Max Planck Institute for Multidisciplinary Sciences

Publications

Journal Article (153)

1.

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Loreau, V.; Koolhaas, W. H.; Chan, E. H.; De Boissier, P.; Brouilly, N.; Avosani, S.; Sane, A.; Pitaval, C.; Reiter, S.; Luis, N. M. et al.; Mangeol, P.; von Philipsborn, A. C.; Rupprecht, J.-F.; Görlich, D.; Habermann, B. H.; Schnorrer, F.: Titin-dependent biomechanical feedback tailors sarcomeres to specialized muscle functions in insects. Science Advances 11 (19), eads8716 (2025)

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Solà Colom, M.; Fu, Z.; Gunkel, P.; Güttler, T.; Trakhanov, S.; Srinivasan, V.; Gregor, K.; Pleiner, T.; Görlich, D.: A checkpoint function for Nup98 in nuclear pore formation suggested by novel inhibitory nanobodies. The EMBO Journal 43 (11), pp. 2198 - 2232 (2024)

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3.

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Fu, L.; Weiskopf, E.N.; Akkermans, O.; Swanson, N.A.; Cheng, S.; Schwartz, T.U.; Görlich, D.: HIV-1 capsids enter the FG phase of nuclear pores like a transport receptor. Nature 626, pp. 843 - 851 (2024)

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Aksu, M.; Kumar, P.; Güttler, T.; Taxer, W.; Gregor, K.; Mußil, B.; Rymarenko, O.; Stegmann, K.M.; Dickmanns, A.; Gerber, S. et al.; Reineking, W.; Schulz, C.; Henneck, T.; Mohamed, A.; Pohlmann, G.; Ramazanoglu, M.; Mese, K.; Groß, U.; Ben-Yedidia, T.; Ovadia, O.; Fischer, D.W.; Kamensky, M.; Reichman, A.; Baumgärtner, W.; von Köckritz-Blickwede, M.; Dobbelstein, M.; Görlich, D.: Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters. Antiviral Research 221, 105778 (2024)

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Zibat, A.; Zhang, X.; Dickmanns, A.; Stegmann, K.M.; Dobbelstein, A.W.; Alachram, H.; Soliwoda, R.; Salinas, G.; Groß, U.; Görlich, D. et al.; Kschischo, M.; Wollnik, B.; Dobbelstein, M.: N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody. iScience 26 (10), 107786 (2023)

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6.

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Gunkel, P.; Iino, H.; Krull, S.; Cordes, V. C.: An evolutionarily conserved bimodular domain anchors ZC3HC1 and its yeast homologue Pml39p to the nuclear basket. Molecular Biology of the Cell 34 (5), ar40 (2023)

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7.

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Weber, M.; von der Emde, H.; Leutenegger, M.; Gunkel, P.; Sambandan, S.; Khan, T. A.; Keller-Findeisen, J.; Cordes, V. C.; Hell, S. W.: MINSTED nanoscopy enters the Ångström localization range. Nature Biotechnology 41, pp. 569 - 576 (2023)

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8.

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Ng, S. C.; Biswas, A.; Huyton, T.; Schünemann, J.; Reber, S.; Görlich, D.: Barrier-properties of Nup98 FG phases ruled by FG motif identity and inter-FG spacer length. Nature Communications 14, 747 (2023)

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9.

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Loreau, V.; Rees, R.; Chan, E. H.; Taxer, W.; Gregor, K.; Mußil, B.; Pitaval, C.; Luis, N. M.; Mangeol, P.; Schnorrer, F. et al.; Görlich, D.: A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins. eLife 12, e79343 (2023)

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10.

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Schueder, F.; Mangeol, P.; Chan, E. H.; Rees, R.; Schünemann, J.; Jungmann, R.; Görlich, D.; Schnorrer, F.: Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nanoarchitecture in flight muscles. eLife 12, e79344 (2023)

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11.

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Ng, S. C.; Görlich, D.: A simple thermodynamic description of phase separation of Nup98 FG domains. Nature Communications 13, 6172 (2022)

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12.

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Huyton, T.; Jaiswal, M.; Taxer, W.; Fischer, M.; Görlich, D.: Crystal structures of FNIP/FGxxFN motif-containing leucine-rich repeat proteins. Scientific Reports 12, 16430 (2022)

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13.

