Max Planck Institute for Multidisciplinary Sciences

Publications

Journal Article (119)

1.

Journal Article

Scodellaro, R.; Zschüntzsch, J.; Hell, A.-K.; Alves, F.: A first explainable-AI-based workflow integrating forward-forward and backpropagation-trained networks of label-free multiphoton microscopy images to assess human biopsies of rare neuromuscular disease. Computer Methods and Programs in Biomedicine 265, 108733 (2025)

MPG.PuRe

publisher-version

2.

Journal Article

Ferrari, D. P.; Cobanoglu, O.; Sayedipour, S.; Luna, O.; Ferkel, S. A. M.; Agorku, D.; Perez, Y.; Cruz, L. J.; Albericio, F.; Trottein, F. et al.; Alves, F.; Markus, M. A.; Ramos Gomes, F.: Anti-Tumor Efficacy of a Mesothelin-Based Nanovaccine in a KPC Orthotopic Mouse Model of Pancreatic Cancer. Vaccines 13 (3), 314 (2025)

MPG.PuRe

publisher-version

3.

Journal Article

Sagar, M. M. R.; D'Amico, L.; Longo, E.; Persson, I. M.; Deyhle, R.; Tromba, G.; Bayat, S.; Alves, F.; Dullin, C.: Air artifact suppression in phase contrast micro-CT using conditional generative adversarial networks. Journal of Synchrotron Radiation (accepted)

MPG.PuRe

4.

Journal Article

Dullin, C.; Alves, F.: Einsatz von künstlicher Intelligenz in der Endoskopie zur Analyse von Gewebebiopsien. Die Gastroenterologie 20, pp. 44 - 53 (2025)

MPG.PuRe

5.

Journal Article

Ferreira, N.; Kulkarni, A.; Agorku, D.; Midelashvili, T.; Hardt, O.; Legler, T. J.; Ströbel, P.; Conradi, L.-C.; Alves, F.; Ramos Gomes, F. et al.; Markus, M. A.: OrganoIDNet: a deep learning tool for identification of therapeutic effects in PDAC organoid-PBMC co-cultures from time-resolved imaging data. Cellular Oncology 48, pp. 101 - 122 (2025)

MPG.PuRe

publisher-version

6.

Journal Article

Frohn, J.; Böddeker, F.; Reichardt, M.; Bruns, H.; Czajka, T.; Khan, A.; Broche, L.; Krisch, M.; Bravin, A.; Alves, F. et al.; Zschüntzsch, J.; Salditt, T.: Three-dimensional structure of entire hydrated murine hearts at histological resolution. Scientific Reports 15, 2766 (2025)

MPG.PuRe

publisher-version

7.

Journal Article

Papantonis, A.; Rogalla, S.; Dullin, C.; Alves, F.; Bohnenberger, H.: Neue Methoden am Übergang von der Forschung in die Routinediagnostik. Die Pathologie (2025)

MPG.PuRe

8.

Journal Article

Nolte, P.; Gröger, C. J.; Frey, C.; Richter, H.; Will, F.; Bäuerle, T.; Schilling, A. F.; Alves, F.; Rußmann, C.; Dullin, C.: Automated Targeted Sectioning of Resin-embedded Hard Tissue Specimen Using Micro-computed Tomography in Combination with Laser Microtomy. IEEE Transactions on Biomedical Engineering (2025)

MPG.PuRe

9.

Journal Article

Napp, J.; Siebel, P.; Rausch, H.; Kuchta, K.; Efferth, T.; Alves, F.; Ellenrieder, V.; Cameron, S.: Prolonged survival by combination treatment with a standardized herbal extract from Japanese Kampo-medicine (Juzentaihoto) and gemcitabine in an orthotopic transplantation pancreatic cancer model. Frontiers in Oncology 14, 1454291 (2024)

MPG.PuRe

publisher-version

10.

Journal Article

Notter, S.; Choezom, D.; Griebel, T.; Ramos Gomes, F.; Möbius, W.; De Oliveira, T.; Conradi, L.-C.; Alves, F.; Feldmann, C.: High-Load Core@Shell Nanocarriers with Irinotecan and 5-Fluorouracil for Combination Chemotherapy in Colorectal Cancer. Small Science 4 (11), 2400196 (2024)

MPG.PuRe

publisher-version

11.

Journal Article

Arora, B.; Kulkarni, A.; Markus, M. A.; Ramos Gomes, F.; Bohnenberger, H.; Ströbel, P.; Alves, F.; Klein, O.: MALDI imaging combined with two-photon microscopy reveals local differences in the heterogeneity of colorectal cancer. npj Imaging 2, 35 (2024)

MPG.PuRe

publisher-version

12.

