Publications

Max Planck Institute for Multidisciplinary Sciences

Journal Article (294)

151.

Journal Article

Miotto, M. C.; Valiente-Gabioud, A. A.; Rossetti, G.; Zweckstetter, M.; Carloni, P.; Selenko, P.; Griesinger, C.; Binolfi, A.; Fernández, C. O.: Copper binding to the N-terminally acetylated, naturally occurring form of alpha-synuclein induces local helical folding. Journal of the American Chemical Society 137 (20), pp. 6444 - 6447 (2015)

MPG.PuRe

152.

Journal Article

Fonseca-Ornelas, L.; Eisbach, S. E.; Paulat, M.; Giller, K.; Fernandez, C. O.; Outeiro, T. F.; Becker, S.; Zweckstetter, M.: Small molecule-mediated stabilization of vesicle-associated helical alpha-synuclein inhibits pathogenic misfolding and aggregation. Nature Communications 5, 5857 (2014)

MPG.PuRe

publisher-version

supplementary-material

153.

Journal Article

Bajaj, R.; Munari, F.; Becker, S.; Zweckstetter, M.: Interaction of the intermembrane space domain of Tim23 protein with mitochondrial membranes. Journal of Biological Chemistry 289 (50), pp. 34620 - 34626 (2014)

MPG.PuRe

publisher-version

154.

Journal Article

Miotto, M. C.; Binolfi, A.; Zweckstetter, M.; Griesinger, C.; Fernandez, C. O.: Bioinorganic chemistry of synucleinopathies: Deciphering the binding features of Met motifs and His-50 in AS-Cu(I) interactions. Journal of Inorganic Biochemistry 141, pp. 208 - 211 (2014)

MPG.PuRe

publisher-version

supplementary-material

155.

Journal Article

Yao, X.; Becker, S.; Zweckstetter, M.: A six-dimensional alpha proton detection-based APSY experiment for backbone assignment of intrinsically disordered proteins. Journal of Biomolecular NMR 60 (4), pp. 231 - 240 (2014)

MPG.PuRe

supplementary-material

156.

Journal Article

Parigi, G.; Rezaei-Ghaleh, N.; Giachetti, A.; Becker, S.; Fernandez, C.; Blackledge, M.; Griesinger, C.; Zweckstetter, M.; Luchinat, C.: Long-range correlated dynamics in intrinsically disordered proteins. Journal of the American Chemical Society 136 (46), pp. 16201 - 16209 (2014)

MPG.PuRe

publisher-version

supplementary-material

157.

Journal Article

Yao, X.; Dürr, U. H. N.; Gattin, Z.; Laukat, Y.; Narayanan, R.L.; Brückner, A. K.; Meisinger, C.; Lange, A.; Becker, S.; Zweckstetter, M.: NMR-based detection of hydrogen/deuterium exchange in liposome-embedded membrane proteins. PLOS One 9 (11), e112374 (2014)

MPG.PuRe

publisher-version

158.

Journal Article

Bajaj, R.; Jaremko, L.; Jaremko, M.; Becker, S.; Zweckstetter, M.: Molecular basis of the dynamic structure of the TIM23 complex in the mitochondrial intermembrane space. Structure 22 (10), pp. 1501 - 1511 (2014)

MPG.PuRe

publisher-version

supplementary-material

supplementary-material

159.

Journal Article

Wysoczanski, P.; Schneider, C.; Xiang, S. Q.; Munari, F.; Trowitzsch, S.; Wahl, M. C.; Lührmann, R.; Becker, S.; Zweckstetter, M.: Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex. Nature Structural and Molecular Biology 21 (10), pp. 911 - 918 (2014)

MPG.PuRe

publisher-version

supplementary-material

160.

Journal Article

Yin, G.; Lopes da Fonseca, T.; Eisbach, S. E.; Anduaga, A. M.; Breda, C.; Orcellet, M. L.; Szegő, E. M.; Guerreiro, P.; Lázaro, D. F.; Braus, G. H. et al.; Fernandez, C. O.; Griesinger, C.; Becker, S.; Goody, R. S.; Itzen, A.; Giorgini, F.; Outeiro, T. F.; Zweckstetter, M.: α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner. Neurobiology of Disease 70, pp. 149 - 161 (2014)

MPG.PuRe

publisher-version

161.

