Publications

Max Planck Institute for Multidisciplinary Sciences

Journal Article (508)

201.

Journal Article

Özcan, A.; Pausch, P.; Linden, A.; Wulf, A.; Schühle, K.; Heider, J.; Urlaub, H.; Heimerl, T.; Bange, G.; Randau, L.: Type IV CRISPR RNA processing and effector complex formation in Aromatoleum aromaticum. Nature Microbiology 4 (1), pp. 89 - 96 (2019)

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202.

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Ramani, A.; Mariappan, A.; Gottardo, M.; Mandad, S.; Urlaub, H.; Avidor-Reiss, T.; Riparbelli, M.; Giuliano, C.; Debec, A.; Feederle, R. et al.; Gopalakrishnan, J.: Plk1/Polo phosphorylates Sas-4 at the onset of mitosis for an efficient recruitment of pericentriolar material to centrosomes. Cell Reports 25 (13), pp. 3618 - 3630 (2018)

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203.

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Brüning, L.; Hackert, P.; Martin, R.; Gallesio, J. D.; Aquino, G. R. R.; Urlaub, H.; Sloan, K. E.; Bohnsack, M. T.: RNA helicases mediate structural transitions and compositional changes in pre-ribosomal complexes. Nature Communications 9, 5383 (2018)

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204.

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Braun, J.; Fischer, S.; Xu, Z. Z.; Dalia, S.; Ghoneim, D. H.; Gimbel, A. T.; Plessmann, U.; Urlaub, H.; Mathews, D. H.; Weigand, J. E.: Identification of new high affinity targets for Roquin based on structural conservation. Nucleic Acids Research 46 (22), pp. 12109 - 12125 (2018)

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205.

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Mariappan, A.; Soni, K.; Schorpp, K.; Zhao, F.; Minakar, A.; Zheng, X.; Mandad, S.; Macheleidt, I.; Ramani, A.; Kubelka, T. et al.; Dawidowski, M.; Golfmann, K.; Wason, A.; Yang, C.; Simons, J.; Schmalz, H. G.; Hyman, A. A.; Aneja, R.; Ullrich, R.; Urlaub, H.; Odenthal, M.; Büttner, R.; Li, H.; Sattler, M.; Hadian, K.; Gopalakrishnan, J.: Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells. The EMBO Journal, In press (e99876) (2018)

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206.

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Mandad, S.; Rahman, R. U.; Centeno, T. P.; Vidal, R. O.; Wildhagen, H.; Rammner, B.; Keihani, S.; Opazo, F.; Urban, I.; Ischebeck, T. et al.; Kirli, K.; Benito, E.; Fischer, A.; Yousefi, R. Y.; Dennerlein, S.; Rehling, P.; Feussner, I.; Urlaub, H.; Bonn, S.; Rizzoli, S. O.; Fornasiero, E. F.: The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain. Scientific Reports 8, 16913 (2018)

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207.

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Oroz, J.; Chang, B. J.; Wysoczanski, P.; Lee, C. T.; Perez-Lara, A.; Chakraborty, P.; Hofele, R. V.; Baker, J. D.; Blair, L. J.; Biernat, J. et al.; Urlaub, H.; Mandelkow, E.; Dickey, C. A.; Zweckstetter, M.: Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex. Nature Communications 9, 4532 (2018)

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208.

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Buskin, A.; Zhu, L.; Chichagova, V.; Basu, B.; Mozafarri Jovin, S.; Dolan, D.; Droop, A.; Collin, J.; Bronstein, R.; Mehrotra, S. et al.; Farkas, M.; Hilgen, G.; White, K.; Pan, K. T.; Treumann, A.; Hallam, D.; Bialas, K.; Chung, G.; Mellough, C.; Ding, Y.; Krasnogor, N.; Przyborski, S.; Zwolinski, S.; Al-Aama, J.; Alharthi, S.; Xu, Y.; Wheway, G.; Szymanska, K.; McKibbin, M.; Inglehearn, C. F.; Elliott, D. J.; Lindsay, S.; Ali, R. R.; Steel, D. H.; Armstrong, L.; Sernagor, E.; Urlaub, H.; Pierce, E.; Lührmann, R.; Grellscheid, S. N.; Johnson, C. A.; Lako, M.: Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa. Nature Communications 9, 4234 (2018)

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209.

