Publications

Journal Article (466)

1.
Journal Article
Phelan, J. D.; Scheich, S.; Choi, J.; Wright, G. W.; Häupl, B.; Young, R. M.; Rieke, S. A.; Pape, M.; Ji, Y.; Urlaub, H. et al.; Bolomsky, A.; Doebele, C.; Zindel, A.; Wotapek, T.; Kasbekar, M.; Collinge, B.; Huang, D. W.; Coulibaly, Z. A.; Morris, V. M.; Zhuang, X.; Enssle, J. C.; Yu, X.; Xu, W.; Yang, Y.; Zhao, H.; Wang, Z.; Tran, A. D.; Shoemaker, C. J.; Shevchenko, G.; Hodson, D. J.; Shaffer, A. L.; Staudt, L. M.; Oellerich, T.: Response to Bruton’s tyrosine kinase inhibitors in aggressive lymphomas linked to chronic selective autophagy. Cancer Cell 42 (2), pp. 238 - 252.e9 (2024)
2.
Journal Article
Düring, J.; Wolter, M.; Toplak, J. J.; Torres, C.; Dybkov, O.; Fokkens, T. J.; Bohnsack, K. E.; Urlaub, H.; Steinchen, W.; Dienemann, C. et al.; Lorenz, S.: Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1. Nature Structural & Molecular Biology 31, pp. 364 - 377 (2024)
3.
Journal Article
Soh, W. T.; Roetschke, H. P.; Cormican, J. A.; Teo, B.F.; Chiam, N. C.; Raabe, M.; Pflanz, R.; Henneberg, F.; Becker, S.; Chari, A. et al.; Liu, H.; Urlaub, H.; Liepe, J.; Mishto, M.: Protein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing. Nature Communications 15 (1), 1147 (2024)
4.
Journal Article
Kokic, G.; Yakoub, G.; van den Heuvel, D.; Wondergem, A. P.; van der Meer, P. J.; van der Weegen, Y.; Chernev, A.; Fianu, I.; Fokkens, T. J.; Lorenz, S. et al.; Urlaub, H.; Cramer, P.; Luijsterburg, M. S.: Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair. Nature Structural & Molecular Biology (2024)
5.
Journal Article
Carmona, A.; Carboni, E.; Gomes, L.C.; Roudeau, S.; Maass, F.; Lenz, C.; Ortega, R.; Lingor, P.: Metal dyshomeostasis in the substantia nigra of patients with Parkinson's disease or multiple sclerosis. Journal of Neurochemistry 168 (2), pp. 128 - 141 (2024)
6.
Journal Article
Cepeda, A. P.; Ninov, M.; Neef, J.; Parfentev, I.; Kusch, K.; Reisinger, E.; Jahn, R.; Moser, T.; Urlaub, H.: Proteomic Analysis Reveals the Composition of Glutamatergic Organelles of Auditory Inner Hair Cells. Molecular & Cellular Proteomics 23 (2), 100704 (2024)
7.
Journal Article
Egbert, J. R.; Silbern, I.; Uliasz, T. F.; Lowther, K. M.; Yee, S.-P.; Urlaub, H.; Jaffe, L. A.: Phosphatases modified by LH signaling in ovarian follicles: testing their role in regulating the NPR2 guanylyl cyclase. Biology of Reproduction 110 (1), pp. 102 - 115 (2024)
8.
Journal Article
Altas, B.; Tuffy, L. P.; Patrizi, A.; Dimova, K.; Soykan, T.; Brandenburg, C.; Romanowski, A. J.; Whitten, J. R.; Robertson, C. D.; Khim, S. N. et al.; Crutcher, G. W.; Ambrozkiewicz, M.; Yagensky, O.; Krüger-Burg, D. D.; Hammer, M.; Hsiao, H.-H.; Laskowski, P. R.; Dyck, L.; Puche, A. C.; Sassoè-Pognetto, M.; Chua, J. J. E.; Urlaub, H.; Jahn, O.; Brose, N.; Poulopoulos, A.: Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory versus Inhibitory Synapses. Biological Psychiatry, in press (2023)
9.
Journal Article
Kanwal, N.; Krogh, N.; Memet, I.; Lemus-Diaz, N.; Thomé, C. C.; Welp, L. M.; Mizi, A.; Hackert, P.; Papantonis, A.; Urlaub, H. et al.; Nielsen, H.; Bohnsack, K. E.; Bohnsack, M. T.: GPATCH4 regulates rRNA and snRNA 2′-O-methylation in both DHX15-dependent and DHX15-independent manners. Nucleic Acids Research, gkad1202 (2023)
10.