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Modepalli, S.; Martinez-Morilla, S.; Venkatesan , S.; Fasano, J.; Paulsen, K.; Görlich, D.; Hattangadi, S.; Kupfer, G. M.: An In Vivo Model for Elucidating the Role of an Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine Erythropoiesis. Experimental Hematology 114, pp. 22 - 32 (2022)

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14.

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Blaurock, C.; Breithaupt, A.; Weber, S.; Wylezich, C.; Keller, M.; Mohl, B.-P.; Görlich, D.; Groschup, M. H.; Sadeghi, B.; Höper, D. et al.; Mettenleiter, T. C.; Balkema-Buschmann, A.: Compellingly high SARS-CoV-2 susceptibility of Golden Syrian hamsters suggests multiple zoonotic infections of pet hamsters during the COVID-19 pandemic. Scientific Reports 12, 15069 (2022)

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15.

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Gunkel, P.; Cordes, V. C.: ZC3HC1 is a structural element of the nuclear basket effecting interlinkage of TPR polypeptides. Molecular Biology of the Cell 33 (9), ar82 (2022)

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16.

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Stegmann, K. M.; Dickmanns, A.; Heinen, N.; Blaurock, C.; Karrasch, T.; Breithaupt, A.; Klopfleisch, R.; Uhlig, N.; Eberlein, V.; Issmail, L. et al.; Herrmann, S. T.; Schreieck, A.; Peelen, E.; Kohlhof, H.; Sadeghi, B.; Riek, A.; Speakman, J. R.; Groß, U.; Görlich, D.; Vitt, D.; Müller, T.; Grunwald, T.; Pfaender, S.; Balkema-Buschmann, A.; Dobbelstein, M.: Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication. iScience 25 (5), 104293 (2022)

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17.

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Najbauer, E. E.; Ng, S. C.; Griesinger, C.; Görlich, D.; Andreas, L. B.: Atomic resolution dynamics of cohesive interactions in phase-separated Nup98 FG domains. Nature Communications 13, 1494 (2022)

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18.

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García-García, M.; Sánchez-Perales, S.; Jarabo, P.; Calvo, E.; Huyton, T.; Fu, L.; Ng, S. C.; Sotodosos-Alonso, L.; Vázquez, J.; Casas-Tintó, S. et al.; Görlich, D.; Echarri, A.; Del Pozo, M. A.: Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP. Nature Communications 13, 1174 (2022)

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19.

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Güttler, T.; Dobbelstein, M.; Görlich, D.: Therapeutische Nanobodies gegen SARS-CoV-2. Biospektrum 28, pp. 39 - 42 (2022)

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20.

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Güttler, T.; Aksu, M.; Dickmanns, A.; Stegmann, K. M.; Gregor, K.; Rees, R.; Taxer, W.; Rymarenko, O.; Schünemann, J.; Dienemann, C. et al.; Gunkel, P.; Mussil, B.; Krull, J.; Teichmann, U.; Groß, U.; Cordes, V.; Dobbelstein, M.; Görlich, D.: Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies. EMBO Journal 40 (19), e107985 (2021)

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21.

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Stegmann, K. M.; Dickmanns, A.; Gerber, S.; Nikolova, V.; Klemke, L.; Manzini, V.; Schlösser, D.; Bierwirth, C.; Freund, J.; Sitte, M. et al.; Lugert, R.; Salinas, G.; Meister, T. L.; Pfaender, S.; Görlich, D.; Wollnik, B.; Groß, U.; Dobbelstein, M.: The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models. Virus Research 302, 198469 (2021)

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22.

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Ng, S. C.; Güttler, T.; Görlich, D.: Recapitulation of selective nuclear import and export with a perfectly repeated 12mer GLFG peptide. Nature Communications 12, 4047 (2021)

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23.

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Frost, R.; Débarre, D.; Jana, S.; Bano, F.; Schünemann, J.; Görlich, D.; Richter, R. P.: A method to quantify molecular diffusion within thin solvated polymer films: A case study on films of natively unfolded nucleoporins. ACS Nano 14 (8), pp. 9938 - 9952 (2020)

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24.

Journal Article

Serres, M. P.; Samwer, M.; Truong Quang, B. A.; Lavoie, G.; Perera, U.; Görlich, D.; Charras, G.; Petronczki, M.; Roux, P. P.; Paluch, E. K.: F-actin interactome reveals vimentin as a key regulator of actin organization and cell mechanics in mitosis. Developmental Cell 52 (2), pp. 210 - 222 (2020)

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25.

