Max Planck Institute for Multidisciplinary Sciences

Publications

Journal Article (404)

1.

Journal Article

Preobraschenski, J.; Kreutzberger, A. J. B.; Ganzella, M.; Münster-Wandowski, A.; Kreutzberger, M. A. B.; Oolsthorn, L. H. M.; Seibert, S.; Kiessling, V.; Riedel, D.; Witkowska, A. et al.; Ahnert-Hilger, G.; Tamm, L. K.; Jahn, R.: Synaptophysin accelerates synaptic vesicle fusion by expanding the membrane upon neurotransmitter loading. Science Advances 11 (17), eads4661 (2025)

MPG.PuRe

publisher-version

2.

Journal Article

Höltje, M.; Wolkowicz, A.; Brunk, I.; Baron, J.; Ahnert‐Hilger, G.: Gα_o1 and Gα_o1/Gα_o2 deletion differentially affect hippocampal mossy fiber tract anatomy and neuronal morphogenesis. Journal of Neurochemistry 169 (2), e16248 (2025)

MPG.PuRe

3.

Journal Article

Altas, B.; Tuffy, L. P.; Patrizi, A.; Dimova, K.; Soykan, T.; Brandenburg, C.; Romanowski, A. J.; Whitten, J. R.; Robertson, C. D.; Khim, S. N. et al.; Crutcher, G. W.; Ambrozkiewicz, M.; Yagensky, O.; Krüger-Burg, D. D.; Hammer, M.; Hsiao, H.-H.; Laskowski, P. R.; Dyck, L.; Puche, A. C.; Sassoè-Pognetto, M.; Chua, J. J. E.; Urlaub, H.; Jahn, O.; Brose, N.; Poulopoulos, A.: Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory versus Inhibitory Synapses. Biological Psychiatry 96 (10), pp. 815 - 828 (2024)

MPG.PuRe

4.

Journal Article

Neuhaus, C.; Alfken, J.; Frost, J.; Matthews, L.; Hoffmann, C.; Ganzella, M.; Milovanovic, D.; Salditt, T.: Morphology and intervesicle distances in condensates of synaptic vesicles and synapsin. Biophysical Journal 123 (23), pp. 4123 - 4134 (2024)

MPG.PuRe

publisher-version

5.

Journal Article

Pribicevic, S.; Graham, A. C.; Cafiso, D. S.; Perez-Lara, A.; Jahn, R.: Intermediate steps in the formation of neuronal SNARE complexes. Journal of Biological Chemistry 300 (8), 107591 (2024)

MPG.PuRe

6.

Journal Article

Qiu, H.; Wu, X.; Ma, X.; Li, S.; Cai, Q.; Ganzella, M.; Ge, L.; Zhang, H.; Zhang, M.: Short-distance vesicle transport via phase separation. Cell 187 (9), pp. 2175 - 2193.e21 (2024)

MPG.PuRe

7.

Journal Article

Koike, S.; Jahn, R.: Rab GTPases and phosphoinositides fine-tune SNAREs dependent targeting specificity of intracellular vesicle traffic. Nature Communications 15 (1), 2508 (2024)

MPG.PuRe

publisher-version

8.

Journal Article

Cepeda, A. P.; Ninov, M.; Neef, J.; Parfentev, I.; Kusch, K.; Reisinger, E.; Jahn, R.; Moser, T.; Urlaub, H.: Proteomic Analysis Reveals the Composition of Glutamatergic Organelles of Auditory Inner Hair Cells. Molecular & Cellular Proteomics 23 (2), 100704 (2024)

MPG.PuRe

publisher-version

9.

Journal Article

Zhao, Y.; Fang, Q.; Sharma, S.; Jakhanwal, S.; Jahn, R.; Lindau, M.: All SNAP25 molecules in the vesicle–plasma membrane contact zone change conformation during vesicle priming. Proceedings of the National Academy of Sciences of the United States of America 121 (2), e2309161121 (2024)

MPG.PuRe

publisher-version

10.

Journal Article

Alfken, J.; Neuhaus, C.; Major, A.; Taskina, A.; Hoffmann, C.; Ganzella, M.; Petrovic, A.; Zwicker, D.; Fernández-Busnadiego, R.; Jahn, R. et al.; Milovanovic, D.; Salditt, T.: Vesicle condensation induced by synapsin: condensate size, geometry, and vesicle shape deformations. European Physical Journal E 47 (1), 8 (2024)

MPG.PuRe

publisher-version

11.

