NMR-based Structural Biology

Analysis of biomolecules in solid and liquid phases using NMR spectroscopy

Press releases & research news

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Cancer protein p53 observed in action

August 10, 2026

Researchers have visualized, for the first time, how the three-dimensional structure of the cancer protein p53 changes dynamically over time – from super-fast trillionths of a second to microseconds, which are one million times slower. In the fight against cancer, understanding the dynamics of these structures might help develop drugs that target p53.

Hope for Huntington's Disease

June 29, 2026

An experimental drug has been shown to alleviate symptoms of Huntington's disease and extend lifespan in mouse models.

Yearbook Article (2010)

Lock pick or bunch of keys: what proteins and safecrackers have in common
Novel NMR spectroscopic parameters allowed to determine not only the average structure of the protein ubiquitin but in addition the description of a faithful ensemble of the protein in solution. The ensemble reflected especially the previously inaccessible time window between 5 ns and 50 µs. The ensemble revealed the mechanism of protein protein recognition for this protein. If this was general new strategies for modulation of protein protein recognition would open up that could be used for more efficient drug development. (in German)