Max Planck Institute for Multidisciplinary Sciences

Publications

Journal Article (142)

1.

Journal Article

Coles, N. P.; Elsheikh, S.; Gouda, A.; Quesnel, A.; Butler, L.; Achadu, O. J.; Islam, M.; Kalesh, K.; Occhipinti, A.; Angione, C. et al.; Marles-Wright, J.; Koss, D. J.; Thomas, A. J.; Outeiro, T. F.; Filippou, P. S.; Khundakar, A. A.: A modified α-synuclein seed amplification assay in Lewy body dementia using Raman spectroscopy and machine learning analysis. Journal of Neuroscience Methods 425, 110617 (2026)

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2.

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Domingues, N.; Calcagni’, A.; Freire, S.; Pires, J.; Casqueiro, R.; Salazar, I. L.; Herz, N. J.; Huynh, T.; Wieciorek, K.; Outeiro, T. F. et al.; Girão, H.; Milosevic, I.; Ballabio, A.; Raimundo, N.: Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling. EMBO Reports (2025)

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3.

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Ayoub, S.; Arabi, M.; Al-Najjar, Y.; Laswi, I.; Outeiro, T. F.; Chaari, A.: Glycation in Alzheimer’s Disease and Type 2 Diabetes: The Prospect of Dual Drug Approaches for Therapeutic Interventions. Molecular Neurobiology 62, pp. 14859 - 14882 (2025)

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4.

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Outeiro, T. F.; Höglinger, G.; Lang, A. E.; Vieira, T. C. R. G.: Protein misfolding: understanding biology to classify and treat synucleinopathies. Journal of Neural Transmission 132, pp. 1645 - 1654 (2025)

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5.

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Vasili, E.; König, A.; Al-Azzani, M.; Bosbach, C.; Gatzemeier, L. M.; Thom, S.; Chegão, A.; Miranda, H. V.; Steinem, C.; Erskine, D. et al.; Outeiro, T. F.: Glycation of alpha-synuclein enhances aggregation and neuroinflammatory responses. npj Parkinson's Disease 11, 307 (2025)

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6.

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Brücke, C.; Al-Azzani, M.; Ramalingam, N.; Ramón, M.; Sousa, R. L.; Buratti, F.; Zech, M.; Sicking, K.; Amaral, L.; Gelpi, E. et al.; Chandran, A.; Agarwal, A.; Chaves, S. R.; Fernández, C. O.; Dettmer, U.; Lautenschläger, J.; Zweckstetter, M.; Busnadiego, R. F.; Zimprich, A.; Outeiro, T. F.: A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features. Molecular Neurodegeneration 20, 98 (2025)

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7.

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Al‐Azzani, M.; Weber, S.; Ramalingam, N.; Ramón, M.; Shvachiy, L.; Mestre, G.; Zech, M.; Sicking, K.; de Opakua, A. I.; Jayanthi, V. et al.; Amaral, L.; Agarwal, A.; Chandran, A.; Chaves, S. R.; Winkelmann, J.; Trenkwalder, C.; Schwager, M.; Pauli, S.; Dettmer, U.; Fernández, C. O.; Lautenschläger, J.; Zweckstetter, M.; Busnadiego, R. F.; Mollenhauer, B.; Outeiro, T. F.: A Novel α-Synuclein K58N Missense Variant in a Patient with Parkinson's Disease. Movement Disorders (2025)

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Lungu, R.; Fernandes, F. F.; Pires Monteiro, S.; Outeiro, T. F.; Shemesh, N.: Neural and vascular contributions to sensory impairments in a human alpha-synuclein transgenic mouse model of Parkinson’s disease. Journal of Cerebral Blood Flow and Metabolism 45 (9), pp. 1654 - 1669 (2025)

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9.