Journal Article

Tan, L.; Zschüntzsch, J.; Meyer, S.; Stobbe, A.; Bruex, H.; Regensburger, A. P.; Claßen, M.; Alves, F.; Jüngert, J.; Rother, U. et al.; Li, Y.; Danko, V.; Lang, W.; Türk, M.; Schmidt, S.; Vorgerd, M.; Schlaffke, L.; Woelfle, J.; Hahn, A.; Mensch, A.; Winterholler, M.; Trollmann, R.; Heiß, R.; Wagner, A. L.; Raming, R.; Knieling, F.: Non-invasive optoacoustic imaging of glycogen-storage and muscle degeneration in late-onset Pompe disease. Nature Communications 15, 7843 (2024)

MPG.PuRe

publisher-version

13.

Journal Article

Agorku, D. J.; Bosio, A.; Alves, F.; Ströbel, P.; Hardt, O.: Colorectal cancer-associated fibroblasts inhibit effector T cells via NECTIN2 signaling. Cancer Letters 595, 216985 (2024)

MPG.PuRe

publisher-version

14.

Journal Article

Kulkarni, A.; Ferreira, N.; Scodellaro, R.; Choezom, D.; Alves, F.: A Curated Cell Life Imaging Dataset of Immune-enriched Pancreatic Cancer Organoids with Pre-trained AI Models. Scientific Data 11, 820 (2024)

MPG.PuRe

publisher-version

15.

Journal Article

Sabljo, K.; Ischyropoulou, M.; Napp, J.; Alves, F.; Feldmann, C.: High-load nanoparticles with a chemotherapeutic SN-38/FdUMP drug cocktail. Nanoscale 16, pp. 14853 - 14860 (2024)

MPG.PuRe

publisher-version

16.

Journal Article

Ferrari, D. P.; Ramos Gomes, F.; Alves, F.; Markus, M. A.: KPC-luciferase-expressing cells elicit an anti-tumor immune response in a mouse model of pancreatic cancer. Scientific Reports 14, 13602 (2024)

MPG.PuRe

publisher-version

17.

Journal Article

Arora, B.; Kulkarni, A.; Markus, M. A.; Ströbel, P.; Bohnenberger, H.; Alves, F.; Ramos-Gomes, F.: Label-free quantification of imaging features in the extracellular matrix of left and right-sided colon cancer tissues. Scientific Reports 14, 7510 (2024)

MPG.PuRe

publisher-version

18.

Journal Article

Dullin, C.; Albers , J.; Tagat, A.; Lorenzon, A.; D'Amico, L.; Chiriotti, S.; Sodini, N.; Dreossi, D.; Alves, F.; Bergamaschi, A. et al.; Tromba, G.: In vivo low-dose phase-contrast CT for quantification of functional and anatomical alterations in lungs of an experimental allergic airway disease mouse model. Frontiers in medicine 11, 1338846 (2024)

MPG.PuRe

publisher-version

19.

Journal Article

D'Amico, L.; Svetlove, A.; Longo, E.; Meyer, R.; Senigagliesi, B.; Saccomano, G.; Nolte, P.; Wagner, W. L.; Wielpuetz, M. O.; Leitz, D. H. W. et al.; Duerr, J.; Mall, M. A.; Casalis, L.; Köster, S.; Alves, F.; Tromba, G.; Dullin, C.: Characterization of transient and progressive pulmonary fibrosis by spatially correlated phase contrast microCT, classical histopathology and atomic force microscopy. Computers in Biology and Medicine 169, 107947 (2024)

MPG.PuRe

20.

Journal Article

Luna, O. F.; Perez, Y. V.; Ferrari, D. P.; Sayedipour, S. S.; Royo, M.; Acosta, G. A.; Cruz, L. J.; Alves, F.; Agner, E.; Sydnes, M. O. et al.; Albericio, F.: Impact of N-Terminal PEGylation on Synthesis and Purification of Peptide-Based Cancer Epitopes for Pancreatic Ductal Adenocarcinoma (PDAC). ACS Omega 9 (32), pp. 34544 - 34554 (2024)

MPG.PuRe

publisher-version

21.

Journal Article

Rudolph, D.; Ischyropoulou, M.; Pfeifer, J.; Napp, J.; Schepers, U.; Alves, F.; Feldmann, C.: Cocktail of lipophilic and hydrophilic chemotherapeutics in high-load core@shell nanocarriers to treat pancreatic tumours. Nanoscale Advances 6, pp. 973 - 984 (2024)

MPG.PuRe

publisher-version

22.

