Publications

Fokkens, T. J.; Rauh, E. T.; Wolter, M.; Sebald, H.; Mitnacht, M.; Ainatzi, S.; Sprick, S.; Teschke, L.; Eisenhuth, N.; Huibregtse, J. M. et al.; Butter, F.; Urlaub, H.; Karnkowska, A.; Steinchen, W.; Schleicher, U.; Janzen, C. J.; Lorenz, S.: A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity. Molecular Cell 85 (19), pp. 3711 - 3728.e11 (2025)

Orth, B.; Pohl, P.; Aust, F.; Ji, Y.; Seenivasan, A.; Dybkov, O.; Liang, X. J.; Bock, L.; Leidner, F.; Levantovsky, S. et al.; Schardey, P.; Sander, P.; Disch, N. J.; Trautz, M. L.; Mizi, A.; Papantonis, A.; Lenz, C.; Grubmüller, H.; Steinchen, W.; Behrends, C.; Urlaub, H.; Gehringer, M.; Lorenz, S.: Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1. Nature Communications 16, 8182 (2025)

Ainatzi, S.; Kaufmann, S. V.; Silbern, I.; Georgiev, S. V.; Lorenz, S.; Rizzoli, S. O.; Urlaub, H.: Ca²⁺-triggered (de)ubiquitination events in synapses. Molecular & Cellular Proteomics 24 (4), 100946 (2025)

Ambrozkiewicz, M. C.; Lorenz, S.: Understanding ubiquitination in neurodevelopment by integrating insights across space and time. Nature Structural & Molecular Biology 32, pp. 14 - 22 (2025)

Kokic, G.; Yakoub, G.; van den Heuvel, D.; Wondergem, A. P.; van der Meer, P. J.; van der Weegen, Y.; Chernev, A.; Fianu, I.; Fokkens, T. J.; Lorenz, S. et al.; Urlaub, H.; Cramer, P.; Luijsterburg, M. S.: Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair. Nature Structural & Molecular Biology 31, pp. 536 - 547 (2024)

Düring, J.; Wolter, M.; Toplak, J. J.; Torres, C.; Dybkov, O.; Fokkens, T. J.; Bohnsack, K. E.; Urlaub, H.; Steinchen, W.; Dienemann, C. et al.; Lorenz, S.: Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1. Nature Structural & Molecular Biology 31, pp. 364 - 377 (2024)

Fatalska, A.; Hodgson, G.; Freund, S.M.V.; Maslen, S.L.; Morgan, T.; Thorkelsson, S.R.; van Slegtenhorst, M.; Lorenz, S.; Andreeva, A.; Kaat, L.D. et al.; Bertolotti, A.: Recruitment of trimeric eIF2 by phosphatase non-catalytic subunit PPP1R15B. Molecular Cell 84 (3), pp. 506 - 521.e11 (2024)

Pettitt, S. J.; Shao, N.; Zatreanu, D.; Frankum, J.; Bajrami, I.; Brough, R.; Krastev, D. B.; Roumeliotis, T. I.; Choudhary, J. S.; Lorenz, S. et al.; Rust, A.; de Bono, J. S.; Yap, T. A.; Tutt, A. N. J.; Lord, C. J.: A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-∆11q splice variant. Oncogene 42, pp. 2701 - 2709 (2023)

Zhou, H.; Carpenter, T.; Fu, X.; Jin, B.; Ody, B.; Hassan, M. S.; Jacobs, S. E.; Cheung, J.; Nicholson, E. M.; Turlington, M. et al.; Zhao, B.; Lorenz, S.; Cropp, A.; Yin, J.: Linkage-Specific Synthesis of Di-ubiquitin Probes Enabled by the Incorporation of Unnatural Amino Acid ThzK. ChemBioChem: A European Journal of Chemical Biology 23 (8), e202200133 (2022)

Orth, B.; Sander, B.; Möglich, A.; Diederichs, K.; Eilers, M.; Lorenz, S.: Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1. Structure 29 (11), pp. 1230 - 1240 (2021)

Nair, R. M.; Seenivasan, A.; Liu, B.; Chen, D.; Lowe, E. D.; Lorenz, S.: Reconstitution and structural analysis of a HECT ligase-ubiquitin complex via an activity-based probe. ACS Chemical Biology 16 (9), pp. 1615 - 1621 (2021)

Lorenz, S.; Rittinger, K.: Advanced rules of relays. Nature Chemical Biology 16 (11), pp. 1158 - 1159 (2020)