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Shaib, A. H.; Chouaib, A. A.; Chowdhury, R.; Altendorf, J.; Mihaylov, D.; Zhang, C.; Krah, D.; Imani, V.; Spencer, R. K. W.; Georgiev, S. V. et al.; Mougios, N.; Monga, M.; Reshetniak, S.; Mimoso, T.; Chen, H.; Fatehbasharzad, P.; Crzan, D.; Saal, K.-A.; Alawieh, M. M.; Alawar, N.; Eilts, J.; Kang, J.; Soleimani, A.; Müller, M.; Pape, C.; Alvarez, L.; Trenkwalder, C.; Mollenhauer, B.; Outeiro, T. F.; Köster, S.; Preobraschenski, J.; Becherer, U.; Moser, T.; Boyden, E. S.; Aricescu, A. R.; Sauer, M.; Opazo, F.; Rizzoli, S. O.: One-step nanoscale expansion microscopy reveals individual protein shapes. Nature Biotechnology 43, pp. 1539 - 1547 (2025)

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10.

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Santos, P. I.; Hojas García-Plaza, I.; Shaib, A.; Rhee, J. S.; Chouaib, A. A.; Brose, N.; Rizzoli, S. O.; Daniel, J.; Outeiro, T. F.: Glutamatergic synaptic resilience to overexpressed human alpha-synuclein. npj Parkinson's Disease 11, 238 (2025)

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11.

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Costa, M.; Wang, D.-W.; Zhao, K.-D.; Yuan, L.; Krisko, A.; Li, J.-Y.; Outeiro, T. F.; Li, W.: Aggregation potency and proinflammatory effects of SARS-CoV-2 proteins. Scientific Reports 15, 28446 (2025)

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12.

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Rocha, G. S.; Freire, M. A. M.; Falcao, D.; Outeiro, T. F.; Lima, R. R.; Santos, J. R.: Neurodegeneration in Parkinson’s disease: are we looking at the right spot? Molecular Brain 18 (1), 68 (2025)

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13.

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Yalçin, M.; Grande, V.; Outeiro, T. F.; Relógio, A.: Circadian clock dysfunction in Parkinson’s disease: mechanisms, consequences, and therapeutic strategy. npj Parkinson's Disease 11, 213 (2025)

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14.

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Outeiro, T. F.: Alpha-synuclein in Parkinson's disease: the debate that must go on. Parkinsonism & Related Disorders 136, 107850 (2025)

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15.

Journal Article

Outeiro, T. F.; Vieira, T. C. R. G.: Preface to the Special Issue “History, Biology and Pathobiology of Prions: A Field of Renewed Hopes”. Journal of Neurochemistry 169 (7), e70156 (2025)

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16.

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Yuan, L.; Mao, L.-H.; Huang, Y.-Y.; Outeiro, T. F.; Li, W.; Vieira, T. C. R. G.; Li, J.-Y.: Stress granules: emerging players in neurodegenerative diseases. Translational Neurodegeneration 14, 22 (2025)

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17.

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Ali, T. T.; Merghani, M.; Al-Azzani, M.; Gatzemeier, L. M.; Hoppert, M.; Kaloyanova, D.; Outeiro, T. F.; Neumann, P.; Popova, B.; Braus, G. H.: Rationally designed peptides inhibit the formation of α-synuclein fibrils and oligomers. European Journal of Medicinal Chemistry 289, 117452 (2025)

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18.

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Amaral, L.; Martins, M.; Côrte-Real, M.; Outeiro, T. F.; Chaves, S. R.; Rego, A.: The neurotoxicity of pesticides: Implications for Parkinson's disease. Chemosphere 377, 144348 (2025)

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19.

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Koss, D. J.; Todd, O.; Menon, H.; Anderson, Z.; Yang, T.; Findlay, L.; Graham, B.; Palmowski, P.; Porter, A.; Morrice, N. et al.; Walker, L.; Attems, J.; Ghanem, S. S.; El-Agnaf, O.; LeBeau, F. E.; Erskine, D.; Outeiro, T. F.: A reciprocal relationship between markers of genomic DNA damage and alpha-synuclein pathology in dementia with Lewy bodies. Molecular Neurodegeneration 20, 34 (2025)

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20.

