Publications
Zeitschriftenartikel (242)
1.
Zeitschriftenartikel
Brain iron enrichment attenuates α-synuclein spreading after injection of preformed fibrils. Journal of Neurochemistry 159 (3), S. 554 - 573 (2021)
2.
Zeitschriftenartikel
Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease. NPJ Parkinsons Disease 7, 65 (2021)
3.
Zeitschriftenartikel
Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils. Nature Communications 12, 4231 (2021)
4.
Zeitschriftenartikel
Liquid–liquid phase separation of tau: From molecular biophysics to physiology and disease. Protein Science 30 (7), S. 1294 - 1314 (2021)
5.
Zeitschriftenartikel
Low-Expressing synucleinopathy mouse models based on oligomer-forming mutations and C-terminal truncation of α-synuclein. Frontiers in Neuroscience 15, 643391 (2021)
6.
Zeitschriftenartikel
Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis. Nature Communications 12, 3396 (2021)
7.
Zeitschriftenartikel
Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity. Frontiers in Aging Neuroscience 13, 635760 (2021)
8.
Zeitschriftenartikel
Special issue: Multicomponent lipid membranes—how molecular organisation leads to function. European Biophysics Journal 50 (2), S. 107 - 108 (2021)
9.
Zeitschriftenartikel
Cooperativity of membrane-protein and protein–protein interactions control membrane remodeling by epsin 1 and affects clathrin-mediated endocytosis. Cellular and Molecular Life Sciences 78 (5), S. 2355 - 2370 (2021)
10.
Zeitschriftenartikel
Structure, gating and interactions of the voltage-dependent anion channel. European Biophysics Journal 50 (2), S. 159 - 172 (2021)
11.
Zeitschriftenartikel
Membrane-embedded TSPO: an NMR view. European Biophysics Journal 50 (2), S. 173 - 180 (2021)
12.
Zeitschriftenartikel
A novel SNCA A30G mutation causes familial Parkinsonʼs disease. Movement Disorders, In Press (2021)
13.
Zeitschriftenartikel
Structural Flexibility of Cyclosporine A Is Mediated by Amide Cis–Trans Isomerization and the Chameleonic Roles of Calcium. Journal of Physical Chemistry B 125 (5), S. 1378 - 1391 (2021)
14.
Zeitschriftenartikel
Interplay between tau and α‐synuclein liquid–liquid phase separation. Protein Science, In Press (2021)
15.
Zeitschriftenartikel
Disease‐associated tau phosphorylation hinders tubulin assembly within tau condensates. Angewandte Chemie International Edition 60 (2), S. 726 - 730 (2021)
16.
Zeitschriftenartikel
Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils. Scientific Reports 10, 21210 (2020)
17.
Zeitschriftenartikel
Molecular basis of the interaction of Hsp90 with its co‐chaperone Hop. Protein Science 29 (12), S. 2422 - 2432 (2020)
18.
Zeitschriftenartikel
Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war. Nature Communications 11, 6046 (2020)
19.
Zeitschriftenartikel
Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates. Nature Communications 11, 6041 (2020)
20.
Zeitschriftenartikel
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization. Scientific Reports 10, 12827 (2020)
21.
Zeitschriftenartikel
Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution. Science Advances 6 (30), eaba3916 (2020)
22.
Zeitschriftenartikel
A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol. Nature Communications 11, 2729 (2020)
23.
Zeitschriftenartikel
Determination of complex small molecule structures using molecular alignment simulation. Angewandte Chemie International Edition 59 (15), S. 6172 - 6176 (2020)
24.
Zeitschriftenartikel
Molecular basis of the interaction of cyclophilin A with alpha-synuclein. Angewandte Chemie International Edition 132 (14), S. 5692 - 5695 (2020)
25.
Zeitschriftenartikel
Biomolecular condensation of the microtubule-associated protein tau. Seminars in Cell and Developmental Biology 99, S. 202 - 214 (2020)
26.
Zeitschriftenartikel
Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2. Proceedings of the National Academy of Sciences of the United States of America 117 (6), S. 2948 - 2956 (2020)
27.
Zeitschriftenartikel
Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies. Biochimica et Biophysica Acta-Proteins and Proteomics 1868 (1), 140298 (2020)
28.
