Publications
Zeitschriftenartikel (242)
1.
Zeitschriftenartikel
159 (3), S. 554 - 573 (2021)
Brain iron enrichment attenuates α-synuclein spreading after injection of preformed fibrils. Journal of Neurochemistry 2.
Zeitschriftenartikel
7, 65 (2021)
Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease. NPJ Parkinsons Disease 3.
Zeitschriftenartikel
12, 4231 (2021)
Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils. Nature Communications 4.
Zeitschriftenartikel
30 (7), S. 1294 - 1314 (2021)
Liquid–liquid phase separation of tau: From molecular biophysics to physiology and disease. Protein Science 5.
Zeitschriftenartikel
15, 643391 (2021)
Low-Expressing synucleinopathy mouse models based on oligomer-forming mutations and C-terminal truncation of α-synuclein. Frontiers in Neuroscience 6.
Zeitschriftenartikel
12, 3396 (2021)
Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis. Nature Communications 7.
Zeitschriftenartikel
13, 635760 (2021)
Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity. Frontiers in Aging Neuroscience 8.
Zeitschriftenartikel
50 (2), S. 107 - 108 (2021)
Special issue: Multicomponent lipid membranes—how molecular organisation leads to function. European Biophysics Journal 9.
Zeitschriftenartikel
78 (5), S. 2355 - 2370 (2021)
Cooperativity of membrane-protein and protein–protein interactions control membrane remodeling by epsin 1 and affects clathrin-mediated endocytosis. Cellular and Molecular Life Sciences 10.
Zeitschriftenartikel
50 (2), S. 159 - 172 (2021)
Structure, gating and interactions of the voltage-dependent anion channel. European Biophysics Journal 11.
Zeitschriftenartikel
50 (2), S. 173 - 180 (2021)
Membrane-embedded TSPO: an NMR view. European Biophysics Journal 12.
Zeitschriftenartikel
A novel SNCA A30G mutation causes familial Parkinsonʼs disease. Movement Disorders, In Press (2021)
13.
Zeitschriftenartikel
125 (5), S. 1378 - 1391 (2021)
Structural Flexibility of Cyclosporine A Is Mediated by Amide Cis–Trans Isomerization and the Chameleonic Roles of Calcium. Journal of Physical Chemistry B 14.
Zeitschriftenartikel
Interplay between tau and α‐synuclein liquid–liquid phase separation. Protein Science, In Press (2021)
15.
Zeitschriftenartikel
60 (2), S. 726 - 730 (2021)
Disease‐associated tau phosphorylation hinders tubulin assembly within tau condensates. Angewandte Chemie International Edition 16.
Zeitschriftenartikel
10, 21210 (2020)
Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils. Scientific Reports 17.
Zeitschriftenartikel
29 (12), S. 2422 - 2432 (2020)
Molecular basis of the interaction of Hsp90 with its co‐chaperone Hop. Protein Science 18.
Zeitschriftenartikel
11, 6046 (2020)
Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war. Nature Communications 19.
Zeitschriftenartikel
11, 6041 (2020)
Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates. Nature Communications 20.
Zeitschriftenartikel
10, 12827 (2020)
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization. Scientific Reports 21.
Zeitschriftenartikel
6 (30), eaba3916 (2020)
Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution. Science Advances 22.
Zeitschriftenartikel
11, 2729 (2020)
A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol. Nature Communications 23.
Zeitschriftenartikel
59 (15), S. 6172 - 6176 (2020)
Determination of complex small molecule structures using molecular alignment simulation. Angewandte Chemie International Edition 24.
Zeitschriftenartikel
132 (14), S. 5692 - 5695 (2020)
Molecular basis of the interaction of cyclophilin A with alpha-synuclein. Angewandte Chemie International Edition 25.
Zeitschriftenartikel
99, S. 202 - 214 (2020)
Biomolecular condensation of the microtubule-associated protein tau. Seminars in Cell and Developmental Biology 26.
Zeitschriftenartikel
117 (6), S. 2948 - 2956 (2020)
Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2. Proceedings of the National Academy of Sciences of the United States of America 27.
Zeitschriftenartikel
1868 (1), 140298 (2020)
Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies. Biochimica et Biophysica Acta-Proteins and Proteomics 28.
