Max Planck Institute for Multidisciplinary Sciences

Publications

Journal Article (129)

1.

Journal Article

Ali, T. T.; Merghani, M.; Al-Azzani, M.; Gatzemeier, L. M.; Hoppert, M.; Kaloyanova, D.; Outeiro, T. F.; Neumann, P.; Popova, B.; Braus, G. H.: Rationally designed peptides inhibit the formation of α-synuclein fibrils and oligomers. European Journal of Medicinal Chemistry 289, 117452 (2025)

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2.

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Amaral, L.; Martins, M.; Côrte-Real, M.; Outeiro, T. F.; Chaves, S. R.; Rego, A.: The neurotoxicity of pesticides: Implications for Parkinson's disease. Chemosphere 377, 144348 (2025)

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3.

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Outeiro, T. F.: Alpha-synuclein in Parkinson's disease: the debate that must go on. Parkinsonism & Related Disorders, 107850 (2025)

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4.

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Koss, D. J.; Todd, O.; Menon, H.; Anderson, Z.; Yang, T.; Findlay, L.; Graham, B.; Palmowski, P.; Porter, A.; Morrice, N. et al.; Walker, L.; Attems, J.; Ghanem, S. S.; El-Agnaf, O.; LeBeau, F. E.; Erskine, D.; Outeiro, T. F.: A reciprocal relationship between markers of genomic DNA damage and alpha-synuclein pathology in dementia with Lewy bodies. Molecular Neurodegeneration 20, 34 (2025)

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5.

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Laurent, C.; Poncet, G.; Herskovits, T.; Alves de Sousa, R.; Le Corre, L.; Al-Azzani, M.; Koenig, A.; Birman, S.; Outeiro, T. F.; Mansuy, D. et al.; Dairou, J.: Inhibition of the Parkinson’s Disease-Related Protein DJ-1 by Endogenous Neurotoxins of the 1,2,3,4-Tetrahydroisoquinoline Family. ACS Chemical Neuroscience 16 (6), pp. 1034 - 1042 (2025)

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6.

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Flores-León, M.; Outeiro, T. F.: Expanding our understanding of synucleinopathies: proteinopathy, proteinopenia, and lipidopathy. The FEBS Journal (2025)

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7.

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Coles, N. P.; Elsheikh, S.; Quesnel, A.; Butler, L.; Jennings, C.; Tarzi, C.; Achadu, O. J.; Islam, M.; Kalesh, K.; Occhipinti, A. et al.; Angione, C.; Marles-Wright, J.; Koss, D. J.; Thomas, A. J.; Outeiro, T. F.; Filippou, P. S.; Khundakar, A. A.: Molecular Insights into α-Synuclein Fibrillation: A Raman Spectroscopy and Machine Learning Approach. ACS Chemical Neuroscience 16 (4), pp. 687 - 698 (2025)

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8.

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Outeiro, T. F.; Höglinger, G.; Lang, A. E.; Vieira, T. C. R. G.: Protein misfolding: understanding biology to classify and treat synucleinopathies. Journal of Neural Transmission (2025)

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9.

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Lang, A. E.; Höglinger, G. U.; Adler, C. H.; Berg, D.; Klein, C.; Outeiro, T. F.; Poewe, W.; Postuma, R.; Stoessl, A. J.: Initial biological classification of Lewy body diseases: No consensus on terminology. Alzheimer's & Dementia 21 (2), e14449 (2025)

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10.

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da Silva, I. S.; Cardoso, A. R.; Reimer, L.; König, A.; van Riesen, C.; Outeiro, T. F.; Jensen, P. H.; Sales, M. G. F.: α-Synuclein plastic antibody applied to monitor monomeric structures and discriminate aggregated forms in human CSF. Biosensors and Bioelectronics 268, 116880 (2025)

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11.