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Fornasiero, E. F.; Mandad, S.; Wildhagen, H.; Alevra, M.; Rammner, B.; Keihani, S.; Opazo, F.; Urban, I.; Ischebeck, T.; Sakib, M. S. et al.; Fard, M. K.; Kirli, K.; Centeno, T. P.; Vidal, R. O.; Rahman, R. U.; Benito, E.; Fischer, A.; Dennerlein, S.; Rehling, P.; Feussner, I.; Bonn, S.; Simons, M.; Urlaub, H.; Rizzoli, S. O.: Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions. Nature Communications 9, 4230 (2018)

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210.

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Lavdovskaia, E.; Kolander, E.; Steube, E.; Mai, M. M.; Urlaub, H.; Richter-Dennerlein, R.: The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis. Nucleic Acids Research 46 (16), pp. 8471 - 8482 (2018)

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211.

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Blaschke, M.; Koepp, R.; Lenz, C.; Kruppa, J.; Jung, K.; Siggelkow, H.: Crohn's disease patient serum changes protein expression in a human mesenchymal stem cell model in a linear relationship to patients' disease stage and to bone mineral density. Journal of Clinical and Translational Endocrinology 13, pp. 26 - 38 (2018)

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212.

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Bohnenberger, H.; Kaderali, L.; Ströbel, P.; Yepes, D.; Pleßmann, U.; Dharia, N. Y.; Yao, S.; Heydt, C.; Merkelbach‐Bruse, S.; Emmert, A. et al.; Hoffmann, J.; Bodemeyer, J.; Reuter‐Jessen, K.; Lois, A. M.; Dröge, L. H.; Baumeister, P.; Walz, C.; Biggemann, L.; Walter, R.; Häupl, B.; Comoglio, F.; Pan, K. T.; Scheich, S.; Lenz, C.; Küffer, S.; Bremmer, F.; Kitz, J.; Sitte, M.; Beißbarth, T.; Hinterthaner, M.; Sebastian, M.; Lotz, J.; Schildhaus, H. U.; Wolff, H.; Danner, B. C.; Brandts, C.; Büttner, R.; Canis, M.; Stegmaier, K.; Serve, H.; Urlaub, H.; Oellerich, T.: Comparative proteomics reveals a diagnostic signature for pulmonary head-and-neck cancer metastasis. EMBO Molecular Medicine 10 (9), e8428 (2018)

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213.

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Vos, S. M.; Farnung, L.; Böhning, M.; Wigge, C.; Linden, A.; Urlaub, H.; Cramer, P.: Structure of activated transcription complex Pol II-DSIF-PAF-SPT6. Nature 560 (7720), pp. 607 - 612 (2018)

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214.

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Vos, S. M.; Farnung, L.; Urlaub, H.; Cramer, P.: Structure of paused transcription complex Pol II–DSIF–NELF. Nature 560 (7720), pp. 601 - 606 (2018)

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215.

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Mühlhausen, S.; Schmitt, H. D.; Pan, K. T.; Plessmann, U.; Urlaub, H.; Hurst, L. D.; Kollmar, M.: Endogenous stochastic decoding of the CUG codon by competing Ser- and Leu-tRNAs in Ascoidea asiatica. Current Biology 28 (13), pp. 2046 - 2057 (2018)

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216.

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Aksu, M.; Pleiner, T.; Karaca, S.; Kappert, C.; Dehne, H. J.; Seibel, K.; Urlaub, H.; Bohnsack, M. T.; Görlich, D.: Xpo7 is a broad-spectrum exportin and a nuclear import receptor. Journal of Cell Biology 217 (7), pp. 2329 - 2340 (2018)

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217.

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Cyganek, L.; Tiburcy, M.; Sekeres, K.; Gerstenberg, K.; Bohnenberger, H.; Lenz, C.; Henze, S.; Stauske, M.; Salinas, G.; Zimmermann, W. H. et al.; Hasenfuss, G.; Guan, K.: Deep phenotyping of human induced pluripotent stem cell-derived atrial and ventricular cardiomyocytes. JCI Insight 3 (12), e99941 (2018)

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218.

