Publications

1.

Journal Article

Rodríguez-González, I.; Kohlhause, D.; Lenz, C.; Urlaub, H.; Spillner, C.; Kehlenbach, R. H.: VAPA at the inner nuclear membrane affects nuclear lamins and nuclear morphology. Journal of Cell Science 139 (12), jcs264298 (2026)

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2.

Journal Article

Kanzow, P.; Lenz, C.; Schlarmann, F.; Barke, S.; Rohland, B.; Schmidt, A.; Gorshkova, A.; Neuenroth, L.; Wiegand, A.: Saliva and salivary pellicle composition and proteomic profile in smokers vs. non-smokers and its effect on dental erosion. Journal of Dentistry 166, 106517 (2026)

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3.

Journal Article

Kohlhause, D.; Spillner, C.; Zapata, V. A.; Lenz, C.; Urlaub, H.; Kohl, T.; Lehnart, S. E.; Gerace, L.; Kehlenbach, R. H.: The nuclear envelope protein TMEM209 is an integral component of the nuclear pore complex and interacts with Nup210. Journal of Cell Science (2026)

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4.

Journal Article

Neumann, P.; Dybkov, O.; Urlaub, H.; Ficner, R.; Dickmanns, A.: Alphafold 3-guided insights into the Importinβ: Importin7 heterodimer interaction and its binding to histone H1. Structure (2026)

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5.

Journal Article

Machado de Amorim, A.; Xue, G.; He, W.; Dittmers, T.; Lewandowski, S.; Perez-Borrajero, C.; Bethmann, J.; Mateva, N.; Krage, C.; Nandana, V. et al.; Loll, B.; Hilal, T.; Hennig, J.; Urlaub, H.; Marzluff, W. F.; Chakrabarti, S.: Mechanistic insights into recruitment and regulation of the RNA helicase UPF1 in replication-dependent histone mRNA decay. Nature Communications 17, 155 (2026)

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6.

Journal Article

Auvray, M.; Koenen, T.; Dybkov, O.; Urlaub, H.; Lukinavičius, G.: Biocompatible sulfonium-based covalent probes for endogenous tubulin fluorescence nanoscopy in live and fixed cells. Nature Communications 16, 11107 (2025)

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7.

Journal Article

Rathore, S.; Conrad, J.; De Silva, D.; Ferrari, A.; Bouquio, D.; Kim, H.-J.; Salvatori, R.; Linden, A.; Dybkov, O.; Urlaub, H. et al.; Ott, M.; Barrientos, A.: The late stages of yeast mitoribosome large subunit biogenesis. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1872 (8), 120051 (2025)

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8.

Journal Article

Ghosh Dastidar, N.; Freyer, N. S.; Petrychenko, V.; de A. P. Schwarzer, A. C.; Peng, B.-Z.; Samatova, E.; Kothe, C.; Schmidt, M.; Peske, F.; Politi, A. Z. et al.; Urlaub, H.; Fischer, N.; Rodnina, M. V.; Wohlgemuth, I.: Selective silencing of antibiotic-tethered ribosomes as a resistance mechanism against aminoglycosides. Nature Communications 16, 9568 (2025)

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9.

Journal Article

Walshe, J. L.; Ochmann, M.; Neef, U.; Dybkov, O.; Dienemann, C.; Oberthür, C.; Zheenbekova, A.; Urlaub, H.; Cramer, P.: Molecular mechanism of co-transcriptional H3K36 methylation by SETD2. Nature Communications 16, 9565 (2025)

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10.

Journal Article

Avilov, I.; Horokhovskyi, Y.; Mehta, P.; Welp, L.; Jakobi, J.; Cai, M.; Orzechowski, A.; Urlaub, H.; Liepe, J.; Lenart, P.: Phosphoproteomic identification of Mos–MAPK targets in meiotic cell cycle and asymmetric oocyte divisions. Journal of Cell Biology 224 (12), e202312140 (2025)

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11.

Journal Article

Reshetniak, S.; Bogaciu, C. A.; Bonn, S.; Brose, N.; Cooper, B. H.; D'Este, E.; Fauth, M.; Fernández‐Busnadiego, R.; Fiosins, M.; Fischer, A. et al.; Georgiev, S. V.; Jakobs, S.; Klumpp, S.; Köster, S.; Lange, F.; Lipstein, N.; Macarrón‐Palacios, V.; Milovanovic, D.; Moser, T.; Müller, M.; Opazo, F.; Outeiro, T. F.; Pape, C.; Priesemann, V.; Rehling, P.; Salditt, T.; Schlüter, O.; Simeth, N.; Steinem, C.; Tchumatchenko, T.; Tetzlaff, C.; Tirard, M.; Urlaub, H.; Wichmann, C.; Wolf, F.; Rizzoli, S. O.: The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function. The Journal of Physiology 603 (20), pp. 5935 - 5964 (2025)

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12.

