Publications
Journal Article (126)
1.
Journal Article
379, pp. 996 - 1003 (2023)
Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase. Science 2.
Journal Article
119 (52), e2215799119 (2022)
Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain. Proceedings of the National Academy of Sciences of the United States of America 3.
Journal Article
12, pp. 2397 - 2422 (2022)
Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity. Journal of Parkinson's Disease: JPD 4.
Journal Article
41 (24), e112006 (2022)
LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus. The EMBO Journal 5.
Journal Article
269, 104721 (2022)
Ectosomes and exosomes modulate neuronal spontaneous activity. Journal of Proteomics 6.
Journal Article
8 (35), eabo4946 (2022)
Structural insights into crista junction formation by the Mic60-Mic19 complex. Science Advances 7.
Journal Article
76, 102441 (2022)
Frontiers in the enzymology of thiamin diphosphate-dependent enzymes. Current Opinion in Structural Biology 8.
Journal Article
23 (14), 7749 (2022)
miR449 Protects Airway Regeneration by Controlling AURKA/HDAC6-Mediated Ciliary Disassembly. International Journal of Molecular Sciences 9.
Journal Article
50 (9), pp. 5282 - 5298 (2022)
Conformational rearrangements upon start codon recognition in human 48S translation initiation complex. Nucleic Acids Research 10.
Journal Article
110 (9), pp. 1483 - 1497 (2022)
Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3. Neuron 11.
Journal Article
144, pp. 11270 - 11282 (2022)
19F Electron-nuclear double resonance reveals interaction between redox-active tyrosines across the α/β interface of E. coli ribonucleotide reductase. Journal of the American Chemical Society 12.
Journal Article
11, 1289 (2021)
Chromatography-free purification strategies for large biological macromolecular complexes involving fractionated PEG precipitation and density gradients. Life 13.
Journal Article
11 (12), 1289 (2021)
Chromatography-free purification strategies for large biological macromolecular complexes involving fractionated PEG precipitation and density gradients. Life 14.
Journal Article
12 (1), 5933 (2021)
Structural mechanism of GTPase-powered ribosome-tRNA movement. Nature Communications 15.
Journal Article
596 (7871), pp. 296 - 300 (2021)
Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature 16.
Journal Article
593 (7859), pp. 460 - 464 (2021)
A lysine–cysteine redox switch with an NOS bridge regulates enzyme function. Nature 17.
Journal Article
370 (6523), eabc3753 (2020)
Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science 18.
Journal Article
587 (7832), pp. 157 - 161 (2020)
Atomic-resolution protein structure determination by cryo-EM. Nature 19.
Journal Article
16 (11), p. 1237-1245 (2020)
Structural basis for antibiotic action of the B1 antivitamin 2′-methoxy-thiamine. Nature Chemical Biology 20.
Journal Article
80 (1), pp. 127 - 139.e6 (2020)
Structural insights into the roles of metazoan-specific splicing factors in the human step 1 spliceosome. Molecular Cell 21.
Journal Article
11, 4106 (2020)
Mechanism of ribosome rescue by alternative ribosome-rescue factor B. Nature Communications 22.
Journal Article
6 (30), eaba3916 (2020)
Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution. Science Advances 23.
Journal Article
583 (7815), pp. 310 - 313 (2020)
Molecular architecture of the human 17S U2 snRNP. Nature 24.
Journal Article
180 (6), pp. 1130 - 1143.e20 (2020)
Discovery of a regulatory subunit of the yeast fatty acid synthase. Cell 25.
Journal Article
11 (11), a032417 (2019)
Structural insights into nuclear pre-mRNA splicing in higher eukaryotes. Cold Spring Harbor Perspectives in Biology 26.
Journal Article
116 (35), pp. 17280 - 17289 (2019)
Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site. Proceedings of the National Academy of Sciences of the United States of America 27.
Journal Article
27 (7), pp. 1124 - 1136 (2019)
Structural and functional analyses of the human PDH complex suggest a "Division-of-Labor" mechanism by local E1 and E3 clusters. Structure 28.
