Publications

52.

Journal Article

Medina, L.; González-Lizárraga, F.; Dominguez-Meijide, A.; Ploper, D.; Parrales, V.; Sequeira, S.; Cima-Omori, M.-S.; Zweckstetter, M.; Bel, E. D.; Michel, P. P. et al.; Outeiro, T. F.; Raisman-Vozari, R.; Chehín, R.; Socias, S. B.: Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity. Frontiers in Aging Neuroscience 13, 635760 (2021)

MPG.PuRe

53.

Journal Article

de Groot, B. L.; Janshoff, A.; Steinem, C.; Zweckstetter, M.: Special issue: Multicomponent lipid membranes—how molecular organisation leads to function. European Biophysics Journal 50 (2), pp. 107 - 108 (2021)

MPG.PuRe

54.

Journal Article

Kroppen, B.; Teske, N.; Yambire, K. F.; Denkert, N.; Mukherjee, I.; Tarasenko, D.; Jaipuria, G.; Zweckstetter, M.; Milosevic, I.; Steinem, C. et al.; Meinecke, M.: Cooperativity of membrane-protein and protein–protein interactions control membrane remodeling by epsin 1 and affects clathrin-mediated endocytosis. Cellular and Molecular Life Sciences 78 (5), pp. 2355 - 2370 (2021)

MPG.PuRe

55.

Journal Article

Najbauer, E.; Becker, S.; Giller, K.; Zweckstetter, M.; Lange, A.; Steinem, C.; de Groot, B. L.; Griesinger, C.; Andreas, L. B.: Structure, gating and interactions of the voltage-dependent anion channel. European Biophysics Journal 50 (2), pp. 159 - 172 (2021)

MPG.PuRe

56.

Journal Article

Rivière, G.; Jaipuria, G.; Andreas, L. B.; Leonov, A.; Giller, K.; Becker, S.; Zweckstetter, M.: Membrane-embedded TSPO: an NMR view. European Biophysics Journal 50 (2), pp. 173 - 180 (2021)

MPG.PuRe

57.

Journal Article

Liu, H.; Koros, C.; Strohäker, T.; Schulte, C.; Bozi, M.; Varvaresos, S.; de Opakua, A. I.; Simitsi, A. M.; Bougea, A.; Voumvourakis, K. et al.; Maniati, M.; Papageorgiou, S. G.; Hauser, A.‐.; Becker, S.; Zweckstetter, M.; Stefanis, L.; Gasser, T.: A novel SNCA A30G mutation causes familial Parkinsonʼs disease. Movement Disorders, In Press (2021)

MPG.PuRe

58.

Journal Article

Gray, A. L. H.; Steren, C. A.; Haynes, I. W.; Bermejo, G. A.; Favretto, F.; Zweckstetter, M.; Do, T. D.: Structural Flexibility of Cyclosporine A Is Mediated by Amide Cis–Trans Isomerization and the Chameleonic Roles of Calcium. Journal of Physical Chemistry B 125 (5), pp. 1378 - 1391 (2021)

MPG.PuRe

59.

Journal Article

Sieger, A.; Rankovic, M.; Favretto, F.; Ukmar‐Godec, T.; Strohäker, T.; Becker, S.; Zweckstetter, M.: Interplay between tau and α‐synuclein liquid–liquid phase separation. Protein Science, In Press (2021)

MPG.PuRe

60.

Journal Article

Savastano, A.; Flores, D.; Kadavath, H.; Biernat, J.; Mandelkow, E.; Zweckstetter, M.: Disease‐associated tau phosphorylation hinders tubulin assembly within tau condensates. Angewandte Chemie International Edition 60 (2), pp. 726 - 730 (2021)

MPG.PuRe

61.

Journal Article

Savastano, A.; Jaipuria, G.; Andreas, L. B.; Mandelkow, E.; Zweckstetter, M.: Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils. Scientific Reports 10, 21210 (2020)

MPG.PuRe

62.