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Karabinos, A.; Schünemann, J.; Parry, D. A. D.: Promiscuous dimerization between the Caenorhabditis elegans IF proteins and a hypothesis to explain how multiple IFs persist over evolutionary time. Journal of Molecular Evolution 87 (7-8), pp. 221 - 230 (2019)

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26.

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Pump, W. C.; Schulz, R.; Huyton, T.; Kunze-Schumacher, H.; Martens, J.; Ho, G. G. T.; Blasczyk, R.; Bade-Doeding, C.: Releasing the concept of HLA-allele specific peptide anchors in viral infections: A non-canonical naturally presented human cytomegalovirus-derived HLA-A*24:02 restricted peptide drives exquisite immunogenicity. HLA: Immune Response Genetics 94 (1), pp. 25 - 38 (2019)

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27.

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Aksu, M.; Trakhanov, S.; Vera Rodriguez, A.; Görlich, D.: Structural basis for the nuclear import and export functions of the biportin Pdr6/Kap122. Journal of Cell Biology 218 (6), pp. 1839 - 1852 (2019)

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28.

Journal Article

Vera Rodriguez, A.; Frey, S.; Görlich, D.: Engineered SUMO/protease system identifies Pdr6 as a bidirectional nuclear transport receptor. The Journal of Cell Biology 218 (6), pp. 2006 - 2020 (2019)

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29.

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Ho, G. G. T.; Heinen, F. J.; Huyton, T.; Blasczy, R.; Bade-Döding, C.: HLA-F*01:01 presents peptides with N-terminal flexibility and a preferred length of 16 residues. Immunogenetics 51 (5-6), pp. 353 - 360 (2019)

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30.

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Pump, W. C.; Kraemer, T.; Huyton, T.; Hò, G. G. T.; Blasczyk, R.; Bade-Doeding, C.: Between innate and adaptive immune responses: NKG2A, NKG2C, and CD8⁺ T cell recognition of HLA-E restricted self-peptides acquired in the absence of HLA-Ia. International Journal of Molecular Sciences 20 (6), 1454 (2019)

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31.

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Mandad, S.; Rahman, R. U.; Centeno, T. P.; Vidal, R. O.; Wildhagen, H.; Rammner, B.; Keihani, S.; Opazo, F.; Urban, I.; Ischebeck, T. et al.; Kirli, K.; Benito, E.; Fischer, A.; Yousefi, R. Y.; Dennerlein, S.; Rehling, P.; Feussner, I.; Urlaub, H.; Bonn, S.; Rizzoli, S. O.; Fornasiero, E. F.: The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain. Scientific Reports 8, 16913 (2018)

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32.

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Simper, G. S.; Ho, G. G. T.; Celik, A. A.; Huyton, T.; Kuhn, J.; Kunze-Schumacher, H.; Blasczyk, R.; Bade-Döding, C.: Carbamazepine-mediated adverse drug reactions: CBZ-10,11-epoxide but not carbamazepine induces the alteration of peptides presented by HLA-B*15:02. Journal of Immunology Research 2018, 5086503 (2018)

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33.

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Aksu, M.; Pleiner, T.; Karaca, S.; Kappert, C.; Dehne, H. J.; Seibel, K.; Urlaub, H.; Bohnsack, M. T.; Görlich, D.: Xpo7 is a broad-spectrum exportin and a nuclear import receptor. Journal of Cell Biology 217 (7), pp. 2329 - 2340 (2018)

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34.

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Frey, S.; Rees, R.; Schünemann, J.; Ng, S. C.; Fünfgeld, K.; Huyton, T.; Görlich, D.: Surface properties determining passage rates of proteins through nuclear pores. Cell 174 (1), pp. 202 - 217 (2018)

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35.

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Alexeeva, M.; Guragain, P.; Tesfahun, A. N.; Tomkuviene, M.; Arshad, A.; Gerasimaite, R.; Rugenaite, A.; Urbanaviciute, G.; Bjoras, M.; Laerdahl, J. K. et al.; Klungland, A.; Klimasauskas, S.; Bjelland, S.: Excision of the doubly methylated base N-4,5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins. Philosophical Transactions of the Royal Society B: Biological Sciences 373 (1748), 20170337 (2018)

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36.