Journal Article

Jaremko, L.; Jaremko, M.; Becker, S.; Zweckstetter, M.: Toward the functional oligomerization state of tryptophan-rich sensory proteins. Protein Science 23 (8), pp. 1154 - 1160 (2014)

MPG.PuRe

publisher-version

supplementary-material

162.

Journal Article

Jensen, M. R.; Zweckstetter, M.; Huang, J.; Blackledge, M.: Exploring free-energy landscapes of intrinsically disordered proteins at atomic resolution using NMR spectroscopy. Chemical Reviews 114 (13), pp. 6632 - 6660 (2014)

MPG.PuRe

163.

Journal Article

Xiang, S. Q.; Zweckstetter, M.: Detection of a transient intramolecular hydrogen bond using (l)J(NH) scalar couplings. Journal of Magnetic Resonance 243, pp. 93 - 97 (2014)

MPG.PuRe

164.

Journal Article

Villinger, S.; Giller, K.; Bayrhuber, M.; Lange, A.; Griesinger, C.; Becker, S.; Zweckstetter, M.: Nucleotide interactions of the human voltage-dependent anion channel. Journal of Biological Chemistry 289 (19), pp. 13397 - 13406 (2014)

MPG.PuRe

publisher-version

165.

Journal Article

Miotto, M. C.; Rodriguez, E. E.; Valiente-Gabioud, A. A.; Torres-Monserrat, V.; Binolfi, A.; Quintanar, L.; Zweckstetter, M.; Griesinger, C.; Fernandez, C. O.: Site-specific copper-catalyzed oxidation of alpha-synuclein: Tightening the link between metal binding and protein oxidative damage in Parkinson's disease. Inorganic Chemistry 53 (9), pp. 4350 - 4358 (2014)

MPG.PuRe

supplementary-material

166.

Journal Article

Munari, F.; Gajda, M. J.; Hiragami-Hamada, K.; Fischle, W.; Zweckstetter, M.: Characterization of the effects of phosphorylation by CK2 on the structure and binding properties of human HP1 beta. FEBS Letters 588 (7), pp. 1094 - 1099 (2014)

MPG.PuRe

publisher-version

supplementary-material

167.

Journal Article

Rezaei-Ghaleh, N.; Amininasab, M.; Giller, K.; Kumar, S.; Stuendl, A.; Schneider, A.; Becker, S.; Walter, J.; Zweckstetter, M.: Turn plasticity distinguishes different modes of amyloid-beta aggregation. Journal of the American Chemical Society 136 (13), pp. 4913 - 4919 (2014)

MPG.PuRe

publisher-version

supplementary-material

168.

Journal Article

Jaremko, L.; Jaremko, M.; Giller, K.; Becker, S.; Zweckstetter, M.: Structure of the mitochondrial translocator protein in complex with a diagnostic ligand. Science 343 (6177), pp. 1363 - 1366 (2014)

MPG.PuRe

supplementary-material

169.

Journal Article

Karagoz, G. E.; Duarte, A. M. S.; Akoury, E.; Ippel, H.; Biernat, J.; Luengo, T. M.; Radli, M.; Didenko, T.; Nordhues, B. A.; Veprintsev, D. B. et al.; Dickey, C. A.; Mandelkow, E.; Zweckstetter, M.; Boelens, R.; Madl, T.; Rudiger, S. G. D.: Hsp90-Tau complex reveals molecular basis for specificity in chaperone action. Cell 156 (5), pp. 963 - 974 (2014)

MPG.PuRe

publisher-version

supplementary-material

supplementary-material

170.

Journal Article

Schwalbe, M.; Ozenne, V.; Bibow, S.; Jaremko, M.; Jaremko, L.; Gajda, M. J.; Jensen, M. R.; Biernat, J.; Becker, S.; Mandelkow, E. et al.; Zweckstetter, M.; Blackledge, M.: Predictive atomic resolution descriptions of intrinsically disordered hTau40 and alpha-synuclein in solution from NMR and small angle scattering. Structure 22 (2), pp. 238 - 249 (2014)

MPG.PuRe

publisher-version

supplementary-material

171.

Journal Article

Buhl, T.; Braun, A.; Forkel, S.; Moebius, W.; van Werven, L.; Jahn, O.; Rezaei-Ghaleh, N.; Zweckstetter, M.; Mempel, M.; Schoen, M. P. et al.; Haennssle, H. A.: Internalization routes of cell-penetrating melanoma antigen peptides into human dendritic cells. Experimental Dermatology 23 (1), pp. 20 - 26 (2014)

MPG.PuRe

publisher-version

172.

