Publications

2.

Journal Article

Fu, L.; Weiskopf, E.N.; Akkermans, O.; Swanson, N.A.; Cheng, S.; Schwartz, T.U.; Görlich, D.: HIV-1 capsids enter the FG phase of nuclear pores like a transport receptor. Nature 626, pp. 843 - 851 (2024)

MPG.PuRe

3.

Journal Article

Aksu, M.; Kumar, P.; Güttler, T.; Taxer, W.; Gregor, K.; Mußil, B.; Rymarenko, O.; Stegmann, K.M.; Dickmanns, A.; Gerber, S. et al.; Reineking, W.; Schulz, C.; Henneck, T.; Mohamed, A.; Pohlmann, G.; Ramazanoglu, M.; Mese, K.; Groß, U.; Ben-Yedidia, T.; Ovadia, O.; Fischer, D.W.; Kamensky, M.; Reichman, A.; Baumgärtner, W.; von Köckritz-Blickwede, M.; Dobbelstein, M.; Görlich, D.: Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters. Antiviral Research 221, 105778 (2024)

MPG.PuRe

4.

Journal Article

Zibat, A.; Zhang, X.; Dickmanns, A.; Stegmann, K.M.; Dobbelstein, A.W.; Alachram, H.; Soliwoda, R.; Salinas, G.; Groß, U.; Görlich, D. et al.; Kschischo, M.; Wollnik, B.; Dobbelstein, M.: N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody. iScience 26 (10), 107786 (2023)

MPG.PuRe

5.

Journal Article

Gunkel, P.; Iino, H.; Krull, S.; Cordes, V. C.: An evolutionarily conserved bimodular domain anchors ZC3HC1 and its yeast homologue Pml39p to the nuclear basket. Molecular Biology of the Cell 34 (5), ar40 (2023)

MPG.PuRe

6.

Journal Article

Ng, S. C.; Biswas, A.; Huyton, T.; Schünemann, J.; Reber, S.; Görlich, D.: Barrier-properties of Nup98 FG phases ruled by FG motif identity and inter-FG spacer length. Nature Communications 14, 747 (2023)

MPG.PuRe

7.

Journal Article

Loreau, V.; Rees, R.; Chan, E. H.; Taxer, W.; Gregor, K.; Mußil, B.; Pitaval, C.; Luis, N. M.; Mangeol, P.; Schnorrer, F. et al.; Görlich, D.: A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins. eLife 12, e79343 (2023)

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8.

Journal Article

Schueder, F.; Mangeol, P.; Chan, E. H.; Rees, R.; Schünemann, J.; Jungmann, R.; Görlich, D.; Schnorrer, F.: Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nanoarchitecture in flight muscles. eLife 12, e79344 (2023)

MPG.PuRe

9.

Journal Article

Weber, M.; von der Emde, H.; Leutenegger, M.; Gunkel, P.; Sambandan, S.; Khan, T. A.; Keller-Findeisen, J.; Cordes, V. C.; Hell, S. W.: MINSTED nanoscopy enters the Ångström localization range. Nature Biotechnology (2022)

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10.

Journal Article

Ng, S. C.; Görlich, D.: A simple thermodynamic description of phase separation of Nup98 FG domains. Nature Communications 13, 6172 (2022)

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pre-print

11.

Journal Article

Huyton, T.; Jaiswal, M.; Taxer, W.; Fischer, M.; Görlich, D.: Crystal structures of FNIP/FGxxFN motif-containing leucine-rich repeat proteins. Scientific Reports 12, 16430 (2022)

MPG.PuRe

12.

Journal Article

Modepalli, S.; Martinez-Morilla, S.; Venkatesan , S.; Fasano, J.; Paulsen, K.; Görlich, D.; Hattangadi, S.; Kupfer, G. M.: An In Vivo Model for Elucidating the Role of an Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine Erythropoiesis. Experimental Hematology 114, pp. 22 - 32 (2022)

MPG.PuRe

13.

Journal Article

Blaurock, C.; Breithaupt, A.; Weber, S.; Wylezich, C.; Keller, M.; Mohl, B.-P.; Görlich, D.; Groschup, M. H.; Sadeghi, B.; Höper, D. et al.; Mettenleiter, T. C.; Balkema-Buschmann, A.: Compellingly high SARS-CoV-2 susceptibility of Golden Syrian hamsters suggests multiple zoonotic infections of pet hamsters during the COVID-19 pandemic. Scientific Reports 12, 15069 (2022)

MPG.PuRe

14.

