Cellular Logistics

Transport processes between nucleus and cytoplasm

Press releases & research news

PAINTing <em>Drosophila</em> muscles with nanobodies positions protein giants

Researchers succeeded to visualize Drosophila sarcomeres at super-resolution with the help of nanobodies and single molecule blinks. more

Dirk Görlich receives WLA Prize 2022

The World Laureates Association (WLA) honors our director for his discoveries in the field of cellular logistics. He had key roles in elucidating the principles of transport between the nucleus and cytoplasm, the prize committee emphasized. The prize is worth 10 million Chinese yuan (about 1.4 million euros) and was ceremoniously awarded on November 6 at the 5th WLA Forum in Shanghai. more

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Yearbook Article (2009)
Logistics on smallest possible space: Transport processes between cell nucleus and cytoplasm
The cell nucleus is enclosed by the nuclear envelope, lacks protein synthesis and therefore imports each and every protein from the cytosol. Conversely, the nucleus supplies the cytoplasm with nuclear products, such as ribosomes, tRNAs and mRNAs. The permeability barrier of nuclear pore complexes controls all this exchange. This permeability barrier is an "intelligent" hydrogel with truly remarkable properties. It excludes inert macromolecules, but permits an up to 20,000-fold faster entry of cargoes, when these are bound to appropriate nuclear transport receptors. (in German) more
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