Journal Article

Lott, A.; Oroz, J.; Zweckstetter, M.: Molecular basis of the interaction of Hsp90 with its co‐chaperone Hop. Protein Science 29 (12), pp. 2422 - 2432 (2020)

MPG.PuRe

63.

Journal Article

Favretto, F.; Flores, D.; Baker, J. D.; Strohäker, T.; Andreas, L. B.; Blair, L. J.; Becker, S.; Zweckstetter, M.: Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war. Nature Communications 11, 6046 (2020)

MPG.PuRe

64.

Journal Article

Savastano, A.; Ibanez de Opakua, A.; Rankovic, M.; Zweckstetter, M.: Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates. Nature Communications 11, 6041 (2020)

MPG.PuRe

65.

Journal Article

Dominguez-Meijide, A.; Vasili, E.; König, A.; Cima-Omori, M.-S.; Ibáñez de Opakua, A.; Leonov, A.; Ryazanov, S.; Zweckstetter, M.; Griesinger, C.; Outeiro, T. F.: Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization. Scientific Reports 10, 12827 (2020)

MPG.PuRe

66.

Journal Article

Ukmar-Godec, T.; Fang, P.; Ibáñez de Opakua, A.; Henneberg, F.; Godec, A.; Pan, K. T.; Cima-Omori, M.-S.; Chari, A.; Mandelkow, E.; Urlaub, H. et al.; Zweckstetter, M.: Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution. Science Advances 6 (30), eaba3916 (2020)

MPG.PuRe

67.

Journal Article

Gerdes, C.; Waal, N.; Offner, T.; Fornasiero, E. F.; Wender, N.; Verbarg, H.; Manzini, I.; Trenkwalder, C.; Mollenhauer, B.; Strohäker, T. et al.; Zweckstetter, M.; Becker, S.; Rizzoli, S. O.; Basmanav, F. B.; Opazo, F.: A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol. Nature Communications 11, 2729 (2020)

MPG.PuRe

68.

Journal Article

de Opakua, A. I.; Klama, F.; Ndukwe, I. E.; Martin, G. E.; Williamson, T. R.; Zweckstetter, M.: Determination of complex small molecule structures using molecular alignment simulation. Angewandte Chemie International Edition 59 (15), pp. 6172 - 6176 (2020)

MPG.PuRe

69.

Journal Article

Favretto, F.; Baker, J.; Strohäker, T.; Andreas, L.; Blair, L.; Becker, S.; Zweckstetter, M.: Molecular basis of the interaction of cyclophilin A with alpha-synuclein. Angewandte Chemie International Edition 132 (14), pp. 5692 - 5695 (2020)

MPG.PuRe

70.

Journal Article

Ukmar-Godec, T.; Wegmann, S.; Zweckstetter, M.: Biomolecular condensation of the microtubule-associated protein tau. Seminars in Cell and Developmental Biology 99, pp. 202 - 214 (2020)

MPG.PuRe

pre-print

71.

Journal Article

Hamann, F.; Schmitt, A.; Favretto, F.; Hofele, R.; Neumann, P.; Xiang, S. Q.; Urlaub, H.; Zweckstetter, M.; Ficner, R.: Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2. Proceedings of the National Academy of Sciences of the United States of America 117 (6), pp. 2948 - 2956 (2020)

MPG.PuRe

72.

Journal Article

Masaracchia, C.; König, A.; Valiente-Gabioud, A. A.; Peralta, P.; Favretto, F.; Strohäker, T.; Lázaro, D. F.; Zweckstetter, M.; Fernandez, C. O.; Outeiro, T. F.: Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies. Biochimica et Biophysica Acta-Proteins and Proteomics 1868 (1), 140298 (2020)

MPG.PuRe

73.

Journal Article

Strohäker, T.; Jung, B. C.; Liou, S. H.; Fernandez, C. O.; Riedel, D.; Becker, S.; Halliday, G. M.; Bennati, M.; Kim, W. S.; Lee, S. J. et al.; Zweckstetter, M.: Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts. Nature Communications 10, 5535 (2019)

MPG.PuRe

74.