Journal Article

Gunkel, P.; Cordes, V. C.: ZC3HC1 is a structural element of the nuclear basket effecting interlinkage of TPR polypeptides. Molecular Biology of the Cell 33 (9), ar82 (2022)

MPG.PuRe

15.

Journal Article

Najbauer, E. E.; Ng, S. C.; Griesinger, C.; Görlich, D.; Andreas, L. B.: Atomic resolution dynamics of cohesive interactions in phase-separated Nup98 FG domains. Nature Communications 13, 1494 (2022)

MPG.PuRe

16.

Journal Article

Güttler, T.; Aksu, M.; Dickmanns, A.; Stegmann, K. M.; Gregor, K.; Rees, R.; Taxer, W.; Rymarenko, O.; Schünemann, J.; Dienemann, C. et al.; Gunkel, P.; Mussil, B.; Krull, J.; Teichmann, U.; Groß, U.; Cordes, V.; Dobbelstein, M.; Görlich, D.: Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies. EMBO Journal 40 (19), e107985 (2021)

MPG.PuRe

17.

Journal Article

Stegmann, K. M.; Dickmanns, A.; Gerber, S.; Nikolova, V.; Klemke, L.; Manzini, V.; Schlösser, D.; Bierwirth, C.; Freund, J.; Sitte, M. et al.; Lugert, R.; Salinas, G.; Meister, T. L.; Pfaender, S.; Görlich, D.; Wollnik, B.; Groß, U.; Dobbelstein, M.: The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models. Virus Research 302, 198469 (2021)

MPG.PuRe

18.

Journal Article

Ng, S. C.; Güttler, T.; Görlich, D.: Recapitulation of selective nuclear import and export with a perfectly repeated 12mer GLFG peptide. Nature Communications 12, 4047 (2021)

MPG.PuRe

19.

Journal Article

Frost, R.; Débarre, D.; Jana, S.; Bano, F.; Schünemann, J.; Görlich, D.; Richter, R. P.: A method to quantify molecular diffusion within thin solvated polymer films: A case study on films of natively unfolded nucleoporins. ACS Nano 14 (8), pp. 9938 - 9952 (2020)

MPG.PuRe

20.

Journal Article

Serres, M. P.; Samwer, M.; Truong Quang, B. A.; Lavoie, G.; Perera, U.; Görlich, D.; Charras, G.; Petronczki, M.; Roux, P. P.; Paluch, E. K.: F-actin interactome reveals vimentin as a key regulator of actin organization and cell mechanics in mitosis. Developmental Cell 52 (2), pp. 210 - 222 (2020)

MPG.PuRe

ZIP

21.

Journal Article

Karabinos, A.; Schünemann, J.; Parry, D. A. D.: Promiscuous dimerization between the Caenorhabditis elegans IF proteins and a hypothesis to explain how multiple IFs persist over evolutionary time. Journal of Molecular Evolution 87 (7-8), pp. 221 - 230 (2019)

MPG.PuRe

22.

Journal Article

Pump, W. C.; Schulz, R.; Huyton, T.; Kunze-Schumacher, H.; Martens, J.; Ho, G. G. T.; Blasczyk, R.; Bade-Doeding, C.: Releasing the concept of HLA-allele specific peptide anchors in viral infections: A non-canonical naturally presented human cytomegalovirus-derived HLA-A*24:02 restricted peptide drives exquisite immunogenicity. HLA: Immune Response Genetics 94 (1), pp. 25 - 38 (2019)

MPG.PuRe

23.

Journal Article

Aksu, M.; Trakhanov, S.; Vera Rodriguez, A.; Görlich, D.: Structural basis for the nuclear import and export functions of the biportin Pdr6/Kap122. Journal of Cell Biology 218 (6), pp. 1839 - 1852 (2019)

MPG.PuRe

24.

Journal Article

Vera Rodriguez, A.; Frey, S.; Görlich, D.: Engineered SUMO/protease system identifies Pdr6 as a bidirectional nuclear transport receptor. The Journal of Cell Biology 218 (6), pp. 2006 - 2020 (2019)

MPG.PuRe

25.

Journal Article

Ho, G. G. T.; Heinen, F. J.; Huyton, T.; Blasczy, R.; Bade-Döding, C.: HLA-F*01:01 presents peptides with N-terminal flexibility and a preferred length of 16 residues. Immunogenetics 51 (5-6), pp. 353 - 360 (2019)

MPG.PuRe

26.

