Publications of Reinhard Lührmann

Li, Y.; Fischer, P.; Wang, M.; Zhou, Q.; Song, A.; Yuan, R.; Meng, W.; Chen, F. X.; Lührmann, R.; Lau, B. et al.; Hurt, E.; Cheng, J.: Structural insights into spliceosome fidelity: DHX35–GPATCH1- mediated rejection of aberrant splicing substrates. Cell Research 35, pp. 296 - 308 (2025)

Zhang, Z.; Kumar, V.; Dybkov, O.; Will, C. L.; Zhong, J.; Ludwig, S. E. J.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Structural insights into the cross-exon to cross-intron spliceosome switch. Nature 630, pp. 1012 - 1019 (2024)

Atkinson, R.; Georgiou, M.; Yang, C.; Szymanska, K.; Lahat, A.; Vasconcelos, E.J.R.; Ji, Y.; Moya Molina, M.; Collin, J.; Queen, R. et al.; Dorgau, B.; Watson, A.; Kurzawa-Akanbi, M.; Laws, R.; Saxena, A.; Shyan Beh, C.; Siachisumo, C.; Goertler, F.; Karwatka, M.; Davey, T.; Inglehearn, C.F.; McKibbin, M.; Lührmann, R.; Steel, D.H.; Elliott, D.J.; Armstrong, L.; Urlaub, H.; Ali, R.R.; Grellscheid, S.-N.; Johnson, C.A.; Mozaffari-Jovin, S.; Lako, M.: PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects. Nature Communications 15, 3138 (2024)

Zhang, Z.; Kumar, V.; Dybkov, O.; Will, C. L.; Urlaub, H.; Stark, H.; Lührmann, R.: Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins. The EMBO Journal 43, pp. 1065 - 1088 (2024)

Dybkov, O.; Preußner, M.; El Ayoubi, L.; Feng, V.-Y.; Harnisch, C.; Merz, K.; Leupold, P.; Yudichev, P.; Agafonov, D. E.; Will, C. L. et al.; Girard, C.; Dienemann, C.; Urlaub, H.; Kastner, B.; Heyd, F.; Lührmann, R.: Regulation of 3′ splice site selection after step 1 of splicing by spliceosomal C* proteins. Science Advances 9 (9), eadf178 (2023)

Georgiou, M.; Yang, C.; Atkinson, R.; Pan, K.‐.; Buskin, A.; Molina, M. M.; Collin, J.; Al‐Aama, J.; Goertler, F.; Ludwig, S. E. J. et al.; Davey, T.; Lührmann, R.; Nagaraja‐Grellscheid, S.; Johnson, C. A.; Ali, R.; Armstrong, L.; Korolchuk, V.; Urlaub, H.; Mozaffari‐Jovin, S.; Lako, M.: Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient‐induced pluripotent stem cell‐derived retinal pigment epithelium cells. Clinical and Translational Medicine 12 (3), e759 (2022)

Zhang, Z.; Rigo, N.; Dybkov, O.; Fourmann, J. B.; Will, C. L.; Kumar, V.; Urlaub, H.; Stark, H.; Lührmann, R.: Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature 596 (7871), pp. 296 - 300 (2021)

Yildirim, A.; Mozaffari-Jovin, S.; Wallisch, A. K.; Schäfer, J.; Ludwig, S. E. J.; Urlaub, H.; Lührmann, R.; Wolfrum, U.: SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes. Nucleic Acids Research 49 (10), pp. 5845 - 5866 (2021)

Zhang, S.; Aibara, S.; Vos, S. M.; Agafonov, D.; Lührmann, R.; Cramer, P.: Structure of a transcribing RNA polymerase II–U1 snRNP complex. Science 371 (6526), pp. 305 - 309 (2021)

Townsend, C.; Leelaram, M. N.; Agafonov, D. E.; Dybkov, O.; Will, C. L.; Bertram, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science 370 (6523), eabc3753 (2020)