Journal Article
Wicke, D.; Neumann, P.; Goessringer, M.; Chernev, A.; Davydov, S.; Poehlein, A.; Daniel, R.; Urlaub, H.; Hartmann, R. K.; Ficner, R. et al.; Stuelke, J.: The previously uncharacterized RnpM (YlxR) protein modulates the activity of ribonuclease P in Bacillus subtilis in vitro. Nucleic Acids Research 52 (3), pp. 1404 - 1409 (2023)
11.
Journal Article
Jentoft, I. M. A.; Bäuerlein, F. J.B.; Welp, L. M.; Cooper, B. H.; Petrovic, A.; So, C.; Penir, S. M.; Politi, A. Z.; Horokhovskyi, Y.; Takala, I. et al.; Eckel, H.; Moltrecht, R.; Lenart, P.; Cavazza, T.; Liepe, J.; Brose, N.; Urlaub, H.; Fernández-Busnadiego, R.; Schuh, M.: Mammalian oocytes store proteins for the early embryo on cytoplasmic lattices. Cell 186 (24), pp. 5308 - 5327.e25 (2023)
12.
Journal Article
Dreyer, A.; Lenz, C.; Groß, U.; Bohne, W.; Zautner, A.E.: Characterization of Campylobacter jejuni proteome profiles in co-incubation scenarios. Frontiers in Microbiology 14, 1247211 (2023)
13.
Journal Article
Saxena, K.; Roverato, N. D.; Reithmann, M.; Mah, M. M.; Schregle, R.; Schmidtke, G.; Silbern, I.; Urlaub, H.; Aichem, A.: FAT10 is phosphorylated by IKKβ to inhibit the antiviral type-I interferon response. Life science alliance 7 (1), e202101282 (2023)
14.
Journal Article
Chen, Y.; Kokic, G.; Dienemann, C.; Dybkov, O.; Urlaub, H.; Cramer, P.: Structure of the transcribing RNA polymerase II–Elongin complex. Nature Structural & Molecular Biology 30, pp. 1925 - 1935 (2023)
15.
Journal Article
Binotti, B.; Ninov, M.; Cepeda, A. P.; Ganzella, M.; Matti, U.; Riedel, D.; Urlaub, H.; Sambandan, S.; Jahn, R.: ATG9 resides on a unique population of small vesicles in presynaptic nerve terminals. Autophagy (2023)
16.
Journal Article
Gruenberger, F.; Schmid, G.; El Ahmad, Z.; Fenk, M.; Vogl, K.; Reichelt, R.; Hausner, W.; Urlaub, H.; Lenz, C.; Grohmann, D.: Uncovering the temporal dynamics and regulatory networks of thermal stress response in a hyperthermophile using transcriptomics and proteomics. mBio 14 (6), e02174-23 (2023)
17.
Journal Article
Alfaro, A. J.; Dittner, C.; Becker, J.; Loft, A.; Mhamane, A.; Maida, A.; Georgiadi, A.; Tsokanos, F.-F.; Klepac, K.; Molocea, C.-E. et al.; El-Merahbi, R.; Motzler, K.; Geppert, J.; Karikari, R. A.; Szendroedi, J.; Feuchtinger, A.; Hofmann, S.; Karaca, S.; Urlaub, H.; Berriel Diaz, M.; Melchior, F.; Herzig, S.: Fasting-sensitive SUMO-switch on Prox1 controls hepatic cholesterol metabolism. EMBO Reports 24 (10), e55981| (2023)
18.
Journal Article
Chowdhury, A.; Boshnakovska, A.; Aich, A.; Methi, A.; Vergel Leon, A. M.; Silbern, I.; Lüchtenborg, C.; Cyganek, L.; Prochazka, J.; Sedlacek, R. et al.; Lindovsky, J.; Wachs, D.; Nichtova, Z.; Zudova, D.; Koubkova, G.; Fischer, A.; Urlaub, H.; Brügger, B.; Katschinski, D. M.; Dudek, J.; Rehling, P.: Metabolic switch from fatty acid oxidation to glycolysis in knock-in mouse model of Barth syndrome. Embo Molecular Medicine 15 (9), e17399 (2023)
19.
Journal Article
Grahn, E.; Kaufmann, S. V.; Askarova, M.; Ninov, M.; Welp, L. M.; Berger, T.K.; Urlaub, H.; Kaupp, U.B.: Control of intracellular pH and bicarbonate by CO2 diffusion into human sperm. Nature Communications 14, 5395 (2023)
20.