Journal Article

Binotti, B.; Ninov, M.; Cepeda, A. P.; Ganzella, M.; Matti, U.; Riedel, D.; Urlaub, H.; Sambandan, S.; Jahn, R.: ATG9 resides on a unique population of small vesicles in presynaptic nerve terminals. Autophagy 20 (4), pp. 883 - 901 (2024)

MPG.PuRe

publisher-version

12.

Journal Article

Jahn, R.; Cafiso, D. C.; Tamm, L. K.: Mechanisms of SNARE proteins in membrane fusion. Nature Reviews Molecular Cell Biology 25, pp. 101 - 118 (2024)

MPG.PuRe

13.

Journal Article

Hoffmann, C.; Rentsch, J.; Tsunoyama, T.A.; Chhabra, A.; Aguilar Perez, G.; Chowdhury, R.; Trnka, F.; Korobeinikov, A.A.; Shaib, A.H.; Ganzella, M. et al.; Giannone, G.; Rizzoli, S.O.; Kusumi, A.; Ewers, H.; Milovanovic, D.: Synapsin condensation controls synaptic vesicle sequestering and dynamics. Nature Communications 14 (1), 6730 (2023)

MPG.PuRe

publisher-version

14.

Journal Article

Stief, T.; Gremer, L.; Pribicevic, S.; Espinueva, D. F.; Vormann, K.; Biehl, R.; Jahn, R.; Pérez-Lara, Á.; Lakomek, N.-A.: Intrinsic Disorder of the Neuronal SNARE Protein SNAP25a in its Pre-fusion Conformation. Journal of Molecular Biology 435 (10), 168069 (2023)

MPG.PuRe

15.

Journal Article

Roig Adam, A.; Martínez-López, J.A.; van der Spek, S.J.F.; Achsel, T.; Andres-Alonso, M.; Bagni, C.; Bayés, À.; Biederer, T.; Brose, N.; Chua, J.J.E. et al.; Coba, M.P.; Cornelisse, L.N.; de Juan-Sanz, J.; Goldschmidt, H.L.; Gundelfinger, E.D.; Huganir, R.L.; Imig, C.; Jahn, R.; Jung, H.; Kaeser, P.S.; Kim, E.; Koopmans, F.; Kreutz, M.R.; Lipstein, N.; MacGillavry, H.D.; McPherson, P.S.; O’Connor, V.; Pielot, R.; Ryan, T.A.; Sala, C.; Sheng, M.; Smalla, K.-H.; Thomas, P.D.; Toonen, R.F.; van Weering, J.R.T.; Verpelli, C.; Sullivan, P.F.; Smit, A.B.; Verhage, M.; Hjerling-Leffler, J.: Transcriptional diversity in specific synaptic gene sets discriminates cortical neuronal identity. Biology Direct 18, 22 (2023)

MPG.PuRe

publisher-version

16.

Journal Article

Weber, M.; von der Emde, H.; Leutenegger, M.; Gunkel, P.; Sambandan, S.; Khan, T. A.; Keller-Findeisen, J.; Cordes, V. C.; Hell, S. W.: MINSTED nanoscopy enters the Ångström localization range. Nature Biotechnology 41, pp. 569 - 576 (2023)

MPG.PuRe

publisher-version

17.

Journal Article

Kosmidis, E.; Shuttle, C. G.; Preobraschenski, J.; Ganzella, M.; Johnson, P. J.; Veshaguri, S.; Holmkvist, J.; Moller, M. P.; Marantos, O.; Marcoline, F. et al.; Grabe, M.; Pedersen, J. L.; Jahn, R.; Stamou, D.: Regulation of the mammalian-brain V-ATPase through ultraslow mode-switching. Nature 611 (7937), pp. 827 - 834 (2022)

MPG.PuRe

18.

Journal Article

Birinci, Y.; Preobraschenski, J.; Ganzella, M.; Jahn, R.; Park, Y.: Author Correction: Isolation of large dense-core vesicles from bovine adrenal medulla for functional studies. Scientific Reports 12, 16738 (2022)

MPG.PuRe

publisher-version

19.

Journal Article

Komorowski, K.; Preobraschenski, J.; Ganzella, M.; Alfken, J.; Neuhaus, C.; Jahn, R.; Salditt, T.: Neurotransmitter uptake of synaptic vesicles studied by X-ray diffraction. European Biophysics Journal 51, pp. 465 - 482 (2022)

MPG.PuRe

publisher-version

20.