Journal Article

Pellkofer, H.; Ihler, F.; Weiss, B. G.; Trothe, J.; Kadavath, H.; Chongtham, M.; Kunadt, M.; Riedel, D.; Lornsen, F.; Wilken, P. et al.; Bartels, C.; Hirschel, S.; Russo, S. G.; Stransky, E.; Trojan, L.; Schmidt, B.; Mandelkow, E.; Zweckstetter, M.; Canis, M.; Schneider, A.: Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer's disease from bioptic olfactory mucosa. European Archives of Psychiatry and Clinical Neuroscience 269 (8), pp. 973 - 984 (2019)

MPG.PuRe

75.

Journal Article

Zhang, D.; Bedogni, F.; Boterberg, S.; Camfield, C.; Camfield, P.; Charman, T.; Curfs, L.; Einspieler, C.; Esposito, G.; De Filippis, B. et al.; Goin-Kochel, R. P.; Höglinger, G. U.; Holzinger, D.; Iosif, A. M.; Lancioni, G. E.; Landsberger, N.; Laviola, G.; Marco, E. M.; Müller, M.; Neul, J. L.; Nielsen-Saines, K.; Nordahl-Hansen, A.; O'Reilly, M. F.; Ozonoff, S.; Poustka, L.; Roeyers, h.; Rankovic, M.; Sigafoos, J.; Tammimies, K.; Townend, G. S.; Zwaigenbaum, L.; Zweckstetter, M.; Bölte, S.; Marschik, P. B.: Towards a consensus on developmental regression. Neuroscience and Biobehavioral Reviews 107, pp. 3 - 5 (2019)

MPG.PuRe

76.

Journal Article

Mavroeidi, P.; Arvanitaki, F.; Karakitsou, A. K.; Vetsi, M.; Kloukina, I.; Zweckstetter, M.; Giller, K.; Becker, S.; Sorrentino, Z. A.; Giasson, B. I. et al.; Jensen, P. H.; Stefanis, L.; Xilouri, M.: Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models. Acta Neuropathologica 138 (3), pp. 415 - 441 (2019)

MPG.PuRe

77.

Journal Article

Oroz, J.; Blair, L. J.; Zweckstetter, M.: Dynamic Aha1 co-chaperone binding to human Hsp90. Protein Science 28 (9), pp. 1545 - 1551 (2019)

MPG.PuRe

78.

Journal Article

Ambadipudi, S.; Reddy,, J. G.; Biernat, J.; Mandelkow, E.; Zweckstetter, M.: Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau. Chemical Science 10 (26), pp. 6503 - 6507 (2019)

MPG.PuRe

79.

Journal Article

Ukmar-Godec, T.; Hutten, S.; Grieshop, M. P.; Rezaei-Ghaleh, N.; Cima-Omori, M. O.; Biernat, J.; Mandelkow, E.; Söding, J.; Dormann, D.; Zweckstetter, M.: Lysine/RNA-interactions drive and regulate biomolecular condensation. Nature Communications 10 (1), 2909 (2019)

MPG.PuRe

80.

Journal Article

Rezaei-Ghaleh, N.; Parigi, G.; Zweckstetter, M.: Reorientational dynamics of amyloid-β from NMR spin relaxation and molecular simulation. Journal of Physical Chemistry Letters 10, pp. 3369 - 3375 (2019)

MPG.PuRe

81.

Journal Article

Albert, N. L.; Unterrainer, M.; Brendel, M.; Kaiser, L.; Zweckstetter, M.; Cumming, P.; Bartenstein, P.: In response to: The validity of ¹⁸F-GE180 as a TSPO imaging agent. European Journal of Nuclear Medicine and Molecular Imaging 46 (6), pp. 1208 - 1211 (2019)

MPG.PuRe

82.

Journal Article

Gong, J.; Szego, E. M.; Leonov, A.; Benito, E.; Becker, S.; Fischer, A.; Zweckstetter, M.; Outeiro, T.; Schneider, A.: Translocator protein ligand protects against neurodegeneration in the MPTP mouse model of Parkinsonism. Journal of Neuroscience 39 (19), pp. 3752 - 3769 (2019)

MPG.PuRe

83.

