liesche-Starnecker, F.; Zweckstetter, M.; Lingor, P.: Alpha-synuclein fibrils amplified from multiple system atrophy and Parkinson's disease patient brain spread after intracerebral injection into mouse brain. Brain Pathology 33 (5), e13196 (2023)
15.
Journal Article
Buratti, F. A.; Fernández, C. O.; Zweckstetter, M.: Parkinson's disease-linked V15A mutation facilitates α-synuclein aggregation by reducing membrane affinity. Protein Science 32 (8), e4693 (2023)
16.
Journal Article
Yu, T.; Flores-Solis, D.; Eastep, G.N.; Becker, S.; Zweckstetter, M.: Phosphatidylserine-dependent structure of synaptogyrin remodels the synaptic vesicle membrane. Nature Structural and Molecular Biology 30, pp. 926 - 934 (2023)
17.
Journal Article
Ramirez, L.M.; Zweckstetter, M.: Molecular-level interplay between intrinsically disordered clients and Hsp90. Current Opinion in Chemical Biology 74, 102304 (2023)
18.
Journal Article
Edkins, A. L. L.; Zweckstetter, M.; Sawarkar, R.: Tenth International Symposium on the Hsp90 chaperone machine. Cell Stress and Chaperones 28, pp. 231 - 237 (2023)
19.
Journal Article
Pantoja, C.F.; Ibáñez de Opakua, A.; Cima-Omori, M.-S.; Zweckstetter, M.: Determining the Physico-Chemical Composition of Biomolecular Condensates from Spatially-Resolved NMR. Angewandte Chemie International Edition 62 (17), e202218078 (2023)
20.
Journal Article
Rosado-Ramos, R.; Poças, G. M.; Marques, D.; Foito, A.; Sevillano, D. M.; Lopes-da-Silva, M.; Gonçalves, L. G.; Menezes, R.; Ottens, M.; Stewart, D. et al.; de Opakua, A. I.; Zweckstetter, M.; Seabra, M. C.; Mendes, C. S.; Outeiro, T. F.; Domingos, P. M.; Santos, C. N.: Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage. Nature Communications 14, 1918 (2023)
21.
Journal Article
Abyzov, A.; Mandelkow, E.; Zweckstetter, M.; Rezaei-Ghaleh, N.: Fast Motions Dominate Dynamics of Intrinsically Disordered Tau Protein at High Temperatures. Chemistry – A European Journal 29 (17), e202203493 (2023)
22.
Journal Article
Boeynaems, S.; Chong, S.; Gsponer, J.; Holt, L.; Milovanovic, D.; Mitrea, D. M.; Mueller-Cajar, O.; Portz, B.; Reilly, J. F.; Reinkemeier, C. D. et al.; Sabari, B. R.; Sanulli, S.; Shorter, J.; Sontag, E.; Strader, L.; Stachowiak, J.; Weber, S. C.; White, M.; Zhang, H.; Zweckstetter, M.; Elbaum-Garfinkle, S.; Kriwacki, R.: Phase Separation in Biology and Disease; Current Perspectives and Open Questions. Journal of Molecular Biology 435 (5), 167971 (2023)
23.
Journal Article
Jiang, L.; Chakraborty, P.; Zhang, L.; Wong, M.; Hill, S. E.; Webber, C. J.; Libera, J.; Blair, L. J.; Wolozin, B.; Zweckstetter, M.: Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress. Science Advances 9 (5), eadd9789 (2023)
24.
Journal Article
Chakraborty, P.; Rivière, G.; Hebestreit, A.; de Opakua, A.I.; Vorberg, I.M.; Andreas, L. B.; Zweckstetter, M.: Acetylation discriminates disease-specific tau deposition. Nature Communications 14 (1), 5919 (2023)
25.
Journal Article
Flores-Solis, D.; Lushpinskaia, I.P.; Polyansky, A.A.; Changiarath, A.; Boehning, M.; Mirkovic, M.; Walshe, J.; Pietrek, L.M.; Cramer, P.; Stelzl, L.S. et al.; Zagrovic, B.; Zweckstetter, M.: Driving forces behind phase separation of the carboxy-terminal domain of RNA polymerase II. Nature Communications 14 (1), 5979 (2023)
26.
Journal Article
Lushpinskaia, I. P. P.; Flores-Solis, D.; Zweckstetter, M.: Structure and phase separation of the C-terminal domain of RNA polymerase II. Biological Chemistry 404 (8-9), pp. 839 - 844 (2023)
27.