Journal Article

Schwalbe, M.; Biernat, J.; Bibow, S.; Ozenne, V.; Jensen, M. R.; Kadavath, H.; Blackledge, M.; Mandelkow, E.; Zweckstetter, M.: Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2. Biochemistry 52 (50), pp. 9068 - 9079 (2013)

MPG.PuRe

supplementary-material

173.

Journal Article

Xiang, S. Q.; Gapsys, V.; Kim, H. Y.; Bessonov, S.; Hsiao, H. H.; Möhlmann, S.; Klaukien, V.; Ficner, R.; Becker, S.; Urlaub, H. et al.; Lührmann, R.; de Groot, B.; Zweckstetter, M.: Phosphorylation drives a dynamic switch in serine/arginine-rich proteins. Structure 21 (12), pp. 2162 - 2174 (2013)

MPG.PuRe

publisher-version

supplementary-material

174.

Journal Article

Rezaei-Ghaleh, N.; Klama, F.; Munari, F.; Zweckstetter, M.: Predicting the rotational tumbling of dynamic multidomain proteins and supramolecular complexes. Angewandte Chemie International Edition 52 (43), pp. 11410 - 11414 (2013)

MPG.PuRe

supplementary-material

175.

Journal Article

Taschenberger, G.; Toloe, J.; Tereshchenko, J.; Akerboom, J.; Wales, P.; Benz, R.; Becker, S.; Outeiro, T. F.; Looger, L. L.; Bähr, M. et al.; Zweckstetter, M.; Kügler, S.: Beta-synuclein aggregates and induces neurodegeneration in dopaminergic neurons. Annals of Neurology 74 (1), pp. 109 - 118 (2013)

MPG.PuRe

publisher-version

176.

Journal Article

Bouter, I.; Dittrich, K.; Wittnam, J. L.; Rezaei-Ghaleh, N.; Pillot, T.; Papot-Coutourier, S.; Lefebvre, T.; Sprenger, F.; Wirths, O.; Zweckstetter, M. et al.; Bayer, T. A.: N-truncated amyloid beta (A beta) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits. Acta Neuropathologica 126 (2), pp. 189 - 205 (2013)

MPG.PuRe

publisher-version

177.

Journal Article

Aggarwal, S.; Snaidero, N.; Pähler, G.; Frey, S.; Sanchez, P.; Zweckstetter, M.; Janshoff, A.; Schneider, A.; Weil, M. T.; Schaap, I. A. T. et al.; Görlich, D.; Simons, M.: Myelin membrane assembly is driven by a phase transition of myelin basic proteinsiInto a cohesive protein meshwork. PLoS Biology 11 (6), e1001577 (2013)

MPG.PuRe

178.

Journal Article

Wagner, J.; Ryazanov, S.; Leonov, A.; Levin, J.; Shi, S.; Schmidt, F.; Prix, C.; Pan-Montojo, F.; Bertsch, U.; Mitteregger-Kretzschmar, G. et al.; Geissen, M.; Eiden, M.; Leidel, F.; Hirschberger, T.; Deeg, A. A.; Krauth, J.; Zinth, W.; Tavan, P.; Pilger, J.; Zweckstetter, M.; Frank, T.; Baehr, M.; Weishaupt, J. H.; Uhr, M.; Urlaub, H.; Teichmann, U.; Samwer, M.; Bötzel, K.; Groschup, M.; Kretzschmar, H.; Griesinger, C.; Giese, A.: Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathologica 125 (6), pp. 795 - 813 (2013)

MPG.PuRe

publisher-version

supplementary-material

supplementary-material

179.

Journal Article

Zweckstetter, M.: Conserved amyloid core structure of stop mutants of the human prion protein. Prion 7 (3), pp. 193 - 197 (2013)

MPG.PuRe

180.

Journal Article

Munari, F.; Rezaei-Ghaleh, N.; Xiang, S. Q.; Fischle, W.; Zweckstetter, M.: Structural plasticity in human heterochromatin protein 1 beta. PLoS One 8 (4), e60887 (2013)

MPG.PuRe

publisher-version

181.