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Fonseca-Fonseca, L. A.; Fuentes, N. P.; Sánchez, J. R.; Iglesias, Á. T.; Outeiro, T. F.; Silva, V. D. A. d.; Costa, S. L.; Núñez-Figueredo, Y.: Correlational assessment of the effects of JM-20 in a rat model of parkinsonism. Behavioural Brain Research 476, 115269 (2025)

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12.

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Coles, N. P.; Elsheikh, S.; Quesnel, A.; Butler, L.; Achadu, O.; Islam, M.; Kalesh, K.; Occhipinti, A.; Angione, C.; Marles-Wright, J. et al.; Koss, D. J.; Thomas, A. J.; Outeiro, T. F.; Filippou, P. S.; Khundakar, A. A.: Alpha-synuclein aggregation induces prominent cellular lipid changes as revealed by Raman spectroscopy and machine learning analysis. Brain Communications 7 (2), fcaf133 (2025)

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13.

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Soares, E. S.; Queiroz, L. Y.; Gerhardt, E.; Prediger, R. D. S.; Outeiro, T. F.; Cimarosti, H. I.: SUMOylation modulates mitochondrial dynamics in an in vitro rotenone model of Parkinson's disease. Molecular and Cellular Neuroscience 131, 103969 (2024)

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14.

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Amaro-Leal, Â.; Afonso, A. I.; Machado, F.; Shvachiy, L.; Rocha, I.; Outeiro, T. F.; Geraldes, V.: Dose-Dependent Cognitive Decline, Anxiety, and Locomotor Impairments Induced by Doxorubicin: Evidence from an Animal Model. Biology 13 (11), 939 (2024)

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15.

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de Bruyn, E.; Dorn, A.E.; Rossetti, G.; Fernandez, C.; Outeiro, T. F.; Schulz, J.B.; Carloni, P.: Impact of Phosphorylation on the Physiological Form of Human alpha-Synuclein in Aqueous Solution. Journal of Chemical Information and Modeling 64 (21), pp. 8215 - 8226 (2024)

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16.

Journal Article

Abdelrasol, H.; Chopra, A.; Shvachiy, L.; Beutner, D.; Outeiro, T. F.; Setz, C.: Stress granules formation in HEI-OC1 auditory cells and in H4 human neuroglioma cells secondary to cisplatin exposure. Cell Stress 8 (1), pp. 83 - 98 (2024)

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17.

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Gatzemeier, L. M.; Meyer, F.; Outeiro, T. F.: Synthesis and Semi-Synthesis of Alpha-Synuclein: Insight into the Chemical Complexity of Synucleinopathies. Chembiochem 25 (20), e202400253 (2024)

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18.

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Shaib, A. H.; Chouaib, A. A.; Chowdhury, R.; Altendorf, J.; Mihaylov, D.; Zhang, C.; Krah, D.; Imani, V.; Spencer, R. K. W.; Georgiev, S. V. et al.; Mougios, N.; Monga, M.; Reshetniak, S.; Mimoso, T.; Chen, H.; Fatehbasharzad, P.; Crzan, D.; Saal, K.-A.; Alawieh, M. M.; Alawar, N.; Eilts, J.; Kang, J.; Soleimani, A.; Müller, M.; Pape, C.; Alvarez, L.; Trenkwalder, C.; Mollenhauer, B.; Outeiro, T. F.; Köster, S.; Preobraschenski, J.; Becherer, U.; Moser, T.; Boyden, E. S.; Aricescu, A. R.; Sauer, M.; Opazo, F.; Rizzoli, S. O.: One-step nanoscale expansion microscopy reveals individual protein shapes. Nature Biotechnology (2024)

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19.

