Max Planck Institute for Multidisciplinary Sciences

Publications

Journal Article (126)

1.

Journal Article

Hicks, K. G.; Cluntun, A. A.; Schubert, H. L.; Hackett, S. R.; Berg, J. A.; Leonard, P. G.; Ajalla Aleixo, M. A.; Zhou, Y.; Bott, A. J.; Salvatore, S. R. et al.; Chang, F.; Blevins, A.; Barta, P.; Tilley, S.; Leifer, A.; Guzman, A.; Arok, A.; Fogarty, S.; Winter, J. M.; Ahn, H.-C.; Allen, K. N.; Block, S.; Cardoso, I. A.; Ding, J.; Dreveny, I.; Gasper, W. C.; Ho, Q.; Matsuura, A.; Palladino, M. J.; Prajapati, S.; Sun, P.; Tittmann, K.; Tolan, D. R.; Unterlass, J.; Van Demark, A. P.; Vander Heiden, M. G.; Webb, B. A.; Yun, C.-H.; Zhao, P.; Wang, B.; Schopfer, F. J.; Hill, C. P.; Nonato, M. C.; Muller, F. L.; Cox, J. E.; Rutter, J.: Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase. Science 379, pp. 996 - 1003 (2023)

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2.

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Liu, T.; Stephan, T.; Chen, P.; Keller-Findeisen, J.; Chen, J.; Riedel, D.; Yang, Z.; Jakobs, S.; Chen, Z.: Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain. Proceedings of the National Academy of Sciences of the United States of America 119 (52), e2215799119 (2022)

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3.

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Brás, I. C.; Khani, M. H.; Vasili, E.; Möbius, W.; Riedel, D.; Parfentev, I.; Gerhardt, E.; Fahlbusch, C.; Urlaub, H.; Zweckstetter, M. et al.; Gollisch, T.; Outeiro, T. F.: Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity. Journal of Parkinson's Disease: JPD 12, pp. 2397 - 2422 (2022)

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4.

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Wu, Z.; Berlemann, L. A.; Bader, V.; Sehr, D. A.; Dawin, E.; Covallero, A.; Meschede, J.; Angersbach, L.; Showkat, C.; Michaelis, J. B. et al.; Muench, C.; Rieger, B.; Namgaladze, D.; Herrera, M. G.; Fiesel, F. C.; Springer, W.; Mendes, M.; Stepien, J.; Barkovits, K.; Marcus, K.; Sickmann, A.; Dittmar, G.; Busch, K. B.; Riedel, D.; Brini, M.; Tatzelt, J.; Cali, T.; Winklhofer, K. F.: LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus. The EMBO Journal 41 (24), e112006 (2022)

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5.

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Brás, I. C.; Khani, M. H.; Riedel, D.; Parfentev, I.; Gerhardt, E.; van Riesen, C.; Urlaub, H.; Gollisch, T.; Outeiro, T. F.: Ectosomes and exosomes modulate neuronal spontaneous activity. Journal of Proteomics 269, 104721 (2022)

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6.

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Bock-Bierbaum, T.; Funck, K.; Wollweber, F.; Lisicki, E.; von der Malsburg, K.; von der Malsburg, A.; Laborenz, J.; Noel, J. K.; Hessenberger, M.; Jungbluth, S. et al.; Bernert, C.; Kunz, S.; Riedel, D.; Lilie, H.; Jakobs, S.; van der Laan, M.; Daumke, O.: Structural insights into crista junction formation by the Mic60-Mic19 complex. Science Advances 8 (35), eabo4946 (2022)

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7.

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Prajapati, S.; Rabe von Pappenheim, F.; Tittmann, K.: Frontiers in the enzymology of thiamin diphosphate-dependent enzymes. Current Opinion in Structural Biology 76, 102441 (2022)

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8.

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Wildung, M.; Herr, C.; Riedel, D.; Wiedwald, C.; Moiseenko, A.; Ramirez, F.; Tasena, H.; Heimerl, M.; Alevra, M.; Movsisyan, N. et al.; Schuldt, M.; Volceanov-Hahn, L.; Provoost, S.; Noethe-Menchen, T.; Urrego, D.; Freytag, B.; Wallmeier, J.; Beisswenger, C.; Bals, R.; van den Berge, M.; Timens, W.; Hiemstra, P. S.; Brandsma, C.-A.; Maes, T.; Andreas, S.; Heijink, I. H.; Pardo, L. A.; Lize, M.: miR449 Protects Airway Regeneration by Controlling AURKA/HDAC6-Mediated Ciliary Disassembly. International Journal of Molecular Sciences 23 (14), 7749 (2022)

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9.

