Publications

2.

Journal Article

Obeng, E. M.; Fianu, I.; Danquah, M. K.: Multivalent ACE2 engineering-A promising pathway for advanced coronavirus nanomedicine development. Nano Today 46, 101580 (2022)

MPG.PuRe

3.

Journal Article

Frieg, B.; Geraets, J. A.; Strohaeker, T.; Dienemann, C.; Mavroeidi, P.; Jung, B. C.; Kim, W. S.; Lee, S.-J.; Xilouri, M.; Zweckstetter, M. et al.; Schroeder, G. F.: Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein. Communications Biology 5 (1), 1040 (2022)

MPG.PuRe

4.

Journal Article

de Opakua, A. I.; Geraets, J. A.; Frieg, B.; Dienemann, C.; Savastano, A.; Rankovic, M.; Cima-Omori, M.-S.; Schröder, G. F.; Zweckstetter, M.: Molecular interactions of FG nucleoporin repeats at high resolution. Nature Chemistry 14, pp. 1278 - 1285 (2022)

MPG.PuRe

5.

Journal Article

Antonschmidt, L.; Matthes, D.; Dervişoğlu, R.; Frieg, B.; Dienemann, C.; Leonov, A.; Nimerovsky, E.; Sant, V.; Ryazanov, S.; Giese, A. et al.; Schröder, G.; Becker, S.; de Groot, B. L.; Griesinger, C.; Andreas, L. B.: The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils. Nature Communications 13, pp. 5385 - 5394 (2022)

MPG.PuRe

6.

Journal Article

Farnung, L.; Ochmann, M.; Garg, G.; Vos, S.; Cramer, P.: Structure of a backtracked hexasomal intermediate of nucleosome transcription. Molecular Cell 82 (17), pp. 3126 - 3134.e7 (2022)

MPG.PuRe

7.

Journal Article

Fietze, T.; Wilk, P.; Kabinger, F.; Anoosheh, S.; Hofer, A.; Lundin, D.; Feiler, C. G.; Weiss, M. S.; Loderer, C.: HUG Domain Is Responsible for Active Dimer Stabilization in an NrdJd Ribonucleotide Reductase. Biochemistry 61 (15), pp. 1633 - 1641 (2022)

MPG.PuRe

8.

Journal Article

Xiong, L.; Tolen, E. A.; Choi, J.; Velychko, S.; Caizzi, L.; Velychko, T.; Adachi, K.; MacCarthy, C. M.; Lidschreiber, M.; Cramer, P. et al.; Schöler, H. R.: Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells. eLife 11, e71533 (2022)

MPG.PuRe

9.

Journal Article

Dombrowski, M.; Engeholm, M.; Dienemann, C.; Dodonova, S. O.; Cramer, P.: Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory. Nature Structural and Molecular Biology 29 (5), pp. 493 - 501 (2022)

MPG.PuRe

10.

Journal Article

Sahu, B.; Hartonen, T.; Pihlajamaa, P.; Wei, B.; Dave, K.; Zhu, F.; Kaasinen, E.; Lidschreiber, K.; Lidschreiber, M.; Daub, C. O. et al.; Cramer, P.; Kivioja, T.; Taipale, J.: Sequence determinants of human gene regulatory elements. Nature Genetics 54 (3), pp. 283 - 294 (2022)

MPG.PuRe

11.

Journal Article

Downes, D. J.; Smith, A. L.; Karpinska, M. A.; Velychko, T.; Rue-Albrecht, K.; Sims, D.; Milne, T. A.; Davies, J. O. J.; Oudelaar, A. M.; Hughes, J. R.: Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture. Nature Protocols 17 (2), pp. 445 - 475 (2022)

MPG.PuRe

12.

Journal Article

Baar, T.; Dümcke, S.; Gressel, S.; Schwalb, B.; Dilthey, A.; Cramer, P.; Tresch, A.: RNA transcription and degradation of Alu retrotransposons depends on sequence features and evolutionary history. G3: Genes, Genomes, Genetics 12 (5), jkac054 (2022)

MPG.PuRe

13.

