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Inducing sterile pyramidal neuronal death in mice to model distinct aspects of gray matter encephalitis. Acta Neuropathologica Communications 102.
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Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2. Journal of Biological Chemistry 103.
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Discovery of KV1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges. Medicinal Research Reviews 104.
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Defining genome architecture at base-pair resolution. Nature 105.
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Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex. Nature Communications 106.
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Liquid–liquid phase separation of tau: From molecular biophysics to physiology and disease. Protein Science 107.
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GROMACS implementation of free energy calculations with non-pairwise variationally derived intermediates. Computer Physics Communications 108.
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Thermodynamic modeling reveals widespread multivalent binding by RNA-binding proteins. Bioinformatics 109.
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Preadult polytoxicomania—strong environmental underpinnings and first genetic hints. Molecular Psychiatry 110.
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Recapitulation of selective nuclear import and export with a perfectly repeated 12mer GLFG peptide. Nature Communications 111.
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Evaluation and optimization of high-field asymmetric waveform ion-mobility spectrometry for multiplexed quantitative site-specific N-glycoproteomics. Analytical Chemistry 112.
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Lateral gate dynamics of the bacterial translocon during cotranslational membrane protein insertion. Proceedings of the National Academy of Sciences of the USA 113.
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Cyanate formation via photolytic splitting of dinitrogen. JACS Au 114.
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Coordinated bi-directional trafficking of synaptic vesicle and active zone proteins in peripheral nerves. Biochemical and Biophysical Research Communications 115.
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Mitochondrial protein abundance gradients require the distribution of separated mitochondria. Biology 116.
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Dissecting and modeling photic and melanopsin effects to predict sleep disturbances induced by irregular light exposure in mice. Preoceedings of the National Academy of Sciences of the USA 117.
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The positive switching fluorescent protein Padron2 enables live-cell reversible saturable optical linear fluorescence transitions (RESOLFT) nanoscopy without sequential illumination steps. ACS Nano 118.
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Live fluorescence imaging of F-actin organization in chick whole embryo cultures using SiR-actin. Cells 119.
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A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker. Nature Communications 120.
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Chiral high-harmonic generation and spectroscopy on solid surfaces using polarization-tailored strong fields. Nature Communications 121.
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Low-Expressing synucleinopathy mouse models based on oligomer-forming mutations and C-terminal truncation of α-synuclein. Frontiers in Neuroscience 122.
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Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling. Nature Communications 123.
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Tight docking of membranes before fusion represents a novel, metastable state with unique properties. Nature Communications 124.
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Going to extremes: A metagenomic journey into the dark matter of life. FEMS Microbiology Letters 125.
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Human genomics of the humoral immune response against polyomaviruses. Virus Evolution 126.
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Deep learning-based post-processing of real-time MRI to assess and quantify dynamic wrist movement in health and disease. Diagnostics 127.
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Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis. Nature Communications 128.
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Statistical analysis of ENDOR spectra. Proceedings of the National Academy of Sciences of the USA 129.
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SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes. Nucleic Acids Research 130.
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Structures of mammalian RNA polymerase II pre-initiation complexes. Nature 131.
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NO binding energies to and diffusion barrier on Pd obtained with velocity-resolved kinetics. The Journal of Physical Chemistry C 132.
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Structure of the human Mediator-RNA polymerase II pre-initiation complex. Nature 133.
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Chemical dynamics from the gas-phase to surfaces. Natural Sciences 134.
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Spontaneous serum autoantibody fluctuations: To be or not to be. Molecular Psychiatry 135.
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Structure and function of SARS-CoV-2 polymerase. Current Opinion in Virology 136.
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[11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates. European Journal of Nuclear Medicine and Molecular Imaging 137.
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The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II. Journal of Biological Chemistry 138.
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Multiple inducers and novel roles of autoantibodies against the obligatory NMDAR subunit NR1: a translational study from chronic life stress to brain injury. Molecular Psychiatry 139.
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Ultrafast spot-profile LEED of a charge-density wave phase transition. Applied Physics Letters 140.
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Extreme parsimony in ATP consumption by 20S complexes in the global disassembly of single SNARE complexes. Nature Communications 141.
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Toolbox for quantifying memory in dynamics along reaction coordinates. Physical Review Research 142.
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Ruler elements in chromatin remodelers set nucleosome array spacing and phasing. Nature Communications 143.
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Parental genome unification is highly error-prone in mammalian embryos. Cell 144.
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Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2. Communications Biology 145.
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A lysine–cysteine redox switch with an NOS bridge regulates enzyme function. Nature 146.
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Detection of water molecules on the radical transfer pathway of ribonucleotide reductase by 17O electron–nuclear double resonance spectroscopy. The Journal of the American Chemical Society 147.
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Proton detected solid-state NMR of membrane proteins at 28 Tesla (1.2 GHz) and 100 kHz magic-angle spinning. Biomolecules 148.
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Direct visualization of amlodipine intervention into living cells by means of fluorescence microscopy. Molecules 149.
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Itk promotes the integration of TCR and CD28 costimulation through its direct substrates SLP-76 and Gads. The Journal of Immunology 150.
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Insights into the molecular mechanism of amyloid filament formation: Segmental folding of α-synuclein on lipid membranes. Science Advances