Zeitschriftenartikel
Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts. Nature Communications 10, 5535 (2019)
29.
Zeitschriftenartikel
Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer's disease from bioptic olfactory mucosa. European Archives of Psychiatry and Clinical Neuroscience 269 (8), S. 973 - 984 (2019)
30.
Zeitschriftenartikel
Towards a consensus on developmental regression. Neuroscience and Biobehavioral Reviews 107, S. 3 - 5 (2019)
31.
Zeitschriftenartikel
Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models. Acta Neuropathologica 138 (3), S. 415 - 441 (2019)
32.
Zeitschriftenartikel
Dynamic Aha1 co-chaperone binding to human Hsp90. Protein Science 28 (9), S. 1545 - 1551 (2019)
33.
Zeitschriftenartikel
Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau. Chemical Science 10 (26), S. 6503 - 6507 (2019)
34.
Zeitschriftenartikel
Lysine/RNA-interactions drive and regulate biomolecular condensation. Nature Communications 10 (1), 2909 (2019)
35.
Zeitschriftenartikel
Reorientational dynamics of amyloid-β from NMR spin relaxation and molecular simulation. Journal of Physical Chemistry Letters 10, S. 3369 - 3375 (2019)
36.
Zeitschriftenartikel
In response to: The validity of 18F-GE180 as a TSPO imaging agent. European Journal of Nuclear Medicine and Molecular Imaging 46 (6), S. 1208 - 1211 (2019)
37.
Zeitschriftenartikel
Translocator protein ligand protects against neurodegeneration in the MPTP mouse model of Parkinsonism. Journal of Neuroscience 39 (19), S. 3752 - 3769 (2019)
38.
Zeitschriftenartikel
Structure and functions of microtubule associated proteins tau and MAP2c: Similarities and differences. Biomolecules 9 (3), 105 (2019)
39.
Zeitschriftenartikel
Upregulated levels and pathological aggregation of abnormally phosphorylated Tau-Protein in children with neurodevelopmental disorders. Neuroscience and Biobehavioral Reviews 98, S. 1 - 9 (2019)
40.
Zeitschriftenartikel
Insights into cholesterol/membrane protein interactions using paramagnetic solid-state NMR. Chemistry - A European Journal 24 (66), S. 17606 - 17611 (2018)
41.
Zeitschriftenartikel
Local and global dynamics in intrinsically disordered synuclein. Angewandte Chemie International Edition 57 (46), S. 15262 - 15266 (2018)
42.
Zeitschriftenartikel
Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex. Nature Communications 9, 4532 (2018)
43.
Zeitschriftenartikel
Interaction of Cu(i) with the Met-X3-Met motif of alpha-synuclein: Binding ligands, affinity and structural features. Metallomics 10 (10), S. 1383 - 1389 (2018)
44.
Zeitschriftenartikel
RNA polymerase II clustering through carboxy-terminal domain phase separation. Nature Structural and Molecular Biology 25 (9), S. 833 - 840 (2018)
45.
Zeitschriftenartikel
Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics. Journal of Biological Chemistry 293 (34), S. 13297 - 13309 (2018)
46.
Zeitschriftenartikel
The solution structure of monomeric CCL5 in complex with a doubly sulfated N-terminal segment of CCR5. FEBS Journal 285 (11), S. 1988 - 2003 (2018)
47.
Zeitschriftenartikel
Challenges and approaches to understand cholesterol-binding impact on membrane protein function: An NMR view. Cellular and Molecular Life Sciences 75 (12), S. 2137 - 2151 (2018)
48.
Zeitschriftenartikel
The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease. Nanoscale 10 (19), S. 9174 - 9185 (2018)
49.
Zeitschriftenartikel
Mapping interactions with the chaperone network reveals factors that protect against tau aggregation. Nature Structural and Molecular Biology 25 (5), S. 384 - 393 (2018)
50.
Zeitschriftenartikel
The binding mode of a repeat-like Tau sequence with tubulin. Angewandte Chemie International Edition 57 (12), S. 3246 - 3250 (2018)
51.
Zeitschriftenartikel
Pathophysiological consequences of neuronal alpha-Synuclein overexpression: Impacts on ion homeostasis, stress signaling, mitochondrial integrity, and electrical activity. Frontiers in Molecular Neuroscience 11, 49 (2018)
52.