Journal Article

Fokkens, T. J.; Rauh, E. T.; Wolter, M.; Sebald, H.; Mitnacht, M.; Ainatzi, S.; Sprick, S.; Teschke, L.; Eisenhuth, N.; Huibregtse, J. M. et al.; Butter, F.; Urlaub, H.; Karnkowska, A.; Steinchen, W.; Schleicher, U.; Janzen, C. J.; Lorenz, S.: A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity. Molecular Cell 85 (19), pp. 3711 - 3728.e11 (2025)

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13.

Journal Article

Orth, B.; Pohl, P.; Aust, F.; Ji, Y.; Seenivasan, A.; Dybkov, O.; Liang, X. J.; Bock, L.; Leidner, F.; Levantovsky, S. et al.; Schardey, P.; Sander, P.; Disch, N. J.; Trautz, M. L.; Mizi, A.; Papantonis, A.; Lenz, C.; Grubmüller, H.; Steinchen, W.; Behrends, C.; Urlaub, H.; Gehringer, M.; Lorenz, S.: Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1. Nature Communications 16, 8182 (2025)

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14.

Journal Article

Scholl, L.-S.; Demleitner, A. F.; Riedel, J.; Adachi, S.; Neuenroth, L.; Meijs, C.; Tzeplaeff, L.; Caldi Gomes, L.; Galhoz, A.; Cordts, I. et al.; Lenz, C.; Menden, M.; Lingor, P.: Identification and validation of a tear fluid-derived protein biomarker signature in patients with amyotrophic lateral sclerosis. Acta Neuropathologica Communications 13, 187 (2025)

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15.

Journal Article

Fenech, E. J.; Kupervaser, M.; Boshnakovska, A.; Ravid, S.; Castro, I. G.; Asraf, Y.; Callegari, S.; Lenz, C.; Urlaub, H.; Rehling, P. et al.; Schuldiner, M.: Profiling the LAM Family of Contact Site Tethers Provides Insights into Their Regulation and Function. Contact 8, pp. 1 - 17 (2025)

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16.

Journal Article

Welp, L. M.; Wulf, A.; Chernev, A.; Horokhovskyi, Y.; Moshkovskii, S.; Dybkov, O.; Neumann, P.; Pašen, M.; Siraj, A.; Raabe, M. et al.; Göthert, H.; Walshe, J.; Infante, D. A.; de A P Schwarzer, A.; Dickmanns, A.; Johannsson, S.; Schmitzová, J.; Wohlgemuth, I.; Netz, E.; He, Y.; Fritzemeier, K.; Delanghe, B.; Viner, R.; Vos, S.; Oberbeckmann, E.; Bohnsack, K.; Bohnsack, M.; Cramer, P.; Ficner, R.; Kohlbacher, O.; Liepe, J.; Sachsenberg, T.; Urlaub, H.: Chemical crosslinking extends and complements UV crosslinking in analysis of RNA/DNA nucleic acid–protein interaction sites by mass spectrometry. Nucleic Acids Research 53 (15), gkaf727 (2025)

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17.

Journal Article

Zheenbekova, A.; Walshe, J. L.; Ochmann, M.; Bäuerle, M.; Neef, U.; Maier, K. C.; Rus, P.; Yan, Y.; Urlaub, H.; Cramer, P. et al.; Žumer, K.: IWS1 positions downstream DNA to globally stimulate Pol II elongation. Nature Communications 16, 7747 (2025)

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18.

Journal Article

Grune, J.; Lenz, C.; Cochain, C.; Momin, N.: More than myocytes: The heart's electrical ensemble. The Journal of Physiology (2025)

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19.

Journal Article

Cretu, C.; Chernev, A.; Szabó, C. Z. K.; Pena, V.; Urlaub, H.; Moser, T.; Preobraschenski, J.: Structural insights into lipid membrane binding by human ferlins. The EMBO Journal 44 (14), pp. 3926 - 3958 (2025)

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20.

Journal Article

Urbach, L.; Wieland, L.; Penz, F.; Samuel, R. D.; Küffer, S.; Klein, L.; Lenz, C.; Sax, U.; Ghadimi, M.; Schulz-Heddergott, R. et al.; Hessmann, E.; Ellenrieder, V.; Dusetti, N.; Singh, S. K.: TP53 missense–specific transcriptional plasticity drives resistance against cell cycle inhibitors in pancreatic cancer. Science Advances 11 (27), eadu2339 (2025)

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21.