Journal Article

Jaremko, M.; Jaremko, L.; Kim, H. Y.; Cho, M. K.; Schwieters, C. D.; Giller, K.; Becker, S.; Zweckstetter, M.: Cold denaturation of a protein dimer monitored at atomic resolution. Nature Chemical Biology 9 (4), pp. 264 - 270 (2013)

MPG.PuRe

publisher-version

supplementary-material

182.

Journal Article

Jinwal, U. K.; Akoury, E.; Abisambra, J. F.; O'Leary, J. C.; Thompson, A. D.; Blair, L. J.; Jin, Y.; Bacon, J.; Nordhues, B. A.; Cockman, M. et al.; Zhang, J.; Li, P.; Zhang, B.; Borysov, S.; Uversky, V. N.; Biernat, J.; Mandelkow, E.; Gestwicki, J. E.; Zweckstetter, M.; Dickey, C. A.: Imbalance of Hsp70 family variants fosters tau accumulation. FASEB Journal 27 (4), pp. 1450 - 1459 (2013)

MPG.PuRe

183.

Journal Article

Akoury, E.; Pickardt, M.; Gajda, M. J.; Biernat, J.; Mandelkow, E.; Zweckstetter, M.: Mechanistic basis of phenothiazine-driven inhibition of Tau aggregation. Angewandte Chemie-International Edition 52 (12), pp. 3511 - 3515 (2013)

MPG.PuRe

supplementary-material

184.

Journal Article

Xiang, S. Q.; Narayanan, R. L.; Becker, S.; Zweckstetter, M.: N-H spin-spin couplings: Probing hydrogen bonds in proteins. Angewandte Chemie-International Edition 52 (12), pp. 3525 - 3528 (2013)

MPG.PuRe

supplementary-material

185.

Journal Article

Skora, L.; Fonseca, L.; Hofele, R. V.; Riedel, D.; Giller, K.; Watzlawik, J.; Schulz-Schaeffer, W. J.; Urlaub, H.; Becker, S.; Zweckstetter, M.: Burial of the polymorphic residue 129 in amyloid fibrils of prion stop mutants. Journal of Biological Chemistry 288 (5), pp. 2994 - 3002 (2013)

MPG.PuRe

publisher-version

supplementary-material

186.

Journal Article

Akoury, E.; Gajda, M.; Pickhardt, M.; Biernat, J.; Pornsuwan, S.; Griesinger, C.; Mandelkow, E.; Zweckstetter, M.: Inhibition of tau filament formation by conformational modulation. Journal of the American Chemical Society 135 (7), pp. 2853 - 2862 (2013)

MPG.PuRe

publisher-version

publisher-version

187.

Journal Article

Skora, L.; Zweckstetter, M.: Determination of amyloid core structure using chemical shifts. Protein Science 21 (12), pp. 1948 - 1953 (2012)

MPG.PuRe

publisher-version

supplementary-material

188.

Journal Article

Kroth, H.; Ansaloni, A.; Varisco, Y.; Jan, A.; Sreenivasachary, N.; Rezaei-Ghaleh, N.; Giriens, V.; Lohmann, S.; López-Deber, M. P.; Adolfsson, O. et al.; Pihlgren, M.; Paganetti, P.; Froestl, W.; Nagel-Steger, L.; Willbold, D.; Schrader, T.; Zweckstetter, M.; Pfeifer, A.; Lashuel, H. A.; Muhs, A.: Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation. Journal of Biological Chemistry 287 (41), pp. 34786 - 34800 (2012)

MPG.PuRe

publisher-version

supplementary-material

189.

Journal Article

Munari, F.; Soeroes, S.; Zenn, H. M.; Schomburg, A.; Kost, N.; Schröder, S.; Klingberg, R.; Rezaei-Ghaleh, N.; Stützer, A.; Gelato, K. A. et al.; Walla, P. J.; Becker, S.; Schwarzer, D.; Zimmermann, B.; Fischle, W.; Zweckstetter, M.: Methylation of K9 in histone H3 directs alternative modes of highly dynamic interaction of heterochromatin protein hHP1β with the nucleosome. Journal of Biological Chemistry 287 (40), pp. 33756 - 33765 (2012)

MPG.PuRe

publisher-version

supplementary-material

190.