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Fonseca-Gomes, J.; Costa-Coelho, T.; Ferreira-Manso, M.; Inteiro-Oliveira, S.; Vaz, S.H.; Alemãn-Serrano, N.; Atalaia-Barbacena, H.; Ribeiro-Rodrigues, L.; Ramalho, R.M.; Pinto, R. et al.; Vicente Miranda, H.; Tanqueiro, S.R.; de Almeida-Borlido, C.; Ramalho, M.J.; Miranda-Lourenço, C.; Belo, R.F.; Ferreira, C.B.; Neves, V.; Rombo, D.M.; Viais, R.; Martins, I.C.; Jerónimo-Santos, A.; Caetano, A.; Manso, N.; Mäkinen, P.; Marttinen, M.; Takalo, M.; Bremang, M.; Pike, I.; Haapasalo, A.; Loureiro, J.A.; Pereira, M.C.; Santos, N.C.; Outeiro, T. F.; Castanho, M.A.R.B.; Fernandes, A.; Hiltunen, M.; Duarte, C.B.; Castrén, E.; de Mendonça, A.; Sebastião, A.M.; Rodrigues, T.M.; Diógenes, M.J.: A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's disease. Molecular Therapy 32 (10), pp. 3372 - 3401 (2024)

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20.

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da Silva Correia, A.; Schmitz, M.; Fischer, A.; da Silva Correia, S.; Simonetti, F. L.; Saher, G.; Goya‐Maldonado, R.; Arora, A. S.; Fischer, A.; Outeiro, T. F. et al.; Zerr, I.: Cellular prion protein acts as mediator of amyloid beta uptake by caveolin‐1 causing cellular dysfunctions in vitro and in vivo. Alzheimer's & Dementia 20 (10), pp. 6776 - 6792 (2024)

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21.

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Amaral, L.; Mendes, F.; Côrte-Real, M.; Rego, A.; Outeiro, T. F.; Chaves, S. R.: A versatile yeast model identifies the pesticides cymoxanil and metalaxyl as risk factors for synucleinopathies. Chemosphere 364, 143039 (2024)

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22.

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Gasparotto, J.; Somensi, N.; Girardi, C. S.; Bittencourt, R. R.; de Oliveira, L. M.; Hoefel, L. P.; Scheibel, I. M.; Peixoto, D. O.; Fonseca Moreira, J. C.; Outeiro, T. F. et al.; Gelain, D. P.: Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson's disease. Journal of Neurochemistry 168 (8), pp. 1608 - 1624 (2024)

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23.

Journal Article

Plácido, E.; Koss, D. J.; Outeiro, T. F.; Brocardo, P. S.: Altered hippocampal doublecortin expression in Parkinson's disease. Journal of Neurochemistry 168 (8), pp. 1514 - 1526 (2024)

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24.

Journal Article

Vieira, T. C. R. G.; Barros, C. A.; Domingues, R.; Outeiro, T. F.: PrP meets alpha-synuclein: Molecular mechanisms and implications for disease. Journal of Neurochemistry 168 (8), pp. 1625 - 1639 (2024)

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25.

Journal Article

König, A.; Outeiro, T. F.: Diabetes and Parkinson's Disease: Understanding Shared Molecular Mechanisms. Journal of Parkinson's Disease 14 (5), pp. 917 - 924 (2024)

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26.

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Goedert, M.; Griesinger, C.; Outeiro, T. F.; Riek, R.; Schröder, G. F.; Spillantini, M. G.: Abandon the NAC in α-synuclein. Lancet Neurology 23 (7), p. 669 (2024)

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27.

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Doerje, N. M.; Shvachiy, L.; Kueck, F.; Outeiro, T. F.; Strenzke, N.; Beutner, D.; Setz, C.: Age-related alterations in efferent medial olivocochlear-outer hair cell and primary auditory ribbon synapses in CBA/J mice. Frontiers in Cellular Neuroscience 18, 1412450 (2024)

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28.

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Erdmann, L.; Santos, P.; Rieper, P.; Klafki, H. W.; Beutner, D.; Wiltfang, J.; Outeiro, T. F.; Setz, C.: Automated Capillary Electrophoresis Immunoblot for the Detection of Alpha-Synuclein in Mouse Tissue. Journal of Parkinson's Disease: JPD 14 (4), pp. 681 - 692 (2024)

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29.