Journal Article

De Benito-Bueno, A.; Socuellamos, P. G.; Merinero, Y. G.; Cercos, P.; Izquierdo, C.; Daniel-Mozo, M.; Marin-Olivero, I.; Perez-Lara, A.; Gonzalez-Vera, J. A.; Orte, A. et al.; Albert, A.; Martin-Martinez, M.; Gutierrez-Rodriguez, M.; Valenzuela, C.: Modulation of K_V4.3-KChIP2 Channels by IQM-266: Role of DPP6 and KCNE2. International Journal of Molecular Sciences 23 (16), 9170 (2022)

MPG.PuRe

publisher-version

21.

Journal Article

Upmanyu, N.; Jin, J.; von der Emde, H.; Ganzella, M.; Bösche, L.; Malviya, V. N.; Zhuleku, E.; Politi, A. Z.; Ninov, M.; Silbern, I. et al.; Leutenegger, M.; Urlaub, H.; Riedel, D.; Preobraschenski, J.; Milosevic, I.; Hell, S. W.; Jahn, R.; Sambandan, S.: Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3. Neuron 110 (9), pp. 1483 - 1497 (2022)

MPG.PuRe

publisher-version

22.

Journal Article

Chang, H.-F.; Schirra, C.; Ninov, M.; Hahn, U.; Ravichandran, K.; Krause, E.; Becherer, U.; Bálint, Š.; Harkiolaki, M.; Urlaub, H. et al.; Valitutti, S.; Baldari, C. T.; Dustin, M. L.; Jahn, R.; Rettig, J.: Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes. Nature Communications 13, 1029 (2022)

MPG.PuRe

publisher-version

23.

Journal Article

Koike, S.; Jahn, R.: SNARE proteins: zip codes in vesicle targeting? Biochemical Journal 479 (3), pp. 273 - 288 (2022)

MPG.PuRe

publisher-version

24.

Journal Article

Mühlhausen, S.; Schmitt, H. D.; Plessmann, U.; Mienkus, P.; Sternisek, P.; Perl, T.; Weig, M.; Urlaub, H.; Bader, O.; Kollmar, M.: Proteogenomics analysis of CUG codon translation in the human pathogen Candida albicans. BMC Biology 19, 258 (2021)

MPG.PuRe

publisher-version

25.

Journal Article

Binotti, B.; Jahn, R.; Pérez-Lara, A.: An overview of the synaptic vesicle lipid composition. Archives of Biochemistry and Biophysics 709, 108966 (2021)

MPG.PuRe

publisher-version

26.

Journal Article

Chen, Y.; Vos, S. M.; Dienemann, C.; Ninov, M.; Urlaub, H.; Cramer, P.: Allosteric transcription stimulation by RNA polymerase II super elongation complex. Molecular Cell 81 (16), pp. 3386 - 3399.e10 (2021)

MPG.PuRe

27.

Journal Article

Juranek, J. K.; Mukherjee, K.; Jahn, R.; Li, J.-Y.: Coordinated bi-directional trafficking of synaptic vesicle and active zone proteins in peripheral nerves. Biochemical and Biophysical Research Communications 559, pp. 92 - 98 (2021)

MPG.PuRe

publisher-version

28.

Journal Article

Witkowska, A.; Heinz, L. P.; Grubmüller, H.; Jahn, R.: Tight docking of membranes before fusion represents a novel, metastable state with unique properties. Nature Communications 12, 3606 (2021)

MPG.PuRe

29.

Journal Article

Kim, C.; Shon, M. J.; Kim, S. H.; Eun, G. S.; Ryu, J.-K.; Hyeon, C.; Jahn, R.; Yoon, T.-Y.: Extreme parsimony in ATP consumption by 20S complexes in the global disassembly of single SNARE complexes. Nature Communications 12, 3206 (2021)

MPG.PuRe

30.

Journal Article

Grothe, T.; Nowak, J.; Jahn, R.; Walla, P. J.: Selected tools to visualize membrane interactions. European Biophysics Journal 50 (2), pp. 211 - 222 (2021)

MPG.PuRe

publisher-version

31.

Journal Article

Wittig, S.; Ganzella, M.; Kostmann, S.; Barth, M.; Riedel, D.; Perez-Lara, A.; Jahn, R.; Schmidt, C.: Cross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes. Nature Communications 12, 858 (2021)

MPG.PuRe

publisher-version

32.

Journal Article

Wu, X.; Ganzella, M.; Zhou, J.; Zhu, S.; Jahn, R.; Zhang, M.: Vesicle tethering on the surface of phase-separated active zone condensates. Molecular Cell 81 (1), pp. 13 - 24.e7 (2021)

MPG.PuRe

33.

