Publikationen
Zeitschriftenartikel (389)
1.
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Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3. Neuron, In Press (2022)
2.
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12 (3), e759 (2022)
Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient‐induced pluripotent stem cell‐derived retinal pigment epithelium cells. Clinical and Translational Medicine 3.
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Database search engines and target database features impinge upon the identification of post‐translationally cis‐spliced peptides in HLA class I immunopeptidomes. Proteomics, In Press; 2100226 (2022)
4.
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22 (24), 13271 (2021)
Sequestosome 1 is part of the interaction network of VAPB. International Journal of Molecular Sciences 5.
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22 (22), 12584 (2021)
Quantitative analysis of the cardiac phosphoproteome in response to acute β-adrenergic receptor stimulation in vivo. International Journal of Molecular Sciences 6.
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374 (6569), S. 883 - 887 (2021)
Structural basis of Integrator-mediated transcription regulation. Science 7.
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184 (23), S. 5824 - 5837.e15 (2021)
An in vitro system to silence mitochondrial gene expression. Cell 8.
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12, 6152 (2021)
The RNA helicase Dbp7 promotes domain V/VI compaction and stabilization of inter-domain interactions during early 60S assembly. Nature Communications 9.
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598 (7880), S. 368 - 372 (2021)
Structural basis of human transcription–DNA repair coupling. Nature 10.
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12, 5715 (2021)
Mapping protein interactions in the active TOM-TIM23 supercomplex. Nature Communications 11.
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596 (7871), S. 296 - 300 (2021)
Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature 12.
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24 (8), S. 1151 - 1162 (2021)
A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines. Nature Neuroscience 13.
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81 (16), S. 3386 - 3399.e10 (2021)
Allosteric transcription stimulation by RNA polymerase II super elongation complex. Molecular Cell 14.
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93 (25), S. 8846 - 8855 (2021)
Evaluation and optimization of high-field asymmetric waveform ion-mobility spectrometry for multiplexed quantitative site-specific N-glycoproteomics. Analytical Chemistry 15.
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15, 643391 (2021)
Low-Expressing synucleinopathy mouse models based on oligomer-forming mutations and C-terminal truncation of α-synuclein. Frontiers in Neuroscience 16.
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12, 3672 (2021)
Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling. Nature Communications 17.
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49 (10), S. 5845 - 5866 (2021)
SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes. Nucleic Acids Research 18.
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296, 100734 (2021)
The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II. Journal of Biological Chemistry 19.
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593 (7859), S. 460 - 464 (2021)
A lysine–cysteine redox switch with an NOS bridge regulates enzyme function. Nature 20.
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206 (10), S. 2322 - 2337 (2021)
Itk promotes the integration of TCR and CD28 costimulation through its direct substrates SLP-76 and Gads. The Journal of Immunology 21.
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49 (6), S. 3507 - 3523 (2021)
Methylated HNRNPK acts on RPS19 to regulate ALOX15 synthesis in erythropoiesis. Nucleic Acids Research 22.
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12, 1830 (2021)
Translation error clusters induced by aminoglycoside antibiotics. Nature Communications 23.
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10, e63868 (2021)
Exocyst-mediated membrane trafficking of the lissencephaly-associated ECM receptor dystroglycan is required for proper brain compartmentalization. eLife 24.
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12 (1), S. 185 - 203 (2021)
Extracellular vesicles derived from neural progenitor cells: A preclinical evaluation for stroke treatment in mice. Translational Stroke Research 25.
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595 (2), S. 157 - 168 (2021)
Defining the architecture of the human TIM22 complex by chemical crosslinking. FEBS Letters 26.
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13 (1), S. 380 - 387 (2021)
Post-translational modifications soften vimentin intermediate filaments. Nanoscale 27.
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18 (12), S. 2466 - 2479 (2021)
Structural model of the M7G46 methyltransferase TrmB in complex with tRNA. RNA Biology 28.
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20, 100061 (2021)
Protein phosphorylation in depolarized synaptosomes: Dissecting primary effects of calcium from synaptic vesicle cycling. Molecular and Cellular Proteomics 29.
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370 (6523), eabc3753 (2020)
Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science 30.
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48 (22), S. 12929 - 12942 (2020)
Dual function of GTPBP6 in biogenesis and recycling of human mitochondrial ribosomes. Nucleic Acids Research 31.
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19 (12), S. 2157 - 2167 (2020)
OpenPepXL: An open-source tool for sensitive identification of cross-linked peptides in XL-MS. Molecular and Cellular Proteomics 32.
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28 (11), S. 1259 - 1268 (2020)
Toward increased reliability, transparency, and accessibility in cross-linking mass spectrometry. Structure 33.
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117 (42), S. 26318 - 26327 (2020)
Rewiring of B cell receptor signaling by Epstein–Barr virus LMP2A. Proceedings of the National Academy of Sciences of the USA 34.