Journal Article

Sagar, M. M. R.; Svetlove, A.; D’Amico, L.; Pinkert-Leetsch, D.; Missbach-Guentner, J.; Longo, E.; Tromba, G.; Bohnenberger, H.; Alves, F.; Dullin, C.: Optical clearing: an alternative sample preparation method for propagation based phase contrast μCT. Frontiers in Physics 12, 1433895 (2024)

MPG.PuRe

publisher-version

23.

Journal Article

Cobanoglu, O.; Delval, L.; Ferrari, D. P.; Deruyter, L.; Heumel, S.; Wolowczuk, I.; Hussein, A.; Menevse, A. N.; Bernard, D.; Beckhove, P. et al.; Alves, F.; Trottein, F.: Depletion of preexisting B-cell lymphoma 2-expressing senescent cells before vaccination impacts antigen-specific antitumor immune responses in old mice. Aging Cell 22 (12), e14007 (2023)

MPG.PuRe

publisher-version

24.

Journal Article

Garnier, N.; Berghout, J.; Zygmunt, A.; Singh, D.; Huang, K. A.; Kantz, W.; Blankart, C. R.; Gillner, S.; Zhao, J.; Roettger, R. et al.; Saier, C.; Kirschner, J.; Schenk, J.; Atkins, L.; Ryan, N.; Zarakowska, K.; Zschuentzsch, J.; Zuccolo, M.; Muellenborn, M.; Man, Y.-S.; Goodman, L.; Trad, M.; Chalandon, A. S.; Sansen, S.; Martinez-Fresno, M.; Badger, S.; Walther van Olden, R.; Rothmann, R.; Lehner, P.; Tschohl, C.; Baillon, L.; Gumus, G.; Gross, E.; Stefanov, R.; Iskrov, G.; Raycheva, R.; Kostadinov, K.; Mitova, E.; Einhorn, M.; Einhorn, Y.; Schepers, J.; Huebner, M.; Alves, F.; Iskandar, R.; Mayer, R.; Renieri, A.; Piperkova, A.; Gut, I.; Beltran, S.; Matthiesen, M. E.; Poetz, M.; Hansson, M.; Trollmann, R.; Agolini, E.; Ottombrino, S.; Novelli, A.; Bertini, E.; Selvatici, R.; Farne, M.; Fortunato, F.; Ferlini, A.: Genetic newborn screening and digital technologies: A project protocol based on a dual approach to shorten the rare diseases diagnostic path in Europe. PLOS ONE 18 (11), e0293503 (2023)

MPG.PuRe

publisher-version

25.

Journal Article

Ischyropoulou, M.; Sabljo, K.; Schneider, L.; Niemeyer, C. M.; Napp, J.; Feldmann, C.; Alves, F.: High‐Load Gemcitabine Inorganic–Organic Hybrid Nanoparticles as an Image‐Guided Tumor‐Selective Drug‐Delivery System to Treat Pancreatic Cancer. Advanced Materials 35 (46), 2305151 (2023)

MPG.PuRe

publisher-version

26.

Journal Article

Khan, A.; Markus, M. A.; Svetlove, A.; Hülsmann, S.; Alves, F.; Dullin, C.: Longitudinal x-ray based lung function measurement for monitoring Nintedanib treatment response in a mouse model of lung fibrosis. Scientific Reports 13 (1), 18637 (2023)

MPG.PuRe

publisher-version

27.

Journal Article

Nolte, P.; Brettmacher, M.; Gröger, C. J.; Gellhaus, T.; Svetlove, A.; Schilling, A. F.; Alves, F.; Russmann, C.; Dullin, C.: Spatial correlation of 2D hard-tissue histology with 3D microCT scans through 3D printed phantoms. Scientific Reports 13 (1), 18479 (2023)

MPG.PuRe

publisher-version

28.

Journal Article

Markus, M. A.; Ferrari, D. P.; Alves, F.; Ramos Gomes, F.: Effect of tissue fixation on the optical properties of structural components assessed by non-linear microscopy imaging. Biomedical Optics Express 14 (8), pp. 3988 - 4002 (2023)

MPG.PuRe

publisher-version

29.

Journal Article

Pinkert-Leetsch, D.; Frohn, J.; Ströbel, P.; Alves, F.; Salditt, T.; Missbach-Guentner, J.: Three-dimensional analysis of human pancreatic cancer specimens by phase-contrast based X-ray tomography – the next dimension of diagnosis. Cancer Imaging 23, 43 (2023)

MPG.PuRe

publisher-version

30.

