Publications of Olexandr Dybkov

Dybkov, O.; Preußner, M.; El Ayoubi, L.; Feng, V.-Y.; Harnisch, C.; Merz, K.; Leupold, P.; Yudichev, P.; Agafonov, D. E.; Will, C. L. et al.; Girard, C.; Dienemann, C.; Urlaub, H.; Kastner, B.; Heyd, F.; Lührmann, R.: Regulation of 3′ splice site selection after step 1 of splicing by spliceosomal C* proteins. Science Advances 9 (9), eadf178 (2023)

Fianu, I.; Chen, Y.; Dienemann, C.; Dybkov, O.; Linden, A.; Urlaub, H.; Cramer, P.: Structural basis of Integrator-mediated transcription regulation. Science 374 (6569), pp. 883 - 887 (2021)

Gomkale, R.; Linden, A.; Neumann, P.; Schendzielorz, A. B.; Stoldt, S.; Dybkov, O.; Kilisch, M.; Schulz, C.; Cruz-Zaragoza, L. D.; Schwappach, B. et al.; Ficner, R.; Jakobs, S.; Urlaub, H.; Rehling, P.: Mapping protein interactions in the active TOM-TIM23 supercomplex. Nature Communications 12, 5715 (2021)

Zhang, Z.; Rigo, N.; Dybkov, O.; Fourmann, J. B.; Will, C. L.; Kumar, V.; Urlaub, H.; Stark, H.; Lührmann, R.: Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature 596 (7871), pp. 296 - 300 (2021)

Townsend, C.; Leelaram, M. N.; Agafonov, D. E.; Dybkov, O.; Will, C. L.; Bertram, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science 370 (6523), eabc3753 (2020)

Netz, E.; Dijkstra, T. M. H.; Sachsenberg, T.; Zimmermann, L.; Walzer, M.; Monecke, T.; Ficner, R.; Dybkov, O.; Urlaub, H.; Kohlbacher, O.: OpenPepXL: An open-source tool for sensitive identification of cross-linked peptides in XL-MS. Molecular and Cellular Proteomics 19 (12), pp. 2157 - 2167 (2020)

Liess, A. K. L.; Kucerova, A.; Schweimer, K.; Schlesinger, D.; Dybkov, O.; Urlaub, H.; Mansfeld, J.; Lorenz, S.: Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S. Science Signaling 13 (654), eaba8208 (2020)

Bertram, K.; El Ayoubi, L.; Dybkov, O.; Agafonov, D.; Will, C. L.; Hartmuth, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Structural insights into the roles of metazoan-specific splicing factors in the human step 1 spliceosome. Molecular Cell 80 (1), pp. 127 - 139.e6 (2020)

Zhang, Z.; Will, C. L.; Bertram, K.; Dybkov, O.; Hartmuth, K.; Agafonov, D. E.; Hofele, R. V.; Urlaub, H.; Kastner, B.; Lührmann, R. et al.; Stark, H.: Molecular architecture of the human 17S U2 snRNP. Nature 583 (7815), pp. 310 - 313 (2020)

Liess, A. K. L.; Kucerova, A.; Schweimer, K.; Yu, L.; Roumeliotis, T. I.; Diebold, M.; Dybkov, O.; Sotriffer, C.; Urlaub, H.; Choudhary, J. S. et al.; Mansfeld, J.; Lorenz, S.: Autoinhibition mechanism of the ubiquitin-conjugating enzyme UBE2S by autoubiquitination. Structure 27 (8), pp. 1195 - 1210 (2019)

Rocha de Moura, T.; Mozaffari-Jovin, S.; Szabo, C. Z. K.; Schmitzova, J.; Dybkov, O.; Cretu, C.; Kachala, M.; Svergun, D.; Urlaub, H.; Lührmann, R. et al.; Pena, V.: Prp19/Pso4 is an autoinhibited ubiquitin ligase activated by stepwise assembly of three splicing factors. Molecular Cell 69 (6), pp. 979 - 992 (2018)

Haselbach, D.; Komarov, I.; Agafonov, D. E.; Hartmuth, K.; Graf, B.; Dybkov, O.; Urlaub, H.; Kastner, B.; Lührmann, R.; Stark, H.: Structure and conformational dynamics of the human spliceosomal B^act complex. Cell 172 (3), pp. 454 - 464, e1-e5 (2018)

Bertram, K.; Agafonov, D. E.; Dybkov, O.; Haselbach, D.; Leelaram, M. N.; Will, C. L.; Urlaub, H.; Kastner, B.; Lührmann, R.; Stark, H.: Cryo-EM structure of a pre-catalytic human spliceosome primed for activation. Cell 170 (4), pp. 701 - 713, e1 - e4 (2017)

Said, N.; Krupp, F.; Anedchenko, E.; Santos, K. F.; Dybkov, O.; Huang, Y. H.; Lee, C. T.; Loll, B.; Behrmann, E.; Bürger, J. et al.; Mielke, T.; Loerke, J.; Urlaub, H.; Spahn, C. M. T.; Weber, G.; Wahl, M. C.: Structural basis for λN-dependent processive transcription antitermination. Nature Microbiology 2 (7), 17062 (2017)

Bertram, K.; Agafonov, D. E.; Liu, W.; Dybkov, O.; Will, C. L.; Hartmuth, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 542 (7641), pp. 318 - 323 (2017)

Cretu, C.; Schmitzova, J.; Ponce-Salvatierra, A.; Dybkov, O.; De Laurentiis, E.; Sharma, K.; Will, C. L.; Urlaub, H.; Lührmann, R.; Pena, V.: Molecular architecture of SF3b and structural consequences of its cancer-related mutations. Molecular Cell 64 (2), pp. 307 - 319 (2016)

Rauhut, R.; Fabrizio, P.; Dybkov, O.; Hartmuth, K.; Pena, V.; Chari, A.; Kumar, V.; Lee, C. T.; Urlaub, H.; Kastner, B. et al.; Stark, H.; Lührmann, R.: Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 353 (6306), pp. 1399 - 1405 (2016)

Fourmann, J. B.; Dybkov, O.; Agafonov, D. E.; Tauchert, M. J.; Urlaub, H.; Ficner, R.; Fabrizio, P.; Lührmann, R.: The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction. eLife 5, e15564 (2016)

Agafonov, D. E.; Kastner, B.; Dybkov, O.; Hofele, R. V.; Liu, W.; Urlaub, H.; Lührmann, R.; Stark, H.: Molecular architecture of the human U4/U6.U5 tri-snRNP. Science 351 (6280), pp. 1416 - 1420 (2016)

Rasche, N.; Dybkov, O.; Schmitzova, J.; Akyildiz, B.; Fabrizio, P.; Lührmann, R.: Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. EMBO Journal 31 (6), pp. 1591 - 1604 (2012)