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Laurent, C.; Poncet, G.; Herskovits, T.; Alves de Sousa, R.; Le Corre, L.; Al-Azzani, M.; Koenig, A.; Birman, S.; Outeiro, T. F.; Mansuy, D. et al.; Dairou, J.: Inhibition of the Parkinson’s Disease-Related Protein DJ-1 by Endogenous Neurotoxins of the 1,2,3,4-Tetrahydroisoquinoline Family. ACS Chemical Neuroscience 16 (6), pp. 1034 - 1042 (2025)

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21.

Journal Article

Flores-León, M.; Outeiro, T. F.: Expanding our understanding of synucleinopathies: proteinopathy, proteinopenia, and lipidopathy. The FEBS Journal 292 (18), pp. 4774 - 4788 (2025)

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22.

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Coles, N. P.; Elsheikh, S.; Quesnel, A.; Butler, L.; Jennings, C.; Tarzi, C.; Achadu, O. J.; Islam, M.; Kalesh, K.; Occhipinti, A. et al.; Angione, C.; Marles-Wright, J.; Koss, D. J.; Thomas, A. J.; Outeiro, T. F.; Filippou, P. S.; Khundakar, A. A.: Molecular Insights into α-Synuclein Fibrillation: A Raman Spectroscopy and Machine Learning Approach. ACS Chemical Neuroscience 16 (4), pp. 687 - 698 (2025)

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23.

Journal Article

Lang, A. E.; Höglinger, G. U.; Adler, C. H.; Berg, D.; Klein, C.; Outeiro, T. F.; Poewe, W.; Postuma, R.; Stoessl, A. J.: Initial biological classification of Lewy body diseases: No consensus on terminology. Alzheimer's & Dementia 21 (2), e14449 (2025)

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24.

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da Silva, I. S.; Cardoso, A. R.; Reimer, L.; König, A.; van Riesen, C.; Outeiro, T. F.; Jensen, P. H.; Sales, M. G. F.: α-Synuclein plastic antibody applied to monitor monomeric structures and discriminate aggregated forms in human CSF. Biosensors and Bioelectronics 268, 116880 (2025)

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25.

Journal Article

Fonseca-Fonseca, L. A.; Fuentes, N. P.; Sánchez, J. R.; Iglesias, Á. T.; Outeiro, T. F.; Silva, V. D. A. d.; Costa, S. L.; Núñez-Figueredo, Y.: Correlational assessment of the effects of JM-20 in a rat model of parkinsonism. Behavioural Brain Research 476, 115269 (2025)

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26.

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Coles, N. P.; Elsheikh, S.; Quesnel, A.; Butler, L.; Achadu, O.; Islam, M.; Kalesh, K.; Occhipinti, A.; Angione, C.; Marles-Wright, J. et al.; Koss, D. J.; Thomas, A. J.; Outeiro, T. F.; Filippou, P. S.; Khundakar, A. A.: Alpha-synuclein aggregation induces prominent cellular lipid changes as revealed by Raman spectroscopy and machine learning analysis. Brain Communications 7 (2), fcaf133 (2025)

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27.

Journal Article

Soares, E. S.; Queiroz, L. Y.; Gerhardt, E.; Prediger, R. D. S.; Outeiro, T. F.; Cimarosti, H. I.: SUMOylation modulates mitochondrial dynamics in an in vitro rotenone model of Parkinson's disease. Molecular and Cellular Neuroscience 131, 103969 (2024)

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28.

Journal Article

Amaro-Leal, Â.; Afonso, A. I.; Machado, F.; Shvachiy, L.; Rocha, I.; Outeiro, T. F.; Geraldes, V.: Dose-Dependent Cognitive Decline, Anxiety, and Locomotor Impairments Induced by Doxorubicin: Evidence from an Animal Model. Biology 13 (11), 939 (2024)

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29.

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de Bruyn, E.; Dorn, A.E.; Rossetti, G.; Fernandez, C.; Outeiro, T. F.; Schulz, J.B.; Carloni, P.: Impact of Phosphorylation on the Physiological Form of Human alpha-Synuclein in Aqueous Solution. Journal of Chemical Information and Modeling 64 (21), pp. 8215 - 8226 (2024)

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30.

