Max-Planck-Institut für Multidisziplinäre Naturwissenschaften

Publikationen

Zeitschriftenartikel (129)

1.

Zeitschriftenartikel

Ferreira, N.; Agorku, D.; Rosa, A.; Roosz, J.; Christ, L.; Anderle, N.; Kulkarni, A.; Hussein, A.; Sayedipour, S. S.; Luna, O. F. et al.; Legler, T.; Ströbel, P.; Albericio, F.; Cruz, L.; Beckhove, P.; Loskill, P.; Alves, F.; Markus, M. A.; Ramos-Gomes, F.: Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines. Advanced Science (2025)

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2.

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Choezom, D.; Notter, S.; Griebel, T.; Ferreira, N.; Gruetz, J.; Kulkarni, A.; Schröter, M.; Lukinavičius, G.; Möbius, W.; Conradi, L.-C. et al.; Feldmann, C.; Alves, F.: Macropinocytic Uptake and pH-Responsive Endolysosomal Processing Drive Sustained Chemotherapeutic Efficacy of High-Load Core@Shell Nanocarriers in Colorectal Cancer. Small Science (2025)

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3.

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Scodellaro, R.; Kulkarni, A.; Alves, F.; Schröter, M.: Training convolutional neural networks with the Forward–Forward Algorithm. Scientific Reports 15, 38461 (2025)

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4.

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Herbsleb, L.; Wild, D.; Gröger, H.; Schubert, T.; Steyer, A. M.; Hennies, J.; Alves, F.; Feldmann, C.; Walter, A.: 3D correlative light and electron microscopy reveals the uptake and processing of inorganic-organic hybrid nanoparticles into cancer cells. Nanomedicine: Nanotechnology, Biology and Medicine 70, 102872 (2025)

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5.

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Rodriguez, G. G.; von Petersdorff-Campen, C.; Korchak, S.; Sucre, O.; Santi, M. D.; Elsasser, J.; Mei, R.; Fries, L. M.; Felger, J.; Markus, A. et al.; Alves, F.; Glöggler, S.: Biological J-Coupling Spectroscopy at Low Magnetic Field. Small Science 5 (11), 2500268 (2025)

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6.

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Dullin, C.; Reiser, J.; Wagner, W. L.; Longo, E.; Prašek, M.; Contillo, A.; Sodini, N.; Dreossi, D.; Confalonieri, P.; Salton, F. et al.; Confalonieri, M.; Baratella, E.; Cova, M. A.; Benke, C. V.; Sagar, M. M. R.; D’Amico, L.; Albers, J.; Svetlove, A.; Duke, E.; Flisikowska, T.; Flisikowski, K.; Wielpütz, M. O.; Biederer, J.; Kauczor, H.-U.; Alves, F.; Zanconati, F.; Tromba, G.: Formaldehyde vapour fixation enables multiscale phase-contrast imaging and histological validation of human-sized lungs. Scientific Reports 15, 36475 (2025)

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7.

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Rudraiah, P. S.; Herbsleb, L.; Salakova, M.; Gröger, H.; Steyer, A. M.; Alves, F.; Feldmann, C.; Walter, A.: Combining Correlative Cryogenic Fluorescence and Electron Microscopy and Correlative Cryogenic Super-Resolution Fluorescence and X-Ray Tomography-Novel Complementary 3D Cryo-Microscopy Across Scales to Reveal Nanoparticle Internalization Into Cancer Cells. Microscopy Research and Technique (2025)

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8.

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Sokke Rudraiah, P.; Herbsleb, L.; Salakova, M.; Gröger, H.; Steyer, A. M.; Alves, F.; Feldmann, C.; Walter, A.: Combining Correlative Cryogenic Fluorescence and Electron Microscopy and Correlative Cryogenic Super‐Resolution Fluorescence and X‐Ray Tomography—Novel Complementary3DCryo‐Microscopy Across Scales to Reveal Nanoparticle Internalization Into Cancer Cells. Microscopy Research and Technique (2025)

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9.

Zeitschriftenartikel

Kiszka, K. A.; Dullin, C.; Steffens, H.; Koenen, T.; Rothermel, E.; Alves, F.; Gregor, C.: Autonomous bioluminescence emission from transgenic mice. Science Advances 11 (28), eads0463 (2025)

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10.