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Yi, S.-H.; Petrychenko, V.; Schliep, J. E.; Goyal, A.; Linden, A.; Chari, A.; Urlaub, H.; Stark, H.; Rodnina, M. V.; Adio, S. et al.; Fischer, N.: Conformational rearrangements upon start codon recognition in human 48S translation initiation complex. Nucleic Acids Research 50 (9), pp. 5282 - 5298 (2022)

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10.

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Upmanyu, N.; Jin, J.; von der Emde, H.; Ganzella, M.; Bösche, L.; Malviya, V. N.; Zhuleku, E.; Politi, A. Z.; Ninov, M.; Silbern, I. et al.; Leutenegger, M.; Urlaub, H.; Riedel, D.; Preobraschenski, J.; Milosevic, I.; Hell, S. W.; Jahn, R.; Sambandan, S.: Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3. Neuron 110 (9), pp. 1483 - 1497 (2022)

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11.

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Meyer, A.; Kehl, A.; Cui, C.; Reichardt, F. A. K.; Hecker, F.; Funk, L.-M.; Ghosh, M. K.; Pan, K. T.; Urlaub, H.; Tittmann, K. et al.; Stubbe, J.; Bennati, M.: 19F Electron-nuclear double resonance reveals interaction between redox-active tyrosines across the α/β interface of E. coli ribonucleotide reductase. Journal of the American Chemical Society 144, pp. 11270 - 11282 (2022)

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12.

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Henneberg, F.; Chari, A.: Chromatography-free purification strategies for large biological macromolecular complexes involving fractionated PEG precipitation and density gradients. Life 11, 1289 (2021)

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13.

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Henneberg, F.; Chari, A.: Chromatography-free purification strategies for large biological macromolecular complexes involving fractionated PEG precipitation and density gradients. Life 11 (12), 1289 (2021)

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14.

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Petrychenko, V.; Peng, B. Z.; Schwarzer, A. C. d. A. P.; Peske, F.; Rodnina, M. V.; Fischer, N.: Structural mechanism of GTPase-powered ribosome-tRNA movement. Nature Communications 12 (1), 5933 (2021)

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15.

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Zhang, Z.; Rigo, N.; Dybkov, O.; Fourmann, J. B.; Will, C. L.; Kumar, V.; Urlaub, H.; Stark, H.; Lührmann, R.: Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature 596 (7871), pp. 296 - 300 (2021)

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16.

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Wensien, M.; Rabe von Pappenheim, F.; Funk, L. M.; Kloskowski, P.; Curth, U.; Diederichsen, U.; Uranga, J.; Ye, J.; Fang, P.; Pan, K. T. et al.; Urlaub, H.; Mata, R. A.; Sautner, V.; Tittmann, K.: A lysine–cysteine redox switch with an NOS bridge regulates enzyme function. Nature 593 (7859), pp. 460 - 464 (2021)

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17.

Journal Article

Townsend, C.; Leelaram, M. N.; Agafonov, D. E.; Dybkov, O.; Will, C. L.; Bertram, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science 370 (6523), eabc3753 (2020)

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18.

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Yip, K. M.; Fischer, N.; Paknia, E.; Chari, A.; Stark, H.: Atomic-resolution protein structure determination by cryo-EM. Nature 587 (7832), pp. 157 - 161 (2020)

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19.

Journal Article

Rabe von Pappenheim, F.; Aldeghi, M.; Shome, B.; Begley, T.; de Groot, B. L.; Tittmann, K.: Structural basis for antibiotic action of the B1 antivitamin 2′-methoxy-thiamine. Nature Chemical Biology 16 (11), p. 1237-1245 (2020)

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20.

Journal Article

Bertram, K.; El Ayoubi, L.; Dybkov, O.; Agafonov, D.; Will, C. L.; Hartmuth, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Structural insights into the roles of metazoan-specific splicing factors in the human step 1 spliceosome. Molecular Cell 80 (1), pp. 127 - 139.e6 (2020)

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21.

Journal Article

Chan, K.-H.; Petrychenko, V.; Mueller, C.; Maracci, C.; Holtkamp, W.; Wilson, D. N.; Fischer, N.; Rodnina, M. V.: Mechanism of ribosome rescue by alternative ribosome-rescue factor B. Nature Communications 11, 4106 (2020)

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22.

Journal Article

Ukmar-Godec, T.; Fang, P.; Ibáñez de Opakua, A.; Henneberg, F.; Godec, A.; Pan, K. T.; Cima-Omori, M.-S.; Chari, A.; Mandelkow, E.; Urlaub, H. et al.; Zweckstetter, M.: Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution. Science Advances 6 (30), eaba3916 (2020)

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23.

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Zhang, Z.; Will, C. L.; Bertram, K.; Dybkov, O.; Hartmuth, K.; Agafonov, D. E.; Hofele, R. V.; Urlaub, H.; Kastner, B.; Lührmann, R. et al.; Stark, H.: Molecular architecture of the human 17S U2 snRNP. Nature 583 (7815), pp. 310 - 313 (2020)

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24.