Journal Article

Shao, R.; Kumar, B.; Lidschreiber, K.; Lidschreiber, M.; Cramer, P.; Elsässer, S. J.: Distinct transcription kinetics of pluripotent cell states. Molecular Systems Biology 18 (1), e10407 (2022)

MPG.PuRe

14.

Journal Article

Fianu, I.; Chen, Y.; Dienemann, C.; Dybkov, O.; Linden, A.; Urlaub, H.; Cramer, P.: Structural basis of Integrator-mediated transcription regulation. Science 374 (6569), pp. 883 - 887 (2021)

MPG.PuRe

15.

Journal Article

Kokic, G.; Wagner, F. R.; Chernev, A.; Urlaub, H.; Cramer, P.: Structural basis of human transcription–DNA repair coupling. Nature 598 (7880), pp. 368 - 372 (2021)

MPG.PuRe

16.

Journal Article

Aibara, S.; Dienemann, C.; Cramer, P.: Structure of an inactive RNA polymerase II dimer. Nucleic Acids Research 49 (18), pp. 10747 - 10755 (2021)

MPG.PuRe

17.

Journal Article

García-Martínez, J.; Medina, D. A.; Bellvís, P.; Sun, M.; Cramer, P.; Chávez, S.; Pérez-Ortín, J. E.: The total mRNA concentration buffering system in yeast is global rather than gene-specific. RNA 27 (10), pp. 1281 - 1290 (2021)

MPG.PuRe

18.

Journal Article

Güttler, T.; Aksu, M.; Dickmanns, A.; Stegmann, K. M.; Gregor, K.; Rees, R.; Taxer, W.; Rymarenko, O.; Schünemann, J.; Dienemann, C. et al.; Gunkel, P.; Mussil, B.; Krull, J.; Teichmann, U.; Groß, U.; Cordes, V.; Dobbelstein, M.; Görlich, D.: Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies. EMBO Journal 40 (19), e107985 (2021)

MPG.PuRe

19.

Journal Article

Bhatta, A.; Dienemann, C.; Cramer, P.; Hillen, H.: Structural basis of RNA processing by human mitochondrial RNase P. Nature Structural and Molecular Biology 28 (9), pp. 713 - 723 (2021)

MPG.PuRe

20.

Journal Article

Cramer, P.: AlphaFold2 and the future of structural biology. Nature Structural and Molecular Biology 28 (9), pp. 704 - 705 (2021)

MPG.PuRe

21.

Journal Article

Kabinger, F.; Stiller, C.; Schmitzova, J.; Dienemann, C.; Kokic, G.; Hillen, H. S.; Höbartner, C.; Cramer, P.: Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis. Nature Structural and Molecular Biology 28 (9), pp. 740 - 746 (2021)

MPG.PuRe

22.

Journal Article

Jochheim, F. A.; Tegunov, D.; Hillen, H. S.; Schmitzova, J.; Kokic, G.; Dienemann, C.; Cramer, P.: The structure of a dimeric form of SARS-CoV-2 polymerase. Communications Biology 4, 999 (2021)

MPG.PuRe

23.

Journal Article

Zumer, K.; Maier, K. C.; Farnung, L.; Jaeger, M. G.; Rus, P.; Winter, G.; Cramer, P.: Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo. Molecular Cell 81 (15), pp. 3096 - 3109.e8 (2021)

MPG.PuRe

24.

Journal Article

Wang, H.; Xiong, L.; Cramer, P.: Structures and implications of TBP–nucleosome complexes. Proceedings of the National Academy of Sciences of the USA 118 (30), e2108859118 (2021)

MPG.PuRe

25.

Journal Article

Schilbach, S.; Aibara, S.; Dienemann, C.; Grabbe, F.; Cramer, P.: Structure of RNA polymerase II pre-initiation complex at 2.9 Å defines initial DNA opening. Cell 184 (15), pp. 4064 - 4072.e28 (2021)

MPG.PuRe

26.

Journal Article

Chen, Y.; Vos, S. M.; Dienemann, C.; Ninov, M.; Urlaub, H.; Cramer, P.: Allosteric transcription stimulation by RNA polymerase II super elongation complex. Molecular Cell 81 (16), pp. 3386 - 3399.e10 (2021)

MPG.PuRe

27.