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Celik, A. A.; Simper, G. S.; Huyton, T.; Blasczyk, R.; Bade-Döding, C.: HLA-G mediated immune regulation is impaired by a single amino acid exchange in the alpha 2 domain. Human Immunology 79 (6), pp. 453 - 462 (2018)

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37.

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Ananth, A.; Genua, M.; Aissaoui, N.; Diaz, L.; Eisele, N. B.; Frey, S.; Dekker, C.; Richter, R. P.; Görlich, D.: Reversible immobilization of proteins in sensors and solid-state nanopores. Small 14 (18), 1703357 (2018)

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38.

Journal Article

Bucevicius, J.; Lukinavicius, G.; Gerasimaite, R.: The use of Hoechst dyes for DNA staining and beyond. Chemosensors 6 (2), 18 (2018)

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39.

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Pleiner, T.; Bates, M.; Görlich, D.: A toolbox of anti-mouse and anti-rabbit IgG secondary nanobodies. Journal of Cell Biology 217 (3), pp. 1143 - 1154 (2018)

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40.

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Ananth, A. N.; Mishra, A.; Frey, S.; Dwarkasing, A.; Versloot, R.; van der Giessen, E.; Görlich, D.; Onck, P.; Dekker, C.: Spatial structure of disordered proteins dictates conductance and selectivity in Nuclear Pore Complex mimics. eLife 7, e31510 (2018)

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41.

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Karabinos, A.; Schünemann, J.; Parry, D. A. D.: Assembly studies of six intestinal intermediate filament (IF) proteins B2, C1, C2, D1, D2, and E1 in the nematode C-elegans. Cytoskeleton 74 (3), pp. 107 - 113 (2017)

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42.

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Göttfert, F.; Pleiner, T.; Heine, J.; Westphal, V.; Görlich, D.; Sahl, S. J.; Hell, S. W.: Strong signal increase in STED fluorescence microscopy by imaging regions of subdiffraction extent. Proceedings of the National Academy of Sciences of the United States of America 114 (9), pp. 2125 - 2130 (2017)

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43.

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Warda, A. S.; Freytag, B.; Haag, S.; Sloan, K. E.; Görlich, D.; Bohnsack, M.: Effects of the Bowen-Conradi syndrome mutation in EMG1 on its nuclear import, stability and nucleolar recruitment. Human Molecular Genetics 25 (24), pp. 5353 - 5364 (2016)

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44.

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Seehusen, F.; Kiel, K.; Jottini, S.; Wohlsein, P.; Habierski, H.; Seibel, K.; Vogel, T.; Urlaub, H.; Kollmar, M.; Baumgärtner, W. et al.; Teichmann, U.: Axonopathy in the central nervous system is the hallmark of mice with a novel intragenic null mutation of dystonin. Genetics 204 (1), pp. 191 - 203 (2016)

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45.

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Kühn, J.; Wong, L. E.; Pirkuliyeva, S.; Schulz, K.; Schwiegk, C.; Fünfgeld, K.; Keppler, S.; Batista, F. D.; Urlaub, H.; Habeck, M. et al.; Becker, S.; Griesinger, C.; Wienands, J.: The adaptor protein CIN85 assembles intracellular signaling clusters for B cell activation. Science Signaling 9 (434), ra66 (2016)

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46.

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Aksu, M.; Trakhanov, S.; Görlich, D.: Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A. Nature Communications 7, 11952 (2016)

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47.

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Zahn, R.; Osmanovic, D.; Ehret, S.; Callis, C. A.; Frey, S.; Stewart, M.; You, C. J.; Görlich, D.; Hoogenboom, B. W.; Richter, R. P.: A physical model describing the interaction of nuclear transport receptors with FG nucleoporin domain assemblies. eLife 5, e14119 (2016)

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48.

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Schmidt, H. B.; Görlich, D.: Transport selectivity of nuclear pores, phase separation, and membraneless organelles. Trends in Biochemical Sciences 41 (1), pp. 46 - 61 (2016)

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49.

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Kirli, K.; Karaca, S.; Dehne, H. J.; Samwer, M.; Pan, K. T.; Lenz, C.; Urlaub, H.; Görlich, D.: A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. eLife 4, e11466 (2015)

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50.

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Pleiner, T.; Bates, M.; Trakhanov, S.; Lee, C. T.; Schliep, J. E.; Chug, H.; Böhning, M.; Stark, H.; Urlaub, H.; Görlich, D.: Nanobodies: Site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation. eLife 4, e11349 (2015)

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