Zeitschriftenartikel
10, 5535 (2019)
Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts. Nature Communications 29.
Zeitschriftenartikel
269 (8), S. 973 - 984 (2019)
Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer's disease from bioptic olfactory mucosa. European Archives of Psychiatry and Clinical Neuroscience 30.
Zeitschriftenartikel
107, S. 3 - 5 (2019)
Towards a consensus on developmental regression. Neuroscience and Biobehavioral Reviews 31.
Zeitschriftenartikel
138 (3), S. 415 - 441 (2019)
Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models. Acta Neuropathologica 32.
Zeitschriftenartikel
28 (9), S. 1545 - 1551 (2019)
Dynamic Aha1 co-chaperone binding to human Hsp90. Protein Science 33.
Zeitschriftenartikel
10 (26), S. 6503 - 6507 (2019)
Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau. Chemical Science 34.
Zeitschriftenartikel
10 (1), 2909 (2019)
Lysine/RNA-interactions drive and regulate biomolecular condensation. Nature Communications 35.
Zeitschriftenartikel
10, S. 3369 - 3375 (2019)
Reorientational dynamics of amyloid-β from NMR spin relaxation and molecular simulation. Journal of Physical Chemistry Letters 36.
Zeitschriftenartikel
46 (6), S. 1208 - 1211 (2019)
In response to: The validity of 18F-GE180 as a TSPO imaging agent. European Journal of Nuclear Medicine and Molecular Imaging 37.
Zeitschriftenartikel
39 (19), S. 3752 - 3769 (2019)
Translocator protein ligand protects against neurodegeneration in the MPTP mouse model of Parkinsonism. Journal of Neuroscience 38.
Zeitschriftenartikel
9 (3), 105 (2019)
Structure and functions of microtubule associated proteins tau and MAP2c: Similarities and differences. Biomolecules 39.
Zeitschriftenartikel
98, S. 1 - 9 (2019)
Upregulated levels and pathological aggregation of abnormally phosphorylated Tau-Protein in children with neurodevelopmental disorders. Neuroscience and Biobehavioral Reviews 40.
Zeitschriftenartikel
24 (66), S. 17606 - 17611 (2018)
Insights into cholesterol/membrane protein interactions using paramagnetic solid-state NMR. Chemistry - A European Journal 41.
Zeitschriftenartikel
57 (46), S. 15262 - 15266 (2018)
Local and global dynamics in intrinsically disordered synuclein. Angewandte Chemie International Edition 42.
Zeitschriftenartikel
9, 4532 (2018)
Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex. Nature Communications 43.
Zeitschriftenartikel
10 (10), S. 1383 - 1389 (2018)
Interaction of Cu(i) with the Met-X3-Met motif of alpha-synuclein: Binding ligands, affinity and structural features. Metallomics 44.
Zeitschriftenartikel
25 (9), S. 833 - 840 (2018)
RNA polymerase II clustering through carboxy-terminal domain phase separation. Nature Structural and Molecular Biology 45.
Zeitschriftenartikel
293 (34), S. 13297 - 13309 (2018)
Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics. Journal of Biological Chemistry 46.
Zeitschriftenartikel
285 (11), S. 1988 - 2003 (2018)
The solution structure of monomeric CCL5 in complex with a doubly sulfated N-terminal segment of CCR5. FEBS Journal 47.
Zeitschriftenartikel
75 (12), S. 2137 - 2151 (2018)
Challenges and approaches to understand cholesterol-binding impact on membrane protein function: An NMR view. Cellular and Molecular Life Sciences 48.
Zeitschriftenartikel
10 (19), S. 9174 - 9185 (2018)
The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease. Nanoscale 49.
Zeitschriftenartikel
25 (5), S. 384 - 393 (2018)
Mapping interactions with the chaperone network reveals factors that protect against tau aggregation. Nature Structural and Molecular Biology 50.
Zeitschriftenartikel
57 (12), S. 3246 - 3250 (2018)
The binding mode of a repeat-like Tau sequence with tubulin. Angewandte Chemie International Edition 51.
Zeitschriftenartikel
11, 49 (2018)
Pathophysiological consequences of neuronal alpha-Synuclein overexpression: Impacts on ion homeostasis, stress signaling, mitochondrial integrity, and electrical activity. Frontiers in Molecular Neuroscience 52.
