Publikationen

Zeitschriftenartikel (148)

1.
Zeitschriftenartikel
Fu, L.; Weiskopf, E.N.; Akkermans, O.; Swanson, N.A.; Cheng, S.; Schwartz, T.U.; Görlich, D.: HIV-1 capsids enter the FG phase of nuclear pores like a transport receptor. Nature (2024)
2.
Zeitschriftenartikel
Aksu, M.; Kumar, P.; Güttler, T.; Taxer, W.; Gregor, K.; Mußil, B.; Rymarenko, O.; Stegmann, K.M.; Dickmanns, A.; Gerber, S. et al.; Reineking, W.; Schulz, C.; Henneck, T.; Mohamed, A.; Pohlmann, G.; Ramazanoglu, M.; Mese, K.; Groß, U.; Ben-Yedidia, T.; Ovadia, O.; Fischer, D.W.; Kamensky, M.; Reichman, A.; Baumgärtner, W.; von Köckritz-Blickwede, M.; Dobbelstein, M.; Görlich, D.: Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters. Antiviral Research 221, 105778 (2024)
3.
Zeitschriftenartikel
Zibat, A.; Zhang, X.; Dickmanns, A.; Stegmann, K.M.; Dobbelstein, A.W.; Alachram, H.; Soliwoda, R.; Salinas, G.; Groß, U.; Görlich, D. et al.; Kschischo, M.; Wollnik, B.; Dobbelstein, M.: N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody. iScience 26 (10), 107786 (2023)
4.
Zeitschriftenartikel
Gunkel, P.; Iino, H.; Krull, S.; Cordes, V. C.: An evolutionarily conserved bimodular domain anchors ZC3HC1 and its yeast homologue Pml39p to the nuclear basket. Molecular Biology of the Cell 34 (5), ar40 (2023)
5.
Zeitschriftenartikel
Ng, S. C.; Biswas, A.; Huyton, T.; Schünemann, J.; Reber, S.; Görlich, D.: Barrier-properties of Nup98 FG phases ruled by FG motif identity and inter-FG spacer length. Nature Communications 14, 747 (2023)
6.
Zeitschriftenartikel
Loreau, V.; Rees, R.; Chan, E. H.; Taxer, W.; Gregor, K.; Mußil, B.; Pitaval, C.; Luis, N. M.; Mangeol, P.; Schnorrer, F. et al.; Görlich, D.: A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins. eLife 12, e79343 (2023)
7.
Zeitschriftenartikel
Schueder, F.; Mangeol, P.; Chan, E. H.; Rees, R.; Schünemann, J.; Jungmann, R.; Görlich, D.; Schnorrer, F.: Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nanoarchitecture in flight muscles. eLife 12, e79344 (2023)
8.
Zeitschriftenartikel
Weber, M.; von der Emde, H.; Leutenegger, M.; Gunkel, P.; Sambandan, S.; Khan, T. A.; Keller-Findeisen, J.; Cordes, V. C.; Hell, S. W.: MINSTED nanoscopy enters the Ångström localization range. Nature Biotechnology (2022)
9.
Zeitschriftenartikel
Ng, S. C.; Görlich, D.: A simple thermodynamic description of phase separation of Nup98 FG domains. Nature Communications 13, 6172 (2022)
10.
Zeitschriftenartikel
Huyton, T.; Jaiswal, M.; Taxer, W.; Fischer, M.; Görlich, D.: Crystal structures of FNIP/FGxxFN motif-containing leucine-rich repeat proteins. Scientific Reports 12, 16430 (2022)
11.
Zeitschriftenartikel
Modepalli, S.; Martinez-Morilla, S.; Venkatesan , S.; Fasano, J.; Paulsen, K.; Görlich, D.; Hattangadi, S.; Kupfer, G. M.: An In Vivo Model for Elucidating the Role of an Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine Erythropoiesis. Experimental Hematology 114, S. 22 - 32 (2022)
12.
Zeitschriftenartikel
Blaurock, C.; Breithaupt, A.; Weber, S.; Wylezich, C.; Keller, M.; Mohl, B.-P.; Görlich, D.; Groschup, M. H.; Sadeghi, B.; Höper, D. et al.; Mettenleiter, T. C.; Balkema-Buschmann, A.: Compellingly high SARS-CoV-2 susceptibility of Golden Syrian hamsters suggests multiple zoonotic infections of pet hamsters during the COVID-19 pandemic. Scientific Reports 12, 15069 (2022)
13.
