Journal Article (274)

51.
Journal Article
Hamann, F.; Schmitt, A.; Favretto, F.; Hofele, R.; Neumann, P.; Xiang, S. Q.; Urlaub, H.; Zweckstetter, M.; Ficner, R.: Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2. Proceedings of the National Academy of Sciences of the United States of America 117 (6), pp. 2948 - 2956 (2020)
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52.
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Masaracchia, C.; König, A.; Valiente-Gabioud, A. A.; Peralta, P.; Favretto, F.; Strohäker, T.; Lázaro, D. F.; Zweckstetter, M.; Fernandez, C. O.; Outeiro, T. F.: Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies. Biochimica et Biophysica Acta-Proteins and Proteomics 1868 (1), 140298 (2020)
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53.
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Strohäker, T.; Jung, B. C.; Liou, S. H.; Fernandez, C. O.; Riedel, D.; Becker, S.; Halliday, G. M.; Bennati, M.; Kim, W. S.; Lee, S. J. et al.; Zweckstetter, M.: Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts. Nature Communications 10, 5535 (2019)
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54.
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Pellkofer, H.; Ihler, F.; Weiss, B. G.; Trothe, J.; Kadavath, H.; Chongtham, M.; Kunadt, M.; Riedel, D.; Lornsen, F.; Wilken, P. et al.; Bartels, C.; Hirschel, S.; Russo, S. G.; Stransky, E.; Trojan, L.; Schmidt, B.; Mandelkow, E.; Zweckstetter, M.; Canis, M.; Schneider, A.: Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer's disease from bioptic olfactory mucosa. European Archives of Psychiatry and Clinical Neuroscience 269 (8), pp. 973 - 984 (2019)
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55.
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Zhang, D.; Bedogni, F.; Boterberg, S.; Camfield, C.; Camfield, P.; Charman, T.; Curfs, L.; Einspieler, C.; Esposito, G.; De Filippis, B. et al.; Goin-Kochel, R. P.; Höglinger, G. U.; Holzinger, D.; Iosif, A. M.; Lancioni, G. E.; Landsberger, N.; Laviola, G.; Marco, E. M.; Müller, M.; Neul, J. L.; Nielsen-Saines, K.; Nordahl-Hansen, A.; O'Reilly, M. F.; Ozonoff, S.; Poustka, L.; Roeyers, h.; Rankovic, M.; Sigafoos, J.; Tammimies, K.; Townend, G. S.; Zwaigenbaum, L.; Zweckstetter, M.; Bölte, S.; Marschik, P. B.: Towards a consensus on developmental regression. Neuroscience and Biobehavioral Reviews 107, pp. 3 - 5 (2019)
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56.
Journal Article
Mavroeidi, P.; Arvanitaki, F.; Karakitsou, A. K.; Vetsi, M.; Kloukina, I.; Zweckstetter, M.; Giller, K.; Becker, S.; Sorrentino, Z. A.; Giasson, B. I. et al.; Jensen, P. H.; Stefanis, L.; Xilouri, M.: Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models. Acta Neuropathologica 138 (3), pp. 415 - 441 (2019)
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57.
Journal Article
Oroz, J.; Blair, L. J.; Zweckstetter, M.: Dynamic Aha1 co-chaperone binding to human Hsp90. Protein Science 28 (9), pp. 1545 - 1551 (2019)
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58.
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Ambadipudi, S.; Reddy,, J. G.; Biernat, J.; Mandelkow, E.; Zweckstetter, M.: Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau. Chemical Science 10 (26), pp. 6503 - 6507 (2019)
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59.
Journal Article
Ukmar-Godec, T.; Hutten, S.; Grieshop, M. P.; Rezaei-Ghaleh, N.; Cima-Omori, M. O.; Biernat, J.; Mandelkow, E.; Söding, J.; Dormann, D.; Zweckstetter, M.: Lysine/RNA-interactions drive and regulate biomolecular condensation. Nature Communications 10 (1), 2909 (2019)
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60.
Journal Article
Rezaei-Ghaleh, N.; Parigi, G.; Zweckstetter, M.: Reorientational dynamics of amyloid-β from NMR spin relaxation and molecular simulation. Journal of Physical Chemistry Letters 10, pp. 3369 - 3375 (2019)
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61.
