Publications

Journal Article (444)

1.
Journal Article
Dai, Y.; Ignatyeva, N.; Xu, H.; Wali, R.; Toischer, K.; Brandenburg, S.; Lenz, C.; Pronto, J.; Fakuade, F. E.; Sossalla, S. et al.; Zeisberg, E. M.; Janshoff, A.; Kutschka, I.; Voigt, N.; Urlaub, H.; Rasmussen, T. B.; Mogensen, J.; Lehnart, S. E.; Hasenfuss, G.; Ebert, A.: An Alternative Mechanism of Subcellular Iron Uptake Deficiency in Cardiomyocytes. Circulation Research 133 (2), pp. e19 - e46 (2023)
2.
Journal Article
Witzenberger, M.; Burczyk, S.; Settele, D.; Mayer, W.; Welp, L. M.; Heiss, M.; Wagner, M.; Monecke, T.; Janowski, R.; Carell, T. et al.; Urlaub, H.; Hauck, S. M.; Voigt, A.; Niessing, D.: Human TRMT2A methylates tRNA and contributes to translation fidelity. Nucleic Acids Research, gkad565 (2023)
3.
Journal Article
Nguyen, A.; Lugarini, F.; David, C.; Hosnani, P.; Alagöz, Ç.; Friedrich, A.; Schlütermann, D.; Knotkova, B.; Patel, A.; Parfentev, I. et al.; Urlaub, H.; Meinecke, M.; Stork, B.; Faesen, A. C.: Metamorphic proteins at the basis of human autophagy initiation and lipid transfer. Molecular Cell 83 (12), pp. 2077 - 2090.e12 (2023)
4.
Journal Article
Quentin, D.; Schuhmacher, J.S.; Klink, B.U.; Lauer, J.; Shaikh, T.R.; Huis in ’t Veld, P.J.; Welp, L. M.; Urlaub, H.; Zerial, M.; Raunser, S.: Structural basis of mRNA binding by the human FERRY Rab5 effector complex. Molecular Cell 83 (11), pp. 1856 - 1871.e9 (2023)
5.
Journal Article
Schmitzová, J.; Cretu, C.; Dienemann, C.; Urlaub, H.; Pena, V.: Structural basis of catalytic activation in human splicing. Nature 617, pp. 842 - 850 (2023)
6.
Journal Article
Scheich, S.; Chen, J.; Liu, J.; Schnutgen, F.; Enssle, J. C.; Ceribelli, M.; Thomas, C. J.; Choi, J.; Morris, V.; Hsiao, T. et al.; Nguyen, H.; Wang, B.; Bolomsky, A.; Phelan, J. D.; Corcoran, S.; Urlaub, H.; Young, R. M.; Haupl, B.; Wright, G. W.; Huang, D. W.; Ji, Y.; Yu, X.; Xu, W.; Yang, Y.; Zhao, H.; Muppidi, J.; Pan, K.-T.; Oellerich, T.; Staudt, L. M.: Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas. Cancer Discovery, CD-22-1401 (2023)
7.
Journal Article
Cheng, S.; Altmeppen, G.; So, C.; Welp, L.; Penir, S. M.; Ruhwedel, T.; Menelaou, K.; Harasimov, K.; Stützer, A.; Blayney, M. et al.; Elder, K.; Möbius, W.; Urlaub, H.; Schuh, M.: Mammalian Oocytes Store mRNAs in a Mitochondria-Associated Membraneless Compartment. Obstetrical & Gynecological Survey 78 (5), pp. 280 - 281 (2023)
8.
Journal Article
Jia, J.; Hilal, T.; Bohnsack, K. E.; Chernev, A.; Tsao, N.; Bethmann, J.; Arumugam, A.; Parmely, L.; Holton, N.; Loll, B. et al.; Mosammaparast, N.; Bohnsack, M. T.; Urlaub, H.; Wahl, M. C.: Extended DNA threading through a dual-engine motor module of the activating signal co-integrator 1 complex. Nature Communications 14, 1886 (2023)
9.
