NMR-based Structural Biology

Analysis of biomolecules in solid and liquid phases using NMR spectroscopy

Press releases & research news

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Hope for Huntington's Disease

June 29, 2026

An experimental drug has been shown to alleviate symptoms of Huntington's disease and extend lifespan in mouse models. more

New imaging method makes Parkinson’s disease visible in the living brain

May 28, 2026

Researchers have developed a PET tracer that can visualize pathological alpha-synuclein aggregates in the brain. The method could contribute to the development of new therapies and help tailor personalized treatments in the future. (in German) more

Yearbook Article (2010)

Lock pick or bunch of keys: what proteins and safecrackers have in common
Novel NMR spectroscopic parameters allowed to determine not only the average structure of the protein ubiquitin but in addition the description of a faithful ensemble of the protein in solution. The ensemble reflected especially the previously inaccessible time window between 5 ns and 50 µs. The ensemble revealed the mechanism of protein protein recognition for this protein. If this was general new strategies for modulation of protein protein recognition would open up that could be used for more efficient drug development. (in German)