Journal Article

Aibara, S.; Schilbach, S.; Cramer, P.: Structures of mammalian RNA polymerase II pre-initiation complexes. Nature 594 (7861), pp. 124 - 128 (2021)

MPG.PuRe

28.

Journal Article

Rengachari, S.; Schilbach, S.; Aibara, S.; Dienemann, C.; Cramer, P.: Structure of the human Mediator-RNA polymerase II pre-initiation complex. Nature 594 (7861), pp. 129 - 133 (2021)

MPG.PuRe

29.

Journal Article

Osman, S.; Mohammad, E.; Lidschreiber, M.; Stuetzer, A.; Bazsó, F. L.; Maier, K. C.; Urlaub, H.; Cramer, P.: The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II. Journal of Biological Chemistry 296, 100734 (2021)

MPG.PuRe

30.

Journal Article

Oberbeckmann, E.; Niebauer, V.; Watanabe, S.; Farnung, L.; Moldt, M.; Schmid, A.; Cramer, P.; Peterson, C. L.; Eustermann, S.; Hopfner, K.-P. et al.; Korber, P.: Ruler elements in chromatin remodelers set nucleosome array spacing and phasing. Nature Communications 12, 3232 (2021)

MPG.PuRe

31.

Journal Article

Fianu, I.; Dienemann, C.; Aibara, S.; Schilbach, S.; Cramer, P.: Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2. Communications Biology 4, 606 (2021)

MPG.PuRe

32.

Journal Article

Caizzi, L.; Monteiro-Martins, S.; Schwalb, B.; Lysakovskaya, K.; Schmitzova, J.; Sawicka, A.; Chen, Y.; Lidschreiber, M.; Cramer, P.: Efficient RNA polymerase II pause release requires U2 snRNP function. Molecular Cell 81 (9), pp. 1920 - 1934.e9 (2021)

MPG.PuRe

33.

Journal Article

Hillen, H. S.; Markov, D. A.; Wojtas, I. D.; Hofmann, K. B.; Lidschreiber, M.; Cowan, A. T.; Jones, J. L.; Temiakov, D.; Cramer, P.; Anikin, M.: The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3′-UTRs of yeast mitochondrial mRNAs. Proceedings of the National Academy of Sciences of the USA 118 (15), e2009329118 (2021)

MPG.PuRe

34.

Journal Article

Farnung, L.; Ochmann, M.; Engeholm, M.; Cramer, P.: Structural basis of nucleosome transcription mediated by Chd1 and FACT. Nature Structural and Molecular Biology 28 (4), pp. 382 - 387 (2021)

MPG.PuRe

35.

Journal Article

Choi, J.; Lysakovskaia, K.; Stik, G.; Demel, C.; Söding, J.; Tian, T. V.; Graf, T.; Cramer, P.: Evidence for additive and synergistic action of mammalian enhancers during cell fate determination. eLife 10, e65381 (2021)

MPG.PuRe

36.

Journal Article

Rawat, P.; Böhning, M.; Hummel, B.; Aprile-Garcia, F.; Pandit, A. S.; Eisenhardt, N.; Khavaran, A.; Niskanen, E.; Vos, S. M.; Palvimo, J. J. et al.; Pichler, A.; Cramer, P.; Sawarkar, R.: Stress-induced nuclear condensation of NELF drives transcriptional downregulation. Molecular Cell 81 (5), pp. 1013 - 1026.e11 (2021)

MPG.PuRe

37.

Journal Article

Endres, T.; Solvie, D.; Heidelberger, J. B.; Andriolett, V.; Baluapuri, A.; Ade, C. P.; Muhar, M.; Eilers, U.; Vos, S. M.; Cramer, P. et al.; Zuber, J.; Beli, P.; Popov, N.; Wolf, E.; Gallant, P.; Eilers, M.: Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters. Molecular Cell 81 (4), pp. 830 - 844.e13 (2021)

MPG.PuRe

38.

Journal Article

Sawicka, A.; Villamil, G.; Lidschreiber, M.; Darzacq, X.; Dugast‐Darzacq, C.; Schwalb, B.; Cramer, P.: Transcription activation depends on the length of the RNA polymerase II C‐terminal domain. EMBO Journal 40 (9), e107015 (2021)

MPG.PuRe

39.

