Fernanda Ramos-Gomes


The structural heterogeneity of tumors and the interaction of tumor cells with components of the tumor microenvironment as well as their migration to form distant metastases are the main areas of our research group. Label-free characterization of second and third harmonic generating (SHG/THG) structures, such as collagen and lipid droplets, are some of the topics evaluated by my work using ex-vivo and in-vivo deep intra-tumor imaging, including intravital. In particular, microscope techniques such as high-resolution, 2- and 3-photon and light-sheet microscopy are employed.

Additionally, I have a particular interest in how nanoparticles can be used as tracking tools for tumor and immune cells and how they can be exploited to visualize cell-cell and cell-stroma interactions. The preclinical evaluation of novel nanoparticle encapsulated drugs for therapeutic treatments as well as for diagnostic procedures in oncology and inflammation is a vital prerequisite for successful translation into medical application. Moreover, we are involved in numerous collaborations with other partners, including the Karlsruhe Institute of Technology (KIT), the University of Geneva (Switzerland), the University of São Paulo (USP, Brazil) and the Biomedical Primate Research Centre (Netherlands). The close proximity to the University Medical Center Göttingen (UMG) offers us an advantage, putting our work at the interface between basic research and clinical medicine.


  • Deep-learning platform for the identification of novel imaging biomarkers from 3D pathology samples
  • Evaluation of novel FLIM based nanocarriers for drug delivery
  • Assessment of long-term effects of SARS-CoV-2 infection in non-human primates
  • Drug-encapsulating nanoparticles for the treatment of breast cancer
  • Second harmonic nanomaterials for cell tracking
  • Interaction of nanoparticles with tumor and immune cells in the diseased lung and pancreatic cancer
  • Optimization of multiphoton and light sheet microscopy for high-resolution imaging of cancer tissue


Nathalia Ferreira (PhD Student) – co-supervision

Daniele Ferrari (PhD Student) – co-supervision

Bharti Arora (PhD Student) – co-supervision

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