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Abdelrasol, H.; Chopra, A.; Shvachiy, L.; Beutner, D.; Outeiro, T. F.; Setz, C.: Stress granules formation in HEI-OC1 auditory cells and in H4 human neuroglioma cells secondary to cisplatin exposure. Cell Stress 8 (1), pp. 83 - 98 (2024)

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31.

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Gatzemeier, L. M.; Meyer, F.; Outeiro, T. F.: Synthesis and Semi-Synthesis of Alpha-Synuclein: Insight into the Chemical Complexity of Synucleinopathies. Chembiochem 25 (20), e202400253 (2024)

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32.

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Fonseca-Gomes, J.; Costa-Coelho, T.; Ferreira-Manso, M.; Inteiro-Oliveira, S.; Vaz, S.H.; Alemãn-Serrano, N.; Atalaia-Barbacena, H.; Ribeiro-Rodrigues, L.; Ramalho, R.M.; Pinto, R. et al.; Vicente Miranda, H.; Tanqueiro, S.R.; de Almeida-Borlido, C.; Ramalho, M.J.; Miranda-Lourenço, C.; Belo, R.F.; Ferreira, C.B.; Neves, V.; Rombo, D.M.; Viais, R.; Martins, I.C.; Jerónimo-Santos, A.; Caetano, A.; Manso, N.; Mäkinen, P.; Marttinen, M.; Takalo, M.; Bremang, M.; Pike, I.; Haapasalo, A.; Loureiro, J.A.; Pereira, M.C.; Santos, N.C.; Outeiro, T. F.; Castanho, M.A.R.B.; Fernandes, A.; Hiltunen, M.; Duarte, C.B.; Castrén, E.; de Mendonça, A.; Sebastião, A.M.; Rodrigues, T.M.; Diógenes, M.J.: A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's disease. Molecular Therapy 32 (10), pp. 3372 - 3401 (2024)

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33.

Journal Article

da Silva Correia, A.; Schmitz, M.; Fischer, A.; da Silva Correia, S.; Simonetti, F. L.; Saher, G.; Goya‐Maldonado, R.; Arora, A. S.; Fischer, A.; Outeiro, T. F. et al.; Zerr, I.: Cellular prion protein acts as mediator of amyloid beta uptake by caveolin‐1 causing cellular dysfunctions in vitro and in vivo. Alzheimer's & Dementia 20 (10), pp. 6776 - 6792 (2024)

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34.

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Amaral, L.; Mendes, F.; Côrte-Real, M.; Rego, A.; Outeiro, T. F.; Chaves, S. R.: A versatile yeast model identifies the pesticides cymoxanil and metalaxyl as risk factors for synucleinopathies. Chemosphere 364, 143039 (2024)

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35.

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Gasparotto, J.; Somensi, N.; Girardi, C. S.; Bittencourt, R. R.; de Oliveira, L. M.; Hoefel, L. P.; Scheibel, I. M.; Peixoto, D. O.; Fonseca Moreira, J. C.; Outeiro, T. F. et al.; Gelain, D. P.: Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson's disease. Journal of Neurochemistry 168 (8), pp. 1608 - 1624 (2024)

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36.

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Plácido, E.; Koss, D. J.; Outeiro, T. F.; Brocardo, P. S.: Altered hippocampal doublecortin expression in Parkinson's disease. Journal of Neurochemistry 168 (8), pp. 1514 - 1526 (2024)

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37.

Journal Article

Vieira, T. C. R. G.; Barros, C. A.; Domingues, R.; Outeiro, T. F.: PrP meets alpha-synuclein: Molecular mechanisms and implications for disease. Journal of Neurochemistry 168 (8), pp. 1625 - 1639 (2024)

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38.

Journal Article

König, A.; Outeiro, T. F.: Diabetes and Parkinson's Disease: Understanding Shared Molecular Mechanisms. Journal of Parkinson's Disease 14 (5), pp. 917 - 924 (2024)

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39.

Journal Article

Goedert, M.; Griesinger, C.; Outeiro, T. F.; Riek, R.; Schröder, G. F.; Spillantini, M. G.: Abandon the NAC in α-synuclein. Lancet Neurology 23 (7), p. 669 (2024)

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40.

