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NMR-based Structural Biology

Analysis of biomolecules in solid and liquid phases using NMR spectroscopy


Press releases & research news

[Fe]-hydrogenase catalysis visualized using para-hydrogen-enhanced nuclear magnetic resonance spectroscopy

A team from three Max Planck Institutes, the Center for Biostructural Imaging of Neurodegeneration at the University Medical Center Göttingen, the University of Kiel, and the FAccTs GmbH used a chemical peculiarity of hydrogen to amplify the signals of magnetic resonance spectroscopy. In this way, the scientists were able to visualize previously unknown intermediate steps in the conversion of hydrogen. more

Lipid fibrils: A new building block for understanding Alzheimer's disease

Lipids play an important role in the development of Alzheimer's dementia. However, more details about this process were previously unknown. A team of scientists from Göttingen, Jülich, and Düsseldorf has now determined the atomic structures of lipid-fibril complexes for the first time. (in German) more

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Yearbook Article (2010)
Lock pick or bunch of keys: what proteins and safecrackers have in common
Novel NMR spectroscopic parameters allowed to determine not only the average structure of the protein ubiquitin but in addition the description of a faithful ensemble of the protein in solution. The ensemble reflected especially the previously inaccessible time window between 5 ns and 50 µs. The ensemble revealed the mechanism of protein protein recognition for this protein. If this was general new strategies for modulation of protein protein recognition would open up that could be used for more efficient drug development. (in German) more
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