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Scodellaro, R.; Zschüntzsch, J.; Hell, A.-K.; Alves, F.: A first explainable-AI-based workflow integrating forward-forward and backpropagation-trained networks of label-free multiphoton microscopy images to assess human biopsies of rare neuromuscular disease. Computer Methods and Programs in Biomedicine 265, 108733 (2025)

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11.

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Albers, J.; Markus, A.; Svetlove, A.; Kraupner, A.; Briel, A.; Alves, F.; Dullin, C.: Barium nanoparticles enhance efficacy of external beam radiation therapy in a preclinical basal-like mammary cancer mouse model. Scientific Reports 15, 19090 (2025)

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12.

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Papantonis, A.; Rogalla, S.; Dullin, C.; Alves, F.; Bohnenberger, H.: Neue Methoden am Übergang von der Forschung in die Routinediagnostik. Die Pathologie 46, S. 156 - 162 (2025)

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13.

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Sagar, M. M. R.; D'Amico, L.; Longo, E.; Persson, I. M.; Deyhle, R.; Tromba, G.; Bayat, S.; Alves, F.; Dullin, C.: Air artifact suppression in phase contrast micro-CT using conditional generative adversarial networks. Journal of Synchrotron Radiation 32 (3), S. 678 - 689 (2025)

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14.

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Ferrari, D. P.; Çobanoglu, Ö.; Sayedipour, S.; Luna, O.; Ferkel, S. A. M.; Agorku, D.; Perez, Y.; Cruz, L. J.; Albericio, F.; Trottein, F. et al.; Alves, F.; Markus, M. A.; Ramos Gomes, F.: Anti-Tumor Efficacy of a Mesothelin-Based Nanovaccine in a KPC Orthotopic Mouse Model of Pancreatic Cancer. Vaccines 13 (3), 314 (2025)

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15.

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Dullin, C.; Alves, F.: Einsatz von künstlicher Intelligenz in der Endoskopie zur Analyse von Gewebebiopsien. Die Gastroenterologie 20, S. 44 - 53 (2025)

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16.

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Ferreira, N.; Kulkarni, A.; Agorku, D.; Midelashvili, T.; Hardt, O.; Legler, T. J.; Ströbel, P.; Conradi, L.-C.; Alves, F.; Ramos Gomes, F. et al.; Markus, M. A.: OrganoIDNet: a deep learning tool for identification of therapeutic effects in PDAC organoid-PBMC co-cultures from time-resolved imaging data. Cellular Oncology 48, S. 101 - 122 (2025)

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17.

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Frohn, J.; Böddeker, F.; Reichardt, M.; Bruns, H.; Czajka, T.; Khan, A.; Broche, L.; Krisch, M.; Bravin, A.; Alves, F. et al.; Zschüntzsch, J.; Salditt, T.: Three-dimensional structure of entire hydrated murine hearts at histological resolution. Scientific Reports 15, 2766 (2025)

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18.

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Nolte, P.; Gröger, C. J.; Frey, C.; Richter, H.; Will, F.; Bäuerle, T.; Schilling, A. F.; Alves, F.; Rußmann, C.; Dullin, C.: Automated Targeted Sectioning of Resin-embedded Hard Tissue Specimen Using Micro-computed Tomography in Combination with Laser Microtomy. IEEE Transactions on Biomedical Engineering 72 (6), S. 1931 - 1940 (2025)

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19.

Zeitschriftenartikel

Napp, J.; Siebel, P.; Rausch, H.; Kuchta, K.; Efferth, T.; Alves, F.; Ellenrieder, V.; Cameron, S.: Prolonged survival by combination treatment with a standardized herbal extract from Japanese Kampo-medicine (Juzentaihoto) and gemcitabine in an orthotopic transplantation pancreatic cancer model. Frontiers in Oncology 14, 1454291 (2024)

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20.

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Notter, S.; Choezom, D.; Griebel, T.; Ramos Gomes, F.; Möbius, W.; De Oliveira, T.; Conradi, L.-C.; Alves, F.; Feldmann, C.: High-Load Core@Shell Nanocarriers with Irinotecan and 5-Fluorouracil for Combination Chemotherapy in Colorectal Cancer. Small Science 4 (11), 2400196 (2024)

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21.

Zeitschriftenartikel

Arora, B.; Kulkarni, A.; Markus, M. A.; Ramos Gomes, F.; Bohnenberger, H.; Ströbel, P.; Alves, F.; Klein, O.: MALDI imaging combined with two-photon microscopy reveals local differences in the heterogeneity of colorectal cancer. npj Imaging 2, 35 (2024)

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22.

