Publications

1.

Journal Article

Ukmar‐Godec, T.; Yu, T.; de Opakua, A. I.; Pantoja, C. F.; Munari, F.; Zweckstetter, M.: Conformational diversity of human HP1α. Protein Science 33 (7), e5079 (2024)

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2.

Journal Article

Ibáñez de Opakua, A.; Pantoja, C. F.; Cima-Omori, M.-S.; Dienemann, C.; Zweckstetter, M.: Impact of distinct FG nucleoporin repeats on Nup98 self-association. Nature Communications 15, 3797 (2024)

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3.

Journal Article

Antón, R.; Treviño, M.Á.; Pantoja-Uceda, D.; Félix, S.; Babu, M.; Cabrita, E.J.; Zweckstetter, M.; Tinnefeld, P.; Vera, A.M.; Oroz, J.: Alternative low-populated conformations prompt phase transitions in polyalanine repeat expansions. Nature Communications 15 (1), 1925 (2024)

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4.

Journal Article

Zhuang, S.; Chakraborty, P.; Zweckstetter, M.: Regulation of tau by peptidyl-prolyl isomerases. Current Opinion in Structural Biology 84, 102739 (2024)

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5.

Journal Article

Ukmar-Godec, T.; Cima-Omori, M.-S.; Yerkesh, Z.; Eswara, K.; Yu, T.; Ramesh, R.; Riviere, G.; de Opakua, A.I.; Fischle, W.; Zweckstetter, M.: Multimodal interactions drive chromatin phase separation and compaction. Proceedings of the National Academy of Sciences of the United States of America 120 (50), e2308858120 (2023)

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6.

Journal Article

Shen, Z.; Sun, D.; Savastano, A.; Varga, S. J.; Cima-Omori, M.-S.; Becker, S.; Honigmann, A.; Zweckstetter, M.: Multivalent Tau/PSD-95 interactions arrest in vitro condensates and clusters mimicking the postsynaptic density. Nature Communications 14, 6839 (2023)

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7.

Journal Article

Chakraborty, P.; Zweckstetter, M.: Role of aberrant phase separation in pathological protein aggregation. Current Opinion in Structural Biology 82, 102678 (2023)

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8.

Journal Article

Huang, Y.; Wen, J.; Ramirez, L.-M.; Gümüşdil, E.; Pokhrel, P.; Man, V. H.; Ye, H.; Han, Y.; Liu, Y.; Li, P. et al.; Su, Z.; Wang, J.; Mao, H.; Zweckstetter, M.; Perrett, S.; Wu, S.; Gao, M.: Methylene blue accelerates liquid-to-gel transition of tau condensates impacting tau function and pathology. Nature Communications 14, 5444 (2023)

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9.

Journal Article

Zhang, S.; Dauer, K.; Strohäker, T.; Tatenhorst, L.; Gomes, L. C.; Mayer, S.; Jung, B. C.; Kim, W. S. S.; Lee, S.-J.; Becker, S. et al.; Liesche-Starnecker, F.; Zweckstetter, M.; Lingor, P.: Alpha-synuclein fibrils amplified from multiple system atrophy and Parkinson's disease patient brain spread after intracerebral injection into mouse brain. Brain Pathology 33 (5), e13196 (2023)

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10.

Journal Article

Buratti, F. A.; Fernández, C. O.; Zweckstetter, M.: Parkinson's disease-linked V15A mutation facilitates α-synuclein aggregation by reducing membrane affinity. Protein Science 32 (8), e4693 (2023)

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11.

Journal Article

Yu, T.; Flores-Solis, D.; Eastep, G.N.; Becker, S.; Zweckstetter, M.: Phosphatidylserine-dependent structure of synaptogyrin remodels the synaptic vesicle membrane. Nature Structural and Molecular Biology 30, pp. 926 - 934 (2023)

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12.

Journal Article

Ramirez, L.M.; Zweckstetter, M.: Molecular-level interplay between intrinsically disordered clients and Hsp90. Current Opinion in Chemical Biology 74, 102304 (2023)

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13.

Journal Article

Edkins, A. L. L.; Zweckstetter, M.; Sawarkar, R.: Tenth International Symposium on the Hsp90 chaperone machine. Cell Stress and Chaperones 28, pp. 231 - 237 (2023)

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14.

Journal Article

Pantoja, C.F.; Ibáñez de Opakua, A.; Cima-Omori, M.-S.; Zweckstetter, M.: Determining the Physico-Chemical Composition of Biomolecular Condensates from Spatially-Resolved NMR. Angewandte Chemie International Edition 62 (17), e202218078 (2023)

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15.