Journal Article

Tegunov, D.; Xue, L.; Dienemann, C.; Cramer, P.; Mahamid, J.: Multi-particle cryo-EM refinement with M visualizes ribosome-antibiotic complex at 3.5 Å in cells. Nature Methods 18 (2), pp. 186 - 193 (2021)

MPG.PuRe

40.

Journal Article

Zhang, S.; Aibara, S.; Vos, S. M.; Agafonov, D.; Lührmann, R.; Cramer, P.: Structure of a transcribing RNA polymerase II–U1 snRNP complex. Science 371 (6526), pp. 305 - 309 (2021)

MPG.PuRe

41.

Journal Article

Kokic, G.; Hillen, H. S.; Tegunov, D.; Dienemann, C.; Seitz, F.; Schmitzova, J.; Farnung, L.; Siewert, A.; Höbartner, C.; Cramer, P.: Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nature Communications 12, 279 (2021)

MPG.PuRe

42.

Journal Article

Kokic, G.; Hillen, H. S.; Tegunov, D.; Dienemann, C.; Seitz, F.; Schmitzova, J.; Farnung, L.; Siewert, A.; Höbartner, C.; Cramer, P.: Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nature Communications 12, 279 (2021)

MPG.PuRe

43.

Journal Article

Cramer, P.; Kokic, G.; Dienemann, C.; Höbartner, C.; Hillen, H. S.: Coronavirus-Replikation: Mechanismus und Inhibition durch Remdesivir. Biospektrum 27 (1), pp. 49 - 53 (2021)

MPG.PuRe

44.

Journal Article

Kim, K.-P.; Choi, J.; Yoon, J.; Bruder, J. M.; Shin, B.; Kim, J.; Arauzo-Bravo, M. J.; Han, D.; Wu, G.; Han, D. W. et al.; Kim, J.; Cramer, P.; Schöler, H. R.: Permissive epigenomes endow reprogramming competence to transcriptional regulators. Nature Chemical Biology 17 (1), pp. 47 - 56 (2021)

MPG.PuRe

45.

Journal Article

Lidschreiber, K.; Jung, L. A.; von der Emd, H.; von der Emde, H.; Dave, K.; Taipale, J.; Cramer, P.; Lidschreiber, M.: Transcriptionally active enhancers in human cancer cells. Molecular Systems Biology 17 (1), e9873 (2021)

MPG.PuRe

46.

Journal Article

Lykke-Andersen, S.; Zumer, K.; Molska, E. Š.; Rouvière, J. O.; Wu, G.; Demel, C.; Schwalb, B.; Schmid, M.; Cramer, P.; Jensen, T. H.: Integrator is a genome-wide attenuator of non-productive transcription. Molecular Cell, in Press (2020)

MPG.PuRe

47.

Journal Article

Bonekamp, N. A.; Peter, B.; Hillen, H. S.; Felser, A.; Bergbrede, T.; Choidas, A.; Horn, M.; Unger, A.; Di Lucrezia, R.; Atanassov, I. et al.; Li, X.; Koch, U.; Menninger, S.; Boros, J.; Habenberger, P.; Giavalisco, P.; Cramer, P.; Denzel, M. S.; Nussbaumer, P.; Klebl, B.; Falkenberg, M.; Gustafsson, C. M.; Larsson, N.-G.: Small-molecule inhibitors of human mitochondrial DNA transcription. Nature 588 (7839), pp. 712 - 716 (2020)

MPG.PuRe

48.

Journal Article

Osman, S.; Cramer, P.: Structural biology of RNA polymerase II transcription: 20 years on. Annual Review of Cell and Developmental Biology 36, pp. 1 - 34 (2020)

MPG.PuRe

49.

Journal Article

Maier, K. C.; Gressel, S.; Cramer, P.; Schwalb, B.: Native molecule sequencing by nano-ID reveals synthesis and stability of RNA isoforms. Genome Research 30 (9), pp. 1332 - 1344 (2020)

MPG.PuRe

50.

Journal Article

Cramer, P.: Rosalind Franklin and the advent of molecular biology. Cell 182 (4), pp. 787 - 789 (2020)

MPG.PuRe

51.