Journal Article

Singh, K.; Graf, B.; Linden, A.; Sautner, V.; Urlaub, H.; Tittmann, K.; Stark, H.; Chari, A.: Discovery of a regulatory subunit of the yeast fatty acid synthase. Cell 180 (6), pp. 1130 - 1143.e20 (2020)

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25.

Journal Article

Kastner, B.; Will, C. L.; Stark, H.; Lührmann, R.: Structural insights into nuclear pre-mRNA splicing in higher eukaryotes. Cold Spring Harbor Perspectives in Biology 11 (11), a032417 (2019)

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26.

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Watson, E. R.; Grace, C. R. R.; Zhang, W.; Miller, D. J.; Davidson, I. F.; Prabu, J. R.; Yu, S.; Bolhuis, D. L.; Kulko, E. T.; Vollrath, R. et al.; Haselbach, D.; Stark, H.; Peters, J. M.; Brown, N. G.; Sidhu, S. S.; Schulman, B. A.: Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site. Proceedings of the National Academy of Sciences of the United States of America 116 (35), pp. 17280 - 17289 (2019)

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27.

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Prajapati, S.; Haselbach, D.; Wittig, S.; Patel, M. S.; Chari, A.; Schmidt, C.; Stark, H.; Tittmann, K.: Structural and functional analyses of the human PDH complex suggest a "Division-of-Labor" mechanism by local E1 and E3 clusters. Structure 27 (7), pp. 1124 - 1136 (2019)

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28.

Journal Article

Watson, E. R.; Brown, N. G.; Peters, J. M.; Stark, H.; Schulman, B. A.: Posing the APC/C E3 ubiquitin ligase to orchestrate cell division. Trends in Cell Biology 29 (2), pp. 117 - 134 (2019)

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29.

Journal Article

Renaud, J. P.; Chari, A.; Ciferri, C.; Liu, W.; Rémigy, H. W.; Stark, H.; Wiesmann, C.: Cryo-EM in drug discovery: Achievements, limitations and prospects. Nature Reviews Drug Discovery 17 (7), pp. 471 - 492 (2018)

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30.

Journal Article

Haselbach, D.; Komarov, I.; Agafonov, D. E.; Hartmuth, K.; Graf, B.; Dybkov, O.; Urlaub, H.; Kastner, B.; Lührmann, R.; Stark, H.: Structure and conformational dynamics of the human spliceosomal B^act complex. Cell 172 (3), pp. 454 - 464, e1-e5 (2018)

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31.

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Bertram, K.; Agafonov, D. E.; Dybkov, O.; Haselbach, D.; Leelaram, M. N.; Will, C. L.; Urlaub, H.; Kastner, B.; Lührmann, R.; Stark, H.: Cryo-EM structure of a pre-catalytic human spliceosome primed for activation. Cell 170 (4), pp. 701 - 713, e1 - e4 (2017)

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32.

Journal Article

Haselbach, D.; Schrader, J.; Lambrecht, F.; Henneberg, F.; Chari, A.; Stark, H.: Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs. Nature Communications 8, 15578 (2017)

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33.

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Rodnina, M. V.; Fischer, N.; Maracci, C.; Stark, H.: Ribosome dynamics during decoding. Philosophical Transactions of the Royal Society B 372 (1716), 20160182 (2017)

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34.

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Bertram, K.; Agafonov, D. E.; Liu, W.; Dybkov, O.; Will, C. L.; Hartmuth, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 542 (7641), pp. 318 - 323 (2017)

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35.

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Fischer, N.; Neumann, P.; Bock, l. V.; Maracci, C.; Wang, Z.; Paleskava, A.; Konevega, A. L.; Schröder, G. F.; Grubmüller, H.; Ficner, R. et al.; Rodnina, M. V.; Stark, H.: The pathway to GTPase activation of elongation factor SelB on the ribosome. Nature 540 (7631), pp. 80 - 85 (2016)

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36.

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Rauhut, R.; Fabrizio, P.; Dybkov, O.; Hartmuth, K.; Pena, V.; Chari, A.; Kumar, V.; Lee, C. T.; Urlaub, H.; Kastner, B. et al.; Stark, H.; Lührmann, R.: Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 353 (6306), pp. 1399 - 1405 (2016)

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37.

Journal Article

Paknia, E.; Chari, A.; Stark, H.; Fischer, U.: The ribosome cooperates with the assembly chaperone pICln to initiate formation of snRNPs. Cell Reports 16 (12), pp. 3103 - 3112 (2016)

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38.