Journal Article

Rosado-Ramos, R.; Poças, G. M.; Marques, D.; Foito, A.; Sevillano, D. M.; Lopes-da-Silva, M.; Gonçalves, L. G.; Menezes, R.; Ottens, M.; Stewart, D. et al.; de Opakua, A. I.; Zweckstetter, M.; Seabra, M. C.; Mendes, C. S.; Outeiro, T. F.; Domingos, P. M.; Santos, C. N.: Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage. Nature Communications 14, 1918 (2023)

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16.

Journal Article

Abyzov, A.; Mandelkow, E.; Zweckstetter, M.; Rezaei-Ghaleh, N.: Fast Motions Dominate Dynamics of Intrinsically Disordered Tau Protein at High Temperatures. Chemistry – A European Journal 29 (17), e202203493 (2023)

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17.

Journal Article

Boeynaems, S.; Chong, S.; Gsponer, J.; Holt, L.; Milovanovic, D.; Mitrea, D. M.; Mueller-Cajar, O.; Portz, B.; Reilly, J. F.; Reinkemeier, C. D. et al.; Sabari, B. R.; Sanulli, S.; Shorter, J.; Sontag, E.; Strader, L.; Stachowiak, J.; Weber, S. C.; White, M.; Zhang, H.; Zweckstetter, M.; Elbaum-Garfinkle, S.; Kriwacki, R.: Phase Separation in Biology and Disease; Current Perspectives and Open Questions. Journal of Molecular Biology 435 (5), 167971 (2023)

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18.

Journal Article

Jiang, L.; Chakraborty, P.; Zhang, L.; Wong, M.; Hill, S. E.; Webber, C. J.; Libera, J.; Blair, L. J.; Wolozin, B.; Zweckstetter, M.: Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress. Science Advances 9 (5), eadd9789 (2023)

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19.

Journal Article

Chakraborty, P.; Rivière, G.; Hebestreit, A.; de Opakua, A.I.; Vorberg, I.M.; Andreas, L. B.; Zweckstetter, M.: Acetylation discriminates disease-specific tau deposition. Nature Communications 14 (1), 5919 (2023)

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20.

Journal Article

Flores-Solis, D.; Lushpinskaia, I.P.; Polyansky, A.A.; Changiarath, A.; Boehning, M.; Mirkovic, M.; Walshe, J.; Pietrek, L.M.; Cramer, P.; Stelzl, L.S. et al.; Zagrovic, B.; Zweckstetter, M.: Driving forces behind phase separation of the carboxy-terminal domain of RNA polymerase II. Nature Communications 14 (1), 5979 (2023)

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21.

Journal Article

Lushpinskaia, I. P. P.; Flores-Solis, D.; Zweckstetter, M.: Structure and phase separation of the C-terminal domain of RNA polymerase II. Biological Chemistry 404 (8-9), pp. 839 - 844 (2023)

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22.

Journal Article

Chakraborty, P.; Zweckstetter, M.: Phase separation of the microtubule-associated protein tau. Essays in Biochemistry 66 (7), pp. 1013 - 1021 (2022)

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23.

Journal Article

Rafiei, Y.; Salmani, B.; Mirzaei-Behbahani, B.; Taleb, M.; Meratan, A. A.; Ramezani, M.; Nikfarjam, N.; Becker, S.; Rezaei-Ghaleh, N.: Polyphenols-Based Nanosheets of Propolis Modulate Cytotoxic Amyloid Fibril Assembly of α-Synuclein. ACS Chemical Neuroscience 13 (22), pp. 3168 - 3179 (2022)

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24.

Journal Article

Sieme, D.; Griesinger, C.; Rezaei-Ghaleh, N.: Metal Binding to Sodium Heparin Monitored by Quadrupolar NMR. International Journal of Molecular Sciences 23 (21), 13185 (2022)

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25.

Journal Article

Diez, L.; Kapinos, L. E.; Hochmair, J.; Huebschmann, S.; Dominguez-Baquero, A.; Vogt, A.; Rankovic, M.; Zweckstetter, M.; Lim, R. Y. H.; Wegmann, S.: Phosphorylation but Not Oligomerization Drives the Accumulation of Tau with Nucleoporin Nup98. International Journal of Molecular Sciences 23 (7), 3495 (2022)

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26.