Journal Article

Pump, W. C.; Kraemer, T.; Huyton, T.; Hò, G. G. T.; Blasczyk, R.; Bade-Doeding, C.: Between innate and adaptive immune responses: NKG2A, NKG2C, and CD8⁺ T cell recognition of HLA-E restricted self-peptides acquired in the absence of HLA-Ia. International Journal of Molecular Sciences 20 (6), 1454 (2019)

MPG.PuRe

27.

Journal Article

Mandad, S.; Rahman, R. U.; Centeno, T. P.; Vidal, R. O.; Wildhagen, H.; Rammner, B.; Keihani, S.; Opazo, F.; Urban, I.; Ischebeck, T. et al.; Kirli, K.; Benito, E.; Fischer, A.; Yousefi, R. Y.; Dennerlein, S.; Rehling, P.; Feussner, I.; Urlaub, H.; Bonn, S.; Rizzoli, S. O.; Fornasiero, E. F.: The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain. Scientific Reports 8, 16913 (2018)

MPG.PuRe

28.

Journal Article

Simper, G. S.; Ho, G. G. T.; Celik, A. A.; Huyton, T.; Kuhn, J.; Kunze-Schumacher, H.; Blasczyk, R.; Bade-Döding, C.: Carbamazepine-mediated adverse drug reactions: CBZ-10,11-epoxide but not carbamazepine induces the alteration of peptides presented by HLA-B*15:02. Journal of Immunology Research 2018, 5086503 (2018)

MPG.PuRe

29.

Journal Article

Aksu, M.; Pleiner, T.; Karaca, S.; Kappert, C.; Dehne, H. J.; Seibel, K.; Urlaub, H.; Bohnsack, M. T.; Görlich, D.: Xpo7 is a broad-spectrum exportin and a nuclear import receptor. Journal of Cell Biology 217 (7), pp. 2329 - 2340 (2018)

MPG.PuRe

30.

Journal Article

Frey, S.; Rees, R.; Schünemann, J.; Ng, S. C.; Fünfgeld, K.; Huyton, T.; Görlich, D.: Surface properties determining passage rates of proteins through nuclear pores. Cell 174 (1), pp. 202 - 217 (2018)

MPG.PuRe

31.

Journal Article

Alexeeva, M.; Guragain, P.; Tesfahun, A. N.; Tomkuviene, M.; Arshad, A.; Gerasimaite, R.; Rugenaite, A.; Urbanaviciute, G.; Bjoras, M.; Laerdahl, J. K. et al.; Klungland, A.; Klimasauskas, S.; Bjelland, S.: Excision of the doubly methylated base N-4,5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins. Philosophical Transactions of the Royal Society B: Biological Sciences 373 (1748), 20170337 (2018)

MPG.PuRe

32.

Journal Article

Celik, A. A.; Simper, G. S.; Huyton, T.; Blasczyk, R.; Bade-Döding, C.: HLA-G mediated immune regulation is impaired by a single amino acid exchange in the alpha 2 domain. Human Immunology 79 (6), pp. 453 - 462 (2018)

MPG.PuRe

33.

Journal Article

Ananth, A.; Genua, M.; Aissaoui, N.; Diaz, L.; Eisele, N. B.; Frey, S.; Dekker, C.; Richter, R. P.; Görlich, D.: Reversible immobilization of proteins in sensors and solid-state nanopores. Small 14 (18), 1703357 (2018)

MPG.PuRe

34.

Journal Article

Bucevicius, J.; Lukinavicius, G.; Gerasimaite, R.: The use of Hoechst dyes for DNA staining and beyond. Chemosensors 6 (2), 18 (2018)

MPG.PuRe

35.

Journal Article

Pleiner, T.; Bates, M.; Görlich, D.: A toolbox of anti-mouse and anti-rabbit IgG secondary nanobodies. Journal of Cell Biology 217 (3), pp. 1143 - 1154 (2018)

MPG.PuRe

36.

Journal Article

Ananth, A. N.; Mishra, A.; Frey, S.; Dwarkasing, A.; Versloot, R.; van der Giessen, E.; Görlich, D.; Onck, P.; Dekker, C.: Spatial structure of disordered proteins dictates conductance and selectivity in Nuclear Pore Complex mimics. eLife 7, e31510 (2018)

MPG.PuRe

37.