Journal Article
Dybkov, O.; Preußner, M.; El Ayoubi, L.; Feng, V.-Y.; Harnisch, C.; Merz, K.; Leupold, P.; Yudichev, P.; Agafonov, D. E.; Will, C. L. et al.; Girard, C.; Dienemann, C.; Urlaub, H.; Kastner, B.; Heyd, F.; Lührmann, R.: Regulation of 3′ splice site selection after step 1 of splicing by spliceosomal C* proteins. Science Advances 9 (9), eadf178 (2023)
10.
Journal Article
Pörschke, M.; Rodríguez-González, I.; Parfentev, I.; Urlaub, H.; Kehlenbach, R. H.: Transportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein. Journal of Biological Chemistry 299 (3), 102932 (2023)
11.
Journal Article
Schminke, B.; Kauffmann, P.; Brockmeyer, P.; Miosge, N.; Lenz, C.; Schubert, A.: The Proteomes of Oral Cells Change during Co-Cultivation with Aggregatibacter actinomycetemcomitans and Eikenella corrodens. Biomedicines 11 (3), 700 (2023)
12.
Journal Article
Castro-Hernández, R.; Berulava, T.; Metelova, M.; Epple, R.; Centeno, T. P.; Richter, J.; Kaurani, L.; Pradhan, R.; Sakiba, M. S.; Burkhardt, S. et al.; Ninov, M.; Bohnsack, K. E.; Bohnsack, M. T.; Delalle, I.; Fischer, A.: Conserved reduction of m6A RNA modifications during aging and neurodegeneration is linked to changes in synaptic transcripts. Proceedings of the National Academy of Sciences of the United States of America 120 (9), e2204933120 (2023)
13.
Journal Article
Wang, H.; Schilbach, S.; Ninov, M.; Urlaub, H.; Cramer, P.: Structures of transcription preinitiation complex engaged with the +1 nucleosome. Nature Structural and Molecular Biology 30, pp. 226 - 232 (2023)
14.
Journal Article
Keil, P.; Wulf, A.; Kachariya, N.; Reuscher, S.; Huhn, K.; Silbern, I.; Altmuller, J.; Keller, M.; Stehle, R.; Zarnack, K. et al.; Sattler, M.; Urlaub, H.; Sträßer, K.: Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA. Nucleic Acids Research 51 (2), pp. 831 - 851 (2023)
15.
Journal Article
Schoger, E.; Bleckwedel, F.; Germena, G.; Rocha, C.; Tucholla, P.; Sobitov, I.; Möbius, W.; Sitte, M.; Lenz, C.; Samak, M. et al.; Hinkel, R.; Varga, Z. V.; Giricz, Z.; Salinas, G.; Gross, J. C.; Zelarayan, L. C.: Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling. Communications Biology 6 (1), 79 (2023)
16.
Journal Article
Franz, A.; Weber, A. I.; Preussner, M.; Dimos, N.; Stumpf, A.; Ji, Y.; Moreno-Velasquez, L.; Voigt, A.; Schulz, F.; Neumann, A. et al.; Kuropka, B.; Kuehn, R.; Urlaub, H.; Schmitz, D.; Wahl, M. C.; Heyd, F.: Branch point strength controls species-specific CAMK2B alternative splicing and regulates LTP. Life science alliance 6 (3), e202201826 (2022)
17.
Journal Article
Brás, I. C.; Khani, M. H.; Vasili, E.; Möbius, W.; Riedel, D.; Parfentev, I.; Gerhardt, E.; Fahlbusch, C.; Urlaub, H.; Zweckstetter, M. et al.; Gollisch, T.; Outeiro, T. F.: Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity. Journal of Parkinson's Disease: JPD 12, pp. 2397 - 2422 (2022)
18.