Zeitschriftenartikel
Gunkel, P.; Cordes, V. C.: ZC3HC1 is a structural element of the nuclear basket effecting interlinkage of TPR polypeptides. Molecular Biology of the Cell 33 (9), ar82 (2022)
14.
Zeitschriftenartikel
Najbauer, E. E.; Ng, S. C.; Griesinger, C.; Görlich, D.; Andreas, L. B.: Atomic resolution dynamics of cohesive interactions in phase-separated Nup98 FG domains. Nature Communications 13, 1494 (2022)
15.
Zeitschriftenartikel
Güttler, T.; Aksu, M.; Dickmanns, A.; Stegmann, K. M.; Gregor, K.; Rees, R.; Taxer, W.; Rymarenko, O.; Schünemann, J.; Dienemann, C. et al.; Gunkel, P.; Mussil, B.; Krull, J.; Teichmann, U.; Groß, U.; Cordes, V.; Dobbelstein, M.; Görlich, D.: Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies. EMBO Journal 40 (19), e107985 (2021)
16.
Zeitschriftenartikel
Stegmann, K. M.; Dickmanns, A.; Gerber, S.; Nikolova, V.; Klemke, L.; Manzini, V.; Schlösser, D.; Bierwirth, C.; Freund, J.; Sitte, M. et al.; Lugert, R.; Salinas, G.; Meister, T. L.; Pfaender, S.; Görlich, D.; Wollnik, B.; Groß, U.; Dobbelstein, M.: The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models. Virus Research 302, 198469 (2021)
17.
Zeitschriftenartikel
Ng, S. C.; Güttler, T.; Görlich, D.: Recapitulation of selective nuclear import and export with a perfectly repeated 12mer GLFG peptide. Nature Communications 12, 4047 (2021)
18.
Zeitschriftenartikel
Frost, R.; Débarre, D.; Jana, S.; Bano, F.; Schünemann, J.; Görlich, D.; Richter, R. P.: A method to quantify molecular diffusion within thin solvated polymer films: A case study on films of natively unfolded nucleoporins. ACS Nano 14 (8), S. 9938 - 9952 (2020)
19.
Zeitschriftenartikel
Serres, M. P.; Samwer, M.; Truong Quang, B. A.; Lavoie, G.; Perera, U.; Görlich, D.; Charras, G.; Petronczki, M.; Roux, P. P.; Paluch, E. K.: F-actin interactome reveals vimentin as a key regulator of actin organization and cell mechanics in mitosis. Developmental Cell 52 (2), S. 210 - 222 (2020)
20.
Zeitschriftenartikel
Karabinos, A.; Schünemann, J.; Parry, D. A. D.: Promiscuous dimerization between the Caenorhabditis elegans IF proteins and a hypothesis to explain how multiple IFs persist over evolutionary time. Journal of Molecular Evolution 87 (7-8), S. 221 - 230 (2019)
21.
Zeitschriftenartikel
Pump, W. C.; Schulz, R.; Huyton, T.; Kunze-Schumacher, H.; Martens, J.; Ho, G. G. T.; Blasczyk, R.; Bade-Doeding, C.: Releasing the concept of HLA-allele specific peptide anchors in viral infections: A non-canonical naturally presented human cytomegalovirus-derived HLA-A*24:02 restricted peptide drives exquisite immunogenicity. HLA: Immune Response Genetics 94 (1), S. 25 - 38 (2019)
22.
Zeitschriftenartikel
Aksu, M.; Trakhanov, S.; Vera Rodriguez, A.; Görlich, D.: Structural basis for the nuclear import and export functions of the biportin Pdr6/Kap122. Journal of Cell Biology 218 (6), S. 1839 - 1852 (2019)
23.
Zeitschriftenartikel
Vera Rodriguez, A.; Frey, S.; Görlich, D.: Engineered SUMO/protease system identifies Pdr6 as a bidirectional nuclear transport receptor. The Journal of Cell Biology 218 (6), S. 2006 - 2020 (2019)
24.
Zeitschriftenartikel
Ho, G. G. T.; Heinen, F. J.; Huyton, T.; Blasczy, R.; Bade-Döding, C.: HLA-F*01:01 presents peptides with N-terminal flexibility and a preferred length of 16 residues. Immunogenetics 51 (5-6), S. 353 - 360 (2019)
25.