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Tan, L.; Zschüntzsch, J.; Meyer, S.; Stobbe, A.; Bruex, H.; Regensburger, A. P.; Claßen, M.; Alves, F.; Jüngert, J.; Rother, U. et al.; Li, Y.; Danko, V.; Lang, W.; Türk, M.; Schmidt, S.; Vorgerd, M.; Schlaffke, L.; Woelfle, J.; Hahn, A.; Mensch, A.; Winterholler, M.; Trollmann, R.; Heiß, R.; Wagner, A. L.; Raming, R.; Knieling, F.: Non-invasive optoacoustic imaging of glycogen-storage and muscle degeneration in late-onset Pompe disease. Nature Communications 15, 7843 (2024)

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23.

Zeitschriftenartikel

Agorku, D. J.; Bosio, A.; Alves, F.; Ströbel, P.; Hardt, O.: Colorectal cancer-associated fibroblasts inhibit effector T cells via NECTIN2 signaling. Cancer Letters 595, 216985 (2024)

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24.

Zeitschriftenartikel

Kulkarni, A.; Ferreira, N.; Scodellaro, R.; Choezom, D.; Alves, F.: A Curated Cell Life Imaging Dataset of Immune-enriched Pancreatic Cancer Organoids with Pre-trained AI Models. Scientific Data 11, 820 (2024)

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25.

Zeitschriftenartikel

Sabljo, K.; Ischyropoulou, M.; Napp, J.; Alves, F.; Feldmann, C.: High-load nanoparticles with a chemotherapeutic SN-38/FdUMP drug cocktail. Nanoscale 16, S. 14853 - 14860 (2024)

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26.

Zeitschriftenartikel

Ferrari, D. P.; Ramos Gomes, F.; Alves, F.; Markus, M. A.: KPC-luciferase-expressing cells elicit an anti-tumor immune response in a mouse model of pancreatic cancer. Scientific Reports 14, 13602 (2024)

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27.

Zeitschriftenartikel

Arora, B.; Kulkarni, A.; Markus, M. A.; Ströbel, P.; Bohnenberger, H.; Alves, F.; Ramos-Gomes, F.: Label-free quantification of imaging features in the extracellular matrix of left and right-sided colon cancer tissues. Scientific Reports 14, 7510 (2024)

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28.

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Dullin, C.; Albers , J.; Tagat, A.; Lorenzon, A.; D'Amico, L.; Chiriotti, S.; Sodini, N.; Dreossi, D.; Alves, F.; Bergamaschi, A. et al.; Tromba, G.: In vivo low-dose phase-contrast CT for quantification of functional and anatomical alterations in lungs of an experimental allergic airway disease mouse model. Frontiers in medicine 11, 1338846 (2024)

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29.

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D'Amico, L.; Svetlove, A.; Longo, E.; Meyer, R.; Senigagliesi, B.; Saccomano, G.; Nolte, P.; Wagner, W. L.; Wielpuetz, M. O.; Leitz, D. H. W. et al.; Duerr, J.; Mall, M. A.; Casalis, L.; Köster, S.; Alves, F.; Tromba, G.; Dullin, C.: Characterization of transient and progressive pulmonary fibrosis by spatially correlated phase contrast microCT, classical histopathology and atomic force microscopy. Computers in Biology and Medicine 169, 107947 (2024)

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30.

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Luna, O. F.; Perez, Y. V.; Ferrari, D. P.; Sayedipour, S. S.; Royo, M.; Acosta, G. A.; Cruz, L. J.; Alves, F.; Agner, E.; Sydnes, M. O. et al.; Albericio, F.: Impact of N-Terminal PEGylation on Synthesis and Purification of Peptide-Based Cancer Epitopes for Pancreatic Ductal Adenocarcinoma (PDAC). ACS Omega 9 (32), S. 34544 - 34554 (2024)

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31.

Zeitschriftenartikel

Rudolph, D.; Ischyropoulou, M.; Pfeifer, J.; Napp, J.; Schepers, U.; Alves, F.; Feldmann, C.: Cocktail of lipophilic and hydrophilic chemotherapeutics in high-load core@shell nanocarriers to treat pancreatic tumours. Nanoscale Advances 6, S. 973 - 984 (2024)

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32.