Journal Article
Brandenburg, S.; Drews, L.; Schönberger, H.-L.; Jacob, C. F.; Paulke, N. J.; Beuthner, B. E.; Topci, R.; Kohl, T.; Neuenroth, L.; Kutschka, I. et al.; Urlaub, H.; Kück, F.; Leha, A.; Friede, T.; Seidler, T.; Jacobshagen, C.; Toischer, K.; Puls, M.; Hasenfuß, G.; Lenz, C.; Lehnart, S. E.: Direct proteomic and high-resolution microscopy biopsy analysis identifies distinct ventricular fates in severe aortic stenosis. Journal of Molecular and Cellular Cardiology (London) 173, pp. 1 - 15 (2022)
19.
Journal Article
Giménez, E.; Urlaub, H.; Lockhart, L. J. F.: Photo-tuneable protein nitration by sensitiser tris(bipyridine)-Ruthenium(II) chloride complex. Nitric Oxide - Biology and Chemistry 129 (1), pp. 63 - 73 (2022)
20.
Journal Article
Rengachari, S.; Schilbach, S.; Kaliyappan, T.; Gouge, J.; Zumer, K.; Schwarz, J.; Urlaub, H.; Dienemann, C.; Vannini, A.; Cramer, P.: Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II. Nature Structural and Molecular Biology 29, pp. 1159 - 1169 (2022)
21.
Journal Article
Ditte, Z.; Silbern, I.; Ditte, P.; Urlaub, H.; Eichele, G.: Extracellular vesicles derived from the choroid plexus trigger the differentiation of neural stem cells. Journal of extracellular vesicles 11 (11), 12276 (2022)
22.
Journal Article
Brás, I. C.; Khani, M. H.; Riedel, D.; Parfentev, I.; Gerhardt, E.; van Riesen, C.; Urlaub, H.; Gollisch, T.; Outeiro, T. F.: Ectosomes and exosomes modulate neuronal spontaneous activity. Journal of Proteomics 269, 104721 (2022)
23.
Journal Article
Cheng, S.; Altmeppen, G.; So, C.; Welp, L.; Penir, S. M.; Ruhwedel, T.; Menelaou, K.; Harasimov, K.; Stützer, A.; Blayney, M. et al.; Elder, K.; Möbius, W.; Urlaub, H.; Schuh, M.: Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment. Science 378 (6617), eabq4835 (2022)
24.
Journal Article
Bolgi, O.; Silva-Garcia, M.; Ross, B.; Pilla, E.; Kari, V.; Killisch, M.; Spitzner, M.; Stark, N.; Lenz, C.; Weiss, K. et al.; Donzelli, L.; Gorrell, M. D.; Grade, M.; Riemer, J.; Urlaub, H.; Dobbelstein, M.; Huber, R.; Geiss-Friedlander, R.: Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair. EMBO Reports 23 (10), e54136 (2022)
25.
Journal Article
Jarausch, J.; Neuenroth, L.; Andag, R.; Leha, A.; Fischer, A.; Asif, A. R.; Lenz, C.; Eidizadeh, A.: Influence of Shear Stress, Inflammation and BRD4 Inhibition on Human Endothelial Cells: A Holistic Proteomic Approach. Cells 11 (19), 3086 (2022)
26.
Journal Article
Stejerean-Todoran, I.; Zimmermann, K.; Gibhardt, C. S.; Vultur, A.; Ickes, C.; Shannan, B.; Rio, Z. B. d.; Wölling, A.; Cappello, S.; Sung, H.-M. et al.; Shumanska, M.; Zhang, X.; Nanadikar, M.; Latif, M. U.; Wittek, A.; Lange, F.; Waters, A.; Brafford, P.; Wilting, J.; Urlaub, H.; Katschinski, D. M.; Rehling, P.; Lenz, C.; Jakobs, S.; Ellenrieder, V.; Roesch, A.; Schön, M. P.; Herlyn, M.; Stanisz, H.; Bogeski, I.: MCU controls melanoma progression through a redox-controlled phenotype switch. EMBO Reports 23, e54746 (2022)
27.
Journal Article
Krebs, T.; Kilic, I.; Neuenroth, L.; Wasselin, T.; Ninov, M.; Tetens, J.; Lenz, C.: A multiplexed parallel reaction monitoring assay to monitor bovine pregnancy-associated glycoproteins throughout pregnancy and after gestation. PLoS One 17 (9), e0271057 (2022)
28.