Journal Article

Melková, K.; Zapletal, V.; Narasimhan, S.; Jansen, S.; Hritz, J.; Škrabana, R.; Zweckstetter, M.; Ringkjøbing-Jensen, M.; Blackledge, M.; Žídek, L.: Structure and functions of microtubule associated proteins tau and MAP2c: Similarities and differences. Biomolecules 9 (3), 105 (2019)

MPG.PuRe

84.

Journal Article

Rankovic, M.; Zweckstetter, M.: Upregulated levels and pathological aggregation of abnormally phosphorylated Tau-Protein in children with neurodevelopmental disorders. Neuroscience and Biobehavioral Reviews 98, pp. 1 - 9 (2019)

MPG.PuRe

85.

Journal Article

Jaipuria, G.; Giller, K.; Leonov, A.; Becker, S.; Zweckstetter, M.: Insights into cholesterol/membrane protein interactions using paramagnetic solid-state NMR. Chemistry - A European Journal 24 (66), pp. 17606 - 17611 (2018)

MPG.PuRe

86.

Journal Article

Rezaei-Ghaleh, N.; Parigi, G.; Soranno, A.; Holla, A.; Becker, S.; Schuler, B.; Luchinat, C.; Zweckstetter, M.: Local and global dynamics in intrinsically disordered synuclein. Angewandte Chemie International Edition 57 (46), pp. 15262 - 15266 (2018)

MPG.PuRe

pre-print

87.

Journal Article

Oroz, J.; Chang, B. J.; Wysoczanski, P.; Lee, C. T.; Perez-Lara, A.; Chakraborty, P.; Hofele, R. V.; Baker, J. D.; Blair, L. J.; Biernat, J. et al.; Urlaub, H.; Mandelkow, E.; Dickey, C. A.; Zweckstetter, M.: Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex. Nature Communications 9, 4532 (2018)

MPG.PuRe

88.

Journal Article

Gentile, I.; Garro, H. A.; Delgado Ocaña, S.; Gonzalez, N.; Strohäker, T.; Schibich, D.; Quintanar, L.; Sambrotta, L.; Zweckstetter, M.; Griesinger, C. et al.; Menacho Márqueza, M.; Fernandez, C. O.: Interaction of Cu(i) with the Met-X3-Met motif of alpha-synuclein: Binding ligands, affinity and structural features. Metallomics 10 (10), pp. 1383 - 1389 (2018)

MPG.PuRe

89.

Journal Article

Böhning, M.; Dugast-Darzacq, C.; Rankovic, M.; Hansen, A. S.; Yu, T.; Marie-Nelly, H.; McSwiggen, D. T.; Kokic, G.; Dailey, G. M.; Cramer, P. et al.; Darzacq, X.; Zweckstetter, M.: RNA polymerase II clustering through carboxy-terminal domain phase separation. Nature Structural and Molecular Biology 25 (9), pp. 833 - 840 (2018)

MPG.PuRe

pre-print

90.

Journal Article

Melkova, K.; Zapletal, V.; Jansen, S.; Nomilner, E.; Zachrdla, M.; Hritz, J.; Novacek, J.; Zweckstetter, M.; Jensen, M. R.; Blackledge, M. et al.; Zidek, L.: Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics. Journal of Biological Chemistry 293 (34), pp. 13297 - 13309 (2018)

MPG.PuRe

91.

Journal Article

Abayev, M.; Rodrigues, J. P. G. L. M.; Srivastava, G.; Arshava, B.; Jaremko, L.; Jaremko, M.; Naider, F.; Levitt, M.; Anglister, J.: The solution structure of monomeric CCL5 in complex with a doubly sulfated N-terminal segment of CCR5. FEBS Journal 285 (11), pp. 1988 - 2003 (2018)

MPG.PuRe

92.

Journal Article

Jaipuria, G.; Ukmar-Godec, T.; Zweckstetter, M.: Challenges and approaches to understand cholesterol-binding impact on membrane protein function: An NMR view. Cellular and Molecular Life Sciences 75 (12), pp. 2137 - 2151 (2018)

MPG.PuRe

93.