Journal Article

Pantelaiou-Prokaki, G.; Reinhardt, O.; Georges, N. S.; Agorku, D. J.; Hardt, O.; Prokakis, E.; Mieczkowska, I. K.; Deppert, W.; Wegwitz, F.; Alves, F.: Basal-like mammary carcinomas stimulate cancer stem cell properties through AXL-signaling to induce chemotherapy resistance. International Journal of Cancer 152 (9), pp. 1916 - 1932 (2023)

MPG.PuRe

publisher-version

31.

Journal Article

Czaplinska, D.; Ialchina, R.; Andersen, H. B.; Yao, J.; Stigliani, A.; Dannesboe, J.; Flinck, M.; Chen, X.; Mitrega, J.; Gnosa, S. P. et al.; Dmytriyeva, O.; Alves, F.; Napp, J.; Sandelin, A.; Pedersen, S. F.: Crosstalk between tumor acidosis, p53 and extracellular matrix regulates pancreatic cancer aggressiveness. International Journal of Cancer 152 (6), pp. 1210 - 1225 (2023)

MPG.PuRe

publisher-version

32.

Journal Article

Albers, J.; Wagner, W. L.; Fiedler, M. O.; Rothermel, A.; Wuennemann, F.; Di Lillo, F.; Dreossi, D.; Sodini, N.; Baratella, E.; Confalonieri, M. et al.; Arfelli, F.; Kalenka, A.; Lotz, J.; Biederer, J.; Wielpuetz, M. O.; Kauczor, H.-U.; Alves, F.; Tromba, G.; Dullin, C.: High resolution propagation-based lung imaging at clinically relevant X-ray dose levels. Scientific Reports 13 (1), 4788 (2023)

MPG.PuRe

publisher-version

33.

Journal Article

Khorenko, M.; Pfeifer, J.; Napp, J.; Meschkov, A.; Alves, F.; Schepers, U.; Feldmann, C.: Theranostic inorganic–organic hybrid nanoparticles with a cocktail of chemotherapeutic and cytostatic drugs. Journal of Materials Chemistry B 11, pp. 3635 - 3649 (2023)

MPG.PuRe

publisher-version

34.

Journal Article

Nolte, P.; Dullin, C.; Svetlove, A.; Brettmacher, M.; Russmann, C.; Schilling, A. F.; Alves, F.; Stock, B.: Current Approaches for Image Fusion of Histological Data with Computed Tomography and Magnetic Resonance Imaging. Radiology Research and Practice 2022, 6765895 (2022)

MPG.PuRe

publisher-version

35.

Journal Article

Ritschel, C.; Napp, J.; Alves, F.; Feldmann, C.: Monitoring nanoparticle dissolution via fluorescence-colour shift. Nanoscale 14 (43), pp. 16249 - 16255 (2022)

MPG.PuRe

publisher-version

36.

Journal Article

Pinkert-Leetsch, D.; Rost, J. U.; Schmiedeknecht, M. U. H.; Stadelmann, C.; Alves, F.; Missbach-Guentner, J.: The murine male reproductive organ at a glance: Three-dimensional insights and virtual histology using label-free light sheet microcopy. Andrology 10 (8), pp. 1660 - 1672 (2022)

MPG.PuRe

publisher-version

37.

Journal Article

Werner, M.; Dyas, A.; Parfentev, I.; Schmidt, G. E.; Mieczkowska, I. K.; Müller-Kirschbaum, L. C.; Müller, C.; Kalkhof, S.; Reinhardt, O.; Urlaub, H. et al.; Alves, F.; Gallwas, J.; Prokakis, E.; Wegwitz, F.: ROBO3s: a novel ROBO3 short isoform promoting breast cancer aggressiveness. Cell Death and Disease 13, 762 (2022)

MPG.PuRe

publisher-version

38.

Journal Article

Dullin, C.; Svetlove, A.; Zschuntzsch, J.; Alves, F.: Simultaneous assessment of lung morphology and respiratory motion in retrospectively gated in-vivo microCT of free breathing anesthetized mice. Scientific Reports 12 (1), 13299 (2022)

MPG.PuRe

publisher-version

39.

Journal Article

Pfeifer, R.; Henze, J.; Wittich, K.; Gosselink, A.; Kinkhabwala, A.; Gremse, F.; Bleilevens, C.; Bigott, K.; Jungblut, M.; Hardt, O. et al.; Alves, F.; Al Rawashdeh, W.: A multimodal imaging workflow for monitoring CAR T cell therapy against solid tumor from whole-body to single-cell level. Theranostics 12 (11), pp. 4834 - 4850 (2022)

MPG.PuRe

publisher-version

40.