Journal Article

El-Turk, F.; Fauvet, B.; Ashrafi, A.; Ouertatani-Sakouhi, H.; Cho, M. K.; Neri, M.; Cascella, M.; Rothlisberger, U.; Pojer, F.; Zweckstetter, M. et al.; Lashuel, H.: Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: Leucine 46 hydrophobic pocket. PLoS One 7 (9), e0045024 (2012)

MPG.PuRe

publisher-version

191.

Journal Article

Zachariae, U.; Schneider, R.; Briones, R.; Gattin, Z.; Demers, J. P.; Giller, K.; Maier, E.; Zweckstetter, M.; Griesinger, C.; Becker, S. et al.; Benz, R.; de Groot, B. L.; Lange, A.: Beta-barrel mobility underlies closure of the voltage-dependent anion channel. Structure 20 (9), pp. 1540 - 1549 (2012)

MPG.PuRe

publisher-version

supplementary-material

192.

Journal Article

Cho, M. K.; Xiang , S.; Kim, H. Y.; Becker, S.; Zweckstetter, M.: Cold-induced changes in the protein ubiquitin. PLoS One 7 (6), e37270 (2012)

MPG.PuRe

publisher-version

193.

Journal Article

Petroi, D.; Popova, B.; Taheri-Talesh, N.; Irniger, S.; Shapasandzadeh, H.; Zweckstetter, M.; Outeiro, T. F.; Braus, G. H.: Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome. Journal of Biological Chemistry 287 (33), pp. 27567 - 27579 (2012)

MPG.PuRe

publisher-version

supplementary-material

194.

Journal Article

Rezaei-Ghaleh, N.; Blackledge, M.; Zweckstetter, M.: Intrinsically disordered proteins: from sequence and conformational properties toward drug discovery. ChemBioChem 13 (7), pp. 930 - 950 (2012)

MPG.PuRe

195.

Journal Article

Taschenberger, G.; Garrido, M.; Tereshchenko, Y.; Baehr, M.; Zweckstetter, M.; Kuegler, S.: Aggregation of alpha Synuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons. Acta Neuropathologica 123 (5), pp. 671 - 683 (2012)

MPG.PuRe

196.

Journal Article

Berger, R.; Courtieu, J.; Gil, R. R.; Griesinger, C.; Köck, M.; Lesot, P.; Luy, B.; Merlet, D.; Navarro-Vazquez, A.; Reggelin, M. et al.; Reinscheid, U. M.; Thiele, C. M.; Zweckstetter, M.: Is enantiomer assignment possible by NMR spectroscopy using residual dipolar couplings from chiral nonracemic alignment media?—A critical assessment. Angewandte Chemie International Edition 51 (33), pp. 8388 - 8391 (2012)

MPG.PuRe

197.

Journal Article

Daebel, V.; Chinnathambi, S.; Biernat, J.; Schwalbe, M.; Habenstein, B.; Loquet, A.; Akoury, E.; Tepper, K.; Mueller, H.; Baldus, M. et al.; Griesinger, C.; Zweckstetter, M.; Mandelkow, E.; Vijayan, V.; Lange, A.: β-sheet core of Tau paired helical filaments revealed by solid-state NMR. Journal of the American Chemical Society 134 (34), pp. 13982 - 13989 (2012)

MPG.PuRe

publisher-version

198.

Journal Article

Ozenne, V.; Schneider, R.; Yao, M.; Huang, J.-R.; Salmon, L.; Zweckstetter, M.; Jensen, M. R.; Blackledge, M.: Mapping the potential energy landscape of intrinsically disordered proteins at amino acid resolution. Journal of the American Chemical Society 134 (36), pp. 15138 - 15148 (2012)

MPG.PuRe

publisher-version

supplementary-material

199.

Journal Article

Bibow, S.; Ozenne, V.; Biernat, J.; Blackledge, M.; Mandelkow, E.; Zweckstetter, M.: Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau. Journal of the American Chemical Society 133 (40), pp. 15842 - 15845 (2011)

MPG.PuRe

publisher-version

publisher-version

200.

Journal Article

Lamberto, C. R.; Torres-Monserrat, V.; Bertoncini, C. W.; Salvatella, X.; Zweckstetter, M.; Griesinger, C.; Fernandez, C. O.: Toward the discovery of effective polycyclic inhibitors of alpha-Synuclein amyloid assembly. Journal of Biological Chemistry 286 (37), pp. 32036 - 32044 (2011)

MPG.PuRe

publisher-version

publisher-version