Journal Article

Aliakbari, F.; Mohammad-Beigi, H.; Rezaei-Ghaleh, N.; Becker, S.; Esmatabad, F. D.; Seyedi, H. A. E.; Bardania, H.; Marvian, A. T.; Collingwood, J. F.; Christiansen, G. et al.; Zweckstetter, M.; Otzen, D. E.; Morshedi, D.: The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease. Nanoscale 10 (19), pp. 9174 - 9185 (2018)

MPG.PuRe

94.

Journal Article

Mok, S. A.; Condello, C.; Freilich, R.; Gillies, A.; Arhar, T.; Oroz, J.; Kadavath, H.; Julien, O.; Assimon, V. A.; Rauch, J. N. et al.; Dunyak, B. M.; Lee, J.; Tsai, F. T. F.; Wilson, M. R.; Zweckstetter, M.; Dickey, C. A.; Gestwicki, J. E.: Mapping interactions with the chaperone network reveals factors that protect against tau aggregation. Nature Structural and Molecular Biology 25 (5), pp. 384 - 393 (2018)

MPG.PuRe

95.

Journal Article

Kadavath, H.; Cabrales-Fontela, Y.; Jaremko, M.; Jaremko, L.; Overkamp, K.; Biernat, J.; Mandelkow, E.; Zweckstetter, M.: The binding mode of a repeat-like Tau sequence with tubulin. Angewandte Chemie International Edition 57 (12), pp. 3246 - 3250 (2018)

MPG.PuRe

96.

Journal Article

Tolö, J.; Taschenberger, G.; Leite, K.; Stahlberg, M. A.; Spehlbrink, G.; Kues, J.; Munari, F.; Capaldi, S.; Becker, S.; Zweckstetter, M. et al.; Dean, C.; Bähr, M.; Kügler, S.: Pathophysiological consequences of neuronal alpha-Synuclein overexpression: Impacts on ion homeostasis, stress signaling, mitochondrial integrity, and electrical activity. Frontiers in Molecular Neuroscience 11, 49 (2018)

MPG.PuRe

97.

Journal Article

Lasorsa, A.; Natile, G.; Rosato, A.; Tadini-Buoninsegni , F.; Arnesano , F.: Monitoring interactions inside cells by advanced spectroscopies: Overview of copper transporters and cisplatin. Current Medicinal Chemistry 25 (4), pp. 462 - 477 (2018)

MPG.PuRe

98.

Journal Article

Martinez Hernandez, A.; Urbanke, H.; Gillman, A. L.; Lee, J.; Ryazanov, S.; Agbemenyah, H. Y.; Benito, E.; Jain, G.; Kaurani, L.; Grigorian, G. et al.; Leonov, A.; Rezaei-Ghaleh, N.; Wilken, P.; Arce, F. T.; Wagner, J.; Fuhrman, M.; Caruana, M.; Camilleri, A.; Vassallo, N.; Zweckstetter, M.; Benz, R.; Giese, A.; Schneider, A.; Korte, M.; Lal, R.; Griesinger, C.; Eichele, G.; Fischer, A.: The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology. EMBO Molecular Medicine 10 (1), pp. 32 - 47 (2018)

MPG.PuRe

99.

Journal Article

Cabrales-Fontela, Y.; Kadavath, H.; Biernat, J.; Riedel, D.; Mandelkow, E.; Zweckstetter, M.: Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau. Nature Communications 8, 1981 (2017)

MPG.PuRe

100.

Journal Article

Bharat, V.; Siebrecht, M.; Burk, K.; Ahmed, S.; Reissner, C.; Kohansal-Nodehi, M.; Steubler, V.; Zweckstetter, M.; Ting, J. T.; Dean, C.: Capture of dense core vesicles at synapses by JNK-dependent phosphorylation of Synaptotagmin-4. Cell Reports 21 (8), pp. 2118 - 2133 (2017)

MPG.PuRe