Publications
Journal Article (274)
1.
Journal Article
RNA transcription and degradation of Alu retrotransposons depends on sequence features and evolutionary history. G3 Genes, Genomes, Genetics, In Press (2022)
2.
Journal Article
54 (3), pp. 283 - 294 (2022)
Sequence determinants of human gene regulatory elements. Nature Genetics 3.
Journal Article
17 (2), pp. 445 - 475 (2022)
Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture. Nature Protocols 4.
Journal Article
18, e10407 (2022)
Distinct transcription kinetics of pluripotent cell states. Molecular Systems Biology 5.
Journal Article
374 (6569), pp. 883 - 887 (2021)
Structural basis of Integrator-mediated transcription regulation. Science 6.
Journal Article
598 (7880), pp. 368 - 372 (2021)
Structural basis of human transcription–DNA repair coupling. Nature 7.
Journal Article
49 (18), pp. 10747 - 10755 (2021)
Structure of an inactive RNA polymerase II dimer. Nucleic Acids Research 8.
Journal Article
27 (10), pp. 1281 - 1290 (2021)
The total mRNA concentration buffering system in yeast is global rather than gene-specific. RNA 9.
Journal Article
40 (19), e107985 (2021)
Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies. EMBO Journal 10.
Journal Article
28 (9), pp. 713 - 723 (2021)
Structural basis of RNA processing by human mitochondrial RNase P. Nature Structural and Molecular Biology 11.
Journal Article
28 (9), pp. 704 - 705 (2021)
AlphaFold2 and the future of structural biology. Nature Structural and Molecular Biology 12.
Journal Article
28 (9), pp. 740 - 746 (2021)
Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis. Nature Structural and Molecular Biology 13.
Journal Article
4, 999 (2021)
The structure of a dimeric form of SARS-CoV-2 polymerase. Communications Biology 14.
Journal Article
81 (15), pp. 3096 - 3109.e8 (2021)
Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo. Molecular Cell 15.
Journal Article
118 (30), e2108859118 (2021)
Structures and implications of TBP–nucleosome complexes. Proceedings of the National Academy of Sciences of the USA 16.
Journal Article
184 (15), pp. 4064 - 4072.e28 (2021)
Structure of RNA polymerase II pre-initiation complex at 2.9 Å defines initial DNA opening. Cell 17.
Journal Article
81 (16), pp. 3386 - 3399.e10 (2021)
Allosteric transcription stimulation by RNA polymerase II super elongation complex. Molecular Cell 18.
Journal Article
594 (7861), pp. 124 - 128 (2021)
Structures of mammalian RNA polymerase II pre-initiation complexes. Nature 19.
Journal Article
594 (7861), pp. 129 - 133 (2021)
Structure of the human Mediator-RNA polymerase II pre-initiation complex. Nature 20.
Journal Article
296, 100734 (2021)
The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II. Journal of Biological Chemistry 21.
Journal Article
12, 3232 (2021)
Ruler elements in chromatin remodelers set nucleosome array spacing and phasing. Nature Communications 22.
Journal Article
4, 606 (2021)
Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2. Communications Biology 23.
Journal Article
81 (9), pp. 1920 - 1934.e9 (2021)
Efficient RNA polymerase II pause release requires U2 snRNP function. Molecular Cell 24.
Journal Article
118 (15), e2009329118 (2021)
The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3′-UTRs of yeast mitochondrial mRNAs. Proceedings of the National Academy of Sciences of the USA 25.
Journal Article
28 (4), pp. 382 - 387 (2021)
Structural basis of nucleosome transcription mediated by Chd1 and FACT. Nature Structural and Molecular Biology 26.
Journal Article
10, e65381 (2021)
Evidence for additive and synergistic action of mammalian enhancers during cell fate determination. eLife 27.
Journal Article
81 (5), pp. 1013 - 1026.e11 (2021)
Stress-induced nuclear condensation of NELF drives transcriptional downregulation. Molecular Cell 28.
Journal Article
81 (4), pp. 830 - 844.e13 (2021)
Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters. Molecular Cell 29.
Journal Article
40 (9), e107015 (2021)
Transcription activation depends on the length of the RNA polymerase II C‐terminal domain. EMBO Journal 30.
Journal Article
18 (2), pp. 186 - 193 (2021)
Multi-particle cryo-EM refinement with M visualizes ribosome-antibiotic complex at 3.5 Å in cells. Nature Methods 31.
Journal Article
371 (6526), pp. 305 - 309 (2021)
Structure of a transcribing RNA polymerase II–U1 snRNP complex. Science 32.
Journal Article
12, 279 (2021)
Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nature Communications 33.
Journal Article
12, 279 (2021)
Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nature Communications 34.
Journal Article
27 (1), pp. 49 - 53 (2021)
Coronavirus-Replikation: Mechanismus und Inhibition durch Remdesivir. Biospektrum 35.
Journal Article
17 (1), pp. 47 - 56 (2021)
Permissive epigenomes endow reprogramming competence to transcriptional regulators. Nature Chemical Biology 36.
