Publications of Gesine Saher

Saher, G.; Stumpf, S. K.: Cholesterol in myelin biogenesis and hypomyelinating disorders. Biochimica et Biophysica Acta 1851, pp. 1083 - 1094 (2015)

Hammer, C.; Stepniak, B.; Schneider, A.; Papiol, S.; Tantra, M.; Begemann, M.; Sirén, A.-L.; Pardo, L. A.; Sperling, S.; Mohd Jofrry, S. et al.; Gurvich, A.; Jensen, N.; Ostmeier, K.; Lühder, F.; Probst, C.; Martens, H.; Gillis, M.; Saher, G.; Assogna, F.; Spalletta, G.; Stöcker, W.; Schulz, T. F.; Nave, K.-A.; Ehrenreich, H.: Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. Molecular Psychiatry 19 (10), pp. 1143 - 1149 (2014)

Werner, H. B.; Krämer-Albers, E.-M.; Strenzke, N.; Saher, G.; Tenzer, S.; Ohno-Iwashita, Y.; Monasterio-Schrader, P. d.; Möbius, W.; Moser, T.; Griffiths, I. R. et al.; Nave, K.-A.: A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system. Glia 61 (4), pp. 567 - 586 (2013)

Paul, D.; Hoppe, S.; Saher, G.; Krijnse-Locker, J.; Bartenschlager, R.: Morphological and biochemical characterization of the membranous hepatitis C virus replication compartment. Journal of Virology 87 (19), pp. 10612 - 10627 (2013)

Saher, G.; Rudolphi, F.; Corthals, K.; Ruhwedel, T.; Schmidt, K.-F.; Löwel, S.; Dibaj, P.; Barrette, B.; Möbius, W.; Nave, K.-A.: Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet. Nature Medicine 18 (7), pp. 1130 - 1135 (2012)

Fünfschilling, U.; Jockusch, W. J.; Sivakumar, N.; Möbius, W.; Corthals, K.; Li, S.; Quintes, S.; Kim, Y.; Schaap, I. A. T.; Rhee, J.-S. et al.; Nave, K.-A.; Saher, G.: Critical time window of neuronal cholesterol synthesis during neurite outgrowth. The Journal of Neuroscience 32 (22), pp. 7632 - 7645 (2012)

Chrast, R.; Saher, G.; Nave, K.-A.; Verheijen, M. H. G.: Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models. Journal of Lipid Research 52 (3), pp. 419 - 434 (2011)

Kassmann, C. M.; Quintes, S.; Rietdorf, J.; Möbius, W.; Sereda, M. W.; Nientiedt, T.; Saher, G.; Baes, M.; Nave, K.-A.: A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity. FEBS Letters 585 (14), pp. 2205 - 2211 (2011)

Saher, G.; Quintes, S.; Nave, K.-A.: Cholesterol: a novel regulatory role in myelin formation. The Neuroscientist 17 (1), pp. 79 - 93 (2011)

Quintes, S.; Goebbels, S.; Saher, G.; Schwab, M. H.; Nave, K.-A.: Neuron-glia signaling and the protection of axon function by Schwann cells. Journal of the Peripheral Nervous System 15 (1), pp. 10 - 16 (2010)

Saito, K.; Dubreuil, V.; Arai, Y.; Wilsch-Bräuninger, M.; Schwudke, D.; Saher, G.; Miyata, T.; Breier, G.; Thiele, C.; Shevchenko, A. et al.; Nave, K.-A.; Huttner, W. B.: Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis. Proceedings of the National Academy of Sciences of the United States of America 106 (20), pp. 8350 - 8355 (2009)

Saher, G.; Quintes, S.; Möbius, W.; Wehr, M. C.; Krämer-Albers, E.-M.; Brügger, B.; Nave, K.-A.: Cholesterol regulates the endoplasmic reticulum exit of the major membrane protein P0 required for peripheral myelin compaction. The Journal of Neuroscience 29 (19), pp. 6094 - 6104 (2009)

Fünfschilling, U.; Saher, G.; Xiao, L.; Möbius, W.; Nave, K.-A.: Survival of adult neurons lacking cholesterol synthesis in vivo. BMC Neuroscience 8, 1 (2007)

Saher, G.; Brügger, B.; Lappe-Siefke, C.; Möbius, W.; Tozawa, R.-i.; Wehr, M. C.; Wieland, F.; Ishibashi, S.; Nave, K.-A.: High cholesterol level is essential for myelin membrane growth. Nature Neuroscience 8 (4), pp. 468 - 475 (2005)

Saher, G.; Simons, M.: Cholesterol and myelin biogenesis. In: Cholesterol Binding and Cholesterol Transport Proteins: Structure and Function in Health and Disease, 10.1007/978-90-481-8622-8_18, pp. 489 - 508 (Ed. Harris, J. R.). Springer, Dordrecht (2010)

Depp, C.; Sun, T.; Sasmita, A. O.; Spieth, L.; Berghoff, S. A.; Steixner-Kumar, A. A.; Subramanian, S.; Möbius, W.; Göbbels, S.; Saher, G. et al.; Zampar, S.; Wirths, O.; Thalmann, M.; Saito, T.; Saido, T.; Krüger-Burg, D. D.; Kawaguchi, R.; Willem, M.; Haass, C.; Geschwind, D.; Ehrenreich, H.; Stassart, R.; Nave, K.-A.: Ageing-associated myelin dysfunction drives amyloid deposition in mouse models of Alzheimer's disease. (2021)

Altas, B.; Ju, A.; Cruces Solís, H.; Karaca, S.; Winchenbach, J.; Kaplan, Ö.; Schwark, M.; Wieser, G. L.; Chaugule, V. K.; Majoul, I. et al.; Hassan, M. A.; Goel, R.; Wojcik, S. M.; Pichler, A.; Mitkovski, M.; de Hoz, L.; Urlaub, H.; Jahn, O.; Saher, G.; Rhee, J. S.; Kawabe, H.: Physiological and pathophysiological homeostasis of astroglial channel proteins by Nedd4-2. (2019)