Publications of R. Brundiers

Ostermann, N.; Lavie, A.; Padiyar, S.; Brundiers, R.; Veit, T.; Reinstein, J.; Goody, R. S.; Konrad, M.; Schlichting, I.: Potentiating AZT activation: Structure of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP. Journal of Molecular Biology 304, pp. 43 - 53 (2000)

Ostermann, N.; Schlichting, I.; Brundiers, R.; Konrad, M.; Reinstein, J.; Veit, T.; Goody, R. S.; Lavie, A.: Insights into the phosphoryltransfer mechanism of human thymidylate kinase gained from crystal structures of enzyme complexes along the reaction coordinate. Structure 8, pp. 629 - 642 (2000)

Lavie, A.; Konrad, M.; Brundiers, R.; Goody, R. S.; Schlichting, I.; Reinstein, J.: Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P¹-(5′-adenosyl)P⁵-(5′-thymidyl) pentaphosphate (TP₅A) at 2.0 Å resolution: Implications for catalysis and AZT activation. Biochemistry 37, pp. 3677 - 3686 (1998)

Lavie, A.; Ostermann, N.; Brundiers, R.; Goody, R. S.; Reinstein, J.; Konrad, M.; Schlichting, I.: Structural basis for efficient phosphorylation of 3′-azidothymidine monophosphate by Escherichia coli thymidylate kinase. Proceedings of the National Academy of Sciences USA 95, pp. 14045 - 14050 (1998)

Brundiers, R.: Protein-Design an Thymidylatkinasen zur Verbesserung des AZT-Monophosphat Umsatzes. Dissertation, Göttingen (1999)