Zeitschriftenartikel
Pump, W. C.; Kraemer, T.; Huyton, T.; Hò, G. G. T.; Blasczyk, R.; Bade-Doeding, C.: Between innate and adaptive immune responses: NKG2A, NKG2C, and CD8⁺ T cell recognition of HLA-E restricted self-peptides acquired in the absence of HLA-Ia. International Journal of Molecular Sciences 20 (6), 1454 (2019)
26.
Zeitschriftenartikel
Mandad, S.; Rahman, R. U.; Centeno, T. P.; Vidal, R. O.; Wildhagen, H.; Rammner, B.; Keihani, S.; Opazo, F.; Urban, I.; Ischebeck, T. et al.; Kirli, K.; Benito, E.; Fischer, A.; Yousefi, R. Y.; Dennerlein, S.; Rehling, P.; Feussner, I.; Urlaub, H.; Bonn, S.; Rizzoli, S. O.; Fornasiero, E. F.: The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain. Scientific Reports 8, 16913 (2018)
27.
Zeitschriftenartikel
Simper, G. S.; Ho, G. G. T.; Celik, A. A.; Huyton, T.; Kuhn, J.; Kunze-Schumacher, H.; Blasczyk, R.; Bade-Döding, C.: Carbamazepine-mediated adverse drug reactions: CBZ-10,11-epoxide but not carbamazepine induces the alteration of peptides presented by HLA-B*15:02. Journal of Immunology Research 2018, 5086503 (2018)
28.
Zeitschriftenartikel
Aksu, M.; Pleiner, T.; Karaca, S.; Kappert, C.; Dehne, H. J.; Seibel, K.; Urlaub, H.; Bohnsack, M. T.; Görlich, D.: Xpo7 is a broad-spectrum exportin and a nuclear import receptor. Journal of Cell Biology 217 (7), S. 2329 - 2340 (2018)
29.
Zeitschriftenartikel
Frey, S.; Rees, R.; Schünemann, J.; Ng, S. C.; Fünfgeld, K.; Huyton, T.; Görlich, D.: Surface properties determining passage rates of proteins through nuclear pores. Cell 174 (1), S. 202 - 217 (2018)
30.
Zeitschriftenartikel
Alexeeva, M.; Guragain, P.; Tesfahun, A. N.; Tomkuviene, M.; Arshad, A.; Gerasimaite, R.; Rugenaite, A.; Urbanaviciute, G.; Bjoras, M.; Laerdahl, J. K. et al.; Klungland, A.; Klimasauskas, S.; Bjelland, S.: Excision of the doubly methylated base N-4,5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins. Philosophical Transactions of the Royal Society B: Biological Sciences 373 (1748), 20170337 (2018)
31.
Zeitschriftenartikel
Celik, A. A.; Simper, G. S.; Huyton, T.; Blasczyk, R.; Bade-Döding, C.: HLA-G mediated immune regulation is impaired by a single amino acid exchange in the alpha 2 domain. Human Immunology 79 (6), S. 453 - 462 (2018)
32.
Zeitschriftenartikel
Ananth, A.; Genua, M.; Aissaoui, N.; Diaz, L.; Eisele, N. B.; Frey, S.; Dekker, C.; Richter, R. P.; Görlich, D.: Reversible immobilization of proteins in sensors and solid-state nanopores. Small 14 (18), 1703357 (2018)
33.
Zeitschriftenartikel
Bucevicius, J.; Lukinavicius, G.; Gerasimaite, R.: The use of Hoechst dyes for DNA staining and beyond. Chemosensors 6 (2), 18 (2018)
34.
Zeitschriftenartikel
Pleiner, T.; Bates, M.; Görlich, D.: A toolbox of anti-mouse and anti-rabbit IgG secondary nanobodies. Journal of Cell Biology 217 (3), S. 1143 - 1154 (2018)
35.
Zeitschriftenartikel
Ananth, A. N.; Mishra, A.; Frey, S.; Dwarkasing, A.; Versloot, R.; van der Giessen, E.; Görlich, D.; Onck, P.; Dekker, C.: Spatial structure of disordered proteins dictates conductance and selectivity in Nuclear Pore Complex mimics. eLife 7, e31510 (2018)
36.
Zeitschriftenartikel
Karabinos, A.; Schünemann, J.; Parry, D. A. D.: Assembly studies of six intestinal intermediate filament (IF) proteins B2, C1, C2, D1, D2, and E1 in the nematode C-elegans. Cytoskeleton 74 (3), S. 107 - 113 (2017)
37.
