Bioanalytical Mass Spectrometry

The Bioanalytical Mass Spectrometry group works on the analysis of proteins and protein complexes, and on interactions between proteins and nucleic acids, using state-of-the-art mass spectrometric instrumentation. We analyze our samples mainly using electrospray ionisation (ESI) and in special cases matrix-assisted laser desorption/ionisation (MALDI) mass spectrometry. 

Our central research projects are the sensitive high-throughput analysis of proteins (proteomics), the detection of post-translational modifications in proteins and the mass-spectrometric quantification of proteins. Furthermore, we investigate structural aspects of proteins by the mass spectrometric analysis of protein-protein and protein-nucleic acid interactions.

The Bioanalytical Mass Spectrometry group is involved in several collaborative research projects within the Max Planck Institute for Multidisciplinary Sciences. The group does also provides all modern types of mass spectrometric protein analysis as a Core Facility for Proteomics for all researchers at the Max Planck Institute for Multidisciplinary Sciences. Furthermore, the group has a successful, long-term external collaboration with the Center for Internal Medicine at the University Hospital Frankfurt/Main.

In addition, the Bioanalytical Mass Spectrometry group has a branch laboratory, consisting of the Proteomics Resarch Group and the Proteomics Service Facility, at the Institute for Clinical Chemistry at the University Medical Center Göttingen. The Proteomics Service Facility provides mass spectrometric services for the University Medical Center Göttingen and the Medical Faculty and the Proteomics Research Group works independently on clinically relevant research projects.

Press releases & research news

Modular design: New insights into protein factories in human mitochondria

The “power plants” of living cells, the mitochondria, provide the necessary energy, among other things Mitochondria produce some of the proteins required for this themselves – with the help of special protein factories, the mitoribosomes. Researchers in Göttingen have now deciphered how the human cell assembles the mitoribosomes, which consist of proteins and RNA, in a modular fashion. more

Egg cell maintenance: Long-lived proteins may be essential

Female mammals, including humans, are born with all of their egg cells. Some egg cells therefore survive for several decades – and need to remain functional over this long time. Extremely long-lived proteins in the ovary seem to play an important role in this and may help maintain fertility for as long as possible. more

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