Journal Article
29 (2), pp. 117 - 134 (2019)
Posing the APC/C E3 ubiquitin ligase to orchestrate cell division. Trends in Cell Biology 29.
Journal Article
17 (7), pp. 471 - 492 (2018)
Cryo-EM in drug discovery: Achievements, limitations and prospects. Nature Reviews Drug Discovery 30.
Journal Article
172 (3), pp. 454 - 464, e1-e5 (2018)
Structure and conformational dynamics of the human spliceosomal Bact complex. Cell 31.
Journal Article
170 (4), pp. 701 - 713, e1 - e4 (2017)
Cryo-EM structure of a pre-catalytic human spliceosome primed for activation. Cell 32.
Journal Article
8, 15578 (2017)
Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs. Nature Communications 33.
Journal Article
372 (1716), 20160182 (2017)
Ribosome dynamics during decoding. Philosophical Transactions of the Royal Society B 34.
Journal Article
542 (7641), pp. 318 - 323 (2017)
Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 35.
Journal Article
540 (7631), pp. 80 - 85 (2016)
The pathway to GTPase activation of elongation factor SelB on the ribosome. Nature 36.
Journal Article
353 (6306), pp. 1399 - 1405 (2016)
Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 37.
Journal Article
16 (12), pp. 3103 - 3112 (2016)
The ribosome cooperates with the assembly chaperone pICln to initiate formation of snRNPs. Cell Reports 38.
Journal Article
22 (9), pp. 1329 - 1337 (2016)
ATPγS stalls splicing after B complex formation but prior to spliceosome activation. RNA 39.
Journal Article
7, 12523 (2016)
Topology and structure of an engineered human cohesin complex bound to Pds5B. Nature Communications 40.
Journal Article
63 (4), pp. 593 - 607 (2016)
Cryo-EM of mitotic checkpoint complex-bound APC/C reveals reciprocal and conformational regulation of ubiquitin ligation. Molecular Cell 41.
Journal Article
353 (6299), pp. 594 - 598 (2016)
The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science 42.
Journal Article
165 (6), pp. 1440 - 1453 (2016)
Dual RING E3 architectures regulate multiubiquitination and ubiquitin chain elongation by APC/C. Cell 43.
Journal Article
113 (19), pp. E2570 - E2578 (2016)
Mechanism of APC/C-CDC20 activation by mitotic phosphorylation. Proceedings of the National Academy of Sciences of the United States of America 44.
Journal Article
113 (19), pp. E2564 - E2569 (2016)
biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes. Proceedings of the National Academy of Sciences of the United States of America 45.
Journal Article
351 (6280), pp. 1416 - 1420 (2016)
Molecular architecture of the human U4/U6.U5 tri-snRNP. Science 46.
Journal Article
65 (1), pp. 23 - 34 (2016)
Sample preparation of biological macromolecular assemblies for the determination of high-resolution structures by cryo-electron microscopy. Microscopy 47.
Journal Article
4, e11349 (2015)
Nanobodies: Site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation. eLife 48.
Journal Article
12 (9), pp. 859 - 865 (2015)
ProteoPlex: Stability optimization of macromolecular complexes by sparse-matrix screening of chemical space. Nature Methods 49.
Journal Article
23 (9), pp. 1769 - 1775 (2015)
GraDeR: Membrane protein complex preparation for single-particle cryo-EM. Structure 50.
Journal Article
99 (16), pp. 6765 - 6774 (2015)
Expression of enterovirus 71 virus-like particles in transgenic enoki (Flammulina velutipes). Applied Microbiology and Biotechnology 51.
Journal Article
58 (6), pp. 1079 - 1089 (2015)
Molecular basis of transcription-coupled pre-mRNA capping. Molecular Cell 52.
Journal Article
112 (17), pp. 5272 - 5279 (2015)
RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex. Proceedings of the National Academy of Sciences of the United States of America 53.
Journal Article
520 (7548), pp. 567 - 570 (2015)
Structure of the E. coli ribosome–EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM. Nature 54.
