Publications of P. Fabrizio

Fourmann, J. B.; Dybkov, O.; Agafonov, D. E.; Tauchert, M. J.; Urlaub, H.; Ficner, R.; Fabrizio, P.; Lührmann, R.: The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction. eLife 5, e15564 (2016)

Rigo, N.; Sun, C.; Fabrizio, P.; Kastner, B.; Lührmann, R.: Protein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex. EMBO Journal 34 (24), pp. 3059 - 3073 (2015)

Schneider, C.; Agafonov, D. E.; Schmitzova, J.; Hartmuth, K.; Fabrizio, P.; Lührmann, R.: Dynamic contacts of U2, RES, Cwc25, Prp8 and Prp45 proteins with the Pre-mRNA branch-site and 3' splice site during catalytic activation and step 1 catalysis in yeast spliceosomes. PLoS Genetics 11 (9), e1005539 (2015)

Liu, S.; Mozaffari-Jovin, S.; Wollenhaupt, J.; Santos, , K. F.; Theuser, M.; Dunin-Horkawicz, S.; Fabrizio, P.; Bujnicki, J. M.; Lührmann, R.; Wahl, M. C.: A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing. eLife 4, e07320 (2015)

Warkocki, Z.; Schneider, C.; Mozaffari-Jovin, S.; Schmitzova, J.; Höbartner, C.; Fabrizio, P.; Lührmann, R.: The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome. Genes and Development 29 (1), pp. 94 - 107 (2015)

Ohrt, T.; Odenwälder, P.; Dannenberg, J.; Prior , M.; Warkocki, Z.; Schmitzova, J.; Karaduman, R.; Gregor, I.; Enderlein, J.; Fabrizio, P. et al.; Lührmann, R.: Molecular dissection of step 2 catalysis of yeast pre-mRNA splicing investigated in a purified system. RNA 19 (7), pp. 902 - 915 (2013)

Fourmann, J. B.; Schmitzova, J.; Christian, H.; Urlaub, H.; Ficner, R.; Boon, K. L.; Fabrizio, P.; Lührmann, R.: Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system. Genes and Development 27 (4), pp. 413 - 428 (2013)

Rasche, N.; Dybkov, O.; Schmitzova, J.; Akyildiz, B.; Fabrizio, P.; Lührmann, R.: Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. EMBO Journal 31 (6), pp. 1591 - 1604 (2012)

Ohrt, T.; Prior, M.; Dannenberg, J.; Odenwälder, P.; Dybkov, O.; Rasche, N.; Schmitzova, J.; Gregor, I.; Fabrizio, P.; Enderlein, J. et al.; Lührmann, R.: Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS. RNA 18 (6), pp. 1244 - 1256 (2012)

Schmitzova, J.; Rasche, N.; Dybkov, O.; Kramer, K.; Fabrizio, P.; Urlaub, H.; Lührmann, R.; Pena, V.: Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein. EMBO Journal 31 (9), pp. 2222 - 2234 (2012)

Warkocki, Z.; Odenwälder, P.; Schmitzova, J.; Platzmann, F.; Stark, H.; Urlaub, H.; Ficner, R.; Fabrizio, P.; Lührmann, R.: Reconstitution of both steps of S. cerevisiae splicing with purified spliceosomal components. Nature Structural and Molecular Biology 16 (12), pp. 1237 - 1243 (2009)

Fabrizio, P.; Dannenberg, J.; Dube, P.; Kastner, B.; Stark, H.; Urlaub, H.; Lührmann, R.: The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. Molecular Cell 36 (4), pp. 593 - 608 (2009)

Pena, V.; Jovin, S. M.; Fabrizio, P.; Orlowski, J.; Bujnicki, J. M.; Lührmann, R.; Wahl, M. C.: Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase. Molecular Cell 35 (4), pp. 454 - 466 (2009)

Karaduman, R.; Dube, P.; Stark, H.; Fabrizio, P.; Kastner, B.; Luehrmann, R.: Structure of yeast U6 snRNPs: arrangement of Prp24p and the LSm complex as revealed by electron microscopy. RNA 14, pp. 2528 - 2537 (2008)

Haecker, I.; Sander, B.; Golas, M. M.; Wolf, E.; Karagoez, E.; Kastner, B.; Stark, H.; Fabrizio, P.; Luehrmann, R.: Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy. Nature Structural and Molecular Biology 15 (11), pp. 1206 - 1212 (2008)

Pena, V.; Rozov, A.; Fabrizio, P.; Luehrmann, R.; Wahl, M. C.: Structure and function of an RNase H domain at the heart of the spliceosome. The EMBO Journal 27 (21), pp. 2929 - 2940 (2008)

Bartels, C.; Urlaub, H.; Luehrmann, R.; Fabrizio, P.: Mutagenesis suggests several roles of Snu114p in pre- mRNA splicing. Journal of Biological Chemistry 278 (30), pp. 28324 - 28334 (2003)

Bartels, C.; Klatt, C.; Luehrmann, R.; Fabrizio, P.: The ribosomal translocase homologue Snu114p is involved in unwinding U4/U6 RNA during activation of the spliceosome. EMBO Reports 3 (9), pp. 875 - 880 (2002)

Mougin, A.; Gottschalk, A.; Fabrizio, P.; Luehrmann, R.; Branlant, C.: Direct probing of RNA structure and RNA-protein interactions in purifies HeLa cells and yeast spliceosomal U4/U6.U5 tri-snRNP particles. Journal of Biological Chemistry 317 (5), pp. 631 - 649 (2002)

Gottschalk, A.; Kastner, B.; Luehrmann, R.; Fabrizio, P.: The yeast U5 snRNP co-isolated with the U1 snRNP has an unexpected protein composition and includes the splicing factor Aar2p. RNA 7, pp. 1554 - 1566 (2001)