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Agafonov, D. E.; van Santen, M.; Kastner, B.; Dube, P.; Will, C. L.; Urlaub, H.; Lührmann, R.: ATPγS stalls splicing after B complex formation but prior to spliceosome activation. RNA 22 (9), pp. 1329 - 1337 (2016)

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39.

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Hons, M.; Huis in ‘t Veld, P. J.; Kaesler, J.; Rombaut, P.; Schleiffer, A.; Herzog, F.; Stark, H.; Peters, J. M.: Topology and structure of an engineered human cohesin complex bound to Pds5B. Nature Communications 7, 12523 (2016)

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40.

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Yamaguchi, M.; VanderLinden, R.; Weissmann, F.; Qiao, R.; Dube, P.; Brown, N. G.; Haselbach, D.; Zhang, W.; Sidhu, S. S.; Peters, J. M. et al.; Stark, H.; Schulman, B. A.: Cryo-EM of mitotic checkpoint complex-bound APC/C reveals reciprocal and conformational regulation of ubiquitin ligation. Molecular Cell 63 (4), pp. 593 - 607 (2016)

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41.

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Schrader, J.; Henneberg, F.; Mata, R. A.; Tittmann, K.; Schneider, T. R.; Stark, H.; Bourenkov, G.; Chari, A.: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science 353 (6299), pp. 594 - 598 (2016)

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42.

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Brown, N. G.; VanderLinden, R.; Watson, E. R.; Weissmann, F.; Ordureau, A.; Wu, K. P.; Zhang, W.; Yu, S.; Mercredi, P. Y.; Harrison, J. S. et al.; Davidson, I. F.; Qiao, R. P.; Lu, Y.; Dube, P.; Brunner, M. R.; Grace, C. R. R.; Miller, D. J.; Haselbach, D.; Jarvis, M. A.; Yamaguchi, M.; Yanishevski, D.; Petzold, G.; Sidhu, S. S.; Kuhlman, B.; Kirschner, M. W.; Harper, J. W.; Peters, J. M.; Stark, H.; Schulman, B. A.: Dual RING E3 architectures regulate multiubiquitination and ubiquitin chain elongation by APC/C. Cell 165 (6), pp. 1440 - 1453 (2016)

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43.

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Qiao, R. P.; Weissmann, F.; Yamaguchi, M.; Brown, N. G.; VanderLinden, R.; Imre, R.; Jarvis, M. A.; Brunner, M. R.; Davidson, I. F.; Litos, G. et al.; Haselbach, D.; Mechtler, K.; Stark, H.; Schulman, B. A.; Peters, J. M.: Mechanism of APC/C-CDC20 activation by mitotic phosphorylation. Proceedings of the National Academy of Sciences of the United States of America 113 (19), pp. E2570 - E2578 (2016)

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44.

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Weissmann, F.; Petzold, G.; VanderLinden, R.; in'T Veld, P. J. H.; Brown, N. G.; Lampert, F.; Westermann, S.; Stark, H.; Schulman, B. A.; Peters, J. M.: biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes. Proceedings of the National Academy of Sciences of the United States of America 113 (19), pp. E2564 - E2569 (2016)

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45.

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Agafonov, D. E.; Kastner, B.; Dybkov, O.; Hofele, R. V.; Liu, W.; Urlaub, H.; Lührmann, R.; Stark, H.: Molecular architecture of the human U4/U6.U5 tri-snRNP. Science 351 (6280), pp. 1416 - 1420 (2016)

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46.

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Stark, H.; Chari, A.: Sample preparation of biological macromolecular assemblies for the determination of high-resolution structures by cryo-electron microscopy. Microscopy 65 (1), pp. 23 - 34 (2016)

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47.

Journal Article

Pleiner, T.; Bates, M.; Trakhanov, S.; Lee, C. T.; Schliep, J. E.; Chug, H.; Böhning, M.; Stark, H.; Urlaub, H.; Görlich, D.: Nanobodies: Site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation. eLife 4, e11349 (2015)

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48.

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Chari, A.; Haselbach, D.; Kirves, J. M.; Ohmer, J.; Paknia, E.; Fischer, N.; Ganichkin, O.; Moller, V.; Frye, J. J.; Petzold, G. et al.; Jarvis, M.; Tietzel, M.; Grimm, C.; Peters, J. M.; Schulman, B. A.; Tittmann, K.; Markl, J.; Fischer, U.; Stark, H.: ProteoPlex: Stability optimization of macromolecular complexes by sparse-matrix screening of chemical space. Nature Methods 12 (9), pp. 859 - 865 (2015)

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49.

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Hauer, F.; Gerle, C.; Fischer, N.; Oshima, A.; Shinzawa-Itoh, K.; Shimada, S.; Yokoyama, K.; Fujiyoshi, Y.; Stark, H.: GraDeR: Membrane protein complex preparation for single-particle cryo-EM. Structure 23 (9), pp. 1769 - 1775 (2015)

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50.