Journal Article
17 (1), e9873 (2021)
Transcriptionally active enhancers in human cancer cells. Molecular Systems Biology 37.
Journal Article
Integrator is a genome-wide attenuator of non-productive transcription. Molecular Cell, in Press (2020)
38.
Journal Article
588 (7839), pp. 712 - 716 (2020)
Small-molecule inhibitors of human mitochondrial DNA transcription. Nature 39.
Journal Article
36, pp. 1 - 34 (2020)
Structural biology of RNA polymerase II transcription: 20 years on. Annual Review of Cell and Developmental Biology 40.
Journal Article
30 (9), pp. 1332 - 1344 (2020)
Native molecule sequencing by nano-ID reveals synthesis and stability of RNA isoforms. Genome Research 41.
Journal Article
182 (4), pp. 787 - 789 (2020)
Rosalind Franklin and the advent of molecular biology. Cell 42.
Journal Article
48 (14), pp. 7712 - 7727 (2020)
CDK12 globally stimulates RNA polymerase II transcription elongation and carboxyl-terminal domain phosphorylation. Nucleic Acids Research 43.
Journal Article
584 (7819), pp. 154 - 156 (2020)
Structure of replicating SARS-CoV-2 polymerase. Nature 44.
Journal Article
369 (6503), pp. 554 - 557 (2020)
In-cell architecture of an actively transcribing-translating expressome. Science 45.
Journal Article
52 (7), pp. 719 - 727 (2020)
Selective Mediator dependence of cell-type-specifying transcription. Nature Genetics 46.
Journal Article
52 (7), pp. 655 - 661 (2020)
CTCF is dispensable for immune cell transdifferentiation but facilitates an acute inflammatory response. Nature Genetics 47.
Journal Article
27 (7), pp. 668 - 677 (2020)
Structure of complete Pol II–DSIF–PAF–SPT6 transcription complex reveals RTF1 allosteric activation. Nature Structural and Molecular Biology 48.
Journal Article
9, e56178 (2020)
Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations. eLife 49.
Journal Article
220, 103754 (2020)
An experimentally generated peptide database increases the sensitivity of XL-MS with complex samples. Journal of proteomics 50.
Journal Article
580 (7805), pp. 669 - 672 (2020)
Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function. Nature 51.
Journal Article
579 (7799), pp. 448 - 451 (2020)
Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome. Nature 52.
Journal Article
594 (2), pp. 207 - 208 (2020)
500 years after the first circumnavigation of the world: The efforts, rewards and drawbacks of exploration. FEBS Letters 53.
Journal Article
63 (2), pp. 601 - 612 (2020)
Discovery of BAY-985, a highly selective TBK1/IKK epsilon inhibitor. Journal of Medicinal Chemistry 54.
Journal Article
30 (1), pp. 4 - 14 (2020)
Mechanisms for active regulation of biomolecular condensates. Trends in Cell Biology 55.
Journal Article
577, pp. 717 - 720 (2020)
Structure of the transcription coactivator SAGA. Nature 56.
Journal Article
27 (1), pp. 8 - 13 (2020)
Structure of H3K36-methylated nucleosome-PWWP complex reveals multivalent cross-gyre binding. Nature Structural and Molecular Biology 57.
Journal Article
179 (7), pp. 1537 - 1550 (2019)
Structural basis of poxvirus transcription: Vaccinia RNA polymerase complexes. Cell 58.
Journal Article
179 (7), pp. 1525 - 1536 (2019)
Structural basis of poxvirus transcription: Transcribing and capping vaccinia complexes. Cell 59.
Journal Article
16, pp. 1146 - 1152 (2019)
Real-time cryo-electron microscopy data preprocessing with Warp. Nature Methods 60.
Journal Article
47 (17), pp. 9282 - 9295 (2019)
A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5 '-3 ' messenger RNA decay. Nucleic Acids Research 61.
Journal Article
10, 3863 (2019)
Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C. Nature Communications 62.
Journal Article
116 (34), pp. 16866 - 16871 (2019)
Liquid-crystalline phase transitions in lipid droplets are related to cellular states and specific organelle association. Proceedings of the National Academy of Sciences of the United States of America 63.
Journal Article
10 (1), 3603 (2019)
The pause-initiation limit restricts transcription activation in human cells. Nature Communicationsvolume 64.
Journal Article
10 (1), 3138 (2019)
NASC-seq monitors RNA synthesis in single cells. Nature Communications 65.
Journal Article
294, pp. 10663 - 10673 (2019)
Structure of the super-elongation complex subunit AFF4 C-terminal homology domain reveals requirements for AFF homo- and heterodimerization. Journal of Biological Chemistry 66.
Journal Article
10, 2885 (2019)
Structural basis of TFIIH activation for nucleotide excision repair. Nature Communications 67.
Journal Article
8, e47040 (2019)
Transcriptome maps of general eukaryotic RNA degradation factors. eLife 68.