Journal Article

Tellier, M.; Zaborowska, J.; Caizzi, L.; Mohammad, E.; Velychko, T.; Schwalb, B.; Ferrer-Vicens, I.; Blears, D.; Nojima, T.; Cramer, P. et al.; Murphy, S.: CDK12 globally stimulates RNA polymerase II transcription elongation and carboxyl-terminal domain phosphorylation. Nucleic Acids Research 48 (14), pp. 7712 - 7727 (2020)

MPG.PuRe

52.

Journal Article

Hillen, H.; Kokic, G.; Farnung, L.; Dienemann, C.; Tegunov, D.; Cramer, P.: Structure of replicating SARS-CoV-2 polymerase. Nature 584 (7819), pp. 154 - 156 (2020)

MPG.PuRe

53.

Journal Article

O’Reilly, F. J.; Xue, L.; Graziadei, A.; Sinn, L.; Lenz, S.; Tegunov, D.; Blötz, C.; Singh, N.; Hagen, W. J. H.; Cramer, P. et al.; Stülke, J.; Mahamid, J.; Rappsilber, J.: In-cell architecture of an actively transcribing-translating expressome. Science 369 (6503), pp. 554 - 557 (2020)

MPG.PuRe

54.

Journal Article

Jaeger, M. G.; Schwalb, B.; Mackowiak, S. D.; Velychko, T.; Hanzl, A.; Imrichova, H.; Brand, M.; Agerer, B.; Chorn, S.; Nabet, B. et al.; Ferguson, F. M.; Müller, A. C.; Bergthaler, A.; Gray, N. S.; Bradner, J. E.; Bock, C.; Hnisz, D.; Cramer, P.; Winter, G. E.: Selective Mediator dependence of cell-type-specifying transcription. Nature Genetics 52 (7), pp. 719 - 727 (2020)

MPG.PuRe

55.

Journal Article

Stik, G.; Vidal, E.; Barrero, M.; Cuartero, S.; Vila-Casadesús, M.; Mendieta-Esteban, J.; Tian, T. V.; Choi, J.; Berenguer, C.; Abad, A. et al.; Borsari, B.; le Dily, F.; Cramer, P.; Marti-Renom, M. A.; Stadhouders, R.; Graf, T.: CTCF is dispensable for immune cell transdifferentiation but facilitates an acute inflammatory response. Nature Genetics 52 (7), pp. 655 - 661 (2020)

MPG.PuRe

56.

Journal Article

Vos, S. M.; Farnung, L.; Linden, A.; Urlaub, H.; Cramer, P.: Structure of complete Pol II–DSIF–PAF–SPT6 transcription complex reveals RTF1 allosteric activation. Nature Structural and Molecular Biology 27 (7), pp. 668 - 677 (2020)

MPG.PuRe

57.

Journal Article

Farnung, L.; Ochmann, M.; Cramer, P.: Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations. eLife 9, e56178 (2020)

MPG.PuRe

ZIP

58.

Journal Article

Parfentev, I.; Schilbach, S.; Cramer, P.; Urlaub, H.: An experimentally generated peptide database increases the sensitivity of XL-MS with complex samples. Journal of proteomics 220, 103754 (2020)

MPG.PuRe

59.

Journal Article

Dodonova, S. O.; Zhu, F.; Dienemann, C.; Taipale, J.; Cramer, P.: Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function. Nature 580 (7805), pp. 669 - 672 (2020)

MPG.PuRe

pre-print

60.

Journal Article

Wagner, F. R; Dienemann, C.; Wang, H.; Stützer, A.; Tegunov, D.; Urlaub, H.; Cramer, P.: Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome. Nature 579 (7799), pp. 448 - 451 (2020)

MPG.PuRe

61.

Journal Article

Cramer, P.: 500 years after the first circumnavigation of the world: The efforts, rewards and drawbacks of exploration. FEBS Letters 594 (2), pp. 207 - 208 (2020)

MPG.PuRe

62.

Journal Article

Lefranc, J.; Schulze, V. K.; Hillig, R. C.; Briem, H.; Prinz, F.; Mengel, A.; Heinrich, T.; Balint, J.; Rengachari, S.; Irlbacher, H. et al.; Stockigt, D.; Bömer, U.; Bader, B.; Gradl, S. N.; Nising, C. F.; von Nussbaum, F.; Mumberg, D.; Panne, D.; Wengner, A. M.: Discovery of BAY-985, a highly selective TBK1/IKK epsilon inhibitor. Journal of Medicinal Chemistry 63 (2), pp. 601 - 612 (2020)

MPG.PuRe

63.