Zeitschriftenartikel
Göttfert, F.; Pleiner, T.; Heine, J.; Westphal, V.; Görlich, D.; Sahl, S. J.; Hell, S. W.: Strong signal increase in STED fluorescence microscopy by imaging regions of subdiffraction extent. Proceedings of the National Academy of Sciences of the United States of America 114 (9), S. 2125 - 2130 (2017)
38.
Zeitschriftenartikel
Warda, A. S.; Freytag, B.; Haag, S.; Sloan, K. E.; Görlich, D.; Bohnsack, M.: Effects of the Bowen-Conradi syndrome mutation in EMG1 on its nuclear import, stability and nucleolar recruitment. Human Molecular Genetics 25 (24), S. 5353 - 5364 (2016)
39.
Zeitschriftenartikel
Seehusen, F.; Kiel, K.; Jottini, S.; Wohlsein, P.; Habierski, H.; Seibel, K.; Vogel, T.; Urlaub, H.; Kollmar, M.; Baumgärtner, W. et al.; Teichmann, U.: Axonopathy in the central nervous system is the hallmark of mice with a novel intragenic null mutation of dystonin. Genetics 204 (1), S. 191 - 203 (2016)
40.
Zeitschriftenartikel
Kühn, J.; Wong, L. E.; Pirkuliyeva, S.; Schulz, K.; Schwiegk, C.; Fünfgeld, K.; Keppler, S.; Batista, F. D.; Urlaub, H.; Habeck, M. et al.; Becker, S.; Griesinger, C.; Wienands, J.: The adaptor protein CIN85 assembles intracellular signaling clusters for B cell activation. Science Signaling 9 (434), ra66 (2016)
41.
Zeitschriftenartikel
Aksu, M.; Trakhanov, S.; Görlich, D.: Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A. Nature Communications 7, 11952 (2016)
42.
Zeitschriftenartikel
Zahn, R.; Osmanovic, D.; Ehret, S.; Callis, C. A.; Frey, S.; Stewart, M.; You, C. J.; Görlich, D.; Hoogenboom, B. W.; Richter, R. P.: A physical model describing the interaction of nuclear transport receptors with FG nucleoporin domain assemblies. eLife 5, e14119 (2016)
43.
Zeitschriftenartikel
Schmidt, H. B.; Görlich, D.: Transport selectivity of nuclear pores, phase separation, and membraneless organelles. Trends in Biochemical Sciences 41 (1), S. 46 - 61 (2016)
44.
Zeitschriftenartikel
Kirli, K.; Karaca, S.; Dehne, H. J.; Samwer, M.; Pan, K. T.; Lenz, C.; Urlaub, H.; Görlich, D.: A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. eLife 4, e11466 (2015)
45.
Zeitschriftenartikel
Pleiner, T.; Bates, M.; Trakhanov, S.; Lee, C. T.; Schliep, J. E.; Chug, H.; Böhning, M.; Stark, H.; Urlaub, H.; Görlich, D.: Nanobodies: Site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation. eLife 4, e11349 (2015)
46.
Zeitschriftenartikel
Chug, H.; Trakhanov, S.; Hülsmann, B. B.; Pleiner, T.; Görlich, D.: Crystal structure of the metazoan Nup62•Nup58•Nup54 nucleoporin complex. Science 350 (6256), S. 106 - 110 (2015)
47.
Zeitschriftenartikel
Frey, S.; Görlich, D.: The Xenopus laevis Atg4B protease: Insights into substrate recognition and application for tag removal from proteins expressed in pro- and eukaryotic hosts. PLOS One 10 (4), e0125099 (2015)
48.
Zeitschriftenartikel
Schmidt, H. B.; Görlich, D.: Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity. eLife 4, e04251 (2015)
49.
Zeitschriftenartikel
Migliorini, E.; Thakar, D.; Sadir, R.; Pleiner, T.; Baleux, F.; Lortat-Jacob, H.; Coche-Guerente, L.; Richter, R. P.: Well-defined biomimetic surfaces to characterize glycosaminoglycan-mediated interactions on the molecular, supramolecular and cellular levels. Biomaterials 35 (32), S. 8903 - 8915 (2014)
50.
Zeitschriftenartikel
Hattangadi, S. M.; Martinez-Morilla, S.; Patterson, H. C.; Shi, J.; Burke, K.; Avila-Figueroa, A.; Venkatesan, S.; Wang, J.; Paulsen, K.; Görlich, D. et al.; Murata-Hori, M.; Lodish, H. F.: Histones to the cytosol: Exportin 7 is essential for normal terminal erythroid nuclear maturation. Blood 124 (12), S. 1931 - 1940 (2014)
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