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NASC-seq monitors RNA synthesis in single cells. Nature Communications 102.
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Structure of the super-elongation complex subunit AFF4 C-terminal homology domain reveals requirements for AFF homo- and heterodimerization. Journal of Biological Chemistry 103.
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Structural basis of TFIIH activation for nucleotide excision repair. Nature Communications 104.
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Transcriptome maps of general eukaryotic RNA degradation factors. eLife 105.
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74 (4), pp. 674 - 687 (2019)
MYC recruits SPT5 to RNA polymerase II to promote processive transcription elongation. Molecular Cell 106.
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Yeast mitochondrial protein Pet111p binds directly to two distinct targets in COX2 mRNA, suggesting a mechanism of translational activation. Journal of Biological Chemistry 107.
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Structure of the Ty3/Gypsy retrotransposon capsid and the evolution of retroviruses. Proceedings of the National Academy of Sciences of the United States of America 108.
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Global donor and acceptor splicing site kinetics in human cells. eLife 109.
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Functional metagenomics reveals an overlooked diversity and novel features of soil-derived bacterial phosphatases and phytases. mBio 110.
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The implication of early chromatin changes in X chromosome inactivation. Cell 111.
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Promoter distortion and opening in the RNA polymerase II cleft. Molecular Cell 112.
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Organization and regulation of gene transcription. Nature 113.
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Eukaryotic transcription turns 50. Cell 114.
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Structure of transcribing RNA polymerase II-nucleosome complex. Nature Communications 115.
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The APT complex is involved in non-coding RNA transcription and is distinct from CPF. Nucleic Acids Research 116.
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Transcription factor dimerization activates the p300 acetyltransferase. Nature 117.
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The interaction landscape between transcription factors and the nucleosome. Nature 118.
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RNA polymerase II clustering through carboxy-terminal domain phase separation. Nature Structural and Molecular Biology 119.
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Structural basis of mitochondrial transcription. Nature Structural and Molecular Biology 120.
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Structure of activated transcription complex Pol II-DSIF-PAF-SPT6. Nature 121.
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Structure of paused transcription complex Pol II–DSIF–NELF. Nature 122.
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RNA velocity of single cells. Nature 123.
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Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by α-amanitin. Journal of Biological Chemistry 124.
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Distinct mechanisms of transcription initiation by RNA polymerases I and II. Annual Review of Biophysics 125.
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Conserved RNA polymerase II initiation complex structure. Current Opinion in Structural Biology 126.
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The structure of the COPI coat determined within the cell. eLife 127.
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Structural basis of mitochondrial transcription initiation. Cell 128.
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Mechanism of transcription anti-termination in human mitochondria. Cell 129.
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114 (46), pp. 12172 - 12177 (2017)
Mechanism of RNA polymerase II stalling by DNA alkylation. Proceedings of the National Academy of Sciences of the United States of America 130.
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551 (7679), pp. 204 - 209 (2017)
Structures of transcription pre-initiation complex with TFIIH and Mediator. Nature 131.
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Cis-regulatory elements explain most of the mRNA stability variation across genes in yeast. RNA 132.
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Nucleosome-Chd1 structure and implications for chromatin remodelling. Nature 133.
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CDK9-dependent RNA polymerase II pausing controls transcription initiation. eLife 134.
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Structure of a transcribing RNA polymerase II-DSIF complex reveals a multidentate DNA-RNA clamp. Nature Structural and Molecular Biology 135.
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EBF1 binds to EBNA2 and promotes the assembly of EBNA2 chromatin complexes in B cells. PLoS Pathogens 136.
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Structural molecular biology - A personal reflection on the occasion of John Kendrew's 100th birthday. Journal of Molecular Biology 137.
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MCPIP1 exogenous overexpression inhibits pathways regulating MYCN oncoprotein stability in neuroblastoma. Journal of Cellular Biochemistry 138.
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9 angstrom structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments. eLife 139.
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Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex. Nature Communications 140.
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RNA-dependent chromatin association of transcription elongation factors and Pol II CTD kinases. eLife 141.
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Core Mediator structure at 3.4 Å extends model of transcription initiation complex. Nature 142.
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Architecture of a transcribing-translating expressome. Science 143.
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Genome-wide analysis of RNA polymerase II termination at protein-coding genes. Molecular Cell 144.
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Spt5 plays vital roles in the control of sense and antisense transcription elongation. Molecular Cell 145.
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The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA. Nature Communications 146.
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169 (1), pp. 120 - 131 (2017)
Structural basis of RNA polymerase I transcription initiation. Cell 147.
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TT-seq captures enhancer landscapes immediately after T-cell stimulation. Molecular Systems Biology 148.
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Using the Volta phase plate with defocus for cryo-EM single particle analysis. eLife 149.
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Accurate promoter and enhancer identification in 127 ENCODE and roadmap epigenomics cell types and tissues by GenoSTAN. PLoS One 150.
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