Bertram, K.; El Ayoubi, L.; Dybkov, O.; Agafonov, D.; Will, C. L.; Hartmuth, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Structural insights into the roles of metazoan-specific splicing factors in the human step 1 spliceosome. Molecular Cell 80 (1), pp. 127 - 139.e6 (2020)

Zhang, Z.; Will, C. L.; Bertram, K.; Dybkov, O.; Hartmuth, K.; Agafonov, D. E.; Hofele, R. V.; Urlaub, H.; Kastner, B.; Lührmann, R. et al.; Stark, H.: Molecular architecture of the human 17S U2 snRNP. Nature 583 (7815), pp. 310 - 313 (2020)

Cossa, G.; Roeschert, I.; Prinz, F.; Baluapuri, A.; Silveira Vidal, R.; Schülein-Völk, C.; Chang, Y. C.; Ade, C. P.; Mastrobuoni, G.; Girard, C. et al.; Wortmann, L.; Walz, S.; Lührmann, R.; Kempa, S.; Kuster, B.; Wolf, E.; Mumberg, D.; Eilers, M.; Eilers, M.: Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. Molecular Cell 77 (6), pp. 1322 - 1339.e11 (2020)

Lührmann, R.: Kiyoshi Nagai (1949-2019). RNA 26 (2), pp. vii - viii (2020)

Kastner, B.; Will, C. L.; Stark, H.; Lührmann, R.: Structural insights into nuclear pre-mRNA splicing in higher eukaryotes. Cold Spring Harbor Perspectives in Biology 11 (11), a032417 (2019)

Bryen, S. J.; Joshi, H.; Evesson, F. J.; Girard, C.; Ghaoui, R.; Waddell, L. B.; Testa, A. C.; Cummings, B.; Arbuckle, S.; Graf, N. et al.; Webster, R.; MacArthur, D. G.; Laing, N. G.; MR, D.; Lührmann, R.; Cooper, S. T.: Pathogenic abnormal splicing due to intronic deletions that induce biophysical space constraint for spliceosome assembly. American Journal of Human Genetics 105 (3), pp. 573 - 587 (2019)

Keiper, S. M.; Papasaikas, P.; Will, C. L.; Valcárcel, J.; Girard, C.; Lührmann, R.: Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns. Nature Communications 10 (1), 3639 (2019)

Bao, P.; Boon, K. L.; Will, C. L.; Hartmuth, K.; Lührmann, R.: Multiple RNA-RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome. Nucleic Acids Research 46 (22), pp. 12126 - 12138 (2018)

Buskin, A.; Zhu, L.; Chichagova, V.; Basu, B.; Mozafarri Jovin, S.; Dolan, D.; Droop, A.; Collin, J.; Bronstein, R.; Mehrotra, S. et al.; Farkas, M.; Hilgen, G.; White, K.; Pan, K. T.; Treumann, A.; Hallam, D.; Bialas, K.; Chung, G.; Mellough, C.; Ding, Y.; Krasnogor, N.; Przyborski, S.; Zwolinski, S.; Al-Aama, J.; Alharthi, S.; Xu, Y.; Wheway, G.; Szymanska, K.; McKibbin, M.; Inglehearn, C. F.; Elliott, D. J.; Lindsay, S.; Ali, R. R.; Steel, D. H.; Armstrong, L.; Sernagor, E.; Urlaub, H.; Pierce, E.; Lührmann, R.; Grellscheid, S. N.; Johnson, C. A.; Lako, M.: Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa. Nature Communications 9, 4234 (2018)

Roithová, A.; Klimešová, K.; Pánek, J.; Will, C. L.; Lührmann, R.; Stanek, D.; Girard, C.: The Sm-core mediates the retention of partially-assembled spliceosomal snRNPs in Cajal bodies until their full maturation. Nucleic Acids Research 46 (7), pp. 3774 - 3790 (2018)