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13 (654), eaba8208 (2020)
Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S. Science Signaling 35.
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11, 5250 (2020)
Analysis of protein-DNA interactions in chromatin by UV induced cross-linking and mass spectrometry. Nature Communications 36.
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80 (1), S. 127 - 139.e6 (2020)
Structural insights into the roles of metazoan-specific splicing factors in the human step 1 spliceosome. Molecular Cell 37.
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27 (10), S. 2810 - 2827 (2020)
Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo, enhances translation, and modulates splicing. Cell Death and Differentiation 38.
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13 (647), eaaz1436 (2020)
14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban. Science Signaling 39.
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6 (30), eaba3916 (2020)
Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution. Science Advances 40.
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583 (7815), S. 310 - 313 (2020)
Molecular architecture of the human 17S U2 snRNP. Nature 41.
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463 (1), S. 53 - 62 (2020)
The bicistronic gene würmchen encodes two essential components for epithelial development in Drosophila. Developmental Biology 42.
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19 (7), S. 1161 - 1178 (2020)
A Cross-linking mass spectrometry approach defines protein interactions in yeast mitochondria. Molecular and Cellular Proteomics 43.
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27 (7), S. 668 - 677 (2020)
Structure of complete Pol II–DSIF–PAF–SPT6 transcription complex reveals RTF1 allosteric activation. Nature Structural and Molecular Biology 44.
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11, 3145 (2020)
The Archaeal Proteome Project advances knowledge about archaeal cell biology through comprehensive proteomics. Nature Communications 45.
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220, 103754 (2020)
An experimentally generated peptide database increases the sensitivity of XL-MS with complex samples. Journal of proteomics 46.
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7, 146 (2020)
Large database for the analysis and prediction of spliced and non-spliced peptide generation by proteasomes. Scientific Data 47.
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180 (6), S. 1130 - 1143.e20 (2020)
Discovery of a regulatory subunit of the yeast fatty acid synthase. Cell 48.
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579 (7799), S. 448 - 451 (2020)
Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome. Nature 49.
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9 (3), 605 (2020)
Probing the environment of emerin by Enhanced ascorbate peroxidase 2 (APEX2)-mediated proximity labeling. Cells 50.
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116 (3), S. 592 - 604 (2020)
Control of p21Cip by BRAP is critical for cardiomyocyte cell cycle progression and survival. Cardiovascular Research 51.
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9 (3), 639 (2020)
Urine E-cadherin: A Marker for early detection of kidney injury in diabetic patients. Journal of Clinical Medicine 52.
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117 (6), S. 2948 - 2956 (2020)
Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2. Proceedings of the National Academy of Sciences of the United States of America 53.
Zeitschriftenartikel
18 (1), 8 (2020)
Profiling of the muscle-specific dystroglycan interactome reveals the role of Hippo signaling in muscular dystrophy and age-dependent muscle atrophy. BMC Medicine 54.
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10, 3056 (2020)
How to cope with heavy metal ions: Cellular and proteome-level stress response to divalent copper and nickel in Halobacterium salinarum R1 planktonic and biofilm cells. Frontiers in Microbiology 55.
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105 (1), S. 136 - 147 (2020)
The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin - SCL/TAL1-CD44 axis. Haematologica 56.
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577, S. 717 - 720 (2020)
Structure of the transcription coactivator SAGA. Nature 57.
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5 (12), eaay2670 (2019)
The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43. Science Advances 58.
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179 (7), S. 1537 - 1550 (2019)
Structural basis of poxvirus transcription: Vaccinia RNA polymerase complexes. Cell 59.
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10 (1), 5054 (2019)
Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP. Nature Communications 60.
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14 (12), S. 3333 - 3365 (2019)
A mass spectrometry workflow for measuring protein turnover rates in vivo. Nature Protocols 61.
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47 (19), S. 10313 - 10326 (2019)
The hRPC62 subunit of human RNA polymerase III displays helicase activity. Nucleic Acids Research 62.
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294 (44), S. 16241 - 16254 (2019)
Proteomic mapping by rapamycin-dependent targeting of APEX2 identifies binding partners of VAPB at the inner nuclear membrane. The Journal of Biological Chemistry 63.
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LEF1 supports metastatic brain colonization by regulating glutathione metabolism and increasing ROS resistance in breast cancer. International Journal of Cancer, (in press) (2019)
64.
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8 (10), 1129 (2019)
The core proteome of biofilm-grown clinical pseudomonas aeruginosa isolates. Cells 65.
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19 (20), 1840091 (2019)
The response of Haloferax volcanii to salt and temperature stress: A proteome study by label-free mass spectrometry. Proteomics 66.
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2019, 8298524 (2019)
Proteomic comparison of malignant human germ cell tumor cell lines. Disease Markers 67.
