Publications

Brás, I. C.; Khani, M. H.; Vasili, E.; Möbius, W.; Riedel, D.; Parfentev, I.; Gerhardt, E.; Fahlbusch, C.; Urlaub, H.; Zweckstetter, M. et al.; Gollisch, T.; Outeiro, T. F.: Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity. Journal of Parkinson's Disease: JPD 12, pp. 2397 - 2422 (2022)

Chakraborty, P.; Zweckstetter, M.: Phase separation of the microtubule-associated protein tau. Essays in Biochemistry 66 (7), pp. 1013 - 1021 (2022)

de Opakua, A. I.; Geraets, J. A.; Frieg, B.; Dienemann, C.; Savastano, A.; Rankovic, M.; Cima-Omori, M.-S.; Schröder, G. F.; Zweckstetter, M.: Molecular interactions of FG nucleoporin repeats at high resolution. Nature Chemistry 14, pp. 1278 - 1285 (2022)

Sang, D.; Shu, T.; Pantoja, C. F.; de Opakua, A. I.; Zweckstetter, M.; Holt, L. J.: Condensed-phase signaling can expand kinase specificity and respond to macromolecular crowding. Molecular Cell 82 (19), pp. 3693 - 3711.e10 (2022)

Frieg, B.; Geraets, J. A.; Strohaeker, T.; Dienemann, C.; Mavroeidi, P.; Jung, B. C.; Kim, W. S.; Lee, S.-J.; Xilouri, M.; Zweckstetter, M. et al.; Schroeder, G. F.: Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein. Communications Biology 5 (1), 1040 (2022)

Babu, M.; Favretto, F.; Rankovic, M.; Zweckstetter, M.: Peptidyl Prolyl Isomerase A Modulates the Liquid–Liquid Phase Separation of Proline-Rich IDPs. Journal of the American Chemical Society 144 (35), pp. 16157 - 16163 (2022)

Zachrdla, M.; Savastano, A.; de Opakua, A. I.; Cima-Omori, M.-S.; Zweckstetter, M.: Contributions of the N-terminal intrinsically disordered region of the severe acute respiratory syndrome coronavirus 2 nucleocapsid protein to RNA-induced phase separation. Protein Science 31 (9), e4409 (2022)

Buratti, F. A.; Boeffinger, N.; Garro, H. A.; Flores, J. S.; Hita, F. J.; Gonçalves, P. d. C.; Copello, F. d. R.; Lizarraga, L.; Rossetti, G.; Carloni, P. et al.; Zweckstetter, M.; Outeiro, T. F.; Eimer, S.; Griesinger, C.; Fernández, C. O.: Aromaticity at position 39 in α‐synuclein: A modulator of amyloid fibril assembly and membrane‐bound conformations. Protein Science 31 (7), e4360 (2022)

Kumar, S. T.; Mahul-Mellier, A.-L.; Hegde, R. N.; Riviere, G.; Moons, R.; de Opakua, A. I.; Magalhaes, P.; Rostami, I.; Donzelli, S.; Sobott, F. et al.; Zweckstetter, M.; Lashuel, H. A.: A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity. Science Advances 8 (17), eabn0044 (2022)

Min, J.-O.; Strohäker, T.; Jeong, B.-C.; Zweckstetter, M.; Lee, S.-J.: Chicago sky blue 6B inhibits α-synuclein aggregation and propagation. Molecular Brain 15, 27 (2022)

Stelzl, L. S.; Pietrek, L. M.; Holla, A.; Oroz, J.; Sikora, M.; Köfinger, J.; Schuler, B.; Zweckstetter, M.; Hummer, G.: Global Structure of the Intrinsically Disordered Protein Tau Emerges from Its Local Structure. JACS Au 2 (3), pp. 673 - 686 (2022)

Abyzov, A.; Blackledge, M.; Zweckstetter, M.: Conformational Dynamics of Intrinsically Disordered Proteins Regulate Biomolecular Condensate Chemistry. Chemical Reviews 122 (6), pp. 6719 - 6748 (2022)

Diez, L.; Kapinos, L. E.; Hochmair, J.; Huebschmann, S.; Dominguez-Baquero, A.; Vogt, A.; Rankovic, M.; Zweckstetter, M.; Lim, R. Y. H.; Wegmann, S.: Phosphorylation but Not Oligomerization Drives the Accumulation of Tau with Nucleoporin Nup98. International Journal of Molecular Sciences 23 (7), 3495 (2022)

Pantoja, C. F.; Zweckstetter, M.; Rezaei-Ghaleh, N.: Dynamical component exchange in a model phase separating system: an NMR-based approach. PhysChemChemPhys 24 (10), pp. 6169 - 6175 (2022)

Nedaei, H.; Rezaei-Ghaleh, N.; Giller, K.; Becker, S.; Karami, L.; Moosavi-Movahedi, A. A.; Griesinger, C.; Saboury, A. A.: The calcium-free form of atorvastatin inhibits amyloid-β(1–42) aggregation in vitro. Journal of Biological Chemistry 298 (3), 101662 (2022)

Robustelli, P.; Ibanez-de-Opakua, A.; Campbell-Bezat, C.; Giordanetto, F.; Becker, S.; Zweckstetter, M.; Pan, A. C.; Shaw, D. E.: Molecular Basis of Small-Molecule Binding to α-Synuclein. Journal of the American Chemical Society 144 (6), pp. 2501 - 2510 (2022)

Cario, A.; Savastano, A.; Wood, N. B.; Liu, Z.; Previs, M. J.; Hendricks, A. G.; Zweckstetter, M.; Berger, C. L.: The pathogenic R5L mutation disrupts formation of Tau complexes on the microtubule by altering local N-terminal structure. Proceedings of the National Academy of Sciences of the United States of America 119 (7), e2114215119 (2022)

Aillaud, I.; Kaniyappan, S.; Chandupatla, R. R.; Ramirez, L. M.; Alkhashrom, S.; Eichler, J.; Horn, A. H. C.; Zweckstetter, M.; Mandelkow, E.-M.; Sticht, H. et al.; Funke, S. A.: A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro. Alzheimer's Research & Therapy 14, 15 (2022)

Moll, A.; Ramirez, L. M.; Ninov, M.; Schwarz, J.; Urlaub, H.; Zweckstetter, M.: Hsp multichaperone complex buffers pathologically modified Tau. Nature Communications 13, 3668 (2022)