Journal Article
Albert, N. L.; Unterrainer, M.; Brendel, M.; Kaiser, L.; Zweckstetter, M.; Cumming, P.; Bartenstein, P.: In response to: The validity of 18F-GE180 as a TSPO imaging agent. European Journal of Nuclear Medicine and Molecular Imaging 46 (6), pp. 1208 - 1211 (2019)
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62.
Journal Article
Gong, J.; Szego, E. M.; Leonov, A.; Benito, E.; Becker, S.; Fischer, A.; Zweckstetter, M.; Outeiro, T.; Schneider, A.: Translocator protein ligand protects against neurodegeneration in the MPTP mouse model of Parkinsonism. Journal of Neuroscience 39 (19), pp. 3752 - 3769 (2019)
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63.
Journal Article
Melková, K.; Zapletal, V.; Narasimhan, S.; Jansen, S.; Hritz, J.; Škrabana, R.; Zweckstetter, M.; Ringkjøbing-Jensen, M.; Blackledge, M.; Žídek, L.: Structure and functions of microtubule associated proteins tau and MAP2c: Similarities and differences. Biomolecules 9 (3), 105 (2019)
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64.
Journal Article
Rankovic, M.; Zweckstetter, M.: Upregulated levels and pathological aggregation of abnormally phosphorylated Tau-Protein in children with neurodevelopmental disorders. Neuroscience and Biobehavioral Reviews 98, pp. 1 - 9 (2019)
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65.
Journal Article
Jaipuria, G.; Giller, K.; Leonov, A.; Becker, S.; Zweckstetter, M.: Insights into cholesterol/membrane protein interactions using paramagnetic solid-state NMR. Chemistry - A European Journal 24 (66), pp. 17606 - 17611 (2018)
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66.
Journal Article
Rezaei-Ghaleh, N.; Parigi, G.; Soranno, A.; Holla, A.; Becker, S.; Schuler, B.; Luchinat, C.; Zweckstetter, M.: Local and global dynamics in intrinsically disordered synuclein. Angewandte Chemie International Edition 57 (46), pp. 15262 - 15266 (2018)
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67.
Journal Article
Oroz, J.; Chang, B. J.; Wysoczanski, P.; Lee, C. T.; Perez-Lara, A.; Chakraborty, P.; Hofele, R. V.; Baker, J. D.; Blair, L. J.; Biernat, J. et al.; Urlaub, H.; Mandelkow, E.; Dickey, C. A.; Zweckstetter, M.: Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex. Nature Communications 9, 4532 (2018)
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68.
Journal Article
Gentile, I.; Garro, H. A.; Delgado Ocaña, S.; Gonzalez, N.; Strohäker, T.; Schibich, D.; Quintanar, L.; Sambrotta, L.; Zweckstetter, M.; Griesinger, C. et al.; Menacho Márqueza, M.; Fernandez, C. O.: Interaction of Cu(i) with the Met-X3-Met motif of alpha-synuclein: Binding ligands, affinity and structural features. Metallomics 10 (10), pp. 1383 - 1389 (2018)
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69.
Journal Article
Böhning, M.; Dugast-Darzacq, C.; Rankovic, M.; Hansen, A. S.; Yu, T.; Marie-Nelly, H.; McSwiggen, D. T.; Kokic, G.; Dailey, G. M.; Cramer, P. et al.; Darzacq, X.; Zweckstetter, M.: RNA polymerase II clustering through carboxy-terminal domain phase separation. Nature Structural and Molecular Biology 25 (9), pp. 833 - 840 (2018)
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70.
Journal Article
Melkova, K.; Zapletal, V.; Jansen, S.; Nomilner, E.; Zachrdla, M.; Hritz, J.; Novacek, J.; Zweckstetter, M.; Jensen, M. R.; Blackledge, M. et al.; Zidek, L.: Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics. Journal of Biological Chemistry 293 (34), pp. 13297 - 13309 (2018)
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71.