Journal Article

Doerje, N. M.; Shvachiy, L.; Kueck, F.; Outeiro, T. F.; Strenzke, N.; Beutner, D.; Setz, C.: Age-related alterations in efferent medial olivocochlear-outer hair cell and primary auditory ribbon synapses in CBA/J mice. Frontiers in Cellular Neuroscience 18, 1412450 (2024)

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41.

Journal Article

Erdmann, L.; Santos, P.; Rieper, P.; Klafki, H. W.; Beutner, D.; Wiltfang, J.; Outeiro, T. F.; Setz, C.: Automated Capillary Electrophoresis Immunoblot for the Detection of Alpha-Synuclein in Mouse Tissue. Journal of Parkinson's Disease: JPD 14 (4), pp. 681 - 692 (2024)

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42.

Journal Article

Outeiro, T. F.; Antonini, A.; Ferreira, J. J.: Reply to: “Rethinking Parkinson's Disease: A Syndromic Perspective”. Movement Disorders 39 (6), pp. 1080 - 1081 (2024)

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43.

Journal Article

Outeiro, T. F.; Kalia, L. V.; Bezard, E.; Ferrario, J.; Lin, C.-H.; Salama, M.; Standaert, D. G.; Taiwo, L.; Takahashi, R.; Vila, M. et al.; Mollenhauer, B.; Svenningsson, P.; The MDS Basic Science Special Interest Group Steering Committe: Basic Science in Movement Disorders: Fueling the Engine of Translation into Clinical Practice. Movement Disorders 39 (6), pp. 929 - 933 (2024)

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44.

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Thirupathi, A.; Marqueze, L. F.; Outeiro, T. F.; Radak, Z.; Pinho, R. A.: Physical Exercise-Induced Activation of NRF2 and BDNF as a Promising Strategy for Ferroptosis Regulation in Parkinson’s Disease. Neurochemical Research 49, pp. 1643 - 1654 (2024)

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45.

Journal Article

Chopra, A.; Lang, A. E.; Höglinger, G.; Outeiro, T. F.: Towards a biological diagnosis of PD. Parkinsonism & Related Disorders 122, 106078 (2024)

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46.

Journal Article

Galka, D.; Ali, T. T.; Bast, A.; Niederleithinger, M.; Gerhardt, E.; Motosugi, R.; Sakata, E.; Knop, M.; Outeiro, T. F.; Popova, B. et al.; Braus, G. H.: Inhibition of 26S proteasome activity by α-synuclein is mediated by the proteasomal chaperone Rpn14/PAAF1. Aging Cell 23 (5), e14128 (2024)

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47.

Journal Article

Jebali, A.; Rashidi, M.; Keikha, R.; Daliri, K.; Outeiro, T. F.: Novel multifunctional nanoliposomes inhibit α-synuclein fibrillization, attenuate microglial activation, and silence the expression of SNCA gene. Neurología (English Edition) 39 (4), pp. 321 - 328 (2024)

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48.

Journal Article

Oliveira da Silva, M.I.; Santejo, M.; Babcock, I.W.; Magalhães, A.; Minamide, L.S.; Won, S.-J.; Castillo, E.; Gerhardt, E.; Fahlbusch, C.; Swanson, R.A. et al.; Outeiro, T. F.; Taipa, R.; Ruff, M.; Bamburg, J.R.; Liz, M.A.: α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrP^C-CCR5 dependent pathway. Cell Death and Disease 15 (4), 264 (2024)

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49.

Journal Article

Mohammadi, E. L.; Keikha, R.; Outeiro, T. F.; Jebali, A.: Adsorption of alpha-synuclein and inhibition of fibril formation by nanocellulose and gold-coated-nanocellulose. Cellulose 31, pp. 3797 - 3804 (2024)

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50.

Journal Article

Bosbach, C.; Gatzemeier, L. M.; Bloch von Blottnitz, K. I.; König, A.; Diederichsen, U.; Steinem, C.; Outeiro, T. F.: Chemical synthesis of site-selective advanced glycation end products in α-synuclein and its fragments. Organic & Biomolecular Chemistry 22, pp. 2670 - 2676 (2024)

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