Publications

Nair RM, Seenivasan A, Liu B, Chen D, Lowe ED, Lorenz S (2021) Reconstitution and structural analysis of a HECT ligase-ubiquitin complex via an activity-based probe. ACS Chem Biol. 16: 1615-1621. 

 

Orth B, Sander B, Möglich A, Diederichs K, Eilers M, Lorenz S (2021) Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1. Structure 29: 1230-1240.e5. 

 

Lorenz S#, Rittinger K# (2020) Advanced rules of relays. Nature Chem Biol 16:1158-1159.

 

Rill N, Mukhortava A, Lorenz S, Tessmer I (2020) Alkyltransferase-like protein clusters scan DNA rapidly over long distances and recruit NER to alkyl-DNA lesions. Proc Natl Acad Sci USA 17: 9318-9328. 

 

Liess AKL*, Kucerova A*, Schweimer K, Schlesinger D, Dybkov O, Urlaub H, Mansfeld J#, and Lorenz S#: Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S. Sci Signal 13:eaba8208 - featured in: Bremm A. (2020) Hug and hold tight: Dimerization controls the turnover of the ubiquitin-conjugating enzyme UBE2S. Sci Signal 13:eabd9892.

 

Ries LK, Liess AKL, Feiler CG, Spratt DE, Lowe ED, Lorenz S. (2020). Crystal structure of the catalytic C-lobe of the HECT-type ubiquitin ligase E6AP. Protein Sci 29: 1550-1554.

 

Lee HJ, Li CF, Ruan D, He J, Montal ED, Lorenz S, Girnun GD, Chan CH (2019) Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion.
Nat Commun 10: 2625. 

 

Liess A*, Kucerova A*, Schweimer K, Yu L, Roumeliotis T, Diebold M, Dybkov O, Sotriffer C, Urlaub H, Choudhary J, Mansfeld J#, Lorenz S# (2019). Auto-inhibition mechanism of the ubiquitin-conjugating enzyme UBE2S by auto-ubiquitination. Structure 27:1195-1210 - featured in Bodrug T, Brown NG (2019). UBE2S learns self control. Structure 27: 11185-1187. 

 

Deol KK, Lorenz S#, Strieter ER# (2019). Enzymatic logic of ubiquitin chain sssembly. Front Physiol 5: 10:835. 

 

Ries LK, Sander B, Deol KK, Letzelter MA, Strieter ER, Lorenz S (2019). Analysis of ubiquitin recognition by the HECT ligase E6AP provides insight into its linkage specificity. J Biol Chem 294: 6113-6129.

 

Chen D, Gehringer M, Lorenz S (2018) Developing small-molecule inhibitors of HECT-type ubiquitin ligases for therapeutic applications: challenges and opportunities. ChemBioChem 19: 2123-2135.

 

Lorenz S (2017). Structural mechanisms of HECT-type ubiquitin ligases. Biol Chem 399: 127-145.

 

Sander B, Xu W, Eilers M, Popov N, Lorenz S (2017). A conformational switch regulates the ubiquitin ligase HUWE1. eLife 6: e21036.

 

Lorenz S, Bhattacharyya M, Feiler C, Rape M, Kuriyan J (2016). Crystal structure of a Ube2S-ubiquitin conjugate. PLoS One 11: e0147550.

 

Lorenz S, Deng T, Hantschel O, Superti-Furga G, Kuriyan J (2015). Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity. Biochem J 468: 283-291.

 

Lorenz S, Cantor AJ, Rape M, Kuriyan J (2013). Macromolecular juggling by ubiquitylation enzymes. BMC Biology 11: 65.

 

Wickliffe KE, * Lorenz S*#, Wemmer DE, Kuriyan J, Rape M# (2011). The mechanism of linkage-specific ubiquitin chain elongation by a single subunit E2. Cell 144: 769-781.

 

Lorenz S, Vakonakis I, Lowe ED, Campbell ID, Noble ME, Hoellerer MK (2008) Structural analysis of the interactions between paxillin LD motifs and alpha-parvin. Structure 16: 1521-1531.

 

Sumper M, Lorenz S, Brunner E (2003) Biomimetic control of size in the polyamine-directed formation of silica nanospheres. Angew Chem Int Ed 42: 5192-5195.

 

Spudich G, Lorenz S, Marqusee S (2002) Propagation of a single destabilizing mutation throughout the E. coli ribonuclease HI native state. Protein Science 11: 522-528.

 

Kröger N, Lorenz S, Brunner E, Sumper M (2002) Self-assembly of highly phosphorylated silaffins and their function in biosilica morphogenesis. Science 298: 584-586.

 

*Co-first

#Co-corresponding

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