Journal Article
Warth Perez Arias, C. C.; Silbern, I.; Gomes, L. C.; Wartmann, H.; Dambeck, V.; Fanz, J.; Neuenroth, L.; Baehr, M.; Outeiro, T. F.; Bonn, S. et al.; Stadelmann-Nessler, C.; Rizzoli, S. O.; Lenz, C.; Urlaub, H.; Lingor, P.: Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease. Journal of Neurochemistry 166 (5), pp. 862 - 874 (2023)
21.
Journal Article
Wolfram-Schauerte, M.; Pozhydaieva, N.; Grawenhoff, J.; Welp, L. M.; Silbern, I.; Wulf, A.; Billau, F. A.; Glatter, T.; Urlaub, H.; Jäschke, A. et al.; Höfer, K.: A viral ADP-ribosyltransferase attaches RNA chains to host proteins. Nature 620, pp. 1054 - 1062 (2023)
22.
Journal Article
Garg, G.; Dienemann, C.; Farnung, L.; Schwarz, J.; Linden, A.; Urlaub, H.; Cramer, P.: Structural insights into human co-transcriptional capping. Molecular Cell 83 (14), pp. 2464 - 2477.e5 (2023)
23.
Journal Article
Dai, Y.; Ignatyeva, N.; Xu, H.; Wali, R.; Toischer, K.; Brandenburg, S.; Lenz, C.; Pronto, J.; Fakuade, F. E.; Sossalla, S. et al.; Zeisberg, E. M.; Janshoff, A.; Kutschka, I.; Voigt, N.; Urlaub, H.; Rasmussen, T. B.; Mogensen, J.; Lehnart, S. E.; Hasenfuss, G.; Ebert, A.: An Alternative Mechanism of Subcellular Iron Uptake Deficiency in Cardiomyocytes. Circulation Research 133 (2), pp. e19 - e46 (2023)
24.
Journal Article
Witzenberger, M.; Burczyk, S.; Settele, D.; Mayer, W.; Welp, L. M.; Heiss, M.; Wagner, M.; Monecke, T.; Janowski, R.; Carell, T. et al.; Urlaub, H.; Hauck, S. M.; Voigt, A.; Niessing, D.: Human TRMT2A methylates tRNA and contributes to translation fidelity. Nucleic Acids Research, gkad565 (2023)
25.
Journal Article
Nguyen, A.; Lugarini, F.; David, C.; Hosnani, P.; Alagöz, Ç.; Friedrich, A.; Schlütermann, D.; Knotkova, B.; Patel, A.; Parfentev, I. et al.; Urlaub, H.; Meinecke, M.; Stork, B.; Faesen, A. C.: Metamorphic proteins at the basis of human autophagy initiation and lipid transfer. Molecular Cell 83 (12), pp. 2077 - 2090.e12 (2023)
26.
Journal Article
Quentin, D.; Schuhmacher, J.S.; Klink, B.U.; Lauer, J.; Shaikh, T.R.; Huis in ’t Veld, P.J.; Welp, L. M.; Urlaub, H.; Zerial, M.; Raunser, S.: Structural basis of mRNA binding by the human FERRY Rab5 effector complex. Molecular Cell 83 (11), pp. 1856 - 1871.e9 (2023)
27.
Journal Article
Schmitzová, J.; Cretu, C.; Dienemann, C.; Urlaub, H.; Pena, V.: Structural basis of catalytic activation in human splicing. Nature 617, pp. 842 - 850 (2023)
28.
Journal Article
Scheich, S.; Chen, J.; Liu, J.; Schnutgen, F.; Enssle, J. C.; Ceribelli, M.; Thomas, C. J.; Choi, J.; Morris, V.; Hsiao, T. et al.; Nguyen, H.; Wang, B.; Bolomsky, A.; Phelan, J. D.; Corcoran, S.; Urlaub, H.; Young, R. M.; Haupl, B.; Wright, G. W.; Huang, D. W.; Ji, Y.; Yu, X.; Xu, W.; Yang, Y.; Zhao, H.; Muppidi, J.; Pan, K.-T.; Oellerich, T.; Staudt, L. M.: Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas. Cancer Discovery, CD-22-1401 (2023)
29.
Journal Article
Cheng, S.; Altmeppen, G.; So, C.; Welp, L.; Penir, S. M.; Ruhwedel, T.; Menelaou, K.; Harasimov, K.; Stützer, A.; Blayney, M. et al.; Elder, K.; Möbius, W.; Urlaub, H.; Schuh, M.: Mammalian Oocytes Store mRNAs in a Mitochondria-Associated Membraneless Compartment. Obstetrical & Gynecological Survey 78 (5), pp. 280 - 281 (2023)
30.