Journal Article
Linnemannstöns, K.; Karuna M, P.; Witte, L.; Choezom, D.; Honemann-Capito, M.; Lagurin, A. S.; Schmidt, C. V.; Shrikhande, S.; Steinmetz, L.-K.; Möbius, W. et al.; Lenz, C.; Gross, J. C.: Microscopic and biochemical monitoring of endosomal trafficking and extracellular vesicle secretion in an endogenous in vivo model. Journal of extracellular vesicles 11 (9), 12263 (2022)
29.
Journal Article
Werner, M.; Dyas, A.; Parfentev, I.; Schmidt, G. E.; Mieczkowska, I. K.; Müller-Kirschbaum, L. C.; Müller, C.; Kalkhof, S.; Reinhardt, O.; Urlaub, H. et al.; Alves, F.; Gallwas, J.; Prokakis, E.; Wegwitz, F.: ROBO3s: a novel ROBO3 short isoform promoting breast cancer aggressiveness. Cell Death and Disease 13, 762 (2022)
30.
Journal Article
Koutsoumparis, A.; Welp, L.; Wulf, A.; Urlaub, H.; Meierhofer, D.; Börno, S.; Timmermann, B.; Busack, I.; Bringmann, H.: Sleep neuron depolarization promotes protective gene expression changes and FOXO activation. Current Biology 32 (10), pp. 2248 - 2262.e9 (2022)
31.
Journal Article
Kluever, V.; Russo, B.; Mandad, S.; Kumar, N. H.; Alevra, M.; Ori, A.; Rizzoli, S. O.; Urlaub, H.; Schneider, A.; Fornasiero, E. F.: Protein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration. Science Advances 8, eabn4437 (2022)
32.
Journal Article
Yi, S.-H.; Petrychenko, V.; Schliep, J. E.; Goyal, A.; Linden, A.; Chari, A.; Urlaub, H.; Stark, H.; Rodnina, M. V.; Adio, S. et al.; Fischer, N.: Conformational rearrangements upon start codon recognition in human 48S translation initiation complex. Nucleic Acids Research 50 (9), pp. 5282 - 5298 (2022)
33.
Journal Article
Upmanyu, N.; Jin, J.; von der Emde, H.; Ganzella, M.; Bösche, L.; Malviya, V. N.; Zhuleku, E.; Politi, A. Z.; Ninov, M.; Silbern, I. et al.; Leutenegger, M.; Urlaub, H.; Riedel, D.; Preobraschenski, J.; Milosevic, I.; Hell, S. W.; Jahn, R.; Sambandan, S.: Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3. Neuron 110 (9), pp. 1483 - 1497 (2022)
34.
Journal Article
Mishto, M.; Horokhovskyi, Y.; Cormican, J. A.; Yang, X.; Lynham, S.; Urlaub, H.; Liepe, J.: Database search engines and target database features impinge upon the identification of post‐translationally cis‐spliced peptides in HLA class I immunopeptidomes. Proteomics 22 (10), e2100226 (2022)
35.
Journal Article
Wortz, J.; Smith, V.; Fallmann, J.; König, S.; Thuraisingam, T.; Walther, P.; Urlaub, H.; Stadler, P. F.; Allers, T.; Hille, F. et al.; Marchfelder, A.: Cas1 and Fen1 Display Equivalent Functions During Archaeal DNA Repair. Frontiers in Microbiology 13, 822304 (2022)
36.