Journal Article

Söding, J.; Zwicker, D.; Sohrabi-Jahromi, S.; Boehning, M.; Kirschbaum, J.: Mechanisms for active regulation of biomolecular condensates. Trends in Cell Biology 30 (1), pp. 4 - 14 (2020)

MPG.PuRe

64.

Journal Article

Wang, H.; Dienemann, C.; Stützer, A.; Urlaub, H.; Cheung, A. C. M.; Cramer, P.: Structure of the transcription coactivator SAGA. Nature 577, pp. 717 - 720 (2020)

MPG.PuRe

65.

Journal Article

Wang, H.; Farnung, L.; Dienemann, C.; Cramer, P.: Structure of H3K36-methylated nucleosome-PWWP complex reveals multivalent cross-gyre binding. Nature Structural and Molecular Biology 27 (1), pp. 8 - 13 (2020)

MPG.PuRe

66.

Journal Article

Grimm, C.; Hillen, H. S.; Bedenk, K.; Bartuli, J.; Neyer, S.; Zhang, Q.; Hüttenhofer, A.; Erlacher, M.; Dienemann, C.; Schlosser, A. et al.; Urlaub, H.; Böttcher, B.; Szalay, A. A.; Cramer, P.; Fischer, U.: Structural basis of poxvirus transcription: Vaccinia RNA polymerase complexes. Cell 179 (7), pp. 1537 - 1550 (2019)

MPG.PuRe

67.

Journal Article

Hillen, H. S.; Bartuli, J.; Grimm, C.; Dienemann, C.; Bedenk, K.; Szalay, A. A.; Fischer, U.; Cramer, P.: Structural basis of poxvirus transcription: Transcribing and capping vaccinia complexes. Cell 179 (7), pp. 1525 - 1536 (2019)

MPG.PuRe

68.

Journal Article

Tegunov, D.; Cramer, P.: Real-time cryo-electron microscopy data preprocessing with Warp. Nature Methods 16, pp. 1146 - 1152 (2019)

MPG.PuRe

69.

Journal Article

Chang, C. T.; Muthukumar, S.; Weber, R.; Levdansky, Y.; Chen, Y.; Bhandari, D.; Igreja, C.; Wohlbold, L.; Valkov, E.; Izaurralde, E.: A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5 '-3 ' messenger RNA decay. Nucleic Acids Research 47 (17), pp. 9282 - 9295 (2019)

MPG.PuRe

70.

Journal Article

Zhang, S.; Tischer, T.; Barford, D.: Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C. Nature Communications 10, 3863 (2019)

MPG.PuRe

71.

Journal Article

Mahamid, J.; Tegunov, D.; Maiser, A.; Arnold, J.; Leonhardt, H.; Plitzko, J. M.; Baumeister, W.: Liquid-crystalline phase transitions in lipid droplets are related to cellular states and specific organelle association. Proceedings of the National Academy of Sciences of the United States of America 116 (34), pp. 16866 - 16871 (2019)

MPG.PuRe

72.

Journal Article

Gressel, S.; Schwalb, B.; Cramer, P.: The pause-initiation limit restricts transcription activation in human cells. Nature Communicationsvolume 10 (1), 3603 (2019)

MPG.PuRe

73.

Journal Article

Hendriks, G. J.; Jung, L. A.; Larsson, A. J. M.; Lidschreiber, M.; Forsman, O. A.; Lidschreiber, K.; Cramer, P.; Sandberg, R.: NASC-seq monitors RNA synthesis in single cells. Nature Communications 10 (1), 3138 (2019)

MPG.PuRe

74.

Journal Article

Chen, Y.; Cramer, P.: Structure of the super-elongation complex subunit AFF4 C-terminal homology domain reveals requirements for AFF homo- and heterodimerization. Journal of Biological Chemistry 294, pp. 10663 - 10673 (2019)

MPG.PuRe

75.

