NMR-based Structural Biology

Analysis of biomolecules in solid and liquid phases using NMR spectroscopy

Press releases & research news

<p>One of the world´s three most powerful high-resolution 1.2 GHz NMR spectrometers comes to Göttingen</p>

It looks like a giant thermos flask and weighs eight tons. Not only because of that is the new 1.2 GHz spectrometer a heavy weight in the worldwide science community: With its magnetic field strength, it sets new standards in high resolution nuclear magnetic resonance (NMR) spectroscopy: 28.2 Tesla –almost 600,000 times stronger than the earth's magnetic field. Presently, there are only three of these high tech instruments; in addition to Florence and Zurich, there is now one in Göttingen at the Max Planck Institute (MPI) for Biophysical Chemistry. more

Experimental drug interferes with different mechanisms associated to Alzheimer’s disease

The chemical compound anle138b eases cognitive deficits and normalizes gene expression in a mouse model of Alzheimer’s disease and it seems to close harmful openings in the membrane of nerve cells as an international team of researchers including researchers of the MPI for Biophysical Chemistry found out. The scientists suggest that anle138b should be validated in clinical trials for its potential to treat Alzheimer’s and further neurodegenerative diseases. more

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Yearbook Article (2010)
Lock pick or bunch of keys: what proteins and safecrackers have in common
Novel NMR spectroscopic parameters allowed to determine not only the average structure of the protein ubiquitin but in addition the description of a faithful ensemble of the protein in solution. The ensemble reflected especially the previously inaccessible time window between 5 ns and 50 µs. The ensemble revealed the mechanism of protein protein recognition for this protein. If this was general new strategies for modulation of protein protein recognition would open up that could be used for more efficient drug development. (in German) more
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