Journal Article

Outeiro, T. F.; Antonini, A.; Ferreira, J. J.: Reply to: “Rethinking Parkinson's Disease: A Syndromic Perspective”. Movement Disorders 39 (6), pp. 1080 - 1081 (2024)

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30.

Journal Article

Outeiro, T. F.; Kalia, L. V.; Bezard, E.; Ferrario, J.; Lin, C.-H.; Salama, M.; Standaert, D. G.; Taiwo, L.; Takahashi, R.; Vila, M. et al.; Mollenhauer, B.; Svenningsson, P.; The MDS Basic Science Special Interest Group Steering Committe: Basic Science in Movement Disorders: Fueling the Engine of Translation into Clinical Practice. Movement Disorders 39 (6), pp. 929 - 933 (2024)

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31.

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Thirupathi, A.; Marqueze, L. F.; Outeiro, T. F.; Radak, Z.; Pinho, R. A.: Physical Exercise-Induced Activation of NRF2 and BDNF as a Promising Strategy for Ferroptosis Regulation in Parkinson’s Disease. Neurochemical Research 49, pp. 1643 - 1654 (2024)

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32.

Journal Article

Chopra, A.; Lang, A. E.; Höglinger, G.; Outeiro, T. F.: Towards a biological diagnosis of PD. Parkinsonism & Related Disorders 122, 106078 (2024)

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33.

Journal Article

Galka, D.; Ali, T. T.; Bast, A.; Niederleithinger, M.; Gerhardt, E.; Motosugi, R.; Sakata, E.; Knop, M.; Outeiro, T. F.; Popova, B. et al.; Braus, G. H.: Inhibition of 26S proteasome activity by α-synuclein is mediated by the proteasomal chaperone Rpn14/PAAF1. Aging Cell 23 (5), e14128 (2024)

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34.

Journal Article

Jebali, A.; Rashidi, M.; Keikha, R.; Daliri, K.; Outeiro, T. F.: Novel multifunctional nanoliposomes inhibit α-synuclein fibrillization, attenuate microglial activation, and silence the expression of SNCA gene. Neurología (English Edition) 39 (4), pp. 321 - 328 (2024)

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35.

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Oliveira da Silva, M.I.; Santejo, M.; Babcock, I.W.; Magalhães, A.; Minamide, L.S.; Won, S.-J.; Castillo, E.; Gerhardt, E.; Fahlbusch, C.; Swanson, R.A. et al.; Outeiro, T. F.; Taipa, R.; Ruff, M.; Bamburg, J.R.; Liz, M.A.: α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrP^C-CCR5 dependent pathway. Cell Death and Disease 15 (4), 264 (2024)

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36.

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Mohammadi, E. L.; Keikha, R.; Outeiro, T. F.; Jebali, A.: Adsorption of alpha-synuclein and inhibition of fibril formation by nanocellulose and gold-coated-nanocellulose. Cellulose 31, pp. 3797 - 3804 (2024)

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37.

Journal Article

Bosbach, C.; Gatzemeier, L. M.; Bloch von Blottnitz, K. I.; König, A.; Diederichsen, U.; Steinem, C.; Outeiro, T. F.: Chemical synthesis of site-selective advanced glycation end products in α-synuclein and its fragments. Organic & Biomolecular Chemistry 22, pp. 2670 - 2676 (2024)

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38.

Journal Article

da Silva, A. N. R.; Pereira, G. R. C.; Bonet, L. F. S.; Outeiro, T. F.; De Mesquita, J. F.: In silico analysis of alpha‐synuclein protein variants and posttranslational modifications related to Parkinson's disease. Journal of Cellular Biochemistry 125 (3), e30523 (2024)

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39.