Journal Article

Boshnakovska, A.; Pronto, J. R.; Gall, T.; Aich, A.; Prochazka, J.; Nichtova, Z.; Sedlacek, R.; Sobitov, I.; Ainatzi, S.; Lenz, C. et al.; Katschinski, D. M.; Urlaub, H.; Voigt, N.; Rehling, P.; Kremer, L. S.: SMIM20 promotes complex IV biogenesis and Ca²⁺ signaling in mice heart. Cell Reports 44 (6), 115723 (2025)

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22.

Journal Article

Güran, A.; Ji, Y.; Fang, P.; Pan, K.-T.; Urlaub, H.; Avkiran, M.; Lenz, C.; Weeks, K. L.: PP2A-B56α is a key determinant of cardiac protein phosphorylation and functional responses to β-adrenergic signalling. Journal of Molecular and Cellular Cardiology Plus 12, 100301 (2025)

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23.

Journal Article

Soni, K.; Horvath, A.; Dybkov, O.; Schwan, M.; Trakansuebkul, S.; Flemming, D.; Wild, K.; Urlaub, H.; Fischer, T.; Sinning, I.: Structures of aberrant spliceosome intermediates on their way to disassembly. Nature Structural & Molecular Biology 32, pp. 914 - 925 (2025)

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24.

Journal Article

Choezom, D.; Plum, J.-M.; Karuna M, P.; Danieli-Mackay, A.; Lenz, C.; Brockmeyer, P.; Gross, J. C.: The Ceramide-Dependent EV Secretome Differentially Affects Prostate Cancer Cell Migration. Cells 14 (7), 547 (2025)

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25.

Journal Article

Ainatzi, S.; Kaufmann, S. V.; Silbern, I.; Georgiev, S. V.; Lorenz, S.; Rizzoli, S. O.; Urlaub, H.: Ca²⁺-triggered (de)ubiquitination events in synapses. Molecular & Cellular Proteomics 24 (4), 100946 (2025)

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26.

Journal Article

Cormican, J. A.; Medfai, L.; Wawrzyniuk, M.; Pašen, M.; Afrache, H.; Fourny, C.; Khan, S.; Gneiße, P.; Soh, W. T.; Timelli, A. et al.; Nolfi, E.; Pannekoek, Y.; Cope, A.; Urlaub, H.; Sijts, A. J.A. M.; Mishto, M.; Liepe, J.: PEPSeek-mediated identification of novel epitopes from viral and bacterial pathogens and the impact on host cell immunopeptidomes. Molecular & Cellular Proteomics 24 (4), 100937 (2025)

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27.

Journal Article

Gobran, M.; Politi, A. Z.; Welp, L. M.; Jakobi, J.; Urlaub, H.; Lenart, P.: PLK1 inhibition delays mitotic entry revealing changes to the phosphoproteome of mammalian cells early in division. The EMBO Journal 44 (7), pp. 1891 - 1920 (2025)

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28.

Journal Article

Sala, F. A.; Ditter, K.; Dybkov, O.; Urlaub, H.; Hillen, H. S.: Structural basis of Nipah virus RNA synthesis. Nature Communications 16, 2261 (2025)

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supplementary-material

29.

Journal Article

Fendler, N. L.; Ly, J.; Welp, L. M.; Lu, D.; Schulte, F.; Urlaub, H.; Vos, S. M.: Identification and characterization of a human MORC2 DNA binding region that is required for gene silencing. Nucleic Acids Research 53 (4), gkae1273 (2025)

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30.

Journal Article

Sailer, A.-L.; Brendel, J.; Chernev, A.; König, S.; Bischler, T.; Gräfenhan, T.; Urlaub, H.; Gophna, U.; Marchfelder, A.: Internal in-frame translation generates Cas11b, which is important for effective interference in an archaeal CRISPR-Cas system. Frontiers in Microbiology 16, 1543464 (2025)

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31.

Journal Article

Jennrich, J.; Farkas, Á.; Urlaub, H.; Schwappach, B.; Bohnsack, K. E.: The formation of chaperone-rich GET bodies depends on the tetratricopeptide repeat region of Sgt2 and is reversed by NADH. Journal of Cell Science 138 (6), jcs263616 (2025)

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32.

