Publications of K. Hartmuth

Bertram, K.; El Ayoubi, L.; Dybkov, O.; Agafonov, D.; Will, C. L.; Hartmuth, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Structural insights into the roles of metazoan-specific splicing factors in the human step 1 spliceosome. Molecular Cell 80 (1), pp. 127 - 139.e6 (2020)

Zhang, Z.; Will, C. L.; Bertram, K.; Dybkov, O.; Hartmuth, K.; Agafonov, D. E.; Hofele, R. V.; Urlaub, H.; Kastner, B.; Lührmann, R. et al.; Stark, H.: Molecular architecture of the human 17S U2 snRNP. Nature 583 (7815), pp. 310 - 313 (2020)

Bao, P.; Boon, K. L.; Will, C. L.; Hartmuth, K.; Lührmann, R.: Multiple RNA-RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome. Nucleic Acids Research 46 (22), pp. 12126 - 12138 (2018)

Haselbach, D.; Komarov, I.; Agafonov, D. E.; Hartmuth, K.; Graf, B.; Dybkov, O.; Urlaub, H.; Kastner, B.; Lührmann, R.; Stark, H.: Structure and conformational dynamics of the human spliceosomal B^act complex. Cell 172 (3), pp. 454 - 464, e1-e5 (2018)

Bao, P.; Höbartner, C.; Hartmuth, K.; Lührmann, R.: Yeast Prp2 liberates the 5' splice site and the branch site adenosine for catalysis of pre-mRNA splicing. RNA 23 (12), pp. 1770 - 1779 (2017)

Bertram, K.; Agafonov, D. E.; Liu, W.; Dybkov, O.; Will, C. L.; Hartmuth, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 542 (7641), pp. 318 - 323 (2017)

Rauhut, R.; Fabrizio, P.; Dybkov, O.; Hartmuth, K.; Pena, V.; Chari, A.; Kumar, V.; Lee, C. T.; Urlaub, H.; Kastner, B. et al.; Stark, H.; Lührmann, R.: Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 353 (6306), pp. 1399 - 1405 (2016)

Schneider, C.; Agafonov, D. E.; Schmitzova, J.; Hartmuth, K.; Fabrizio, P.; Lührmann, R.: Dynamic contacts of U2, RES, Cwc25, Prp8 and Prp45 proteins with the Pre-mRNA branch-site and 3' splice site during catalytic activation and step 1 catalysis in yeast spliceosomes. PLoS Genetics 11 (9), e1005539 (2015)

Anokhina, M.; Bessonov, S.; Miao, Z. C.; Westhof, E.; Hartmuth, K.; Lührmann, R.: RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core. EMBO Journal 32 (21), pp. 2804 - 2818 (2013)

Girard, C.; Will, C. L.; Peng, J.; Makarov, E. M.; Kastner, B.; Lemm, I.; Urlaub, H.; Hartmuth, K.; Lührmann, R.: Retention of posttranscriptional spliceosomes in nuclear speckles until splicing completion. Nature communications 3, 994 (2012)

Mathew, R.; Hartmuth, K.; Moehlmann, S.; Urlaub, H.; Ficner, R.; Luehrmann, R.: Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome. Nature Structural & Molecular Biology 15 (5), pp. 435 - 443 (2008)

Liu, S.; Li, P.; Dybkov, O.; Nottrott, S.; Hartmuth, K.; Luehrmann, R.; Carlomagno, T.; Wahl, M. C.: Binding of the human Prp31 nop domain to a composite RNA-protein platform in U4 snRNP. Science 316, 5821, pp. 115 - 120 (2007)

Behzadnia, N.; Golas, M. M.; Hartmuth, K.; Sander, B.; Kastner, B.; Deckert, J.; Dube, P.; Will, C. L.; Urlaub, H.; Stark, H. et al.; Luehrmann, R.: Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. The EMBO Journal 26 (6), pp. 1737 - 1748 (2007)

Doenmez, G.; Hartmuth, K.; Kastner, B.; Will, C. L.; Luehrmann, R.: The 5′ end of U2 snRNA is in close proximity to U1 and functional sites of the Pre-mRNA in early spliceosomal complexes. Molecular Cell 25 (3), pp. 399 - 411 (2007)

Schultz, A.; Nottrott, S.; Hartmuth, K.; Luehrmann, R.: RNA structural requirements for the association of the spliceosomal hPrp31 protein with the U4 and U4atac small nuclear ribonucleoprotein. Journal of Biological Chemistry 281 (38), pp. 28278 - 28286 (2006)

Deckert, J.; Hartmuth, K.; Boehringer, D.; Behzadnia, N.; Will, C. L.; Kastner, B.; Stark, H.; Urlaub, H.; Luehrmann, R.: Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions. Molecular and Cellular Biology 26 (14), pp. 5528 - 5543 (2006)

Rhode, B.; Hartmuth, K.; Westhof, E.; Luehrmann, R.: Proximity of conserved U6 and U2 snRNA elements to the 5' splice site region in activated spliceosomes. EMBO Journal 25 (11), pp. 2475 - 2486 (2006)

Dybkov, O.; Will, C. L.; Deckert, J.; Behzadnia, N.; Hartmuth, K.; Luehrmann, R.: U2 snRNA-protein contacts in purified human 17S U2 snRNPs and in spliceosomal A and B complexes. Molecular and Cellular Biology 26 (7), pp. 2803 - 2816 (2006)

Behzadnia, N.; Hartmuth, K.; Will, C. L.; Luehrmann, R.: Functional spliceosomal A complexes can be assembled in vitro in the absence of a penta-snRNP. RNA 12, pp. 1738 - 1746 (2006)

Karaduman, R.; Fabrizio, P.; Hartmuth, K.; Urlaub, H.; Luehrmann, R.: RNA structure and RNA-protein interactions in purified yeast U6 snRNPs. Journal of Molecular Biology 356, pp. 1248 - 1262 (2006)