Publications of Vladimir Pena

Cretu, C.; Chernev, A.; Szabó, C. Z. K.; Pena, V.; Urlaub, H.; Moser, T.; Preobraschenski, J.: Structural insights into lipid membrane binding by human ferlins. The EMBO Journal (2025)

Schmitzová, J.; Cretu, C.; Dienemann, C.; Urlaub, H.; Pena, V.: Structural basis of catalytic activation in human splicing. Nature 617, pp. 842 - 850 (2023)

Cretu, C.; Agrawal, A. A.; Cook, A.; Will, C. L.; Fekkes, P.; Smith, P. G.,.; Lührmann, R.; Larsen, N.; Buonamici, S.; Pena, V.: Structural basis of splicing modulation by antitumor macrolide compounds. Molecular Cell 70 (2), pp. 265 - 273 (2018)

Rocha de Moura, T.; Mozaffari-Jovin, S.; Szabo, C. Z. K.; Schmitzova, J.; Dybkov, O.; Cretu, C.; Kachala, M.; Svergun, D.; Urlaub, H.; Lührmann, R. et al.; Pena, V.: Prp19/Pso4 is an autoinhibited ubiquitin ligase activated by stepwise assembly of three splicing factors. Molecular Cell 69 (6), pp. 979 - 992 (2018)

Cretu, C.; Schmitzova, J.; Ponce-Salvatierra, A.; Dybkov, O.; De Laurentiis, E.; Sharma, K.; Will, C. L.; Urlaub, H.; Lührmann, R.; Pena, V.: Molecular architecture of SF3b and structural consequences of its cancer-related mutations. Molecular Cell 64 (2), pp. 307 - 319 (2016)

Rauhut, R.; Fabrizio, P.; Dybkov, O.; Hartmuth, K.; Pena, V.; Chari, A.; Kumar, V.; Lee, C. T.; Urlaub, H.; Kastner, B. et al.; Stark, H.; Lührmann, R.: Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 353 (6306), pp. 1399 - 1405 (2016)

De, I.; Schmitzova, J.; Pena, V.: The organization and contribution of helicases to RNA splicing. Wiley Interdisciplinary Reviews: RNA 7 (2), pp. 259 - 274 (2016)

Ponce-Salvatierra, A.; Wawrzyniak-Turek, K.; Steuerwald, U.; Höbartner, C.; Pena, V.: Crystal structure of a DNA catalyst. Nature 529 (7585), pp. 231 - 234 (2016)

Antonios, G.; Borgers, H.; Richard, B. C.; Brauss, A.; Meissner, J.; Weggen, S.; Pena, V.; Pillot, T.; Davies, S. T.; Bakrania, P. et al.; Matthews, D.; Brownlees, J.; Bouter, Y.; Bayer, T. A.: Alzheimer therapy with an antibody against N-terminal Abeta 4-X and pyroglutamate Abeta 3-X. Scientific Reports 5, 17338 (2015)

De, I.; Bessonov, S.; Hofele, R.; Dos Santos, K.; Will, C. L.; Urlaub, H.; Lührmann, R.; Pena, V.: The RNA helicase ​Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes. Nature Structural and Molecular Biology 22 (2), pp. 138 - 144 (2015)

Rothé, B.; Saliou, J. M.; Quinternet, M.; Back, R.; Tiotiu, D.; Jacquemin, C.; Loegler, C.; Schlotter, F.; Pena, V.; Eckert, K. et al.; Moréra, S.; Dorsselaer, A. V.; Branlant, C.; Massenet, S.; Sanglier-Cianférani, S.; Manival, X.; Charpentier, B.: Protein Hit1, a novel box C/D snoRNP assembly factor, controls cellular concentration of the scaffolding protein Rsa1 by direct interaction. Nucleic Acids Research 42 (16), pp. 10731 - 10747 (2014)

Schmitzova, J.; Pena, V.: Emerging views about the molecular structure of the spliceosomal catalytic center. RNA Biology 9 (11), pp. 1311 - 1318 (2012)

Santos , K. F.; Mozaffari-Jovin, S.; Weber , G.; Pena, V.; Lührmann, R.; Wahl, M. C.: Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome. Proceedings of the National Academy of Sciences of the United States of America 109 (43), pp. 17418 - 17423 (2012)

Hegele, A.; Kamburov, A.; Grossmann, A.; Sourlis, C.; Wowro, S.; Weimann, M.; Will, C. L.; Pena, V.; Lührmann, R.; Stelzl, U.: Dynamic protein-protein interaction wiring of the human spliceosome. Molecular Cell 45 (4), pp. 567 - 580 (2012)

Schmitzova, J.; Rasche, N.; Dybkov, O.; Kramer, K.; Fabrizio, P.; Urlaub, H.; Lührmann, R.; Pena, V.: Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein. EMBO Journal 31 (9), pp. 2222 - 2234 (2012)

Pena, V.; Jovin, S. M.; Fabrizio, P.; Orlowski, J.; Bujnicki, J. M.; Lührmann, R.; Wahl, M. C.: Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase. Molecular Cell 35 (4), pp. 454 - 466 (2009)

Pena, V.; Rozov, A.; Fabrizio, P.; Luehrmann, R.; Wahl, M. C.: Structure and function of an RNase H domain at the heart of the spliceosome. The EMBO Journal 27 (21), pp. 2929 - 2940 (2008)

Pena, V.; Hothorn, M.; Eberth, A.; Kaschau, N.; Parret, A.; Gremer, L.; Bonneau, F.; Ahmadian, M. R.; Scheffzek, K.: The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction. EMBO Reports 9 (4), pp. 350 - 355 (2008)

Pena, V.; Liu, S.; Bujnicki, J. M.; Luehrmann, R.; Wahl, M. C.: Structure of a multipartite protein-protein interaction domain in splicing factor Prp8 and its link to retinitis pigmentosa. Molecular Cell 25 (4), pp. 615 - 624 (2007)