Journal Article
Jia, J.; Hilal, T.; Bohnsack, K. E.; Chernev, A.; Tsao, N.; Bethmann, J.; Arumugam, A.; Parmely, L.; Holton, N.; Loll, B. et al.; Mosammaparast, N.; Bohnsack, M. T.; Urlaub, H.; Wahl, M. C.: Extended DNA threading through a dual-engine motor module of the activating signal co-integrator 1 complex. Nature Communications 14, 1886 (2023)
31.
Journal Article
Dybkov, O.; Preußner, M.; El Ayoubi, L.; Feng, V.-Y.; Harnisch, C.; Merz, K.; Leupold, P.; Yudichev, P.; Agafonov, D. E.; Will, C. L. et al.; Girard, C.; Dienemann, C.; Urlaub, H.; Kastner, B.; Heyd, F.; Lührmann, R.: Regulation of 3′ splice site selection after step 1 of splicing by spliceosomal C* proteins. Science Advances 9 (9), eadf178 (2023)
32.
Journal Article
Pörschke, M.; Rodríguez-González, I.; Parfentev, I.; Urlaub, H.; Kehlenbach, R. H.: Transportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein. Journal of Biological Chemistry 299 (3), 102932 (2023)
33.
Journal Article
Schminke, B.; Kauffmann, P.; Brockmeyer, P.; Miosge, N.; Lenz, C.; Schubert, A.: The Proteomes of Oral Cells Change during Co-Cultivation with Aggregatibacter actinomycetemcomitans and Eikenella corrodens. Biomedicines 11 (3), 700 (2023)
34.
Journal Article
Castro-Hernández, R.; Berulava, T.; Metelova, M.; Epple, R.; Centeno, T. P.; Richter, J.; Kaurani, L.; Pradhan, R.; Sakiba, M. S.; Burkhardt, S. et al.; Ninov, M.; Bohnsack, K. E.; Bohnsack, M. T.; Delalle, I.; Fischer, A.: Conserved reduction of m6A RNA modifications during aging and neurodegeneration is linked to changes in synaptic transcripts. Proceedings of the National Academy of Sciences of the United States of America 120 (9), e2204933120 (2023)
35.
Journal Article
Wang, H.; Schilbach, S.; Ninov, M.; Urlaub, H.; Cramer, P.: Structures of transcription preinitiation complex engaged with the +1 nucleosome. Nature Structural and Molecular Biology 30, pp. 226 - 232 (2023)
36.
Journal Article
Keil, P.; Wulf, A.; Kachariya, N.; Reuscher, S.; Huhn, K.; Silbern, I.; Altmuller, J.; Keller, M.; Stehle, R.; Zarnack, K. et al.; Sattler, M.; Urlaub, H.; Sträßer, K.: Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA. Nucleic Acids Research 51 (2), pp. 831 - 851 (2023)
37.
Journal Article
Schoger, E.; Bleckwedel, F.; Germena, G.; Rocha, C.; Tucholla, P.; Sobitov, I.; Möbius, W.; Sitte, M.; Lenz, C.; Samak, M. et al.; Hinkel, R.; Varga, Z. V.; Giricz, Z.; Salinas, G.; Gross, J. C.; Zelarayan, L. C.: Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling. Communications Biology 6 (1), 79 (2023)
38.
Journal Article
Franz, A.; Weber, A. I.; Preussner, M.; Dimos, N.; Stumpf, A.; Ji, Y.; Moreno-Velasquez, L.; Voigt, A.; Schulz, F.; Neumann, A. et al.; Kuropka, B.; Kuehn, R.; Urlaub, H.; Schmitz, D.; Wahl, M. C.; Heyd, F.: Branch point strength controls species-specific CAMK2B alternative splicing and regulates LTP. Life science alliance 6 (3), e202201826 (2022)
39.
Journal Article
Brás, I. C.; Khani, M. H.; Vasili, E.; Möbius, W.; Riedel, D.; Parfentev, I.; Gerhardt, E.; Fahlbusch, C.; Urlaub, H.; Zweckstetter, M. et al.; Gollisch, T.; Outeiro, T. F.: Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity. Journal of Parkinson's Disease: JPD 12, pp. 2397 - 2422 (2022)
40.