Journal Article
Brás, I. C.; Khani, M. H.; Vasili, E.; Möbius, W.; Riedel, D.; Parfentev, I.; Gerhardt, E.; Fahlbusch, C.; Urlaub, H.; Zweckstetter, M. et al.; Gollisch, T.; Outeiro, T. F.: Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity. Journal of Parkinson's Disease: JPD 12, pp. 2397 - 2422 (2022)
28.
Journal Article
Chakraborty, P.; Zweckstetter, M.: Phase separation of the microtubule-associated protein tau. Essays in Biochemistry 66 (7), pp. 1013 - 1021 (2022)
29.
Journal Article
de Opakua, A. I.; Geraets, J. A.; Frieg, B.; Dienemann, C.; Savastano, A.; Rankovic, M.; Cima-Omori, M.-S.; Schröder, G. F.; Zweckstetter, M.: Molecular interactions of FG nucleoporin repeats at high resolution. Nature Chemistry 14, pp. 1278 - 1285 (2022)
30.
Journal Article
Sang, D.; Shu, T.; Pantoja, C. F.; de Opakua, A. I.; Zweckstetter, M.; Holt, L. J.: Condensed-phase signaling can expand kinase specificity and respond to macromolecular crowding. Molecular Cell 82 (19), pp. 3693 - 3711.e10 (2022)
31.
Journal Article
Frieg, B.; Geraets, J. A.; Strohaeker, T.; Dienemann, C.; Mavroeidi, P.; Jung, B. C.; Kim, W. S.; Lee, S.-J.; Xilouri, M.; Zweckstetter, M. et al.; Schroeder, G. F.: Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein. Communications Biology 5 (1), 1040 (2022)
32.
Journal Article
Babu, M.; Favretto, F.; Rankovic, M.; Zweckstetter, M.: Peptidyl Prolyl Isomerase A Modulates the Liquid–Liquid Phase Separation of Proline-Rich IDPs. Journal of the American Chemical Society 144 (35), pp. 16157 - 16163 (2022)
33.
Journal Article
Zachrdla, M.; Savastano, A.; de Opakua, A. I.; Cima-Omori, M.-S.; Zweckstetter, M.: Contributions of the N-terminal intrinsically disordered region of the severe acute respiratory syndrome coronavirus 2 nucleocapsid protein to RNA-induced phase separation. Protein Science 31 (9), e4409 (2022)
34.
Journal Article
Buratti, F. A.; Boeffinger, N.; Garro, H. A.; Flores, J. S.; Hita, F. J.; Gonçalves, P. d. C.; Copello, F. d. R.; Lizarraga, L.; Rossetti, G.; Carloni, P. et al.; Zweckstetter, M.; Outeiro, T. F.; Eimer, S.; Griesinger, C.; Fernández, C. O.: Aromaticity at position 39 in α‐synuclein: A modulator of amyloid fibril assembly and membrane‐bound conformations. Protein Science 31 (7), e4360 (2022)
35.
Journal Article
Kumar, S. T.; Mahul-Mellier, A.-L.; Hegde, R. N.; Riviere, G.; Moons, R.; de Opakua, A. I.; Magalhaes, P.; Rostami, I.; Donzelli, S.; Sobott, F. et al.; Zweckstetter, M.; Lashuel, H. A.: A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity. Science Advances 8 (17), eabn0044 (2022)
36.
Journal Article
Min, J.-O.; Strohäker, T.; Jeong, B.-C.; Zweckstetter, M.; Lee, S.-J.: Chicago sky blue 6B inhibits α-synuclein aggregation and propagation. Molecular Brain 15, 27 (2022)
37.
Journal Article
Stelzl, L. S.; Pietrek, L. M.; Holla, A.; Oroz, J.; Sikora, M.; Köfinger, J.; Schuler, B.; Zweckstetter, M.; Hummer, G.: Global Structure of the Intrinsically Disordered Protein Tau Emerges from Its Local Structure. JACS Au 2 (3), pp. 673 - 686 (2022)
38.
Journal Article
Abyzov, A.; Blackledge, M.; Zweckstetter, M.: Conformational Dynamics of Intrinsically Disordered Proteins Regulate Biomolecular Condensate Chemistry. Chemical Reviews 122 (6), pp. 6719 - 6748 (2022)
39.
Journal Article
Diez, L.; Kapinos, L. E.; Hochmair, J.; Huebschmann, S.; Dominguez-Baquero, A.; Vogt, A.; Rankovic, M.; Zweckstetter, M.; Lim, R. Y. H.; Wegmann, S.: Phosphorylation but Not Oligomerization Drives the Accumulation of Tau with Nucleoporin Nup98. International Journal of Molecular Sciences 23 (7), 3495 (2022)
40.