Journal Article
Yao, Y.; Kim, G.; Shafer, S.; Chen, Z.; Kubo, S.; Ji, Y.; Luo, J.; Yang, W.; Perner, S. P.; Kanellopoulou, C. et al.; Park, A. Y.; Jiang, P.; Li, J.; Baris, S.; Aydiner, E.K.; Ertem, D.; Mulder, D. J.; Warner, N.; Griffiths, A. M.; Topf-Olivestone, C.; Kori, M.; Werner, L...; Ouahed, J.; Field, M.; Liu, C.; Schwarz, B.; Bosio, C. M.; Ganesan, S.; Song, J.; Urlaub, H.; Oellerich, T.; Malaker, S. A.; Zheng, L.; Bertozzi, C. R.; Zhang, Y.; Matthews, H.; Montgomery, W.; Shih, H.-Y.; Jiang, J.; Jones, M.; Baras, A.; Shuldiner, A.; Gonzaga-Jauregui, C.; Snapper, S. B.; Muise, A. M.; Shouval, D. S.; Ozen, A.; Pan, K.-T.; Wu, C.; Lenardo, M. J.: Mucus sialylation determines intestinal host-commensal homeostasis. Cell 185 (7), pp. 1172 - 1188.e28 (2022)
37.
Journal Article
Düster, R.; Ji, Y.; Pan, K.-T.; Urlaub, H.; Geyer, M.: Functional characterization of the human Cdk10/Cyclin Q complex. Open Biology 12 (3), 210381 (2022)
38.
Journal Article
Georgiou, M.; Yang, C.; Atkinson, R.; Pan, K.‐.; Buskin, A.; Molina, M. M.; Collin, J.; Al‐Aama, J.; Goertler, F.; Ludwig, S. E. J. et al.; Davey, T.; Lührmann, R.; Nagaraja‐Grellscheid, S.; Johnson, C. A.; Ali, R.; Armstrong, L.; Korolchuk, V.; Urlaub, H.; Mozaffari‐Jovin, S.; Lako, M.: Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient‐induced pluripotent stem cell‐derived retinal pigment epithelium cells. Clinical and Translational Medicine 12 (3), e759 (2022)
39.
Journal Article
Chang, H.-F.; Schirra, C.; Ninov, M.; Hahn, U.; Ravichandran, K.; Krause, E.; Becherer, U.; Bálint, Š.; Harkiolaki, M.; Urlaub, H. et al.; Valitutti, S.; Baldari, C. T.; Dustin, M. L.; Jahn, R.; Rettig, J.: Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes. Nature Communications 13, 1029 (2022)
40.
Journal Article
Fang, P.; Ji, Y.; Oellerich, T.; Urlaub, H.; Pan, K.-T.: Strategies for Proteome-Wide Quantification of Glycosylation Macro- and Micro-Heterogeneity. International Journal of Molecular Sciences 23 (3), 1609 (2022)
41.
Journal Article
Wilke, A. C.; Doebele, C.; Zindel, A.; Lee, K. S.; Rieke, S. A.; Ceribelli, M.; Comoglio, F.; Phelan, J.D.; Wang, J. Q.; Pikman, Y. et al.; Jahn, D.; Häupl, B.; Schneider, C.; Scheich, S.; Tosto, F. A.; Bohnenberger, H.; Stauder, P.; Schnütgen, F.; Slabicki, M.; Coulibaly, Z. A.; Wolf, S.; Bojarczuk, K.; Chapuy, B.; Brandts, C. H.; Stroebel, P.; Lewis, C. A.; Engelke, M.; Xu, X.; Kim, H.; Dang, T. H.; Schmitz, R.; Hodson, D. J.; Stegmaier, K.; Urlaub, H.; Serve, H.; Schmitt, C. A.; Kreuz, F.; Knittel, G.; Rabinowitz, J. D.; Reinhardt, H. C.; Vander Heiden, M. G.; Thomas, C.; Staudt, L. M.; Zenz, T.; Oellerich, T.: SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. Blood 139 (4), pp. 538 - 553 (2022)
42.
Journal Article
Elakad, O.; Häupl, B.; Labitzky, V.; Yao, S.; Küffer, S.; von Hammerstein-Equord, A.; Danner, B. C.; Jücker, M.; Urlaub, H.; Lange, T. et al.; Ströbel, P.; Oellerich, T.; Bohnenberger, H.: Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer. npj Precision Oncology 6, 52 (2022)
43.
Journal Article
Farkas, Á.; Urlaub, H.; Bohnsack, K. E.; Schwappach, B.: Regulated targeting of the monotopic hairpin membrane protein Erg1 requires the GET pathway. Journal of Cell Biology 221 (6), e202201036 (2022)
44.