Journal Article

Hermasch, M. A.; Janning, H.; Perera, R. P.; Schnabel, V.; Rostam, N.; Ramos Gomes, F.; Muschalek, W.; Bennemann, A.; Alves, F.; Ralser, D. J. et al.; Betz, R. C.; Schön, M. P.; Dosch, R.; Frank, J.: Evolutionary distinct roles of γ-secretase subunit nicastrin in zebrafish and humans. Journal of Dermatological Science 105 (2), pp. 80 - 87 (2022)

MPG.PuRe

41.

Journal Article

Ramos-Gomes, F.; Ferreira, N.; Alves, F.; Markus, M. A.: An alternative technique for monitoring the live interaction of monocytes and tumor cells with nanoparticles in the mouse lung. Bio-protocol 12 (2), e4293 (2022)

MPG.PuRe

42.

Journal Article

Sabljo, K.; Napp, J.; Alves, F.; Feldmann, C.: pH-Dependent fluorescence of [La(OH)₂]⁺[ARS]^- hybrid nanoparticles for intracellular pH-sensing. Chemical Communications 58 (67), pp. 9417 - 9420 (2022)

MPG.PuRe

publisher-version

43.

Journal Article

Svetlove, A.; Albers, J.; Huelsmann, S.; Markus, M. A.; Zschuentzsch, J.; Alves, F.; Dullin, C.: Non-Invasive Optical Motion Tracking Allows Monitoring of Respiratory Dynamics in Dystrophin-Deficient Mice. Cells 11 (5), 918 (2022)

MPG.PuRe

publisher-version

44.

Journal Article

Khan, A.; Ramos Gomes, F.; Markus, M. A.; Mietsch, M.; Hinkel, R.; Alves, F.: Label-free imaging of age-related cardiac structural changes in non-human primates using multiphoton nonlinear microscopy. Biomedical Optics Express (2021)

MPG.PuRe

45.

Journal Article

Götze, T.; Soto-Bernardini, M. C.; Zhang, M.; Mießner, H.; Linhoff, L.; Brzózka, M. M.; Velanac, V.; Dullin, C.; Ramos Gomes, F.; Peng, M. et al.; Husseini, H.; Schifferdecker, E.; Fledrich, R.; Sereda, M. W.; Willig, K.; Alves, F.; Rossner, M. J.; Nave, K.-A.; Zhang, W.; Schwab, M. H.: Hyperactivity is a Core Endophenotype of Elevated Neuregulin-1 Signaling in Embryonic Glutamatergic Networks. SCHIZOPHRENIA BULLETIN 47 (5), pp. 1409 - 1420 (2021)

MPG.PuRe

46.

Journal Article

Sier, V. Q.; de Vries, M. R.; van der Vorst, J. R.; Vahrmeijer, A. L.; van Kooten, C.; Cruz, L. J.; de Geus-Oei, L.-F.; Ferreira, V.; Sier, C. F. M.; Alves, F. et al.; Muthana, M.: Cell-based tracers as trojan horses for image-guided surgery. International Journal of Molecular Sciences 22 (2), 755 (2021)

MPG.PuRe

publisher-version

47.

Journal Article

Albers, J.; Svetlove, A.; Alves, J.; Kraupner, A.; di Lillo, F.; Markus, A.; Tromba, G.; Alves, F.; Dullin, C.: Elastic transformation of histological slices allows precise co-registration with microCT data sets for a refined virtual histology approach. Scientific Reports 11, 10846 (2021)

MPG.PuRe

48.

Journal Article

Dullin, C.; di Lillo, F.; Svetlove, A.; Albers, J.; Wagner, W.; Markus, A.; Sodini, N.; Dreossi, D.; Alves, F.; Tromba, G.: Multiscale biomedical imaging at the SYRMEP beamline of Elettra - Closing the gap between preclinical research and patient applications. Physics Open 6, 100050, p. 100050 (2021)

MPG.PuRe

49.

Journal Article

Khan, A.; Markus, A.; Rittmann, T.; Albers, J.; Alves, F.; Hülsmann, S.; Dullin, C.: Simple low dose radiography allows precise lung volume assessment in mice. Scientific Reports 11, 4163 (2021)

MPG.PuRe

50.

Journal Article

Ramos Gomes, F.; Ferreira, N.; Kraupner, A.; Alves, F.; Markus, A.: Ex vivo Live Cell Imaging of Nanoparticle-Cell Interactions in the Mouse Lung. Frontiers in Bioengineering and Biotechnology 8 (2020)

MPG.PuRe

publisher-version