Publications of Hauke S. Hillen

Heinrichs, M.; Finke, A. F.; Aibara, S.; Krempler, A.; Boshnakovska, A.; Rehling, P.; Hillen, H. S.; Richter-Dennerlein, R.: Coupling of ribosome biogenesis and translation initiation in human mitochondria. Nature Communications 16, 3641 (2025)

Bhatta, A.; Kuhle, B.; Yu, R. D.; Spanaus, L.; Ditter, K.; Bohnsack, K. E.; Hillen, H. S.: Molecular basis of human nuclear and mitochondrial tRNA 3′ processing. Nature Structural & Molecular Biology 32, pp. 613 - 624 (2025)

Sala, F. A.; Ditter, K.; Dybkov, O.; Urlaub, H.; Hillen, H. S.: Structural basis of Nipah virus RNA synthesis. Nature Communications 16, 2261 (2025)

Ahrens, F. M.; do Prado, P. F.V.; Hillen, H. S.; Pfannschmidt, T.: The plastid-encoded RNA polymerase of plant chloroplasts. Trends in Plant Science (2025)

Vučković, A.; Freyer, C.; Wredenberg, A.; Hillen, H. S.: The molecular machinery for maturation of primary mtDNA transcripts. Human Molecular Genetics 33 (R1), pp. R19 - R25 (2024)

do Prado, P. F.V.; Ahrens, F.M.; Liebers, M.; Ditz, N.; Braun, H.-P.; Pfannschmidt, T.; Hillen, H. S.: Structure of the multi-subunit chloroplast RNA polymerase. Molecular Cell 84 (5), pp. 910 - 925.e5 (2024)

Poerschke, S.; Oeljeklaus, S.; Cruz-Zaragoza, L.D.; Schenzielorz, A.; Dahal, D.; Hillen, H. S.; Das, H.; Kremer, L.S.; Valpadashi, A.; Breuer, M. et al.; Sattmann, J.; Richter-Dennerlein, R.; Warscheid, B.; Dennerlein, S.; Rehling, P.: Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria. Molecular Cell 84 (2), pp. 345 - 358.e5 (2024)

Wohlfarter, Y.; Eidelpes, R.; Yu, R. D.; Sailer, S.; Koch, J.; Karall, D.; Scholl-Buergi, S.; Amberger, A.; Hillen, H.; Zschocke, J. et al.; Keller, M. A.: ost in promiscuity? An evolutionary and biochemical evaluation of HSD10 function in cardiolipin metabolism. Cellular and Molecular Life Sciences 79 (11), 562 (2022)

Lavdovskaia, E.; Hillen, H. S.; Richter-Dennerlein, R.: Hierarchical folding of the catalytic core during mitochondrial ribosome biogenesis. Trends in Cell Biology 32 (3), pp. 182 - 185 (2022)

Bhatta, A.; Hillen, H.: Mitochondrien: wie die Gene im Kraftwerk der Zelle aktiviert werden. BIOspektrum 28 (1), pp. 18 - 22 (2022)

Bhatta, A.; Hillen, H.: Structural and mechanistic basis of RNA processing by protein-only ribonuclease P enzymes. Trends in Biochemical Sciences 47 (11), pp. 965 - 977 (2022)

Bögershausen, N.; Krawczyk, H. E.; Jamra, R. A.; Lin, S.-J.; Yigit, G.; Hüning, I.; Polo, A. M.; Vona, B.; Huang, K.; Schmidt, J. et al.; Altmüller, J.; Luppe, J.; Platzer, K.; Dörgeloh, B. B.; Busche, A.; Biskup, S.; Mendes, M. I.; Smith, D. E. C.; Salomons, G. S.; Zibat, A.; Bültmann, E.; Nürnberg, P.; Spielmann, M.; Lemke, J. R.; Li, Y.; Zenker, M.; Varshney, G. K.; Hillen, H.; Kratz, C. P.; Wollnik, B.: WARS1 and SARS1: Two tRNA synthetases implicated in autosomal recessive microcephaly. Human Mutations 43 (10), pp. 1454 - 1471 (2022)

Bhatta, A.; Dienemann, C.; Cramer, P.; Hillen, H.: Structural basis of RNA processing by human mitochondrial RNase P. Nature Structural and Molecular Biology 28 (9), pp. 713 - 723 (2021)

Kabinger, F.; Stiller, C.; Schmitzova, J.; Dienemann, C.; Kokic, G.; Hillen, H. S.; Höbartner, C.; Cramer, P.: Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis. Nature Structural and Molecular Biology 28 (9), pp. 740 - 746 (2021)

Jochheim, F. A.; Tegunov, D.; Hillen, H. S.; Schmitzova, J.; Kokic, G.; Dienemann, C.; Cramer, P.: The structure of a dimeric form of SARS-CoV-2 polymerase. Communications Biology 4, 999 (2021)

Hillen, H. S.; Lavdovskaia, E.; Nadler, F.; Hanitsch, E.; Linden, A.; Bohnsack, K. E.; Urlaub, H.; Richter-Dennerlein, R.: Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling. Nature Communications 12, 3672 (2021)

Hillen, H.: Structure and function of SARS-CoV-2 polymerase. Current Opinion in Virology 48, pp. 82 - 90 (2021)

Hillen, H. S.; Markov, D. A.; Wojtas, I. D.; Hofmann, K. B.; Lidschreiber, M.; Cowan, A. T.; Jones, J. L.; Temiakov, D.; Cramer, P.; Anikin, M.: The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3′-UTRs of yeast mitochondrial mRNAs. Proceedings of the National Academy of Sciences of the USA 118 (15), e2009329118 (2021)

Kokic, G.; Hillen, H. S.; Tegunov, D.; Dienemann, C.; Seitz, F.; Schmitzova, J.; Farnung, L.; Siewert, A.; Höbartner, C.; Cramer, P.: Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nature Communications 12, 279 (2021)

Kokic, G.; Hillen, H. S.; Tegunov, D.; Dienemann, C.; Seitz, F.; Schmitzova, J.; Farnung, L.; Siewert, A.; Höbartner, C.; Cramer, P.: Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nature Communications 12, 279 (2021)