Journal Article

Silbern, I.; Pan, K. T.; Fiosins, M.; Bonn, S.; Rizzoli, S. O.; Fornasiero, E. F.; Urlaub, H.; Jahn, R.: Protein phosphorylation in depolarized synaptosomes: Dissecting primary effects of calcium from synaptic vesicle cycling. Molecular and Cellular Proteomics 20, 100061 (2021)

MPG.PuRe

publisher-version

34.

Journal Article

Birinci, Y.; Preobraschenski, J.; Ganzella, M.; Jahn, R.; Park, Y.: Isolation of large dense-core vesicles from bovine adrenal medulla for functional studies. Scientific Reports 10, 7540 (2020)

MPG.PuRe

publisher-version

35.

Journal Article

Luck, R.; Urban, S.; Karakatsani, A.; Harde, E.; Sambandan, S.; Nicholson, L.; Haverkamp, S.; Mann, R.; Martin-Villalba, A.; Schuman, E. M. et al.; Acker-Palmer, A.; de Almodovar, C. R.: VEGF/VEGFR2 signaling regulates hippocampal axon branching during development. eLife 8, e49818 (2019)

MPG.PuRe

publisher-version

36.

Journal Article

Bocker, H. T.; Heinrich, T.; Liebmann, L.; Hennings, J. C.; Seemann, E.; Gerth, M.; Jakovčevski, I.; Preobraschenski, J.; Kessels, M. M.; Westermann, M. et al.; Isbrandt, D.; Jahn, R.; Qualmann, B.; Hübner, C. A.: The Na⁺/H⁺ exchanger Nhe1 modulates network excitability via GABA release. Cerebral Cortex 29 (10), pp. 4263 - 4276 (2019)

MPG.PuRe

37.

Journal Article

Kreutzberger, A. J. B.; Kiessling, V.; Stroupe, C.; Liang, B.; Preobraschenski, J.; Ganzella, M.; Kreutzberger, M. A. B.; Nakamoto, R.; Jahn, R.; Castle, J. D. et al.; Tamm, L. K.: In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties. Nature Communications 10, 3904 (2019)

MPG.PuRe

publisher-version

supplementary-material

supplementary-material

38.

Journal Article

Yagensky, O.; Kohansal-Nodehi, M.; Gunaseelan, S.; Rabe, T.; Zafar, S.; Zerr, I.; Haertig, W.; Urlaub, H.; Chua, J.: Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity. eLife 8, e47498 (2019)

MPG.PuRe

publisher-version

39.

Journal Article

Koopmans, F.; van Nierop, P.; Andres-Alonso, M.; Byrnes, A.; Cijsouw, T.; Coba, M. P.; Cornelisse, L. N.; Farrell, R. J.; Goldschmidt, H. L.; Howrigan, D. P. et al.; Hussain, N. K.; Imig, C.; de Jong, A. P. H.; Jung, H.; Kohansalnodehi, M.; Kramarz, B.; Lipstein, N.; Lovering, R. C.; MacGillavry, H.; Mariano, V.; Mi, H.; Ninov, M.; Osumi-Sutherland, D.; Pielot, R.; Smalla, K. H.; Tang, H.; Tashman, K.; Toonen, R. F. G.; Verpelli, C.; Reig-Viader, R.; Watanabe, K.; van Weering, J.; Achsel, T.; Ashrafi, G.; Asi, N.; Brown, T. C.; De Camilli, P.; Feuermann, M.; Foulger, R. E.; Gaudet, P.; Joglekar, A.; Kanellopoulos, A.; Malenka, R.; Nicoll, R. A.; Pulido, C.; de Juan-Sanz, J.; Sheng, M.; Südhof, T. C.; Tilgner, H. U.; Bagni, C.; Bayés, A.; Biederer, T.; Brose, N.; Chua, J. J. E.; Dieterich, D. C.; Gundelfinger, E. D.; Hoogenraad, C.; Huganir, R. L.; Jahn, R.; Kaeser, P. S.; Kim, E.; Kreutz, M. R.; McPherson, P. S.; Neale, B. M.; O’Connor, V.; Posthuma, D.; Ryan, T. A.; Sala, C.; Feng, G.; Hyman, S. E.; Thomas, P. D.; Smit, A. B.; Verhage, M.: SynGO: An evidence-based, expert-curated knowledge base for the synapse. Neuron 103 (2), pp. 217 - 234 (2019)

MPG.PuRe

40.