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8, e47498 (2019)
Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity. eLife 68.
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140 (8), S. 681 - 693 (2019)
Loss of protein phosphatase 1 regulatory subunit PPP1R3A promotes atrial fibrillation. Circulation 69.
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27 (8), S. 1195 - 1210 (2019)
Autoinhibition mechanism of the ubiquitin-conjugating enzyme UBE2S by autoubiquitination. Structure 70.
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431 (15), S. 2835 - 2851 (2019)
A MICOS-TIM22 association promotes carrier import into human mitochondria. Journal of Molecular Biology 71.
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10, 2885 (2019)
Structural basis of TFIIH activation for nucleotide excision repair. Nature Communications 72.
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A trap mutant reveals the physiological client spectrum of TRC40. Journal of Cerll Science, (in press) (2019)
73.
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18 (6), S. 1197 - 1209 (2019)
Hypoxia-induced changes in SUMO conjugation affect transcriptional regulation under low oxygen. Molecular and Cellular Proteomics 74.
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47 (6), S. 2932 - 2945 (2019)
Broad range of missense error frequencies in cellular proteins. Nucleic Acids Research 75.
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16 (4), S. 557 - 565 (2019)
Stable maintenance of the rudivirus SIRV3 in a carrier state in Sulfolobus islandicus despite activation of the CRISPR-Cas immune response by a second virus SMV1. RNA Biology 76.
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9 (1), 4188 (2019)
Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures. Scientific Reports 77.
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216 (3), 704 (2019)
Human colon organoids reveal distinct physiologic and oncogenic Wnt responses. Journal of Experimental Medicine 78.
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218 (2), 598 (2019)
ROMO1 is a constituent of the human presequence translocase required for YME1L protease import. The Journal of Cell Biology 79.
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16 (4), S. 469 - 480 (2019)
The nuts and bolts of the Haloferax CRISPR-Cas system I-B. RNA Biology 80.
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13 (3), 1800083 (2019)
Proteome profiling by label‐free mass spectrometry reveals differentiated response of Campylobacter jejuni 81–176 to sublethal concentrations of bile acids. Proteomics 81.
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10, 2572 (2019)
An in silico-in vitro pipeline identifying an HLA-A*02:01+ KRAS G12V+ spliced epitope candidate for a broad tumor-immune response in cancer patients. Frontiers in Immunology 82.
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4 (1), S. 89 - 96 (2019)
Type IV CRISPR RNA processing and effector complex formation in Aromatoleum aromaticum. Nature Microbiology 83.
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25 (13), S. 3618 - 3630 (2018)
Plk1/Polo phosphorylates Sas-4 at the onset of mitosis for an efficient recruitment of pericentriolar material to centrosomes. Cell Reports 84.
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9, 5383 (2018)
RNA helicases mediate structural transitions and compositional changes in pre-ribosomal complexes. Nature Communications 85.
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46 (22), S. 12109 - 12125 (2018)
Identification of new high affinity targets for Roquin based on structural conservation. Nucleic Acids Research 86.
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Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells. The EMBO Journal, In press (e99876) (2018)
87.
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8, 16913 (2018)
The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain. Scientific Reports 88.
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9, 4532 (2018)
Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex. Nature Communications 89.
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9, 4234 (2018)
Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa. Nature Communications 90.
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9, 4230 (2018)
Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions. Nature Communications 91.
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46 (16), S. 8471 - 8482 (2018)
The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis. Nucleic Acids Research 92.
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13, S. 26 - 38 (2018)
Crohn's disease patient serum changes protein expression in a human mesenchymal stem cell model in a linear relationship to patients' disease stage and to bone mineral density. Journal of Clinical and Translational Endocrinology 93.
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10 (9), e8428 (2018)
Comparative proteomics reveals a diagnostic signature for pulmonary head-and-neck cancer metastasis. EMBO Molecular Medicine 94.
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560 (7720), S. 607 - 612 (2018)
Structure of activated transcription complex Pol II-DSIF-PAF-SPT6. Nature 95.
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560 (7720), S. 601 - 606 (2018)
Structure of paused transcription complex Pol II–DSIF–NELF. Nature 96.
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28 (13), S. 2046 - 2057 (2018)
Endogenous stochastic decoding of the CUG codon by competing Ser- and Leu-tRNAs in Ascoidea asiatica. Current Biology 97.
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217 (7), S. 2329 - 2340 (2018)
Xpo7 is a broad-spectrum exportin and a nuclear import receptor. Journal of Cell Biology 98.
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3 (12), e99941 (2018)
Deep phenotyping of human induced pluripotent stem cell-derived atrial and ventricular cardiomyocytes. JCI Insight 99.
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8, 8880 (2018)
Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine. Scientific Reports