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Johannsson, S.; Neumann, P.; Wulf, A.; Welp, L. M.; Gerber, H. D.; Krull, M.; Diederichsen, U.; Urlaub, H.; Ficner, R.: Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine. Scientific Reports 8, 8880 (2018)

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219.

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Dihazi, H.; Asif, A. R.; Beißbarth, T.; Bohrer, R.; Feussner, K.; Feussner, I.; Jahn, O.; Lenz, C.; Majcherczyk, A.; Schmidt, B. et al.; Schmitt, K.; Urlaub, H.; Valerius, O.: Integrative omics - from data to biology. Expert Review of Proteomics 15 (6), pp. 463 - 466 (2018)

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220.

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Zaman, U.; Urlaub, H.; Abbasi, A.: Protein profiling of non-model plant Cuminum cyminum by gel-based proteomic approach. Phytochemical Analysis 29 (3), pp. 242 - 249 (2018)

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221.

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Dickmanns, A.; Zschiedrich, C. P.; Arens, J.; Parfentev, I.; Gundlach, J.; Hofele, R.; Neumann, P.; Urlaub, H.; Görke, B.; Ficner, R. et al.; Stulke, J.: Structural basis for the regulatory interaction of the methylglyoxal synthase MgsA with the carbon flux regulator Crh in Bacillus subtilis. The Journal of Biological Chemistry 293 (16), pp. 5781 - 5792 (2018)

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222.

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Batschkus, S.; Cingoez, G.; Urlaub, H.; Miosge, N.; Kirschneck, C.; Meyer-Marcotty, P.; Lenz, C.: A new albumin-depletion strategy improves proteomic research of gingival crevicular fluid from periodontitis patients. Clinical Oral Investigations 22 (3), pp. 1375 - 1384 (2018)

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223.

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Rocha de Moura, T.; Mozaffari-Jovin, S.; Szabo, C. Z. K.; Schmitzova, J.; Dybkov, O.; Cretu, C.; Kachala, M.; Svergun, D.; Urlaub, H.; Lührmann, R. et al.; Pena, V.: Prp19/Pso4 is an autoinhibited ubiquitin ligase activated by stepwise assembly of three splicing factors. Molecular Cell 69 (6), pp. 979 - 992 (2018)

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224.

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Behler, J.; Sharma, K.; Reimann, V.; Wilde, A.; Urlaub, H.; Hess, W. R.: The host-encoded RNase E endonuclease as the crRNA maturation enzyme in a CRISPR-Cas subtype III-Bv system. Nature Microbiology 3 (3), pp. 367 - 377 (2018)

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225.

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Buddeweg, A.; Sharma, K.; Urlaub, H.; Schmitz, R. A.: sRNA41 affects ribosome binding sites within polycistronic mRNAs in Methanosarcina mazei Gö1. Molecular Microbiology 107 (5), pp. 595 - 609 (2018)

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226.

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Sonnleitner, E.; Wulf, A.; Campagne, S.; Pei, X. Y.; Wolfinger, M. T.; Forlani, G.; Prindl, K.; Abdou, L.; Resch, A.; Allain, F. H. et al.; Luisi, B. F.; Urlaub, H.; Bläsi, U.: Interplay between the catabolite repression control protein Crc, Hfq and RNA in Hfq-dependent translational regulation in Pseudomonas aeruginosa. Nucleic Acids Research 46 (3), pp. 1470 - 1485 (2018)

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227.

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Haselbach, D.; Komarov, I.; Agafonov, D. E.; Hartmuth, K.; Graf, B.; Dybkov, O.; Urlaub, H.; Kastner, B.; Lührmann, R.; Stark, H.: Structure and conformational dynamics of the human spliceosomal B^act complex. Cell 172 (3), pp. 454 - 464, e1-e5 (2018)

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228.