Journal Article

Saito, M.; Koike, S.; Holm, K.; Bregolin, F. L.; Hofsäss, H.: External RBS/PIXE analysis for evaluating quantum dots internalization into HeLa cells. Nuclear Instruments and Methods in Physics Research B 450, pp. 173 - 178 (2019)

MPG.PuRe

41.

Journal Article

Raja, M. K.; Preobraschenski, J.; Del Olmo-Cabrera, S.; Martinez-Turrillas, R.; Jahn, R.; Perez-Otano, I.; Wesseling, J. F.: Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts. eLife 8, e40744 (2019)

MPG.PuRe

publisher-version

supplementary-material

42.

Journal Article

Lakomek, N. A.; Yavuz, H.; Jahn, R.; Perez-Lara, A.: Structural dynamics and transient lipid binding of synaptobrevin-2 tune SNARE assembly and membrane fusion. Proceedings of the National Academy of Sciences of the United States of America 116 (18), pp. 8699 - 8708 (2019)

MPG.PuRe

publisher-version

43.

Journal Article

Koike, S.; Jahn, R.: SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors. Nature Communicationsvolume 10, 1608 (2019)

MPG.PuRe

publisher-version

supplementary-material

supplementary-material

supplementary-material

44.

Journal Article

Hubrich, R.; Park, Y.; Mey, I.; Jahn, R.; Steinem, C.: SNARE-mediated fusion of single chromaffin granules with pore-spanning membranes. Biophysical Journal 116 (2), pp. 308 - 318 (2019)

MPG.PuRe

supplementary-material

supplementary-material

45.

Journal Article

Brose, N.; Brunger, A.; Cafiso, D.; Chapman, E. R.; Diao, J.; Hughson, F. M.; Jackson, M. B.; Jahn, R.; Lindau, M.; Ma, C. et al.; Rizo, J.; Shin, Y. K.; Söllner, T. H.; Tamm, L.; Yoon, T. Y.; Zhang, Y.: Synaptic vesicle fusion: Today and beyond. Nature Structural and Molecular Biology 26 (8), pp. 663 - 668 (2019)

MPG.PuRe

46.

Journal Article

Hubrich, B.; Kumar, P.; Neitz, H.; Grunwald, M.; Grothe, T.; Walla, P. J.; Jahn, R.; Diederichsen, U.: PNA hybrid sequences as recognition units in SNARE-protein-mimicking peptides. Angewandte Chemie International Edition 57 (45), pp. 14932 - 14936 (2018)

MPG.PuRe

supplementary-material

47.

Journal Article

Oroz, J.; Chang, B. J.; Wysoczanski, P.; Lee, C. T.; Perez-Lara, A.; Chakraborty, P.; Hofele, R. V.; Baker, J. D.; Blair, L. J.; Biernat, J. et al.; Urlaub, H.; Mandelkow, E.; Dickey, C. A.; Zweckstetter, M.: Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex. Nature Communications 9, 4532 (2018)

MPG.PuRe

publisher-version

48.

Journal Article

Bassereau, P.; Jin, R.; Baumgart, T.; Deserno, M.; Dimova, R.; Frolov, V. A.; Bashkirov, P. V.; Grubmüller, H.; Jahn, R.; Risselada, H. J. et al.; Johannes, L.; Kozlov, M. M.; Lipowsky, R.; Pucadyil, T. J.; Zeno, W. F.; Stachowiak, J. C.; Stamou, D.; Breuer, A.; Lauritsen, L.; Simon, C.; Sykes, C.; Voth, G. A.; Weikl, T. R.: The 2018 biomembrane curvature and remodeling roadmap. Journal of Physics D: Applied Physics 51 (34), 343001 (2018)

MPG.PuRe

publisher-version

49.

Journal Article

Witkowska, A.; Jablonski, L.; Jahn, R.: A convenient protocol for generating giant unilamellar vesicles containing SNARE proteins using electroformation. Scientific Reports 8, 9422 (2018)

MPG.PuRe

publisher-version

50.

Journal Article

Yavuz, H.; Kattan, I.; Hernandez, J. M.; Hofnagel, O.; Witkowska, A.; Raunser, S.; Walla, P. J.; Jahn, R.: Arrest of trans-SNARE zippering uncovers loosely and tightly docked intermediates in membrane fusion. Journal of Biological Chemistry 293 (22), pp. 8645 - 8655 (2018)

MPG.PuRe

publisher-version

supplementary-material