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Sagar, M. M. R.; Svetlove, A.; D’Amico, L.; Pinkert-Leetsch, D.; Missbach-Guentner, J.; Longo, E.; Tromba, G.; Bohnenberger, H.; Alves, F.; Dullin, C.: Optical clearing: an alternative sample preparation method for propagation based phase contrast μCT. Frontiers in Physics 12, 1433895 (2024)

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33.

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Cobanoglu, O.; Delval, L.; Ferrari, D. P.; Deruyter, L.; Heumel, S.; Wolowczuk, I.; Hussein, A.; Menevse, A. N.; Bernard, D.; Beckhove, P. et al.; Alves, F.; Trottein, F.: Depletion of preexisting B-cell lymphoma 2-expressing senescent cells before vaccination impacts antigen-specific antitumor immune responses in old mice. Aging Cell 22 (12), e14007 (2023)

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34.

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Garnier, N.; Berghout, J.; Zygmunt, A.; Singh, D.; Huang, K. A.; Kantz, W.; Blankart, C. R.; Gillner, S.; Zhao, J.; Roettger, R. et al.; Saier, C.; Kirschner, J.; Schenk, J.; Atkins, L.; Ryan, N.; Zarakowska, K.; Zschuentzsch, J.; Zuccolo, M.; Muellenborn, M.; Man, Y.-S.; Goodman, L.; Trad, M.; Chalandon, A. S.; Sansen, S.; Martinez-Fresno, M.; Badger, S.; Walther van Olden, R.; Rothmann, R.; Lehner, P.; Tschohl, C.; Baillon, L.; Gumus, G.; Gross, E.; Stefanov, R.; Iskrov, G.; Raycheva, R.; Kostadinov, K.; Mitova, E.; Einhorn, M.; Einhorn, Y.; Schepers, J.; Huebner, M.; Alves, F.; Iskandar, R.; Mayer, R.; Renieri, A.; Piperkova, A.; Gut, I.; Beltran, S.; Matthiesen, M. E.; Poetz, M.; Hansson, M.; Trollmann, R.; Agolini, E.; Ottombrino, S.; Novelli, A.; Bertini, E.; Selvatici, R.; Farne, M.; Fortunato, F.; Ferlini, A.: Genetic newborn screening and digital technologies: A project protocol based on a dual approach to shorten the rare diseases diagnostic path in Europe. PLOS ONE 18 (11), e0293503 (2023)

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35.

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Ischyropoulou, M.; Sabljo, K.; Schneider, L.; Niemeyer, C. M.; Napp, J.; Feldmann, C.; Alves, F.: High‐Load Gemcitabine Inorganic–Organic Hybrid Nanoparticles as an Image‐Guided Tumor‐Selective Drug‐Delivery System to Treat Pancreatic Cancer. Advanced Materials 35 (46), 2305151 (2023)

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36.

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Khan, A.; Markus, M. A.; Svetlove, A.; Hülsmann, S.; Alves, F.; Dullin, C.: Longitudinal x-ray based lung function measurement for monitoring Nintedanib treatment response in a mouse model of lung fibrosis. Scientific Reports 13 (1), 18637 (2023)

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37.

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Nolte, P.; Brettmacher, M.; Gröger, C. J.; Gellhaus, T.; Svetlove, A.; Schilling, A. F.; Alves, F.; Russmann, C.; Dullin, C.: Spatial correlation of 2D hard-tissue histology with 3D microCT scans through 3D printed phantoms. Scientific Reports 13 (1), 18479 (2023)

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38.

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Markus, M. A.; Ferrari, D. P.; Alves, F.; Ramos Gomes, F.: Effect of tissue fixation on the optical properties of structural components assessed by non-linear microscopy imaging. Biomedical Optics Express 14 (8), S. 3988 - 4002 (2023)

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39.

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Pinkert-Leetsch, D.; Frohn, J.; Ströbel, P.; Alves, F.; Salditt, T.; Missbach-Guentner, J.: Three-dimensional analysis of human pancreatic cancer specimens by phase-contrast based X-ray tomography – the next dimension of diagnosis. Cancer Imaging 23, 43 (2023)

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40.

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Pantelaiou-Prokaki, G.; Reinhardt, O.; Georges, N. S.; Agorku, D. J.; Hardt, O.; Prokakis, E.; Mieczkowska, I. K.; Deppert, W.; Wegwitz, F.; Alves, F.: Basal-like mammary carcinomas stimulate cancer stem cell properties through AXL-signaling to induce chemotherapy resistance. International Journal of Cancer 152 (9), S. 1916 - 1932 (2023)

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41.