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Lin , Y. J.; Liu, W.; Stark, H.; Huang, C. T.: Expression of enterovirus 71 virus-like particles in transgenic enoki (Flammulina velutipes). Applied Microbiology and Biotechnology 99 (16), pp. 6765 - 6774 (2015)

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51.

Journal Article

Martinez-Rucobo, F. W.; Kohler, R.; Waterbeemd, M. v. d.; Heck, A. J.; Hemann, M.; Herzog, F.; Stark, H.; Cramer, P.: Molecular basis of transcription-coupled pre-mRNA capping. Molecular Cell 58 (6), pp. 1079 - 1089 (2015)

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52.

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Brown, N. G.; VanderLinden, R.; Watson, E. R.; Qiao, R. P.; Grace, C. R. R.; Yamaguchi, M.; Weissmann, F.; Frye, J. J.; Dube, P.; Cho, S. E. et al.; Actis, M. L.; Rodrigues, P.; Fujii, N.; Peters, J. M.; Stark, H.; Schulman, B. A.: RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex. Proceedings of the National Academy of Sciences of the United States of America 112 (17), pp. 5272 - 5279 (2015)

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53.

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Fischer, N.; Neumann, P.; Konevega, A. L.; Bock, L. V.; Ficner, R.; Rodnina, M. V.; Stark, H.: Structure of the E. coli ribosome–EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM. Nature 520 (7548), pp. 567 - 570 (2015)

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54.

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Brown, N. G.; Watson, E. R.; Weissmann, F.; Jarvis, M. A.; VanderLinden, R.; Grace, C.R.R.; Frye, J. J.; Qiao, R.; Dube, P.; Petzold, G. et al.; Cho, S. E.; Alsharif, O.; Bao, J.; Davidson, I.F.; Zheng, J. J.; Nourse, A.; Kurinov, I.; Peters, J. M.; Stark, H.; Schulman, B. A.: Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly. Molecular Cell 56 (2), pp. 246 - 260 (2014)

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55.

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Liu, Y.; Neumann, P.; Kuhle, B.; Monecke, T.; Schell, S.; Chari, A.; Ficner, R.: Translation initiation factor eIF3b contains a nine-bladed beta-propeller and interacts with the 40S ribosomal subunit. Structure 22 (6), pp. 923 - 930 (2014)

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56.

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Bock, L. V.; Blau, C.; Schröder, G. F.; Davydov, I. I.; Fischer, N.; Stark, H.; Rodnina, M. V.; Vaiana, A. C.; Grubmüller, H.: Energy barriers and driving forces in tRNA translocation through the ribosome. Nature Structural and Molecular Biology 20 (12), pp. 1390 - 1396 (2013)

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57.

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Doelker, N.; Blanchet, C. E.; Voss, B.; Haselbach, D.; Kappel, C.; Monecke, T.; Svergun, D. I.; Stark, H.; Ficner, R.; Zachariae, U. et al.; Grubmüller, H.; Dickmanns, A.: Structural determinants and mechanism of mammalian CRM1 allostery. Structure 21 (8), pp. 1350 - 1360 (2013)

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58.

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Frye, J.; Brown, N. G.; Petzold, G.; Watson, E. R.; Grace, C. R. R.; Nourse, A.; Jarvis, M. A.; Kriwacki, R. W.; Peters, J. M.; Stark, H. et al.; Schulman, B. A.: Electron microscopy structure of human APC/C-CDH1-EMI1 reveals multimodal mechanism of E3 ligase shutdown. Nature Structural and Molecular Biology 20 (7), pp. 827 - 835 (2013)

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59.

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Grimm, C.; Chari, A.; Pelz, J. P.; Kuper, J.; Kisker, C.; Diederichs, K.; Stark, H.; Schindelin, H.; Fischer, U.: Structural basis of assembly chaperone- mediated snRNP formation. Molecular Cell 49 (4), pp. 692 - 703 (2013)

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60.

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Hauer, F.; Gerle, C.; Kirves, J. M.; Stark, H.: Automated correlation of single particle tilt pairs for Random Conical Tilt and Orthogonal Tilt Reconstructions. Journal of Structural Biology 181 (2), pp. 149 - 154 (2013)

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61.

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Monecke, T.; Haselbach, D.; Voß, D.; Russek, A.; Neumann, P.; Thomson, E.; Hurt, E.; Zachariae, U.; Stark, H.; Grubmüller, H. et al.; Dickmanns, A.; Ficner, R.: Structural basis for cooperativity of CRM1 export complex formation. Proceedings of the National Academy of Sciences of the United States of America 110 (3), pp. 960 - 965 (2013)

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62.

