Publications

Lázaro, D. F.; Castro Dias, M.; Carija, A.; Navarro, S.; Silva Madaleno, C.; Tenreiro, S.; Ventura, S.; Outeiro, T. F.: The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation. Acta Neuropathologica Communications 4, 128 (2016)

Miranda, H. V.; Gomes, M. A.; Branco-Santos, J.; Breda, C.; Lázaro, D. F.; Vaqueiro Lopes, L.; Herrera, F.; Giorgini, F.; Outeiro, T. F.: Glycation potentiates neurodegeneration in models of Huntington's disease. Scientific Reports 6, 36798 (2016)

Villar-Piqué, A.; Lopes da Fonseca, T.; Sant'Anna, R.; Szegö, É. M.; Fonseca-Ornelas, L.; Pinho, R.; Carija, A.; Gerhardt, E.; Masaracchia, C.; Gonzalez, E. A. et al.; Rossetti, G.; Carloni, P.; Fernández, C. O.; Foguel, D.; Milosevic, I.; Zweckstetter, M.; Ventura, S.; Outeiro, T. F.: Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. Proceedings of the National Academy of Sciences of the United States of America 113 (42), pp. E6506 - E6515 (2016)

Letra-Vilela, R.; Sánchez-Sánchez, A. M.; Rocha, A. M.; Martin, V.; Branco-Santos, J.; Puente-Moncada, N.; Santa-Marta, M.; Outeiro, T. F.; Antolín, I.; Rodriguez, C. et al.; Herrera, F.: Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin. Molecular and Cellular Endocrinology 434, pp. 238 - 249 (2016)

Batalha, V. L.; Ferreira, D. G.; Coelho, J. E.; Valadas, J. S.; Gomes, R.; Temido-Ferreira, M.; Shmidt, T.; Baqi, Y.; Buée, L.; Müller, C. E. et al.; Hamdane, M.; Outeiro, T. F.; Bader, M.; Meijsing, S.; Sadri-Vakili, G.; Blum, D.; Lopes, L. V.: The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function. Scientific Reports 6, 31493 (2016)

Lopes da Fonseca, T.; Pinho, R.; Outeiro, T. F.: A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death. Human Molecular Genetics 25 (14), pp. 2959 - 2971 (2016)

Kleinknecht, A.; Popova, B.; Lázaro, D. F.; Pinho, R.; Valerius, O.; Outeiro, T. F.; Braus, G. H.: C-terminal tyrosine residue modifications modulate the protective phosphorylation of Serine 129 of α-synuclein in a yeast model of Parkinson's disease. PLoS Genetics 12 (6), e1006098 (2016)

Miranda, H. V.; El-Agnaf, O. M. A.; Outeiro, T. F.: Glycation in Parkinson's disease and Alzheimer's disease. Movement Disorders 31 (6), pp. 782 - 790 (2016)

Goncalves, S. A.; Macedo, D.; Raquel, H.; Simões, P. D.; Giorgini, F.; Ramalho, J. S.; Barral, D. C.; Moita, L. F.; Outeiro, T. F.: shRNA-based screen identifiers endocytic recycling pathway components that act as genetic modifiers of alpha-synuclein aggregation, secretion and toxicity. PLoS Genetics 12, e1005995 (2016)

Tenreiro, S.; Rosado-Ramos, R.; Gerhardt, E.; Favretto, F.; Magalhães, F.; Popova, B.; Becker, S.; Zweckstetter, M.; Braus, G. H.; Outeiro, T. F.: Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity. Human Molecular Genetics 25 (2), pp. 275 - 290 (2016)