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Czaplinska, D.; Ialchina, R.; Andersen, H. B.; Yao, J.; Stigliani, A.; Dannesboe, J.; Flinck, M.; Chen, X.; Mitrega, J.; Gnosa, S. P. et al.; Dmytriyeva, O.; Alves, F.; Napp, J.; Sandelin, A.; Pedersen, S. F.: Crosstalk between tumor acidosis, p53 and extracellular matrix regulates pancreatic cancer aggressiveness. International Journal of Cancer 152 (6), S. 1210 - 1225 (2023)

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42.

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Albers, J.; Wagner, W. L.; Fiedler, M. O.; Rothermel, A.; Wuennemann, F.; Di Lillo, F.; Dreossi, D.; Sodini, N.; Baratella, E.; Confalonieri, M. et al.; Arfelli, F.; Kalenka, A.; Lotz, J.; Biederer, J.; Wielpuetz, M. O.; Kauczor, H.-U.; Alves, F.; Tromba, G.; Dullin, C.: High resolution propagation-based lung imaging at clinically relevant X-ray dose levels. Scientific Reports 13 (1), 4788 (2023)

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43.

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Khorenko, M.; Pfeifer, J.; Napp, J.; Meschkov, A.; Alves, F.; Schepers, U.; Feldmann, C.: Theranostic inorganic–organic hybrid nanoparticles with a cocktail of chemotherapeutic and cytostatic drugs. Journal of Materials Chemistry B 11, S. 3635 - 3649 (2023)

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44.

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Nolte, P.; Dullin, C.; Svetlove, A.; Brettmacher, M.; Russmann, C.; Schilling, A. F.; Alves, F.; Stock, B.: Current Approaches for Image Fusion of Histological Data with Computed Tomography and Magnetic Resonance Imaging. Radiology Research and Practice 2022, 6765895 (2022)

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45.

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Ritschel, C.; Napp, J.; Alves, F.; Feldmann, C.: Monitoring nanoparticle dissolution via fluorescence-colour shift. Nanoscale 14 (43), S. 16249 - 16255 (2022)

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46.

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Pinkert-Leetsch, D.; Rost, J. U.; Schmiedeknecht, M. U. H.; Stadelmann, C.; Alves, F.; Missbach-Guentner, J.: The murine male reproductive organ at a glance: Three-dimensional insights and virtual histology using label-free light sheet microcopy. Andrology 10 (8), S. 1660 - 1672 (2022)

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47.

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Werner, M.; Dyas, A.; Parfentev, I.; Schmidt, G. E.; Mieczkowska, I. K.; Müller-Kirschbaum, L. C.; Müller, C.; Kalkhof, S.; Reinhardt, O.; Urlaub, H. et al.; Alves, F.; Gallwas, J.; Prokakis, E.; Wegwitz, F.: ROBO3s: a novel ROBO3 short isoform promoting breast cancer aggressiveness. Cell Death and Disease 13, 762 (2022)

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48.

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Dullin, C.; Svetlove, A.; Zschuntzsch, J.; Alves, F.: Simultaneous assessment of lung morphology and respiratory motion in retrospectively gated in-vivo microCT of free breathing anesthetized mice. Scientific Reports 12 (1), 13299 (2022)

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49.

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Pfeifer, R.; Henze, J.; Wittich, K.; Gosselink, A.; Kinkhabwala, A.; Gremse, F.; Bleilevens, C.; Bigott, K.; Jungblut, M.; Hardt, O. et al.; Alves, F.; Al Rawashdeh, W.: A multimodal imaging workflow for monitoring CAR T cell therapy against solid tumor from whole-body to single-cell level. Theranostics 12 (11), S. 4834 - 4850 (2022)

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50.

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Hermasch, M. A.; Janning, H.; Perera, R. P.; Schnabel, V.; Rostam, N.; Ramos Gomes, F.; Muschalek, W.; Bennemann, A.; Alves, F.; Ralser, D. J. et al.; Betz, R. C.; Schön, M. P.; Dosch, R.; Frank, J.: Evolutionary distinct roles of γ-secretase subunit nicastrin in zebrafish and humans. Journal of Dermatological Science 105 (2), S. 80 - 87 (2022)

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