Journal Article

Pantoja, C. F.; Zweckstetter, M.; Rezaei-Ghaleh, N.: Dynamical component exchange in a model phase separating system: an NMR-based approach. PhysChemChemPhys 24 (10), pp. 6169 - 6175 (2022)

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27.

Journal Article

Nedaei, H.; Rezaei-Ghaleh, N.; Giller, K.; Becker, S.; Karami, L.; Moosavi-Movahedi, A. A.; Griesinger, C.; Saboury, A. A.: The calcium-free form of atorvastatin inhibits amyloid-β(1–42) aggregation in vitro. Journal of Biological Chemistry 298 (3), 101662 (2022)

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28.

Journal Article

Dauer née Joppe, K.; Tatenhorst, L.; Caldi Gomes, L.; Zhang, S.; Parvaz, M.; Carboni, E.; Roser, A.-E.; El DeBakey, H.; Bähr, M.; Vogel-Mikuš, K. et al.; Ip, C. W.; Becker, S.; Zweckstetter, M.; Lingor, P.: Brain iron enrichment attenuates α-synuclein spreading after injection of preformed fibrils. Journal of Neurochemistry 159 (3), pp. 554 - 573 (2021)

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29.

Journal Article

Oliveira, L. M. A.; Gasser, T.; Edwards, R.; Zweckstetter, M.; Melki, R.; Stefanis, L.; Lashuel, H. A.; Sulzer, D.; Vekrellis, K.; Halliday, G. M. et al.; Tomlinson, J. J.; Schlossmacher, M.; Jensen, P. H.; Schulze-Hentrich, J.; Riess, O.; Hirst, W.D.; El-Agnaf, O.; Mollenhauer, B.; Lansbury, P.; Outeiro, T. F.: Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease. NPJ Parkinsons Disease 7, 65 (2021)

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30.

Journal Article

Chakraborty, P.; Rivière, G.; Liu, S.; Ibáñez de Opakua, A.; Dervişoğlu, R.; Hebestreit, A.; Andreas, L. B.; Vorberg, I. M.; Zweckstetter, M.: Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils. Nature Communications 12, 4231 (2021)

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31.

Journal Article

Rai, S. K.; Savastano, A.; Singh, P.; Mukhopadhyay, S.; Zweckstetter, M.: Liquid–liquid phase separation of tau: From molecular biophysics to physiology and disease. Protein Science 30 (7), pp. 1294 - 1314 (2021)

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32.

Journal Article

Martinez Hernandez, A.; Silbern, I.; Geffers, I.; Tatenhorst, L.; Becker, S.; Urlaub, H.; Zweckstetter, M.; Griesinger, C.; Eichele, G.: Low-Expressing synucleinopathy mouse models based on oligomer-forming mutations and C-terminal truncation of α-synuclein. Frontiers in Neuroscience 15, 643391 (2021)

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33.

Journal Article

Babu, M.; Favretto, F.; Ibáñez de Opakua, A.; Rankovic, M.; Becker, S.; Zweckstetter, M.: Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis. Nature Communications 12, 3396 (2021)

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34.

Journal Article

Medina, L.; González-Lizárraga, F.; Dominguez-Meijide, A.; Ploper, D.; Parrales, V.; Sequeira, S.; Cima-Omori, M.-S.; Zweckstetter, M.; Bel, E. D.; Michel, P. P. et al.; Outeiro, T. F.; Raisman-Vozari, R.; Chehín, R.; Socias, S. B.: Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity. Frontiers in Aging Neuroscience 13, 635760 (2021)

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35.

Journal Article

de Groot, B. L.; Janshoff, A.; Steinem, C.; Zweckstetter, M.: Special issue: Multicomponent lipid membranes—how molecular organisation leads to function. European Biophysics Journal 50 (2), pp. 107 - 108 (2021)

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36.

Journal Article

Kroppen, B.; Teske, N.; Yambire, K. F.; Denkert, N.; Mukherjee, I.; Tarasenko, D.; Jaipuria, G.; Zweckstetter, M.; Milosevic, I.; Steinem, C. et al.; Meinecke, M.: Cooperativity of membrane-protein and protein–protein interactions control membrane remodeling by epsin 1 and affects clathrin-mediated endocytosis. Cellular and Molecular Life Sciences 78 (5), pp. 2355 - 2370 (2021)

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37.

Journal Article

Najbauer, E.; Becker, S.; Giller, K.; Zweckstetter, M.; Lange, A.; Steinem, C.; de Groot, B. L.; Griesinger, C.; Andreas, L. B.: Structure, gating and interactions of the voltage-dependent anion channel. European Biophysics Journal 50 (2), pp. 159 - 172 (2021)

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38.