Journal Article
Abayev, M.; Rodrigues, J. P. G. L. M.; Srivastava, G.; Arshava, B.; Jaremko, L.; Jaremko, M.; Naider, F.; Levitt, M.; Anglister, J.: The solution structure of monomeric CCL5 in complex with a doubly sulfated N-terminal segment of CCR5. FEBS Journal 285 (11), pp. 1988 - 2003 (2018)
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72.
Journal Article
Jaipuria, G.; Ukmar-Godec, T.; Zweckstetter, M.: Challenges and approaches to understand cholesterol-binding impact on membrane protein function: An NMR view. Cellular and Molecular Life Sciences 75 (12), pp. 2137 - 2151 (2018)
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73.
Journal Article
Aliakbari, F.; Mohammad-Beigi, H.; Rezaei-Ghaleh, N.; Becker, S.; Esmatabad, F. D.; Seyedi, H. A. E.; Bardania, H.; Marvian, A. T.; Collingwood, J. F.; Christiansen, G. et al.; Zweckstetter, M.; Otzen, D. E.; Morshedi, D.: The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease. Nanoscale 10 (19), pp. 9174 - 9185 (2018)
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74.
Journal Article
Mok, S. A.; Condello, C.; Freilich, R.; Gillies, A.; Arhar, T.; Oroz, J.; Kadavath, H.; Julien, O.; Assimon, V. A.; Rauch, J. N. et al.; Dunyak, B. M.; Lee, J.; Tsai, F. T. F.; Wilson, M. R.; Zweckstetter, M.; Dickey, C. A.; Gestwicki, J. E.: Mapping interactions with the chaperone network reveals factors that protect against tau aggregation. Nature Structural and Molecular Biology 25 (5), pp. 384 - 393 (2018)
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75.
Journal Article
Kadavath, H.; Cabrales-Fontela, Y.; Jaremko, M.; Jaremko, L.; Overkamp, K.; Biernat, J.; Mandelkow, E.; Zweckstetter, M.: The binding mode of a repeat-like Tau sequence with tubulin. Angewandte Chemie International Edition 57 (12), pp. 3246 - 3250 (2018)
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76.
Journal Article
Tolö, J.; Taschenberger, G.; Leite, K.; Stahlberg, M. A.; Spehlbrink, G.; Kues, J.; Munari, F.; Capaldi, S.; Becker, S.; Zweckstetter, M. et al.; Dean, C.; Bähr, M.; Kügler, S.: Pathophysiological consequences of neuronal alpha-Synuclein overexpression: Impacts on ion homeostasis, stress signaling, mitochondrial integrity, and electrical activity. Frontiers in Molecular Neuroscience 11, 49 (2018)
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77.
Journal Article
Lasorsa, A.; Natile, G.; Rosato, A.; Tadini-Buoninsegni , F.; Arnesano , F.: Monitoring interactions inside cells by advanced spectroscopies: Overview of copper transporters and cisplatin. Current Medicinal Chemistry 25 (4), pp. 462 - 477 (2018)
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78.
Journal Article
Martinez Hernandez, A.; Urbanke, H.; Gillman, A. L.; Lee, J.; Ryazanov, S.; Agbemenyah, H. Y.; Benito, E.; Jain, G.; Kaurani, L.; Grigorian, G. et al.; Leonov, A.; Rezaei-Ghaleh, N.; Wilken, P.; Arce, F. T.; Wagner, J.; Fuhrman, M.; Caruana, M.; Camilleri, A.; Vassallo, N.; Zweckstetter, M.; Benz, R.; Giese, A.; Schneider, A.; Korte, M.; Lal, R.; Griesinger, C.; Eichele, G.; Fischer, A.: The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology. EMBO Molecular Medicine 10 (1), pp. 32 - 47 (2018)
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79.
Journal Article
Cabrales-Fontela, Y.; Kadavath, H.; Biernat, J.; Riedel, D.; Mandelkow, E.; Zweckstetter, M.: Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau. Nature Communications 8, 1981 (2017)
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80.