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Fard, M. K.; van der Meer, F.; Sánchez, P.; Cantuti-Castelvetri, L.; Mandad, S.; Jäkel, S.; Fornasiero, E. F.; Schmitt, S.; Ehrlich, M.; Starost, L. et al.; Kuhlmann, T.; Sergiou, C.; Schultz, V.; Wrzos, C.; Brück, W.; Urlaub, H.; Dimou, L.; Stadelmann, C.; Simons, M.: BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions. Science Translational Medicine 9 (419), eaam7816 (2017)

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229.

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Bao, P.; Will, C. L.; Urlaub, H.; Boon, K. L.; Lührmann, R.: The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated Bact complex. Genes and Development 31 (23-24), pp. 2416 - 2429 (2017)

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230.

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Ahdash, Z.; Lau, A. M.; Byrne, R. T.; Lammens, K.; Stützer, A.; Urlaub, H.; Booth, P. J.; Reading, E.; Hopfner, K. P.; Politis, A.: Mechanistic insight into the assembly of the HerA-NurA helicase-nuclease DNA end resection complex. Nucleic Acids Research 45 (20), pp. 12025 - 12038 (2017)

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231.

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Hillen, H. S.; Parshin, A. V.; Agaronyan, K.; Morozov, Y. I.; Graber, J. J.; Chernev, A.; Schwinghammer, K.; Urlaub, H.; Anikin, M.; Cramer, P. et al.; Temiakov, D.: Mechanism of transcription anti-termination in human mitochondria. Cell 171 (5), pp. 1082 - 1093 (2017)

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232.

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Schilbach, S.; Hantsche, M.; Tegunov, D.; Dienemann, C.; Wigge, C.; Urlaub, H.; Cramer, P.: Structures of transcription pre-initiation complex with TFIIH and Mediator. Nature 551 (7679), pp. 204 - 209 (2017)

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233.

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Warda, A. S.; Kretschmer, J.; Hackert, P.; Lenz, C.; Urlaub, H.; Höbartner, C.; Sloan, K. E.; Bohnsack, M. T.: Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that targets pre-mRNAs and various non-coding RNAs. EMBO Reports 18 (11), pp. 2004 - 2014 (2017)

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234.

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Scacioc, A.; Schmidt, C.; Hofmann, T.; Urlaub, H.; Kühnel, K.; Perez-Lara, A.: Structure based biophysical characterization of the PROPPIN Atg18 shows Atg18 oligomerization upon membrane binding. Scientific Reports 7, 14008 (2017)

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235.

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Schmidt , C.; Urlaub, H.: Combining cryo-electron microscopy (cryo-EM) and cross-linking mass spectrometry (CX-MS) for structural elucidation of large protein assemblies. Current Opinion in Structural Biology 46, pp. 157 - 168 (2017)

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236.

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Märtens, B.; Sharma, K.; Urlaub, H.; Bläsi, U.: The SmAP2 RNA binding motif in the 3'UTR affects mRNA stability in the crenarchaeum Sulfolobus solfataricus. Nucleic Acids Research 45 (15), pp. 8957 - 8967 (2017)

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Wottawa, M.; Naas, S.; Böttger, J.; van Belle, G. J.; Möbius, W.; Revelo, N. H.; Heidenreich, D.; von Ahlen, M.; Zieseniss, A.; Kröhnert, K. et al.; Lutz, S.; Lenz, C.; Urlaub, H.; Rizzoli, S. O.; Katschinski, D. M.: Hypoxia-stimulated membrane trafficking requires T-plastin. Acta Physiologica 221 (1), pp. 59 - 73 (2017)

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238.

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Bertram, K.; Agafonov, D. E.; Dybkov, O.; Haselbach, D.; Leelaram, M. N.; Will, C. L.; Urlaub, H.; Kastner, B.; Lührmann, R.; Stark, H.: Cryo-EM structure of a pre-catalytic human spliceosome primed for activation. Cell 170 (4), pp. 701 - 713, e1 - e4 (2017)

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239.

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Henning, L. M.; Santos, K. F.; Sticht, J.; Jehle, S.; Lee, C. T.; Wittwer, M.; Urlaub, H.; Stelzl, U.; Wahl, M. C.; Freund, C.: A new role for FBP21 as regulator of Brr2 helicase activity. Nucleic Acids Research 45 (13), pp. 7922 - 7937 (2017)

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240.