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Khoshnevis, S.; Hauer, F.; Milon, P.; Stark, H.; Ficner, R.: Novel insights into the architecture and protein interaction network of yeast eIF3. RNA 18 (12), pp. 2306 - 2319 (2012)

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63.

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Uzunova, K.; Dye, B. T.; Schutz, H.; Ladurner, R.; Petzold, G.; Toyoda, Y.; Jarvis, M. A.; Brown, N. G.; Poser, I.; Novatchkova, M. et al.; Mechtler, K.; Hyman, A. A.; Stark, H.; Schulman, B. A.; Peters, J. M.: APC15 mediates CDC20 autoubiquitylation by APC/C-MCC and disassembly of the mitotic checkpoint complex. Nature Structural and Molecular Biology 19 (11), pp. 1116 - 1123 (2012)

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64.

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Brunotte, L.; Kerber, R.; Shang, W.; Hauer, F.; Hass, M.; Gabriel, M.; Lelke, M.; Busch, C.; Stark, H.; Svergun, D. I. et al.; Betzel, C.; Perbrandt, M.; Guenther, S.: Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy. Journal of Biological Chemistry 286 (44), pp. 38748 - 38756 (2011)

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65.

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Nikolov, M.; Stützer, A.; Mosch, K.; Krasauskas, A.; Soeroes, S.; Stark, H.; Urlaub, H.; Fischle, W.: Chromatin affinity purification and quantitative mass spectrometry defining the interactome of histone modification patterns. Molecular and Cellular Proteomics 10 (11), pp. 10.1074/mcp.M110.005371-1 - 10.1074/mcp.M110.005371–16 (2011)

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66.

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Buschhorn, B. A.; Petzold, G.; Galova, M.; Dube, P.; Kraft, C.; Herzog, F.; Stark, H.; Peters, J. M.: Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1. Nature Structural and Molecular Biology 18, pp. 6 - 13 (2010)

MPG.PuRe

publisher-version

67.

Journal Article

Golas, M. M.; Sander, B.; Bessonov, S.; Grote, M.; Wolf, E.; Kastner, B.; Stark, H.; Lührmann, R.: 3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core. Molecular Cell 40 (6), pp. 927 - 938 (2010)

MPG.PuRe

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supplementary-material

68.

Journal Article

Bessonov, S.; Anokhina, M.; Krasauskas, A.; Golas, M. M.; Sander, B.; Will, C. L.; Urlaub, H.; Stark, H.; Lührmann, R.: Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis. RNA 16 (12), pp. 2384 - 2403 (2010)

MPG.PuRe

publisher-version

69.

Journal Article

Petrovic, A.; Pasqualato, S.; Dube, P.; Krenn, V.; Santaguida, S.; Cittaro, D.; Monzani, S.; Massimiliano, L.; Keller, J.; Tarricone, A. et al.; Maiolica, A.; Stark, H.; Musaccio, A.: The MIS12 complex is a protein interaction hub for outer kinetochore assembly. Journal of Cell Biology 190 (5), pp. 835 - 852 (2010)

MPG.PuRe

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supplementary-material

70.

Journal Article

Sander, B.; Golas, M. M.; Lührmann, R.; Stark, H.: An approach for de novo structure determination of dynamic molecular assemblies by electron cryomicroscopy. Structure 18 (6), pp. 667 - 676 (2010)

MPG.PuRe

publisher-version

71.

Journal Article

Hutchins, J. R. A.; Toyoda, Y.; Hegemann, B.; Poser, I.; Heriche, J. K.; Sykora, M. M.; Augsburg, M.; Hudecz, O.; Buschhorn, B. A.; Bulkescher, J. et al.; Conrad, C.; Comartin, D.; Schleiffer, A.; Sarov, M.; Pozniakovsky, A.; Slabicki, M. M.; Schloissnig, S.; Steinmacher, I.; Leuschner, M.; Ssykor, A.; Lawo, S.; Pelletier, L.; Stark, H.; Nasmyth, K.; Ellenberg, J.; Durbin, R.; Buchholz, F.; Mechtler, K.; Hyman, A. A.; Peters, J. M.: Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science 328 (5978), pp. 593 - 599 (2010)

MPG.PuRe

72.

Journal Article

Fischer, N.; Konevega, A. L.; Wintermeyer, W.; Rodnina, M. V.; Stark, H.: Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy. Nature 466 (7304), pp. 329 - 333 (2010)

MPG.PuRe

73.

Journal Article

Richter, F. M.; Sander, B.; Golas, M. M.; Stark, H.; Urlaub, H.: Merging molecular electron microscopy and mass spectrometry by carbon film-assisted endoproteinase digestion. Molecular and Cellular Proteomics 9, pp. 1729 - 1741 (2010)

MPG.PuRe

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74.