Journal Article
Heidemann, J. L.; Neumann, P.; Krüger, L.; Wicke, D.; Vinhoven, L.; Linden, A.; Dickmanns, A.; Stülke, J.; Urlaub, H.; Ficner, R.: Structural basis for c-di-AMP–dependent regulation of the bacterial stringent response by receptor protein DarB. Journal of Biological Chemistry 298 (7), 102144 (2022)
45.
Journal Article
Jayavelu, A. K.; Wolf, S.; Buettner, F.; Alexe, G.; Häupl, B.; Comoglio, F.; Schneider, C.; Doebele, C.; Fuhrmann, D. C.; Wagner, S. et al.; Donato, E.; Andresen, C.; Wilke, A. C.; Zindel, A.; Jahn, D.; Splettstoesser, B.; Plessmann, U.; Münch, S.; Abou-El-Ardat, K.; Makowka, P.; Acker, F.; Enssle, J. C.; Cremer, A.; Schnütgen, F.; Kurrle, N.; Chapuy, B.; Löber, J.; Hartmann, S.; Wild, P. J.; Wittig, I.; Hübschmann, D.; Kaderali, L.; Cox, J.; Brüne, B.; Röllig, C.; Thiede, C.; Steffen, B.; Bornhäuser, M.; Trumpp, A.; Urlaub, H.; Stegmaier, K.; Serve, H.; Mann, M.; Oellerich, T.: The proteogenomic subtypes of acute myeloid leukemia. Cancer Cell 40 (3), pp. 301 - 317.e12 (2022)
46.
Journal Article
Meyer, A.; Kehl, A.; Cui, C.; Reichardt, F. A. K.; Hecker, F.; Funk, L.-M.; Ghosh, M. K.; Pan, K. T.; Urlaub, H.; Tittmann, K. et al.; Stubbe, J.; Bennati, M.: 19F Electron-nuclear double resonance reveals interaction between redox-active tyrosines across the α/β interface of E. coli ribonucleotide reductase. Journal of the American Chemical Society 144, pp. 11270 - 11282 (2022)
47.
Journal Article
Moll, A.; Ramirez, L. M.; Ninov, M.; Schwarz, J.; Urlaub, H.; Zweckstetter, M.: Hsp multichaperone complex buffers pathologically modified Tau. Nature Communications 13, 3668 (2022)
48.
Journal Article
Richter, A.; Fichtner, A.; Joost, J.; Brockmeyer, P.; Kauffmann, P.; Schliephake, H.; Hammerstein‐Equord, A.; Kueffer, S.; Urlaub, H.; Oellerich, T. et al.; Ströbel, P.; Bohnenberger, H.; Bremmer, F.: Quantitative proteomics identifies biomarkers to distinguish pulmonary from head and neck squamous cell carcinomas by immunohistochemistry. The Journal of Pathology: Clinical Research 8 (1), pp. 33 - 47 (2022)
49.
Journal Article
Richter, A.; Fichtner, A.; Joost, J.; Brockmeyer, P.; Kauffmann, P.; Schliephake, H.; Hammerstein‐Equord, A.; Kueffer, S.; Urlaub, H.; Oellerich, T. et al.; Ströbel, P.; Bohnenberger, H.; Bremmer, F.: Quantitative proteomics identifies biomarkers to distinguish pulmonary from head and neck squamous cell carcinomas by immunohistochemistry. The Journal of Pathology: Clinical Research 8 (1), pp. 33 - 47 (2022)
50.
Journal Article
Weninger, G.; Pochechueva, T.; El Chami, D.; Luo, X.; Kohl, T.; Brandenburg, S.; Urlaub, H.; Guan, K.; Lenz, C.; Lehnart, S. E.: Calpain cleavage of Junctophilin-2 generates a spectrum of calcium-dependent cleavage products and DNA-rich NT1-fragment domains in cardiomyocytes. Scientific Reports 12, 10387 (2022)
Go to Editor View