Journal Article

Yousefi, R.; Cruz-Zaragoza, L.D.; Valpadashi, A.; Hansohn, C.; Dahal, D.; Richter-Dennerlein, R.; Rizzoli, S.; Urlaub, H.; Rehling, P.; Pacheu-Grau, D.: A microscopy-based screen identifies cellular kinases modulating mitochondrial translation. Cell Reports 44 (1), 115143 (2025)

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33.

Journal Article

Di Cianni, N.; Bolsinger, S.; Brendel, J.; Raabe, M.; König, S.; Mitchell, L.; Bischler, T.; Gräfenhan, T.; Read, C.; Erdmann, S. et al.; Allers, T.; Walther, P.; Urlaub, H.; Dyall-Smith, M.; Pfeiffer, F.; Marchfelder, A.: Provirus deletion from Haloferax volcanii affects motility, stress resistance, and CRISPR RNA expression. microLife 6, uqaf008 (2025)

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34.

Journal Article

Xylaki, M.; Chopra, A.; Kyriachenko, Y.; Scherer, J.; Otte, B.; Dakna, M.; Bartl, M.; Weber, S.; Schade, S.; Lenz, C. et al.; Mollenhauer, B.: Proteomic Exploration of L1CAM⁺-Extracellular Vesicles from Plasma of Manifest and Prodromal Parkinson’s Disease. International Journal of Molecular Sciences 26 (23), 11564 (2025)

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35.

Journal Article

Hollstein, M. M.; Traidl, S.; Heetfeld, A.; Forkel, S.; Leha, A.; Alkon, N.; Ruwisch, J.; Lenz, C.; Schön, M. P.; Schmelz, M. et al.; Brunner, P.; Steinhoff, M.; Buhl, T.: Skin microdialysis detects distinct immunologic patterns in chronic inflammatory skin diseases. The Journal of Allergy and Clinical Immunology 154 (6), pp. 1450 - 1461 (2024)

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36.

Journal Article

Lavdovskaia, E.; Hanitsch, E.; Linden, A.; Pašen, M.; Challa, V.; Horokhovskyi, Y.; Roetschke, H. P.; Nadler, F.; Welp, L.; Steube, E. et al.; Heinrichs, M.; Mai, M. M.-Q.; Urlaub, H.; Liepe, J.; Richter-Dennerlein, R.: A roadmap for ribosome assembly in human mitochondria. Nature Structural & Molecular Biology 31, pp. 1898 - 1908 (2024)

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37.

Journal Article

Swarnkar, A.; Leidner, F.; Rout, A. K.; Ainatzi, S.; Schmidt, C. C.; Becker, S.; Urlaub, H.; Griesinger, C.; Grubmüller, H.; Stein, A.: Determinants of chemoselectivity in ubiquitination by the J2 family of ubiquitin-conjugating enzymes. The EMBO Journal 43 (24), pp. 6705 - 6739 (2024)

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38.

Journal Article

Altas, B.; Tuffy, L. P.; Patrizi, A.; Dimova, K.; Soykan, T.; Brandenburg, C.; Romanowski, A. J.; Whitten, J. R.; Robertson, C. D.; Khim, S. N. et al.; Crutcher, G. W.; Ambrozkiewicz, M.; Yagensky, O.; Krüger-Burg, D. D.; Hammer, M.; Hsiao, H.-H.; Laskowski, P. R.; Dyck, L.; Puche, A. C.; Sassoè-Pognetto, M.; Chua, J. J. E.; Urlaub, H.; Jahn, O.; Brose, N.; Poulopoulos, A.: Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory versus Inhibitory Synapses. Biological Psychiatry 96 (10), pp. 815 - 828 (2024)

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39.

Journal Article

Foo, B.; Amedei, H.; Kaur, S.; Jaawan, S.; Boshnakovska, A.; Gall, T.; de Boer, R. A.; Silljé, H. H. W.; Urlaub, H.; Rehling, P. et al.; Lenz, C.; Lehnart, S. E.: Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14^Δ/+ mice hearts. PLOS ONE 19 (10), e0311203 (2024)

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40.

Journal Article

Fokken, C.; Silbern, I.; Shomroni, O.; Pan, K.-T.; Ryazanov, S.; Leonov, A.; Winkler, N.; Urlaub, H.; Griesinger, C.; Becker, D.: Interfering with aggregated α-synuclein in advanced melanoma leads to a major upregulation of MHC class II proteins. Melanoma Research 34 (5), pp. 393 - 407 (2024)

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41.