Journal Article

Uezguen, S.; Akdemir, O.; Hasenpusch, G.; Mauksch, C.; Golas, M. M.; Sander, B.; Stark, H.; Imker, R.; Lutz, J. F.; Rudolph, C.: Characterization of tailor-made copolymers of oligo(ethylene glycol) methyl ether methacrylate and N,N-dimethylaminoethyl methacrylate as nonviral gene transfer agents: Influence of macromolecular structure on gene vector particle properties and transfection efficiency. Biomacromolecules 11 (1), pp. 39 - 50 (2010)

MPG.PuRe

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75.

Journal Article

Warkocki, Z.; Odenwälder, P.; Schmitzova, J.; Platzmann, F.; Stark, H.; Urlaub, H.; Ficner, R.; Fabrizio, P.; Lührmann, R.: Reconstitution of both steps of S. cerevisiae splicing with purified spliceosomal components. Nature Structural and Molecular Biology 16 (12), pp. 1237 - 1243 (2009)

MPG.PuRe

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76.

Journal Article

Elfinger, M.; Pfeifer, C.; Uezguen, S.; Golas, M. M.; Sander, B.; Mauksch, C.; Stark, H.; Aneja, M. K.; Rudolph, C.: Self-assembly of ternary insulin−polyethylenimine (PEI)−DNA nanoparticles for enhanced gene delivery and expression in alveolar epithelial cells. Biomacromolecules 10 (10), pp. 2912 - 2920 (2009)

MPG.PuRe

publisher-version

77.

Journal Article

Wolf, E.; Kastner, B.; Deckert, J.; Merz, C.; Stark, H.; Lührmann, R.: Exon, intron and splice site locations in the spliceosomal B complex. EMBO Journal 28, pp. 2283 - 2292 (2009)

MPG.PuRe

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78.

Journal Article

Andersen, E. S.; Dong, M.; Nielsen, M. M.; Jahn, K.; Subramani, R.; Mamdouh, W.; Golas, M. M.; Sander, B.; Stark, H.; Oliveira, C. L. et al.; Pedersen, J. S.; Birkedal, V.; Besenbacher, F.; Gothelf, K. V.; Kjems, J.: Self-assembly of a nanoscale DNA box with a controllable lid. Nature 459 (7243), pp. 73 - 76 (2009)

MPG.PuRe

publisher-version

79.

Journal Article

Golas, M. M.; Boehm, C.; Sander, B.; Effenberger, K.; Brecht, M.; Stark, H.; Goeringer, H. U.: Snapshots of the RNA editing machine in trypanosomes captured at different assembly stages in vivo. EMBO Journal 28 (6), pp. 766 - 778 (2009)

MPG.PuRe

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80.

Journal Article

Herzog, F.; Primorac, I.; Dube, P.; Lenart, P.; Sander, B.; Mechtler, K.; Stark, H.; Peters, J. M.: Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex. Science 323 (5920), pp. 1477 - 1481 (2009)

MPG.PuRe

81.

Journal Article

Fabrizio, P.; Dannenberg, J.; Dube, P.; Kastner, B.; Stark, H.; Urlaub, H.; Lührmann, R.: The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. Molecular Cell 36 (4), pp. 593 - 608 (2009)

MPG.PuRe

publisher-version

82.

Journal Article

Lührmann, R.; Stark, H.: Structural mapping of spliceosomes by electron microscopy. Current Opinion in Structural Biology 19, pp. 96 - 102 (2009)

MPG.PuRe

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83.

Journal Article

Sanchez, M.; Drechsler, M.; Stark, H.; Lipps, G.: DNA translocation activity of the multifunctional replication protein ORF904 from the archaeal plasmid pRN1. Nucleic Acids Research 37 (20), pp. 6831 - 6848 (2009)

MPG.PuRe

84.

Journal Article

Schmeisser, M.; Heisen, B.; Luettich, M.; Busche, B.; Hauer, F.; Koske, T.; Knauber, K. H.: Parallel, distributed and GPU computing technologies in single-particle electron microscopy. Acta Crystallographica D 65 (7), pp. 659 - 671 (2009)

MPG.PuRe

85.

Journal Article

Karaduman, R.; Dube, P.; Stark, H.; Fabrizio, P.; Kastner, B.; Luehrmann, R.: Structure of yeast U6 snRNPs: arrangement of Prp24p and the LSm complex as revealed by electron microscopy. RNA 14, pp. 2528 - 2537 (2008)

MPG.PuRe

publisher-version

86.

Journal Article

Haecker, I.; Sander, B.; Golas, M. M.; Wolf, E.; Karagoez, E.; Kastner, B.; Stark, H.; Fabrizio, P.; Luehrmann, R.: Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy. Nature Structural and Molecular Biology 15 (11), pp. 1206 - 1212 (2008)

MPG.PuRe

87.

