Publications of D. Fasshauer

Demircioglu, F. E.; Burkhardt, P.; Fasshauer, D.: The SM protein Sly1 accelerates assembly of the ER-Golgi SNARE complex. Proceedings of the National Academy of Sciences of the United States of America 111 (38), pp. 13828 - 13833 (2014)

Colbert, K. N.; Hattendorf, D. A.; Weiss, T. M.; Burkhardt, P.; Fasshauer, D.; Weis, W. I.: Syntaxin1a variants lacking an N-peptide or bearing the LE mutation bind to Munc18a in a closed conformation. Proceedings of the National Academy of Sciences of the United States of America 110 (31), pp. 12637 - 12642 (2013)

Honigmann, A.; van den Bogaart, G.; Iraheta, E.; Risselada, H. J.; Milovanovic, D.; Müller, V.; Müller, S.; Diederichsen, U.; Fasshauer, D.; Grubmüller, H. et al.; Hell, S. W.; Eggeling, C.; Kühnel, K.; Jahn, R.: Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment. Nature Structural and Molecular Biology 20, pp. 679 - 686 (2013)

Jahn, R.; Fasshauer, D.: Molecular machines governing exocytosis of synaptic vesicles. Nature 490 (7419), pp. 201 - 207 (2012)

Meijer, M.; Burkhardt, P.; de Wit, H.; Toonen, R. F.; Fasshauer, D.; Verhage, M.: Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission. The EMBO Journal 31 (9), pp. 2156 - 2168 (2012)

Burkhardt, P.; Stegmann, C. M.; Cooper, B.; Kloepper, T. H.; Imig, C.; Varoqueaux, F.; Wahl, M. C.; Fasshauer, D.: Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis. Proceedings of the National Academy of Sciences of the United States of America 108 (37), pp. 15264 - 15269 (2011)

Wiederhold, K.; Klöpper, T. H.; Walter, A. M.; Stein, A.; Kienle, N.; Sörensen, J. B.; Fasshauer, D.: A coiled coil trigger site is essential for rapid binding of synaptobrevin to the SNARE acceptor complex. Journal of Biological Chemistry 285 (28), pp. 21549 - 21559 (2010)

Walter, A. M.; Wiederhold, K.; Bruns, D.; Fasshauer, D.; Soerensen, J. B.: Synaptobrevin N-terminally bound to syntaxin–SNAP-25 defines the primed vesicle state in regulated exocytosis. The Journal of Cell Biology 188 (3), pp. 401 - 413 (2010)

Domanska, M. K.; Kiessling, V.; Stein, A.; Fasshauer, D.; Tamm, L. K.: Single vesicle millisecond fusion kinetics reveals number of SNARE complexes optimal for fast SNARE-mediated membrane fusion. Journal of Biological Chemistry 284 (46), pp. 32158 - 32166 (2009)

Winter, U.; Chen, X.; Fasshauer, D.: A Conserved Membrane Attachment Site in alpha-SNAP Facilitates N-Ethylmaleimide-sensitive Factor (NSF)-driven SNARE Complex Disassembly. Journal of Biological Chemistry 284 (46), pp. 31817 - 31826 (2009)

Kienle, N.; Kloepper, T. H.; Fasshauer, D.: Differences in the SNARE evolution of fungi and metazoa. Biochemical Society Transactions 37, pp. 787 - 791 (2009)

Wiederhold, K.; Fasshauer, D.: Is assembly of the SNARE complex enough to fuel membrane fusion? Journal of Biological Chemistry 284 (19), pp. 13143 - 13152 (2009)

Kienle, N.; Kloepper, T.; Fasshauer, D.: Phylogeny of the SNARE vesicle fusion machinery yields insights into the conservation of the secretory pathway in fungi. BMC Evolutionary Biology 9, 19 (2009)

Radhakrishnan, A.; Stein, A.; Jahn, R.; Fasshauer, D.: The Ca²⁺ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate. Journal of Biological Chemistry 284, pp. 25749 - 25760 (2009)

Bar-On, D.; Winter, U.; Nachliel, E.; Gutman, M.; Fasshauer, D.; Lang, T.; Ashery, U.: Imaging the assembly and disassembly kinetics of cis-SNARE complexes on native plasma membranes. FEBS Letters 582 (23-24), pp. 3563 - 3568 (2008)

Kloepper, T. H.; Kienle, N.; Fasshauer, D.: SNAREing the basis of multicellularity: consequences of protein family expansion during evolution. Molecular Biology and Evolution 25 (9), pp. 2055 - 2068 (2008)

Barszczewski, M.; Chua, J.; Stein, A.; Winter, U.; Heintzmann, R.; Zilly, F. E.; Fasshauer, D.; Lang, T.; Jahn, R.: A novel site of action for α -SNAP in the SNARE conformational cycle controlling membrane fusion. Molecular Biology of the Cell 19 (3), pp. 776 - 784 (2008)

Burkhardt, P.; Hattendorf, D. A.; Weis, W. I.; Fasshauer, D.: Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide. The EMBO Journal 27 (7), pp. 923 - 933 (2008)

Stein, A.; Radhakrishnan, A.; Riedel, D.; Fasshauer, D.; Jahn, R.: Synaptotagmin activates membrane fusion through a Ca²⁺-dependent trans interaction with phospholipids. Nature Structure & Molecular Biology 14 (10), pp. 904 - 911 (2007)

Kloepper, T. H.; Kienle, N.; Fasshauer, D.: An elaborate classification of SNARE proteins sheds light on the conservation of the eukaryotic endomembrane system. Molecular Biology of the Cell 18 (9), pp. 3463 - 3471 (2007)