Journal Article
Bharat, V.; Siebrecht, M.; Burk, K.; Ahmed, S.; Reissner, C.; Kohansal-Nodehi, M.; Steubler, V.; Zweckstetter, M.; Ting, J. T.; Dean, C.: Capture of dense core vesicles at synapses by JNK-dependent phosphorylation of Synaptotagmin-4. Cell Reports 21 (8), pp. 2118 - 2133 (2017)
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81.
Journal Article
Fonseca-Ornelas, L.; Schmidt, C. D.; Camacho-Zarco, A. R.; Fernandez, C. O.; Becker, S.; Zweckstetter, M.: Small molecule-induced soluble oligomers of α-synuclein with helical structure. Chemistry. A European Journal 23 (53), pp. 13010 - 13014 (2017)
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82.
Journal Article
Miotto, M. C.; Pavese, M. D.; Quintanar, L.; Zweckstetter, M.; Griesinger, C.; Fernández, C. O.: Bioinorganic chemistry of Parkinson's disease: Affinity and structural features of Cu(I) binding to the full-length β-synuclein protein. Inorganic Chemistry 56 (17), pp. 10387 - 10395 (2017)
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83.
Journal Article
Rahban, M.; Salehi, N.; Saboury, A. A.; Hosseinkhani, S.; Karimi-Jafari, M. H.; Firouzi, R.; Rezaei-Ghaleh, N.; Moosavi-Movahedi, A. A.: Histidine substitution in the most flexible fragments of firefly luciferase modifies its thermal stability. Archives of Biochemistry and Biophysics 629, pp. 8 - 18 (2017)
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84.
Journal Article
Ambadipudi, S.; Biernat, J.; Riedel, D.; Mandelkow, E.; Zweckstetter, M.: Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau. Nature Communications 8, 275 (2017)
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85.
Journal Article
Rezaei-Ghaleh, N.; Bakhtiari, D.; Rashidi, A.: Reverse allostasis in biological systems: Minimal conditions and implications. Journal of Theoretical Biology 426, pp. 134 - 139 (2017)
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86.
Journal Article
Baker, J. D.; Shelton, L. B.; Zheng, D. L.; Favretto, F.; Nordhues, B. A.; Darling, A.; Sullivan, L. E.; Sun, Z. Y.; Solanki, P. K.; Martin, M. D. et al.; Suntharalingam, A.; Sabbagh, J. J.; Becker, S.; Mandelkow, E.; Uversky, V. N.; Zweckstetter, M.; Dickey, C. A.; Koren, J.; Blair, L. J.: Human cyclophilin 40 unravels neurotoxic amyloids. PLoS Biology 15 (6), e2001336 (2017)
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87.
Journal Article
Vincente Miranda, H.; Szego, E. M.; Oliveira, L. M.; Breda, C.; Darendelioglu, E.; de Oliveira, R. M.; Ferreira, D. G.; Gomes, M. A.; Rott, R.; Oliveira, M. et al.; Munari, F.; Enguita, F. J.; Simoes, T.; Rodrigues, E. F.; Heinrich, M.; Martins, I. C.; Zamolo, I.; Riess, O.; Cordeiro, C.; Ponces-Freire, A.; Lashuel, H. A.; Santos, N. C.; Lopes, L. V.; Xiang, W.; Jovin, T. M.; Penque, D.; Engelender, S.; Zweckstetter, M.; Klucken, J.; Giorgini, F.; Quintas, A.; Outeiro, T. F.: Glycation potentiates alpha-synuclein-associated neurodegeneration in synucleinopathies. Brain 140 (5), pp. 1399 - 1419 (2017)
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88.
Journal Article
Zweckstetter, M.; Requena, J. R.; Wille, H.: Elucidating the structure of an infectious protein. PLoS Pathogens 13 (4), e1006229 (2017)
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89.
Journal Article
Oroz, J.; Kim, J. H.; Chang, B. J.; Zweckstetter, M.: Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90. Nature Structural and Molecular Biology 24 (4), pp. 407 - 413 (2017)
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90.