Journal Article

Lahiri, S. K.; Lu, J.; Aguilar-Sanchez, Y.; Li, H.; Moreira, L. M.; Hulsurkar, M. M.; Mendoza, A.; Turkieltaub Paredes, M. R.; Navarro-Garcia, J. A.; Munivez, E. et al.; Horist, B.; Moore, O. M.; Weninger, G.; Brandenburg, S.; Lenz, C.; Lehnart, S. E.; Sayeed, R.; Krasopoulos, G.; Srivastava, V.; Zhang, L.; Karch, J. M.; Reilly, S.; Wehrens, X. H.T.: Targeting calpain-2-mediated junctophilin-2 cleavage delays heart failure progression following myocardial infarction. Journal of Molecular and Cellular Cardiology 194, pp. 85 - 95 (2024)

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42.

Journal Article

Sailer, A.-L.; Jevtic, Z.; Stoll, B.; Wörtz, J.; Sharma, K.; Urlaub, H.; Dyall-Smith, M.; Pfeiffer, F.; Marchfelder, A.; Lenz, C.: Iron starvation results in up-regulation of a probable Haloferax volcanii siderophore transporter. Frontiers in Microbiology 15, 1422844 (2024)

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43.

Journal Article

Aich, A.; Boshnakovska, A.; Witte, S.; Gall, T.; Unthan-Fechner, K.; Yousefi, R.; Chowdhury, A.; Dahal, D.; Methi, A.; Kaufmann, S. et al.; Silbern, I.; Prochazka, J.; Nichtova, Z.; Palkova, M.; Raishbrook, M.; Koubkova, G.; Sedlacek, R.; Tröder, S.E.; Zevnik, B.; Riedel, D.; Michanski, S.; Möbius, W.; Ströbel, P.; Lüchtenborg, C.; Giavalisco, P.; Urlaub, H.; Fischer, A.; Brügger, B.; Jakobs, S.; Rehling, P.: Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver. Nature Communications 15, 6914 (2024)

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44.

Journal Article

Amedei, H.; Paul, N. B.; Foo, B.; Neuenroth, L.; Lehnart, S. E.; Urlaub, H.; Lenz, C.: mini-Complexome Profiling (mCP), an FDR-controlled workflow for global targeted detection of protein complexes. Frontiers in Analytical Science 4, 1425190 (2024)

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45.

Journal Article

Bilger, R.; Migur, A.; Wulf, A.; Steglich, C.; Urlaub, H.; Hess, W. R.: A type III-Dv CRISPR-Cas system is controlled by the transcription factor RpaB and interacts with the DEAD-box RNA helicase CrhR. Cell Reports 43 (7), 114485 (2024)

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46.

Journal Article

Zhang, Z.; Kumar, V.; Dybkov, O.; Will, C. L.; Zhong, J.; Ludwig, S. E. J.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Structural insights into the cross-exon to cross-intron spliceosome switch. Nature 630, pp. 1012 - 1019 (2024)

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47.

Journal Article

Harasimov, K.; Gorry, R. L.; Welp, L. M.; Penir, S. M.; Horokhovskyi, Y.; Cheng, S.; Takaoka, K.; Stützer, A.; Frombach, A.-S.; Taylor Tavares, A. L. et al.; Raabe, M.; Haag, S.; Saha, D.; Grewe, K.; Schipper, V.; Rizzoli, S. O.; Urlaub, H.; Liepe, J.; Schuh, M.: The maintenance of oocytes in the mammalian ovary involves extreme protein longevity. Nature Cell Biology 26, pp. 1124 - 1138 (2024)

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48.

Journal Article

Dreyer, A.; Masanta, W. O.; Lugert, R.; Bohne, W.; Groß, U.; Leha, A.; Dakna, M.; Lenz, C.; Zautner, A. E.: Proteome profiling of Campylobacter jejuni 81–176 at 37 °C and 42 °C by label-free mass spectrometry. BMC Microbiology 24, 191 (2024)

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49.

Journal Article

Velychko, T.; Mohammad, E.; Ferrer-Vicens, I.; Parfentev, I.; Werner, M.; Studniarek, C.; Schwalb, B.; Urlaub, H.; Murphy, S.; Cramer, P. et al.; Lidschreiber, M.: CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release. Molecular Cell 84 (12), pp. 2287 - 2303.e10 (2024)

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50.

Journal Article

James, C.; Möller, U.; Spillner, C.; König, S.; Dybkov, O.; Urlaub, H.; Lenz, C.; Kehlenbach, R. H.: Phosphorylation of ELYS promotes its interaction with VAPB at decondensing chromosomes during mitosis. EMBO Reports 25 (5), pp. 2391 - 2417 (2024)

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Publications

Journal Article (527)