Journal Article

Aubrey, L. D.; Ninkina, N.; Ulamec, S. M.; Abramycheva, N. Y.; Vasili, E.; Devine, O. M.; Wilkinson, M.; Mackinnon, E.; Limorenko, G.; Walko, M. et al.; Muwanga, S.; Amadio, L.; Peters, O. M.; Illarioshkin, S. N.; Outeiro, T. F.; Ranson, N. A.; Brockwell, D. J.; Buchman, V. L.; Radford, S. E.: Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid. PNAS 121 (2), e2309700120 (2024)

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40.

Journal Article

Quesnel, A.; Martin, L.D.; Tarzi, C.; Lenis, V.P.; Coles, N.; Islam, M.; Angione, C.; Outeiro, T. F.; Khundakar, A.A.; Filippou, P.S.: Uncovering potential diagnostic and pathophysiological roles of α-synuclein and DJ-1 in melanoma. Cancer Medicine 13 (1), e6900 (2024)

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41.

Journal Article

Chopra, A.; Outeiro, T. F.: Aggregation and beyond: alpha-synuclein-based biomarkers in synucleinopathies. Brain 147 (1), pp. 81 - 90 (2024)

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42.

Journal Article

Malik, N.; Miah, M.-U.; Galgani, A.; McAleese, K.; Walker, L.; LeBeau, F. E.; Attems, J.; Outeiro, T. F.; Thomas, A.; Koss, D. J.: Regional AT-8 reactive tau species correlate with intracellular Aβ levels in cases of low AD neuropathologic change. Acta Neuropathologica 147 (1), 40 (2024)

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43.

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Outeiro, T. F.; Vieira, T. C. R. G.: Prion meeting 2023: implications of a growing field. Prion 18, pp. 68 - 71 (2024)

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44.

Journal Article

Monteiro Neto, J. R.; Ribeiro, G. D.; Magalhães, R. S. S.; Follmer, C.; Outeiro, T. F.; Eleutherio, E. C. A.: Glycation modulates superoxide dismutase 1 aggregation and toxicity in models of sporadic amyotrophic lateral sclerosis. Biochimica et Biophysica Acta-Molecular Basis of Disease 1869 (8), 166835 (2023)

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45.

Journal Article

Flores-Leon, M.; Outeiro, T. F.: More than meets the eye in Parkinson’s disease and other synucleinopathies: from proteinopathy to lipidopathy. Acta Neuropathologica 146, pp. 369 - 385 (2023)

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46.

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Warth Perez Arias, C. C.; Silbern, I.; Gomes, L. C.; Wartmann, H.; Dambeck, V.; Fanz, J.; Neuenroth, L.; Baehr, M.; Outeiro, T. F.; Bonn, S. et al.; Stadelmann-Nessler, C.; Rizzoli, S. O.; Lenz, C.; Urlaub, H.; Lingor, P.: Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease. Journal of Neurochemistry 166 (5), pp. 862 - 874 (2023)

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47.

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Xylaki, M.; Chopra, A.; Weber, S.; Bartl, M.; Outeiro, T. F.; Mollenhauer, B.: Extracellular Vesicles for the Diagnosis of Parkinson's Disease: Systematic Review and Meta-Analysis. Movement Disorders 38 (9), pp. 1585 - 1597 (2023)

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48.

Journal Article

Brembati, V.; Faustini, G.; Longhena, F.; Outeiro, T. F.; Bellucci, A.: Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson’s Disease. International Journal of Molecular Sciences 24 (17), 13435 (2023)

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49.

Journal Article

Sant'Anna, R.; Robbs, B. K. K.; de Freitas, J. A.; dos Santos, P. P.; König, A.; Outeiro, T. F.; Foguel, D.: The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis. Molecular Medicine 29 (1), 111 (2023)

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50.

Journal Article

Shvachiy, L.; Geraldes, V.; Outeiro, T. F.: Uncovering the Molecular Link Between Lead Toxicity and Parkinson's Disease. Antioxidants & redox signaling 39 (4-6), pp. 321 - 335 (2023)

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