Journal Article

Kokic, G.; Chernev, A.; Tegunov, D.; Dienemann, C.; Urlaub, H.; Cramer, P.: Structural basis of TFIIH activation for nucleotide excision repair. Nature Communications 10, 2885 (2019)

MPG.PuRe

76.

Journal Article

Sohrabi-Jahromi, S.; Hofmann, K. B.; Boltendahl, A.; Roth, C.; Gressel, S.; Baejen, C.; Söding, J.; Cramer, P.: Transcriptome maps of general eukaryotic RNA degradation factors. eLife 8, e47040 (2019)

MPG.PuRe

77.

Journal Article

Baluapuri, A.; Hofstetter, J.; Dudvarski Stankovic, N.; Endres, T.; Bhandare, P.; Vos, S. M.; Adhikari, B.; Schwarz, J. D.; Narain, A.; Vogt, M. et al.; Wang, S. Y.; Düster, R.; Jung, L. A.; Vanselow, J. T.; Wiegering, A.; Geyer, M.; Maric, H. M.; Gallant, P.; Walz, S.; Schlosser, A.; Cramer, P.; Eilers, M.; Wolf, E.: MYC recruits SPT5 to RNA polymerase II to promote processive transcription elongation. Molecular Cell 74 (4), pp. 674 - 687 (2019)

MPG.PuRe

78.

Journal Article

Jones, J. L.; Hofmann, K. B.; Cowan, A. T.; Temiakov, D.; Cramer, P.; Anikin, M.: Yeast mitochondrial protein Pet111p binds directly to two distinct targets in COX2 mRNA, suggesting a mechanism of translational activation. Journal of Biological Chemistry 294 (18), pp. 7528 - 7536 (2019)

MPG.PuRe

79.

Journal Article

Dodonova, S. O.; Prinz, S.; Bilanchone, V.; Sandmeyer, S.; Briggs, J. A. G.: Structure of the Ty3/Gypsy retrotransposon capsid and the evolution of retroviruses. Proceedings of the National Academy of Sciences of the United States of America 116 (20), pp. 10048 - 10057 (2019)

MPG.PuRe

80.

Journal Article

Wachutka, L.; Caizzi, L.; Gagneur, J.; Cramer, P.: Global donor and acceptor splicing site kinetics in human cells. eLife 8, e45056 (2019)

MPG.PuRe

81.

Journal Article

Villamizar, G. A. C.; Nacke, H.; Böhning, M.; Herz, K.; Daniel, R.: Functional metagenomics reveals an overlooked diversity and novel features of soil-derived bacterial phosphatases and phytases. mBio 10 (1), e01966-18 (2019)

MPG.PuRe

82.

Journal Article

Zylicz, J. J.; Bousard, A.; Zumer, K.; Dossin, F.; Mohammad, E.; da Rocha, S. T.; Schwalb, B.; Syx, L.; Dingli, F.; Loew, D. et al.; Cramer, P.; Heard, E.: The implication of early chromatin changes in X chromosome inactivation. Cell 176 (1-2), pp. 182 - 197 (2019)

MPG.PuRe

83.

Journal Article

Dienemann, C.; Schwalb, B.; Schilbach, S.; Cramer, P.: Promoter distortion and opening in the RNA polymerase II cleft. Molecular Cell 73 (1), pp. 97 - 106 (2019)

MPG.PuRe

84.

Journal Article

Cramer, P.: Organization and regulation of gene transcription. Nature 573, pp. 45 - 54 (2019)

MPG.PuRe

85.

Journal Article

Cramer, P.: Eukaryotic transcription turns 50. Cell 179 (4), pp. 808 - 812 (2019)

MPG.PuRe

86.

Journal Article

Farnung, L.; Vos, S. M.; Cramer, P.: Structure of transcribing RNA polymerase II-nucleosome complex. Nature Communications 9, 5432 (2018)

MPG.PuRe

87.

Journal Article

Lidschreiber, M.; Easter, A. D.; Battaglia, S.; Rodríguez-Molina, J. B.; Casañal, A.; Carminati, M.; Baejen, C.; Grzechnik, P.; Maier, K. C.; Cramer, P. et al.; Passmore, L. A.: The APT complex is involved in non-coding RNA transcription and is distinct from CPF. Nucleic Acids Research 46 (21), pp. 11528 - 11538 (2018)

MPG.PuRe

88.