Liess, A. K. L.; Kucerova, A.; Schweimer, K.; Schlesinger, D.; Dybkov, O.; Urlaub, H.; Mansfeld, J.; Lorenz, S.: Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S. Science Signaling 13 (654), eaba8208 (2020)

Ries, L. K.; Lies, A. K. L.; Feiler, C. G.; Spratt, D. E.; Lowe, E. D.; Lorenz, S.: Crystal structure of the catalytic C-lobe of the HECT-type ubiquitin ligase E6AP. Protein Science 29 (6), pp. 1550 - 1554 (2020)

Rill, N.; Mukhortava, A.; Lorenz, S.; Tessmer, I.: Alkyltransferase-like protein clusters scan DNA rapidly over long distances and recruit NER to alkyl-DNA lesions. Proceedings of the National Academy of Sciences of the United States of America 117 (17), pp. 9318 - 9328 (2020)

Liess, A. K. L.; Kucerova, A.; Schweimer, K.; Yu, L.; Roumeliotis, T. I.; Diebold, M.; Dybkov, O.; Sotriffer, C.; Urlaub, H.; Choudhary, J. S. et al.; Mansfeld, J.; Lorenz, S.: Autoinhibition mechanism of the ubiquitin-conjugating enzyme UBE2S by autoubiquitination. Structure 27 (8), pp. 1195 - 1210 (2019)

Deol, K. K.; Lorenz, S.; Strieter, E. R.: Enzymatic logic of ubiquitin chain assembly. Frontiers in Physiology 10, 835 (2019)

Lee, H.-J.; Li, C.-F.; Ruan, D.; He, J.; Montal, E. D.; Lorenz, S.; Girnun, G. D.; Chan, C.-H.: Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion. Nature Communications 10, 2625 (2019)

Ries, L. K.; Sander, B.; Deol, K. K.; Letzelter, M.-A.; Strieter, E. R.; Lorenz, S.: Analysis of ubiquitin recognition by the HECT ligase E6AP provides insight into its linkage specificity. Journal of Biological Chemistry 294 (15), pp. 6113 - 6129 (2019)

Chen, D.; Gehringer, M.; Lorenz, S.: Developing Small-Molecule Inhibitors of HECT-Type Ubiquitin Ligases for Therapeutic Applications: Challenges and Opportunities. ChemBioChem: A European Journal of Chemical Biology 19 (20), pp. 2123 - 2135 (2018)

Lorenz, S.: Structural mechanisms of HECT-type ubiquitin ligases. Biological Chemistry 399 (2), pp. 127 - 145 (2017)

Sander, B.; Xu, W.; Eilers, M.; Popov, N.; Lorenz, S.: A conformational switch regulates the ubiquitin ligase HUWE1. eLife 6, e21036 (2017)

Lorenz, S.; Bhattacharyya, M.; Feiler, C.; Rape, M.; Kuriyan, J.: Crystal Structure of a Ube2S-Ubiquitin Conjugate. PLoS One 11, e0147550 (2016)

Lorenz, S.; Deng, P.; Hantschel, O.; Superti-Furga, G.; Kuriyan, J.: Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity. Biochemical Journal 468 (2), pp. 283 - 291 (2015)

Lorenz, S.; Cantor, A. J.; Rape, M.; Kuriyan, J.: Macromolecular juggling by ubiquitylation enzymes. BMC Biology 11, 65 (2013)

Wickliffe, K. E.; Lorenz, S.; Wemmer, D. E.; Kuriyan, J.; Rape, M.: The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2. Cell 144 (5), pp. 769 - 781 (2011)

Lorenz, S.; Vakonakis, I.; Lowe, E. D.; Campbell, I. D.; Noble, M. E.M.; Hoellerer, M. K.: Structural Analysis of the Interactions Between Paxillin LD Motifs and α-Parvin. Structure 16 (10), pp. 1521 - 1531 (2008)

Sumper, M.; Lorenz, S.; Brunner, E.: Biomimetic Control of Size in the Polyamine-Directed Formation of Silica Nanospheres. Angewandte Chemie: International Edition 42 (42), pp. 5192 - 5195 (2003)

Kröger, N.; Lorenz, S.; Brunner, E.; Sumper, M.: Self-Assembly of Highly Phosphorylated Silaffins and Their Function in Biosilica Morphogenesis. Science 298 (5593), pp. 584 - 586 (2002)

Spudich, G.; Lorenz, S.; Marqusee, S.: Propagation of a single destabilizing mutation throughout the Escherichia coli ribonuclease HI native state. Protein Science 11 (3), pp. 522 - 528 (2002)