Journal Article
Pantoja, C. F.; Zweckstetter, M.; Rezaei-Ghaleh, N.: Dynamical component exchange in a model phase separating system: an NMR-based approach. PhysChemChemPhys 24 (10), pp. 6169 - 6175 (2022)
41.
Journal Article
Nedaei, H.; Rezaei-Ghaleh, N.; Giller, K.; Becker, S.; Karami, L.; Moosavi-Movahedi, A. A.; Griesinger, C.; Saboury, A. A.: The calcium-free form of atorvastatin inhibits amyloid-β(1–42) aggregation in vitro. Journal of Biological Chemistry 298 (3), 101662 (2022)
42.
Journal Article
Robustelli, P.; Ibanez-de-Opakua, A.; Campbell-Bezat, C.; Giordanetto, F.; Becker, S.; Zweckstetter, M.; Pan, A. C.; Shaw, D. E.: Molecular Basis of Small-Molecule Binding to α-Synuclein. Journal of the American Chemical Society 144 (6), pp. 2501 - 2510 (2022)
43.
Journal Article
Cario, A.; Savastano, A.; Wood, N. B.; Liu, Z.; Previs, M. J.; Hendricks, A. G.; Zweckstetter, M.; Berger, C. L.: The pathogenic R5L mutation disrupts formation of Tau complexes on the microtubule by altering local N-terminal structure. Proceedings of the National Academy of Sciences of the United States of America 119 (7), e2114215119 (2022)
44.
Journal Article
Aillaud, I.; Kaniyappan, S.; Chandupatla, R. R.; Ramirez, L. M.; Alkhashrom, S.; Eichler, J.; Horn, A. H. C.; Zweckstetter, M.; Mandelkow, E.-M.; Sticht, H. et al.; Funke, S. A.: A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro. Alzheimer's Research & Therapy 14, 15 (2022)
45.
Journal Article
Moll, A.; Ramirez, L. M.; Ninov, M.; Schwarz, J.; Urlaub, H.; Zweckstetter, M.: Hsp multichaperone complex buffers pathologically modified Tau. Nature Communications 13, 3668 (2022)
46.
Journal Article
Dauer née Joppe, K.; Tatenhorst, L.; Caldi Gomes, L.; Zhang, S.; Parvaz, M.; Carboni, E.; Roser, A.-E.; El DeBakey, H.; Bähr, M.; Vogel-Mikuš, K. et al.; Ip, C. W.; Becker, S.; Zweckstetter, M.; Lingor, P.: Brain iron enrichment attenuates α-synuclein spreading after injection of preformed fibrils. Journal of Neurochemistry 159 (3), pp. 554 - 573 (2021)
47.
Journal Article
Oliveira, L. M. A.; Gasser, T.; Edwards, R.; Zweckstetter, M.; Melki, R.; Stefanis, L.; Lashuel, H. A.; Sulzer, D.; Vekrellis, K.; Halliday, G. M. et al.; Tomlinson, J. J.; Schlossmacher, M.; Jensen, P. H.; Schulze-Hentrich, J.; Riess, O.; Hirst, W.D.; El-Agnaf, O.; Mollenhauer, B.; Lansbury, P.; Outeiro, T. F.: Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease. NPJ Parkinsons Disease 7, 65 (2021)
48.
Journal Article
Chakraborty, P.; Rivière, G.; Liu, S.; Ibáñez de Opakua, A.; Dervişoğlu, R.; Hebestreit, A.; Andreas, L. B.; Vorberg, I. M.; Zweckstetter, M.: Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils. Nature Communications 12, 4231 (2021)
49.
Journal Article
Rai, S. K.; Savastano, A.; Singh, P.; Mukhopadhyay, S.; Zweckstetter, M.: Liquid–liquid phase separation of tau: From molecular biophysics to physiology and disease. Protein Science 30 (7), pp. 1294 - 1314 (2021)
50.
Journal Article
Martinez Hernandez, A.; Silbern, I.; Geffers, I.; Tatenhorst, L.; Becker, S.; Urlaub, H.; Zweckstetter, M.; Griesinger, C.; Eichele, G.: Low-Expressing synucleinopathy mouse models based on oligomer-forming mutations and C-terminal truncation of α-synuclein. Frontiers in Neuroscience 15, 643391 (2021)
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