Zeitschriftenartikel
25 (4), S. 462 - 477 (2018)
Monitoring interactions inside cells by advanced spectroscopies: Overview of copper transporters and cisplatin. Current Medicinal Chemistry 53.
Zeitschriftenartikel
10 (1), S. 32 - 47 (2018)
The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology. EMBO Molecular Medicine 54.
Zeitschriftenartikel
8, 1981 (2017)
Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau. Nature Communications 55.
Zeitschriftenartikel
21 (8), S. 2118 - 2133 (2017)
Capture of dense core vesicles at synapses by JNK-dependent phosphorylation of Synaptotagmin-4. Cell Reports 56.
Zeitschriftenartikel
23 (53), S. 13010 - 13014 (2017)
Small molecule-induced soluble oligomers of α-synuclein with helical structure. Chemistry. A European Journal 57.
Zeitschriftenartikel
56 (17), S. 10387 - 10395 (2017)
Bioinorganic chemistry of Parkinson's disease: Affinity and structural features of Cu(I) binding to the full-length β-synuclein protein. Inorganic Chemistry 58.
Zeitschriftenartikel
8, 275 (2017)
Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau. Nature Communications 59.
Zeitschriftenartikel
426, S. 134 - 139 (2017)
Reverse allostasis in biological systems: Minimal conditions and implications. Journal of Theoretical Biology 60.
Zeitschriftenartikel
15 (6), e2001336 (2017)
Human cyclophilin 40 unravels neurotoxic amyloids. PLoS Biology 61.
Zeitschriftenartikel
140 (5), S. 1399 - 1419 (2017)
Glycation potentiates alpha-synuclein-associated neurodegeneration in synucleinopathies. Brain 62.
Zeitschriftenartikel
13 (4), e1006229 (2017)
Elucidating the structure of an infectious protein. PLoS Pathogens 63.
Zeitschriftenartikel
24 (4), S. 407 - 413 (2017)
Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90. Nature Structural and Molecular Biology 64.
Zeitschriftenartikel
15 (3), e2000374 (2017)
The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS Biology 65.
Zeitschriftenartikel
55 (52), S. 16168 - 16171 (2016)
Structure of monomeric transthyretin carrying the clinically important T119M mutation. Angewandte Chemie International Edition 66.
Zeitschriftenartikel
113 (42), S. E6506 - E6515 (2016)
Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. Proceedings of the National Academy of Sciences of the United States of America 67.
Zeitschriftenartikel
113 (42), S. E6506 - E6515 (2016)
Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. Proceedings of the National Academy of Sciences of the United States of Amerca 68.
Zeitschriftenartikel
111 (6), S. 1223 - 1234 (2016)
Voltage dependence of conformational dynamics and subconducting states of VDAC-1. Biophysical Journal 69.
Zeitschriftenartikel
55 (35), S. 101518 - 10521 (2016)
High-resolution NMR determination of the dynamic structure of membrane proteins. Angewandte Chemie International Edition 70.
Zeitschriftenartikel
25 (8), S. 1563 - 1567 (2016)
The protonation state of histidine 111 regulates the aggregation of the evolutionary most conserved region of the human prion protein. Protein Science 71.
Zeitschriftenartikel
291 (31), S. 16059 - 16067 (2016)
Phosphorylation interferes with maturation of amyloid-β fibrillar structure in the N terminus. Journal of Biological Chemistry 72.
Zeitschriftenartikel
22 (25), S. 8685 - 8693 (2016)
Solid-phase synthesis and characterization of N-terminally elongated A beta(-3-x)-peptides. Chemistry-A European Journal 73.
Zeitschriftenartikel
25 (5), S. 1010 - 1020 (2016)
Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer. Protein Science 74.
Zeitschriftenartikel
4, 39 (2016)
Fasudil attenuates aggregation of alpha-synuclein in models of Parkinson's disease. Acta Neuropathologica Communications 75.
Zeitschriftenartikel
7, 11359 (2016)
Phosphorylation modifies the molecular stability of beta-amyloid deposits. Nature Communications 76.
Zeitschriftenartikel
24 (4), S. 585 - 594 (2016)
Molecular plasticity of the human Voltage-Dependent Anion Channel embedded into a membrane. Structure 77.