Journal Article
de Oliveira, R. M.; Miranda, H. V.; Francelle, L.; Pinho, R.; Szegö, E. M.; Martinho, R.; Munari, F.; Lázaro, D. F.; Moniot, S.; Guerreiro, P. et al.; Fonseca, L.; Marijanovic, Z.; Antas, P.; Gerhardt, E.; Enguita, F. J.; Fauvet, B.; Penque, D.; Pais, T. F.; Tong, Q.; Becker, S.; Kügler, S.; Lashuel, H. A.; Steegborn, C.; Zweckstetter, M.; Outeiro, T. F.: The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS Biology 15 (3), e2000374 (2017)
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91.
Journal Article
Kim, J. H.; Oroz, J.; Zweckstetter, M.: Structure of monomeric transthyretin carrying the clinically important T119M mutation. Angewandte Chemie International Edition 55 (52), pp. 16168 - 16171 (2016)
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92.
Journal Article
Gray, F.; Cho, H. J.; Shukla, S.; He, S.; Harris, A.; Boytsov, B.; Jaremko, L.; Jaremko, M.; Demeler, B.; Lawlor, E. R. et al.; Grembecka, J.; Cierpicki, T.: BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization. Nature Communications 7, 13343 (2016)
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93.
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Villar-Piquéa, A.; da Fonsecaa, T. L.; Sant’Annab, R.; Szegöa, E. M.; Fonseca-Ornelas, L.; Pinhoa, R.; Carijac, A.; Gerhardta, E.; Masaracchiaa, C.; Gonzalezf, E. A. et al.; Rossettif, G.; Carlonif, P.; Fernándezi, C. O.; Foguelb, D.; Milosevick, I.; Zweckstetter, M.; Venturac, S.; Outeiro, T. F.: Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. Proceedings of the National Academy of Sciences of the United States of America 113 (42), pp. E6506 - E6515 (2016)
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94.
Journal Article
Riechers, B.; Maes, F.; Akoury, E.; Semin, B.; Gruner, P.; Baret, J. C.: Surfactant adsorption kinetics in microfluidics. Proceedings of the National Academy of Sciences of the United States of America 113 (41), pp. 11465 - 11470 (2016)
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95.
Journal Article
Villar-Piqué, A.; da Fonseca, T. L.; Sant’Anna, R.; Szegö, E. M.; Fonseca-Ornelas, L.; Pinho, R.; Carija, A.; Gerhardt, E.; Masaracchia, C.; Gonzalezf, E. A. et al.; Rossetti, G.; Carloni, P.; Fernández, C. O.; Foguel, D.; Milosevic, I.; Zweckstetter, M.; Ventura, S.; Outeiro, T. F.: Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. Proceedings of the National Academy of Sciences of the United States of Amerca 113 (42), pp. E6506 - E6515 (2016)
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96.
Journal Article
Briones, R.; Weichbrodt, C.; Paltrinieri, L.; Mey, I.; Villinger, S.; Giller, K.; Lange, A.; Zweckstetter, M.; Griesinger, C.; Becker, S. et al.; Steinem, C.; de Groot, B. L.: Voltage dependence of conformational dynamics and subconducting states of VDAC-1. Biophysical Journal 111 (6), pp. 1223 - 1234 (2016)
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97.
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Oroz, J.; Barrera-Vilarmau, S.; Alfonso, C.; Rivas, G.; de Alba, E.: ASC pyrin domain self-associates and binds NLRP3 protein using equivalent binding interfaces. Journal of Biological Chemistry 291 (37), pp. 19487 - 19501 (2016)
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98.
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Jaremko, M.; Jaremko, L.; Villinger, S.; Schmidt, C. D.; Griesinger, C.; Becker, S.; Zweckstetter, M.: High-resolution NMR determination of the dynamic structure of membrane proteins. Angewandte Chemie International Edition 55 (35), pp. 101518 - 10521 (2016)
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99.
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Fonseca-Ornelas, L.; Zweckstetter, M.: The protonation state of histidine 111 regulates the aggregation of the evolutionary most conserved region of the human prion protein. Protein Science 25 (8), pp. 1563 - 1567 (2016)
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100.
Journal Article
Rezaei-Ghaleh, N.; Kumar, S.; Walter, J.; Zweckstetter, M.: Phosphorylation interferes with maturation of amyloid-β fibrillar structure in the N terminus. Journal of Biological Chemistry 291 (31), pp. 16059 - 16067 (2016)
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