Zeitschriftenartikel
Monitoring interactions inside cells by advanced spectroscopies: Overview of copper transporters and cisplatin. Current Medicinal Chemistry 25 (4), S. 462 - 477 (2018)
53.
Zeitschriftenartikel
The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology. EMBO Molecular Medicine 10 (1), S. 32 - 47 (2018)
54.
Zeitschriftenartikel
Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau. Nature Communications 8, 1981 (2017)
55.
Zeitschriftenartikel
Capture of dense core vesicles at synapses by JNK-dependent phosphorylation of Synaptotagmin-4. Cell Reports 21 (8), S. 2118 - 2133 (2017)
56.
Zeitschriftenartikel
Small molecule-induced soluble oligomers of α-synuclein with helical structure. Chemistry. A European Journal 23 (53), S. 13010 - 13014 (2017)
57.
Zeitschriftenartikel
Bioinorganic chemistry of Parkinson's disease: Affinity and structural features of Cu(I) binding to the full-length β-synuclein protein. Inorganic Chemistry 56 (17), S. 10387 - 10395 (2017)
58.
Zeitschriftenartikel
Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau. Nature Communications 8, 275 (2017)
59.
Zeitschriftenartikel
Reverse allostasis in biological systems: Minimal conditions and implications. Journal of Theoretical Biology 426, S. 134 - 139 (2017)
60.
Zeitschriftenartikel
Human cyclophilin 40 unravels neurotoxic amyloids. PLoS Biology 15 (6), e2001336 (2017)
61.
Zeitschriftenartikel
Glycation potentiates alpha-synuclein-associated neurodegeneration in synucleinopathies. Brain 140 (5), S. 1399 - 1419 (2017)
62.
Zeitschriftenartikel
Elucidating the structure of an infectious protein. PLoS Pathogens 13 (4), e1006229 (2017)
63.
Zeitschriftenartikel
Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90. Nature Structural and Molecular Biology 24 (4), S. 407 - 413 (2017)
64.
Zeitschriftenartikel
The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS Biology 15 (3), e2000374 (2017)
65.
Zeitschriftenartikel
Structure of monomeric transthyretin carrying the clinically important T119M mutation. Angewandte Chemie International Edition 55 (52), S. 16168 - 16171 (2016)
66.
Zeitschriftenartikel
Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. Proceedings of the National Academy of Sciences of the United States of America 113 (42), S. E6506 - E6515 (2016)
67.
Zeitschriftenartikel
Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. Proceedings of the National Academy of Sciences of the United States of Amerca 113 (42), S. E6506 - E6515 (2016)
68.
Zeitschriftenartikel
Voltage dependence of conformational dynamics and subconducting states of VDAC-1. Biophysical Journal 111 (6), S. 1223 - 1234 (2016)
69.
Zeitschriftenartikel
High-resolution NMR determination of the dynamic structure of membrane proteins. Angewandte Chemie International Edition 55 (35), S. 101518 - 10521 (2016)
70.
Zeitschriftenartikel
The protonation state of histidine 111 regulates the aggregation of the evolutionary most conserved region of the human prion protein. Protein Science 25 (8), S. 1563 - 1567 (2016)
71.
Zeitschriftenartikel
Phosphorylation interferes with maturation of amyloid-β fibrillar structure in the N terminus. Journal of Biological Chemistry 291 (31), S. 16059 - 16067 (2016)
72.
Zeitschriftenartikel
Solid-phase synthesis and characterization of N-terminally elongated A beta(-3-x)-peptides. Chemistry-A European Journal 22 (25), S. 8685 - 8693 (2016)
73.
Zeitschriftenartikel
Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer. Protein Science 25 (5), S. 1010 - 1020 (2016)
74.
Zeitschriftenartikel
Fasudil attenuates aggregation of alpha-synuclein in models of Parkinson's disease. Acta Neuropathologica Communications 4, 39 (2016)
75.
Zeitschriftenartikel
Phosphorylation modifies the molecular stability of beta-amyloid deposits. Nature Communications 7, 11359 (2016)
76.
Zeitschriftenartikel
Molecular plasticity of the human Voltage-Dependent Anion Channel embedded into a membrane. Structure 24 (4), S. 585 - 594 (2016)
77.