Journal Article

Chari, A.; Golas, M. M.; Klingenhaeger, M.; Neuenkirchen, N.; Sander, B.; Englbrecht, C.; Sickmann, A.; Stark, H.; Fischer, U.: An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. Cell 135 (3), pp. 497 - 509 (2008)

MPG.PuRe

publisher-version

88.

Journal Article

Kastner, B.; Fischer, N.; Golas, M. M.; Sander, B.; Dube, P.; Boehringer, D.; Hartmuth, K.; Deckert, J.; Hauer, F.; Wolf, E. et al.; Uchtenhagen, H.; Urlaub, H.; Herzog, F.; Peters, J. M.; Porschke, D.; Luehrmann, R.; Stark, H.: GraFix: sample preparation for single-particle electron cryomicroscopy. Nature Methods 5 (1), pp. 53 - 55 (2008)

MPG.PuRe

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89.

Journal Article

Sirajuddin, M.; Farkasovsky, M.; Hauer, F.; Kuehlmann, D.; Macara, I. G.; Weyand, M.; Stark, H.; Wittinghofer, A.: Structural insight into filament formation by mammalian septins. Nature 449 (7160), pp. 311 - 315 (2007)

MPG.PuRe

90.

Journal Article

Kuehn-Hoelsken, E.; Dybkov, O.; Sander, B.; Luehrmann, R.; Urlaub, H.: Improved identification of enriched peptide–RNA cross-links from ribonucleoprotein particles (RNPs) by mass spectrometry. Nucleic Acids Research 35 (15), e95 (2007)

MPG.PuRe

91.

Journal Article

Behzadnia, N.; Golas, M. M.; Hartmuth, K.; Sander, B.; Kastner, B.; Deckert, J.; Dube, P.; Will, C. L.; Urlaub, H.; Stark, H. et al.; Luehrmann, R.: Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. The EMBO Journal 26 (6), pp. 1737 - 1748 (2007)

MPG.PuRe

publisher-version

92.

Journal Article

Konevega, A. L.; Fischer, N.; Semenkov, Y. P.; Stark, H.; Wintermeyer, W.; Rodnina, M. V.: Spontaneous reverse movement of mRNA-bound tRNA through the ribosome. Nature Structural Molecular Biology 14, pp. 318 - 324 (2007)

MPG.PuRe

93.

Journal Article

Sander, B.; Golas, M. M.; Makarov, E. M.; Brahms, H.; Kastner, B.; Luehrmann, R.; Stark, H.: Organization of Core Spliceosomal Components U5 snRNA Loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as Revealed by Electron Cryomicroscopy. Molecular Cell 24 (2), pp. 267 - 278 (2006)

MPG.PuRe

publisher-version

94.

Journal Article

Deckert, J.; Hartmuth, K.; Boehringer, D.; Behzadnia, N.; Will, C. L.; Kastner, B.; Stark, H.; Urlaub, H.; Luehrmann, R.: Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions. Molecular and Cellular Biology 26 (14), pp. 5528 - 5543 (2006)

MPG.PuRe

publisher-version

95.

Journal Article

Schellenberg, M. J.; Edwards, R. A.; Ritchie, D. B.; Kent, O. A.; Golas, M. M.; Stark, H.; Luehrmann, R.; Glover, J. N. M.; MacMilan, A. M.: Crystal structure of a core spliceosomal protein interface. Proceedings of the National Academy of Sciences of the United States of America 103 (5), pp. 1266 - 1271 (2006)

MPG.PuRe

publisher-version

96.

Journal Article

Stark, H.; Luehrmann, R.: Cryo-electron microscopy of spliceosomal components. Annual Review of Biophysics and Biomolecular Structure 35, pp. 435 - 457 (2006)

MPG.PuRe

97.

Journal Article

Kuehn-Hoelsken, E.; Lenz, C.; Sander, B.; Luehrmann, R.; Urlaub, H.: Complete MALDI-ToF MS analysis of cross-linked peptide-RNA oligonucleotides derived from nonlabeled UV-irradiated ribonucleoprotein particles. RNA 11 (12), pp. 1915 - 1930 (2005)

MPG.PuRe

publisher-version

98.

Journal Article

Golas, M. M.; Sander, B.; Will, C. L.; Luehrmann, R.; Stark, H.: Major conformational change in the complex SF3b upon integration into the spliceosomal U11/U12 di-snRNP as revealed by electron cryomicroscopy. Molecular Cell 17 (6), pp. 869 - 883 (2005)

MPG.PuRe

publisher-version

99.

Journal Article

Boehringer, D.; Thermann, R.; Ostareck-Lederer, A.; Lewis, J. D.; Stark, H.: Structure of the hepatitis C virus IRES bound to the human 80S ribosome: Remodeling of the HCV IRES. Structure 13, pp. 1695 - 1706 (2005)

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