Journal Article

Karabinos, A.; Schünemann, J.; Parry, D. A. D.: Assembly studies of six intestinal intermediate filament (IF) proteins B2, C1, C2, D1, D2, and E1 in the nematode C-elegans. Cytoskeleton 74 (3), pp. 107 - 113 (2017)

MPG.PuRe

38.

Journal Article

Göttfert, F.; Pleiner, T.; Heine, J.; Westphal, V.; Görlich, D.; Sahl, S. J.; Hell, S. W.: Strong signal increase in STED fluorescence microscopy by imaging regions of subdiffraction extent. Proceedings of the National Academy of Sciences of the United States of America 114 (9), pp. 2125 - 2130 (2017)

MPG.PuRe

39.

Journal Article

Warda, A. S.; Freytag, B.; Haag, S.; Sloan, K. E.; Görlich, D.; Bohnsack, M.: Effects of the Bowen-Conradi syndrome mutation in EMG1 on its nuclear import, stability and nucleolar recruitment. Human Molecular Genetics 25 (24), pp. 5353 - 5364 (2016)

MPG.PuRe

ZIP

40.

Journal Article

Seehusen, F.; Kiel, K.; Jottini, S.; Wohlsein, P.; Habierski, H.; Seibel, K.; Vogel, T.; Urlaub, H.; Kollmar, M.; Baumgärtner, W. et al.; Teichmann, U.: Axonopathy in the central nervous system is the hallmark of mice with a novel intragenic null mutation of dystonin. Genetics 204 (1), pp. 191 - 203 (2016)

MPG.PuRe

41.

Journal Article

Kühn, J.; Wong, L. E.; Pirkuliyeva, S.; Schulz, K.; Schwiegk, C.; Fünfgeld, K.; Keppler, S.; Batista, F. D.; Urlaub, H.; Habeck, M. et al.; Becker, S.; Griesinger, C.; Wienands, J.: The adaptor protein CIN85 assembles intracellular signaling clusters for B cell activation. Science Signaling 9 (434), ra66 (2016)

MPG.PuRe

42.

Journal Article

Aksu, M.; Trakhanov, S.; Görlich, D.: Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A. Nature Communications 7, 11952 (2016)

MPG.PuRe

43.

Journal Article

Zahn, R.; Osmanovic, D.; Ehret, S.; Callis, C. A.; Frey, S.; Stewart, M.; You, C. J.; Görlich, D.; Hoogenboom, B. W.; Richter, R. P.: A physical model describing the interaction of nuclear transport receptors with FG nucleoporin domain assemblies. eLife 5, e14119 (2016)

MPG.PuRe

44.

Journal Article

Schmidt, H. B.; Görlich, D.: Transport selectivity of nuclear pores, phase separation, and membraneless organelles. Trends in Biochemical Sciences 41 (1), pp. 46 - 61 (2016)

MPG.PuRe

45.

Journal Article

Kirli, K.; Karaca, S.; Dehne, H. J.; Samwer, M.; Pan, K. T.; Lenz, C.; Urlaub, H.; Görlich, D.: A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. eLife 4, e11466 (2015)

MPG.PuRe

46.

Journal Article

Pleiner, T.; Bates, M.; Trakhanov, S.; Lee, C. T.; Schliep, J. E.; Chug, H.; Böhning, M.; Stark, H.; Urlaub, H.; Görlich, D.: Nanobodies: Site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation. eLife 4, e11349 (2015)

MPG.PuRe

47.

Journal Article

Chug, H.; Trakhanov, S.; Hülsmann, B. B.; Pleiner, T.; Görlich, D.: Crystal structure of the metazoan Nup62•Nup58•Nup54 nucleoporin complex. Science 350 (6256), pp. 106 - 110 (2015)

MPG.PuRe

48.

Journal Article

Frey, S.; Görlich, D.: The Xenopus laevis Atg4B protease: Insights into substrate recognition and application for tag removal from proteins expressed in pro- and eukaryotic hosts. PLOS One 10 (4), e0125099 (2015)

MPG.PuRe

ZIP

49.

Journal Article

Schmidt, H. B.; Görlich, D.: Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity. eLife 4, e04251 (2015)

MPG.PuRe

50.

Journal Article

Migliorini, E.; Thakar, D.; Sadir, R.; Pleiner, T.; Baleux, F.; Lortat-Jacob, H.; Coche-Guerente, L.; Richter, R. P.: Well-defined biomimetic surfaces to characterize glycosaminoglycan-mediated interactions on the molecular, supramolecular and cellular levels. Biomaterials 35 (32), pp. 8903 - 8915 (2014)

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