Journal Article

Ortega, E.; Rengachari, S.; Ibrahim, Z.; Hoghoughi, N.; Gaucher, J.; Holehouse, A. S.; Khochbin, S.; Panne, D.: Transcription factor dimerization activates the p300 acetyltransferase. Nature 562 (7728), pp. 538 - 544 (2018)

MPG.PuRe

89.

Journal Article

Zhu, F.; Farnung, L.; Kaasinen, E.; Sahu, B.; Yin, Y.; Wei, B.; Dodonova, S. O.; Nitta, K. R.; Morgunova, E.; Taipale, M. et al.; Cramer, P.; Taipale, J.: The interaction landscape between transcription factors and the nucleosome. Nature 562 (7725), pp. 76 - 81 (2018)

MPG.PuRe

90.

Journal Article

Böhning, M.; Dugast-Darzacq, C.; Rankovic, M.; Hansen, A. S.; Yu, T.; Marie-Nelly, H.; McSwiggen, D. T.; Kokic, G.; Dailey, G. M.; Cramer, P. et al.; Darzacq, X.; Zweckstetter, M.: RNA polymerase II clustering through carboxy-terminal domain phase separation. Nature Structural and Molecular Biology 25 (9), pp. 833 - 840 (2018)

MPG.PuRe

pre-print

91.

Journal Article

Hillen, H. S.; Temiakov, D.; Cramer, P.: Structural basis of mitochondrial transcription. Nature Structural and Molecular Biology 25 (9), pp. 754 - 765 (2018)

MPG.PuRe

92.

Journal Article

Vos, S. M.; Farnung, L.; Böhning, M.; Wigge, C.; Linden, A.; Urlaub, H.; Cramer, P.: Structure of activated transcription complex Pol II-DSIF-PAF-SPT6. Nature 560 (7720), pp. 607 - 612 (2018)

MPG.PuRe

Full

ZIP

93.

Journal Article

Vos, S. M.; Farnung, L.; Urlaub, H.; Cramer, P.: Structure of paused transcription complex Pol II–DSIF–NELF. Nature 560 (7720), pp. 601 - 606 (2018)

MPG.PuRe

ZIP

94.

Journal Article

La Manno, G.; Soldatov, R.; Zeisel, A.; Braun, E.; Hochgerner, H.; Petukhov, V.; Lidschreiber, K.; Kastriti, M. E.; Lönnerberg, P.; Furlan, A. et al.; Fan, J.; Borm, L. E.; Liu, Z.; van Bruggen, D.; Guo, J.; He, X.; Barker, R.; Sundström, E.; Castelo-Branco, G.; Cramer, P.; Adameyko, I.; Linnarsson, S.; Kharchenko, P. V.: RNA velocity of single cells. Nature 560 (7719), pp. 494 - 498 (2018)

MPG.PuRe

95.

Journal Article

Liu, X.; Farnung, L.; Wigge, C.; Cramer, P.: Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by α-amanitin. Journal of Biological Chemistry 293 (19), pp. 7189 - 7194 (2018)

MPG.PuRe

96.

Journal Article

Engel, C.; Neyer, S.; Cramer, P.: Distinct mechanisms of transcription initiation by RNA polymerases I and II. Annual Review of Biophysics 47, pp. 425 - 446 (2018)

MPG.PuRe

97.

Journal Article

Hantsche, M.; Cramer, P.: Conserved RNA polymerase II initiation complex structure. Current Opinion in Structural Biology 47, pp. 17 - 22 (2017)

MPG.PuRe

98.

Journal Article

Bykov, Y. S.; Schaffer, M.; Dodonova, S. O.; Albert, S.; Plitzko, J. M.; Baumeister, W.; Engel, B. D.; Briggs, J. A. G.: The structure of the COPI coat determined within the cell. eLife 6, e32493 (2017)

MPG.PuRe

99.

Journal Article

Hillen, H. S.; Morozov, Y. I.; Sarfallah, A.; Temiakov, D.; Cramer, P.: Structural basis of mitochondrial transcription initiation. Cell 171 (5), pp. 1072 - 1081 (2017)

MPG.PuRe