Zeitschriftenartikel
10 (1), S. 79 - 83 (2016)
Backbone and side-chain resonance assignment of the A147T polymorph of mouse TSPO in complex with a high-affinity radioligand. Biomolecular NMR Assignments 78.
Zeitschriftenartikel
131 (4), S. 525 - 537 (2016)
Phosphorylation of the amyloid beta-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity. Acta Neuropathologica 79.
Zeitschriftenartikel
25 (2), S. 275 - 290 (2016)
Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity. Human Molecular Genetics 80.
Zeitschriftenartikel
11 (1), S. 65 - 77 (2016)
Targeting intrinsically disordered proteins in rational drug discovery. Expert Opinion on Drug Discocery 81.
Zeitschriftenartikel
13 (2), S. 128 - 133 (2016)
Retention and splicing complex (RES) - the importance of cooperativity. RNA Biology 82.
Zeitschriftenartikel
290 (46), S. 27582 - 27593 (2015)
Small molecules detected by second-harmonic generation modulate the conformation of monomeric α-synuclein and reduce its aggregation in cell. Journal of Biological Chemistry 83.
Zeitschriftenartikel
11 (11), S. 5513 - 5524 (2015)
Structural ensembles of intrinsically disordered proteins depend strongly on force field: A comparison to experiment. Journal of Chemical Theory and Computation 84.
Zeitschriftenartikel
21 (46), S. 16555 - 16563 (2015)
Conformational flexibility in the transmembrane protein TSPO. Chemistry-A European Journal 85.
Zeitschriftenartikel
63 (3), S. 299 - 307 (2015)
Improved validation of IDP ensembles by one-bond Cα-Hα scalar couplings. Journal of Biomolecular NMR 86.
Zeitschriftenartikel
54 (35), S. 10347 - 10351 (2015)
Folding of the Tau protein on microtubules. Angewandte Chemie International Edition 87.
Zeitschriftenartikel
23 (8), S. 1448 - 1458 (2015)
Structural impact of Tau phosphorylation at threonine 231. Structure 88.
Zeitschriftenartikel
43 (4), S. 566 - 571 (2015)
Structure of the mammalian TSPO/PBR protein. Biochemical Society Transactions 89.
Zeitschriftenartikel
5, 12545 (2015)
Structures of intermediates during RES complex assembly. Scientific Reports 90.
Zeitschriftenartikel
24 (14), S. 3971 - 3981 (2015)
The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics. Human Molecular Genetics 91.
Zeitschriftenartikel
16 (10), S. 1483 - 1489 (2015)
Structural integrity of the A147T polymorph of mammalian TSPO. ChemBioChem 92.
Zeitschriftenartikel
26 (7), S. 349 - 356 (2015)
Lost in translocation: The functions of the 18-kD translocator protein. Trends in Endocrinology and Metabolism 93.
Zeitschriftenartikel
112 (24), S. 7501 - 7506 (2015)
Tau stabilizes microtubules by binding at the interface between tubulin heterodimers. Proceedings of the National Academy of Sciences of the United States of America 94.
Zeitschriftenartikel
129 (5), S. 695 - 713 (2015)
Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation. Acta Neuropathologica 95.
Zeitschriftenartikel
31 (8), S. 1319 - 1321 (2015)
HYCUD: A computational tool for prediction of effective rotational correlation time in flexible proteins. Bioinformatics 96.
Zeitschriftenartikel
290 (15), S. 9412 - 9427 (2015)
Parkinson disease mutant E46K enhances alpha-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo. Journal of Biological Chemistry 97.
Zeitschriftenartikel
61 (3-4), S. 311 - 320 (2015)
Solid-state NMR, electrophysiology and molecular dynamics characterization of human VDAC2. Journal of Biomolecular NMR 98.
Zeitschriftenartikel
54 (1), S. 336 - 339 (2015)
Multiple paramagnetic effects through a tagged reporter protein. Angewandte Chemie International Edition 99.
Zeitschriftenartikel
137 (20), S. 6444 - 6447 (2015)
Copper binding to the N-terminally acetylated, naturally occurring form of alpha-synuclein induces local helical folding. Journal of the American Chemical Society