Journal Article

Rivière, G.; Jaipuria, G.; Andreas, L. B.; Leonov, A.; Giller, K.; Becker, S.; Zweckstetter, M.: Membrane-embedded TSPO: an NMR view. European Biophysics Journal 50 (2), pp. 173 - 180 (2021)

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39.

Journal Article

Liu, H.; Koros, C.; Strohäker, T.; Schulte, C.; Bozi, M.; Varvaresos, S.; de Opakua, A. I.; Simitsi, A. M.; Bougea, A.; Voumvourakis, K. et al.; Maniati, M.; Papageorgiou, S. G.; Hauser, A.‐.; Becker, S.; Zweckstetter, M.; Stefanis, L.; Gasser, T.: A novel SNCA A30G mutation causes familial Parkinsonʼs disease. Movement Disorders, In Press (2021)

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40.

Journal Article

Gray, A. L. H.; Steren, C. A.; Haynes, I. W.; Bermejo, G. A.; Favretto, F.; Zweckstetter, M.; Do, T. D.: Structural Flexibility of Cyclosporine A Is Mediated by Amide Cis–Trans Isomerization and the Chameleonic Roles of Calcium. Journal of Physical Chemistry B 125 (5), pp. 1378 - 1391 (2021)

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41.

Journal Article

Sieger, A.; Rankovic, M.; Favretto, F.; Ukmar‐Godec, T.; Strohäker, T.; Becker, S.; Zweckstetter, M.: Interplay between tau and α‐synuclein liquid–liquid phase separation. Protein Science, In Press (2021)

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42.

Journal Article

Savastano, A.; Flores, D.; Kadavath, H.; Biernat, J.; Mandelkow, E.; Zweckstetter, M.: Disease‐associated tau phosphorylation hinders tubulin assembly within tau condensates. Angewandte Chemie International Edition 60 (2), pp. 726 - 730 (2021)

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43.

Journal Article

Savastano, A.; Jaipuria, G.; Andreas, L. B.; Mandelkow, E.; Zweckstetter, M.: Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils. Scientific Reports 10, 21210 (2020)

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44.

Journal Article

Lott, A.; Oroz, J.; Zweckstetter, M.: Molecular basis of the interaction of Hsp90 with its co‐chaperone Hop. Protein Science 29 (12), pp. 2422 - 2432 (2020)

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45.

Journal Article

Favretto, F.; Flores, D.; Baker, J. D.; Strohäker, T.; Andreas, L. B.; Blair, L. J.; Becker, S.; Zweckstetter, M.: Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war. Nature Communications 11, 6046 (2020)

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46.

Journal Article

Savastano, A.; Ibanez de Opakua, A.; Rankovic, M.; Zweckstetter, M.: Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates. Nature Communications 11, 6041 (2020)

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47.

Journal Article

Dominguez-Meijide, A.; Vasili, E.; König, A.; Cima-Omori, M.-S.; Ibáñez de Opakua, A.; Leonov, A.; Ryazanov, S.; Zweckstetter, M.; Griesinger, C.; Outeiro, T. F.: Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization. Scientific Reports 10, 12827 (2020)

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48.

Journal Article

Ukmar-Godec, T.; Fang, P.; Ibáñez de Opakua, A.; Henneberg, F.; Godec, A.; Pan, K. T.; Cima-Omori, M.-S.; Chari, A.; Mandelkow, E.; Urlaub, H. et al.; Zweckstetter, M.: Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution. Science Advances 6 (30), eaba3916 (2020)

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supplementary-material

49.

Journal Article

Gerdes, C.; Waal, N.; Offner, T.; Fornasiero, E. F.; Wender, N.; Verbarg, H.; Manzini, I.; Trenkwalder, C.; Mollenhauer, B.; Strohäker, T. et al.; Zweckstetter, M.; Becker, S.; Rizzoli, S. O.; Basmanav, F. B.; Opazo, F.: A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol. Nature Communications 11, 2729 (2020)

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Journal Article

de Opakua, A. I.; Klama, F.; Ndukwe, I. E.; Martin, G. E.; Williamson, T. R.; Zweckstetter, M.: Determination of complex small molecule structures using molecular alignment simulation. Angewandte Chemie International Edition 59 (15), pp. 6172 - 6176 (2020)

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Publications

Journal Article (276)