Zeitschriftenartikel
Backbone and side-chain resonance assignment of the A147T polymorph of mouse TSPO in complex with a high-affinity radioligand. Biomolecular NMR Assignments 10 (1), S. 79 - 83 (2016)
78.
Zeitschriftenartikel
Phosphorylation of the amyloid beta-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity. Acta Neuropathologica 131 (4), S. 525 - 537 (2016)
79.
Zeitschriftenartikel
Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity. Human Molecular Genetics 25 (2), S. 275 - 290 (2016)
80.
Zeitschriftenartikel
Targeting intrinsically disordered proteins in rational drug discovery. Expert Opinion on Drug Discocery 11 (1), S. 65 - 77 (2016)
81.
Zeitschriftenartikel
Retention and splicing complex (RES) - the importance of cooperativity. RNA Biology 13 (2), S. 128 - 133 (2016)
82.
Zeitschriftenartikel
Small molecules detected by second-harmonic generation modulate the conformation of monomeric α-synuclein and reduce its aggregation in cell. Journal of Biological Chemistry 290 (46), S. 27582 - 27593 (2015)
83.
Zeitschriftenartikel
Structural ensembles of intrinsically disordered proteins depend strongly on force field: A comparison to experiment. Journal of Chemical Theory and Computation 11 (11), S. 5513 - 5524 (2015)
84.
Zeitschriftenartikel
Conformational flexibility in the transmembrane protein TSPO. Chemistry-A European Journal 21 (46), S. 16555 - 16563 (2015)
85.
Zeitschriftenartikel
Improved validation of IDP ensembles by one-bond Cα-Hα scalar couplings. Journal of Biomolecular NMR 63 (3), S. 299 - 307 (2015)
86.
Zeitschriftenartikel
Folding of the Tau protein on microtubules. Angewandte Chemie International Edition 54 (35), S. 10347 - 10351 (2015)
87.
Zeitschriftenartikel
Structural impact of Tau phosphorylation at threonine 231. Structure 23 (8), S. 1448 - 1458 (2015)
88.
Zeitschriftenartikel
Structure of the mammalian TSPO/PBR protein. Biochemical Society Transactions 43 (4), S. 566 - 571 (2015)
89.
Zeitschriftenartikel
Structures of intermediates during RES complex assembly. Scientific Reports 5, 12545 (2015)
90.
Zeitschriftenartikel
The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics. Human Molecular Genetics 24 (14), S. 3971 - 3981 (2015)
91.
Zeitschriftenartikel
Structural integrity of the A147T polymorph of mammalian TSPO. ChemBioChem 16 (10), S. 1483 - 1489 (2015)
92.
Zeitschriftenartikel
Lost in translocation: The functions of the 18-kD translocator protein. Trends in Endocrinology and Metabolism 26 (7), S. 349 - 356 (2015)
93.
Zeitschriftenartikel
Tau stabilizes microtubules by binding at the interface between tubulin heterodimers. Proceedings of the National Academy of Sciences of the United States of America 112 (24), S. 7501 - 7506 (2015)
94.
Zeitschriftenartikel
Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation. Acta Neuropathologica 129 (5), S. 695 - 713 (2015)
95.
Zeitschriftenartikel
HYCUD: A computational tool for prediction of effective rotational correlation time in flexible proteins. Bioinformatics 31 (8), S. 1319 - 1321 (2015)
96.
Zeitschriftenartikel
Parkinson disease mutant E46K enhances alpha-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo. Journal of Biological Chemistry 290 (15), S. 9412 - 9427 (2015)
97.
Zeitschriftenartikel
Solid-state NMR, electrophysiology and molecular dynamics characterization of human VDAC2. Journal of Biomolecular NMR 61 (3-4), S. 311 - 320 (2015)
98.
Zeitschriftenartikel
Multiple paramagnetic effects through a tagged reporter protein. Angewandte Chemie International Edition 54 (1), S. 336 - 339 (2015)
99.
Zeitschriftenartikel
Copper binding to the N-terminally acetylated, naturally occurring form of alpha-synuclein induces local helical folding. Journal of the American Chemical Society 137 (20), S. 6444 - 6447 (2015)