Journal Article
Brandenburg, S.; Drews, L.; Schönberger, H.-L.; Jacob, C. F.; Paulke, N. J.; Beuthner, B. E.; Topci, R.; Kohl, T.; Neuenroth, L.; Kutschka, I. et al.; Urlaub, H.; Kück, F.; Leha, A.; Friede, T.; Seidler, T.; Jacobshagen, C.; Toischer, K.; Puls, M.; Hasenfuß, G.; Lenz, C.; Lehnart, S. E.: Direct proteomic and high-resolution microscopy biopsy analysis identifies distinct ventricular fates in severe aortic stenosis. Journal of Molecular and Cellular Cardiology (London) 173, pp. 1 - 15 (2022)
41.
Journal Article
Giménez, E.; Urlaub, H.; Lockhart, L. J. F.: Photo-tuneable protein nitration by sensitiser tris(bipyridine)-Ruthenium(II) chloride complex. Nitric Oxide - Biology and Chemistry 129 (1), pp. 63 - 73 (2022)
42.
Journal Article
Rengachari, S.; Schilbach, S.; Kaliyappan, T.; Gouge, J.; Zumer, K.; Schwarz, J.; Urlaub, H.; Dienemann, C.; Vannini, A.; Cramer, P.: Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II. Nature Structural and Molecular Biology 29, pp. 1159 - 1169 (2022)
43.
Journal Article
Ditte, Z.; Silbern, I.; Ditte, P.; Urlaub, H.; Eichele, G.: Extracellular vesicles derived from the choroid plexus trigger the differentiation of neural stem cells. Journal of extracellular vesicles 11 (11), 12276 (2022)
44.
Journal Article
Brás, I. C.; Khani, M. H.; Riedel, D.; Parfentev, I.; Gerhardt, E.; van Riesen, C.; Urlaub, H.; Gollisch, T.; Outeiro, T. F.: Ectosomes and exosomes modulate neuronal spontaneous activity. Journal of Proteomics 269, 104721 (2022)
45.
Journal Article
Cheng, S.; Altmeppen, G.; So, C.; Welp, L.; Penir, S. M.; Ruhwedel, T.; Menelaou, K.; Harasimov, K.; Stützer, A.; Blayney, M. et al.; Elder, K.; Möbius, W.; Urlaub, H.; Schuh, M.: Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment. Science 378 (6617), eabq4835 (2022)
46.
Journal Article
Bolgi, O.; Silva-Garcia, M.; Ross, B.; Pilla, E.; Kari, V.; Killisch, M.; Spitzner, M.; Stark, N.; Lenz, C.; Weiss, K. et al.; Donzelli, L.; Gorrell, M. D.; Grade, M.; Riemer, J.; Urlaub, H.; Dobbelstein, M.; Huber, R.; Geiss-Friedlander, R.: Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair. EMBO Reports 23 (10), e54136 (2022)
47.
Journal Article
Jarausch, J.; Neuenroth, L.; Andag, R.; Leha, A.; Fischer, A.; Asif, A. R.; Lenz, C.; Eidizadeh, A.: Influence of Shear Stress, Inflammation and BRD4 Inhibition on Human Endothelial Cells: A Holistic Proteomic Approach. Cells 11 (19), 3086 (2022)
48.
Journal Article
Stejerean-Todoran, I.; Zimmermann, K.; Gibhardt, C. S.; Vultur, A.; Ickes, C.; Shannan, B.; Rio, Z. B. d.; Wölling, A.; Cappello, S.; Sung, H.-M. et al.; Shumanska, M.; Zhang, X.; Nanadikar, M.; Latif, M. U.; Wittek, A.; Lange, F.; Waters, A.; Brafford, P.; Wilting, J.; Urlaub, H.; Katschinski, D. M.; Rehling, P.; Lenz, C.; Jakobs, S.; Ellenrieder, V.; Roesch, A.; Schön, M. P.; Herlyn, M.; Stanisz, H.; Bogeski, I.: MCU controls melanoma progression through a redox-controlled phenotype switch. EMBO Reports 23, e54746 (2022)
49.
Journal Article
Krebs, T.; Kilic, I.; Neuenroth, L.; Wasselin, T.; Ninov, M.; Tetens, J.; Lenz, C.: A multiplexed parallel reaction monitoring assay to monitor bovine pregnancy-associated glycoproteins throughout pregnancy and after gestation. PLoS One 17 (9), e0271057 (2022)
50.
Journal Article
Linnemannstöns, K.; Karuna M, P.; Witte, L.; Choezom, D.; Honemann-Capito, M.; Lagurin, A. S.; Schmidt, C. V.; Shrikhande, S.; Steinmetz, L.-K.; Möbius, W. et al.; Lenz, C.; Gross, J. C.: Microscopic and biochemical monitoring of endosomal trafficking and extracellular vesicle secretion in an endogenous in vivo model. Journal of extracellular vesicles 11 (9), 12263 (2022)
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