Publications
Journal Article (135)
1.
Journal Article
16, 589 (2025)
Molecular basis for the enzymatic inactivity of class III glutaredoxin ROXY9 on standard glutathionylated substrates. Nature Communications 2.
Journal Article
630, pp. 1012 - 1019 (2024)
Structural insights into the cross-exon to cross-intron spliceosome switch. Nature 3.
Journal Article
43, pp. 1065 - 1088 (2024)
Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins. The EMBO Journal 4.
Journal Article
15 (1), 1147 (2024)
Protein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing. Nature Communications 5.
Journal Article
15, 411 (2024)
Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design. Nature Communications 6.
Journal Article
62 (36), e202304163 (2023)
Mechanisms of Cysteine-Lysine Covalent Linkage - The Role of Reactive Oxygen Species and Competition with Disulfide Bonds. Angewandte Chemie International Edition 7.
Journal Article
31 (6), pp. 689 - 699.e6 (2023)
Structural characterization of human tryptophan hydroxylase 2 reveals that L-Phe is superior to L-Trp as the regulatory domain ligand. Structure 8.
Journal Article
52, pp. 391 - 411 (2023)
Prospects and Limitations of High-Resolution Single-Particle Cryo-Electron Microscopy. Annual Review of Biophysics 9.
Journal Article
379, pp. 996 - 1003 (2023)
Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase. Science 10.
Journal Article
186 (23), e16, pp. 5054 - 5067 (2023)
Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell 11.
Journal Article
119 (52), e2215799119 (2022)
Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain. Proceedings of the National Academy of Sciences of the United States of America 12.
Journal Article
12, pp. 2397 - 2422 (2022)
Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity. Journal of Parkinson's Disease: JPD 13.
Journal Article
41 (24), e112006 (2022)
LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus. The EMBO Journal 14.
Journal Article
269, 104721 (2022)
Ectosomes and exosomes modulate neuronal spontaneous activity. Journal of Proteomics 15.
Journal Article
8 (35), eabo4946 (2022)
Structural insights into crista junction formation by the Mic60-Mic19 complex. Science Advances 16.
Journal Article
76, 102441 (2022)
Frontiers in the enzymology of thiamin diphosphate-dependent enzymes. Current Opinion in Structural Biology 17.
Journal Article
23 (14), 7749 (2022)
miR449 Protects Airway Regeneration by Controlling AURKA/HDAC6-Mediated Ciliary Disassembly. International Journal of Molecular Sciences 18.
Journal Article
50 (9), pp. 5282 - 5298 (2022)
Conformational rearrangements upon start codon recognition in human 48S translation initiation complex. Nucleic Acids Research 19.
Journal Article
110 (9), pp. 1483 - 1497 (2022)
Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3. Neuron 20.
Journal Article
144, pp. 11270 - 11282 (2022)
19F Electron-nuclear double resonance reveals interaction between redox-active tyrosines across the α/β interface of E. coli ribonucleotide reductase. Journal of the American Chemical Society 21.
Journal Article
11, 1289 (2021)
Chromatography-free purification strategies for large biological macromolecular complexes involving fractionated PEG precipitation and density gradients. Life 22.
Journal Article
11 (12), 1289 (2021)
Chromatography-free purification strategies for large biological macromolecular complexes involving fractionated PEG precipitation and density gradients. Life 23.
Journal Article
12 (1), 5933 (2021)
Structural mechanism of GTPase-powered ribosome-tRNA movement. Nature Communications 24.
Journal Article
596 (7871), pp. 296 - 300 (2021)
Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature 25.
Journal Article
593 (7859), pp. 460 - 464 (2021)
A lysine–cysteine redox switch with an NOS bridge regulates enzyme function. Nature 26.
Journal Article
370 (6523), eabc3753 (2020)
Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science 27.
Journal Article
587 (7832), pp. 157 - 161 (2020)
Atomic-resolution protein structure determination by cryo-EM. Nature 28.
Journal Article
16 (11), p. 1237-1245 (2020)
Structural basis for antibiotic action of the B1 antivitamin 2′-methoxy-thiamine. Nature Chemical Biology 29.
Journal Article
80 (1), pp. 127 - 139.e6 (2020)
Structural insights into the roles of metazoan-specific splicing factors in the human step 1 spliceosome. Molecular Cell 30.
Journal Article
11, 4106 (2020)
Mechanism of ribosome rescue by alternative ribosome-rescue factor B. Nature Communications 31.
Journal Article
6 (30), eaba3916 (2020)
Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution. Science Advances 32.
Journal Article
583 (7815), pp. 310 - 313 (2020)
Molecular architecture of the human 17S U2 snRNP. Nature 33.
Journal Article
180 (6), pp. 1130 - 1143.e20 (2020)
Discovery of a regulatory subunit of the yeast fatty acid synthase. Cell 34.
Journal Article
11 (11), a032417 (2019)
Structural insights into nuclear pre-mRNA splicing in higher eukaryotes. Cold Spring Harbor Perspectives in Biology 35.
Journal Article
116 (35), pp. 17280 - 17289 (2019)
Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site. Proceedings of the National Academy of Sciences of the United States of America 36.
Journal Article
27 (7), pp. 1124 - 1136 (2019)
Structural and functional analyses of the human PDH complex suggest a "Division-of-Labor" mechanism by local E1 and E3 clusters. Structure 37.
Journal Article
29 (2), pp. 117 - 134 (2019)
Posing the APC/C E3 ubiquitin ligase to orchestrate cell division. Trends in Cell Biology 38.
Journal Article
17 (7), pp. 471 - 492 (2018)
Cryo-EM in drug discovery: Achievements, limitations and prospects. Nature Reviews Drug Discovery 39.
Journal Article
172 (3), pp. 454 - 464, e1-e5 (2018)
Structure and conformational dynamics of the human spliceosomal Bact complex. Cell 40.
Journal Article
170 (4), pp. 701 - 713, e1 - e4 (2017)
Cryo-EM structure of a pre-catalytic human spliceosome primed for activation. Cell 41.
Journal Article
8, 15578 (2017)
Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs. Nature Communications 42.
Journal Article
372 (1716), 20160182 (2017)
Ribosome dynamics during decoding. Philosophical Transactions of the Royal Society B 43.
Journal Article
542 (7641), pp. 318 - 323 (2017)
Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 44.
Journal Article
540 (7631), pp. 80 - 85 (2016)
The pathway to GTPase activation of elongation factor SelB on the ribosome. Nature 45.
Journal Article
353 (6306), pp. 1399 - 1405 (2016)
Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 46.
Journal Article
16 (12), pp. 3103 - 3112 (2016)
The ribosome cooperates with the assembly chaperone pICln to initiate formation of snRNPs. Cell Reports 47.
Journal Article
22 (9), pp. 1329 - 1337 (2016)
ATPγS stalls splicing after B complex formation but prior to spliceosome activation. RNA 48.
Journal Article
7, 12523 (2016)
Topology and structure of an engineered human cohesin complex bound to Pds5B. Nature Communications 49.
Journal Article
63 (4), pp. 593 - 607 (2016)
Cryo-EM of mitotic checkpoint complex-bound APC/C reveals reciprocal and conformational regulation of ubiquitin ligation. Molecular Cell 50.
Journal Article
353 (6299), pp. 594 - 598 (2016)
The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science