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Batschkus, S.; Atanassov, I.; Lenz, C.; Meyer-Marcotty, P.; Cingöz, G.; Kirschneck, C.; Urlaub, H.; Miosge, N.: Mapping the secretome of human chondrogenic progenitor cells with mass spectrometry. Annals of Anatomy 212, pp. 4 - 10 (2017)

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241.

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Said, N.; Krupp, F.; Anedchenko, E.; Santos, K. F.; Dybkov, O.; Huang, Y. H.; Lee, C. T.; Loll, B.; Behrmann, E.; Bürger, J. et al.; Mielke, T.; Loerke, J.; Urlaub, H.; Spahn, C. M. T.; Weber, G.; Wahl, M. C.: Structural basis for λN-dependent processive transcription antitermination. Nature Microbiology 2 (7), 17062 (2017)

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242.

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Jakhanwal, S.; Lee, C. T.; Urlaub, H.; Jahn, R.: An activated Q-SNARE/SM protein complex as a possible intermediate in SNARE assembly. EMBO Journal 36 (12), pp. 1788 - 1802 (2017)

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243.

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Xu, Y.; Bernecky, C.; Lee, C. T.; Maier, K. C.; Schwalb, B.; Tegunov, D.; Plitzko, J. M.; Urlaub, H.; Cramer, P.: Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex. Nature Communications 8, 15741 (2017)

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244.

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Treiber, T.; Treiber, N.; Plessmann, U.; Harlander, S.; Daiss, J. L.; Eichner, N.; Lehmann, G.; Schall, K.; Urlaub, H.; Meister, G.: A compendium of RNA-binding proteins that regulate microRNA biogenesis. Molecular Cell 66 (2), pp. 270 - 284 (2017)

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245.

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Pan, K. T.; Chen, C. C.; Urlaub, H.; Khoo, K. H.: Adapting data-independent acquisition for mass spectrometry-based protein site-specific N-glycosylation analysis. Analytical Chemistry 89 (8), pp. 4532 - 4539 (2017)

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246.

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Mohr, S.; Doebele, C.; Comoglio, F.; Berg, T.; Beck, J.; Bohnenberger, H.; Alexe, G.; Corso, J.; Ströbel, P.; Wachter, A. et al.; Beissbarth, T.; Schnutgen, F.; Cremer, A.; Haetscher, N.; Göllner, S.; Rouhi, A.; Palmqvist, L.; Rieger, M. A.; Schroeder, T.; Bönig, H.; Müller-Tidow, C.; Kuchenbauer, F.; Schütz, E.; Green, A. R.; Urlaub, H.; Stegmaier, K.; Humphries, R. K.; Serve, H.; Oellerich, T.: Hoxa9 and Meis1 cooperatively induce addiction to Syk signaling by suppressing miR-146a in acute myeloid leukemia. Cancer Cell 31 (4), pp. 549 - 562 (2017)

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247.

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Losensky, G.; Jung, K.; Urlaub, H.; Pfeifer, F.; Fröls, S.; Lenz, C.: Shedding light on biofilm formation of Halobacterium salinarum R1 by SWATH-LC/MS/MS analysis of planktonic and sessile cells. Proteomics 17 (7), 1600111 (2017)

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Sidarovich, A.; Will, C. L.; Anokhina, M. M.; Ceballos, J.; Sievers, S.; Agafonov, D. E.; Samatov, T.; Bao, P.; Kastner, B.; Urlaub, H. et al.; Waldmann, H.; Lührmann, R.: Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation. eLife 6, e23533 (2017)

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249.

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Bertram, K.; Agafonov, D. E.; Liu, W.; Dybkov, O.; Will, C. L.; Hartmuth, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 542 (7641), pp. 318 - 323 (2017)

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Walter, R.; Pan, K. T.; Doebele, C.; Comoglio, F.; Tomska, K.; Bohnenberger, H.; Young, R. M.; Jacobs, L.; Keller, U.; Bönig, H. et al.; Engelke, M.; Rosenwald, A.; Urlaub, H.; Staudt, L. M.; Serve, H.; Zenz, T.; Oellerich, T.: HSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B cell receptor signaling. Blood 129 (5), pp. 598 - 608 (2017)

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