Journal Article
74 (4), pp. 674 - 687 (2019)
MYC recruits SPT5 to RNA polymerase II to promote processive transcription elongation. Molecular Cell 69.
Journal Article
294 (18), pp. 7528 - 7536 (2019)
Yeast mitochondrial protein Pet111p binds directly to two distinct targets in COX2 mRNA, suggesting a mechanism of translational activation. Journal of Biological Chemistry 70.
Journal Article
116 (20), pp. 10048 - 10057 (2019)
Structure of the Ty3/Gypsy retrotransposon capsid and the evolution of retroviruses. Proceedings of the National Academy of Sciences of the United States of America 71.
Journal Article
8, e45056 (2019)
Global donor and acceptor splicing site kinetics in human cells. eLife 72.
Journal Article
10 (1), e01966-18 (2019)
Functional metagenomics reveals an overlooked diversity and novel features of soil-derived bacterial phosphatases and phytases. mBio 73.
Journal Article
176 (1-2), pp. 182 - 197 (2019)
The implication of early chromatin changes in X chromosome inactivation. Cell 74.
Journal Article
73 (1), pp. 97 - 106 (2019)
Promoter distortion and opening in the RNA polymerase II cleft. Molecular Cell 75.
Journal Article
573, pp. 45 - 54 (2019)
Organization and regulation of gene transcription. Nature 76.
Journal Article
179 (4), pp. 808 - 812 (2019)
Eukaryotic transcription turns 50. Cell 77.
Journal Article
9, 5432 (2018)
Structure of transcribing RNA polymerase II-nucleosome complex. Nature Communications 78.
Journal Article
46 (21), pp. 11528 - 11538 (2018)
The APT complex is involved in non-coding RNA transcription and is distinct from CPF. Nucleic Acids Research 79.
Journal Article
562 (7728), pp. 538 - 544 (2018)
Transcription factor dimerization activates the p300 acetyltransferase. Nature 80.
Journal Article
562 (7725), pp. 76 - 81 (2018)
The interaction landscape between transcription factors and the nucleosome. Nature 81.
Journal Article
25 (9), pp. 833 - 840 (2018)
RNA polymerase II clustering through carboxy-terminal domain phase separation. Nature Structural and Molecular Biology 82.
Journal Article
25 (9), pp. 754 - 765 (2018)
Structural basis of mitochondrial transcription. Nature Structural and Molecular Biology 83.
Journal Article
560 (7720), pp. 607 - 612 (2018)
Structure of activated transcription complex Pol II-DSIF-PAF-SPT6. Nature 84.
Journal Article
560 (7720), pp. 601 - 606 (2018)
Structure of paused transcription complex Pol II–DSIF–NELF. Nature 85.
Journal Article
560 (7719), pp. 494 - 498 (2018)
RNA velocity of single cells. Nature 86.
Journal Article
293 (19), pp. 7189 - 7194 (2018)
Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by α-amanitin. Journal of Biological Chemistry 87.
Journal Article
47, pp. 425 - 446 (2018)
Distinct mechanisms of transcription initiation by RNA polymerases I and II. Annual Review of Biophysics 88.
Journal Article
47, pp. 17 - 22 (2017)
Conserved RNA polymerase II initiation complex structure. Current Opinion in Structural Biology 89.
Journal Article
6, e32493 (2017)
The structure of the COPI coat determined within the cell. eLife 90.
Journal Article
171 (5), pp. 1072 - 1081 (2017)
Structural basis of mitochondrial transcription initiation. Cell 91.
Journal Article
171 (5), pp. 1082 - 1093 (2017)
Mechanism of transcription anti-termination in human mitochondria. Cell 92.
Journal Article
114 (46), pp. 12172 - 12177 (2017)
Mechanism of RNA polymerase II stalling by DNA alkylation. Proceedings of the National Academy of Sciences of the United States of America 93.
Journal Article
551 (7679), pp. 204 - 209 (2017)
Structures of transcription pre-initiation complex with TFIIH and Mediator. Nature 94.
Journal Article
23 (11), pp. 1648 - 1659 (2017)
Cis-regulatory elements explain most of the mRNA stability variation across genes in yeast. RNA 95.
Journal Article
550 (7677), pp. 539 - 542 (2017)
Nucleosome-Chd1 structure and implications for chromatin remodelling. Nature 96.
Journal Article
6, e29736 (2017)
CDK9-dependent RNA polymerase II pausing controls transcription initiation. eLife 97.
Journal Article
24 (10), pp. 809 - 815 (2017)
Structure of a transcribing RNA polymerase II-DSIF complex reveals a multidentate DNA-RNA clamp. Nature Structural and Molecular Biology 98.
Journal Article
13 (10), e1006664 (2017)
EBF1 binds to EBNA2 and promotes the assembly of EBNA2 chromatin complexes in B cells. PLoS Pathogens 99.
Journal Article
429 (17), pp. 2603 - 2610 (2017)
Structural molecular biology - A personal reflection on the occasion of John Kendrew's 100th birthday. Journal of Molecular Biology