Journal Article
56 (2), pp. 246 - 260 (2014)
Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly. Molecular Cell 55.
Journal Article
22 (6), pp. 923 - 930 (2014)
Translation initiation factor eIF3b contains a nine-bladed beta-propeller and interacts with the 40S ribosomal subunit. Structure 56.
Journal Article
20 (12), pp. 1390 - 1396 (2013)
Energy barriers and driving forces in tRNA translocation through the ribosome. Nature Structural and Molecular Biology 57.
Journal Article
21 (8), pp. 1350 - 1360 (2013)
Structural determinants and mechanism of mammalian CRM1 allostery. Structure 58.
Journal Article
20 (7), pp. 827 - 835 (2013)
Electron microscopy structure of human APC/C-CDH1-EMI1 reveals multimodal mechanism of E3 ligase shutdown. Nature Structural and Molecular Biology 59.
Journal Article
49 (4), pp. 692 - 703 (2013)
Structural basis of assembly chaperone- mediated snRNP formation. Molecular Cell 60.
Journal Article
181 (2), pp. 149 - 154 (2013)
Automated correlation of single particle tilt pairs for Random Conical Tilt and Orthogonal Tilt Reconstructions. Journal of Structural Biology 61.
Journal Article
110 (3), pp. 960 - 965 (2013)
Structural basis for cooperativity of CRM1 export complex formation. Proceedings of the National Academy of Sciences of the United States of America 62.
Journal Article
18 (12), pp. 2306 - 2319 (2012)
Novel insights into the architecture and protein interaction network of yeast eIF3. RNA 63.
Journal Article
19 (11), pp. 1116 - 1123 (2012)
APC15 mediates CDC20 autoubiquitylation by APC/C-MCC and disassembly of the mitotic checkpoint complex. Nature Structural and Molecular Biology 64.
Journal Article
286 (44), pp. 38748 - 38756 (2011)
Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy. Journal of Biological Chemistry 65.
Journal Article
10 (11), pp. 10.1074/mcp.M110.005371-1 - 10.1074/mcp.M110.005371–16 (2011)
Chromatin affinity purification and quantitative mass spectrometry defining the interactome of histone modification patterns. Molecular and Cellular Proteomics 66.
Journal Article
18, pp. 6 - 13 (2010)
Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1. Nature Structural and Molecular Biology 67.
Journal Article
40 (6), pp. 927 - 938 (2010)
3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core. Molecular Cell 68.
Journal Article
16 (12), pp. 2384 - 2403 (2010)
Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis. RNA 69.
Journal Article
190 (5), pp. 835 - 852 (2010)
The MIS12 complex is a protein interaction hub for outer kinetochore assembly. Journal of Cell Biology 70.
Journal Article
18 (6), pp. 667 - 676 (2010)
An approach for de novo structure determination of dynamic molecular assemblies by electron cryomicroscopy. Structure 71.
Journal Article
328 (5978), pp. 593 - 599 (2010)
Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science 72.
Journal Article
466 (7304), pp. 329 - 333 (2010)
Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy. Nature 73.
Journal Article
9, pp. 1729 - 1741 (2010)
Merging molecular electron microscopy and mass spectrometry by carbon film-assisted endoproteinase digestion. Molecular and Cellular Proteomics 74.
Journal Article
11 (1), pp. 39 - 50 (2010)
Characterization of tailor-made copolymers of oligo(ethylene glycol) methyl ether methacrylate and N,N-dimethylaminoethyl methacrylate as nonviral gene transfer agents: Influence of macromolecular structure on gene vector particle properties and transfection efficiency. Biomacromolecules 75.
Journal Article
16 (12), pp. 1237 - 1243 (2009)
Reconstitution of both steps of S. cerevisiae splicing with purified spliceosomal components. Nature Structural and Molecular Biology 76.
Journal Article
10 (10), pp. 2912 - 2920 (2009)
Self-assembly of ternary insulin−polyethylenimine (PEI)−DNA nanoparticles for enhanced gene delivery and expression in alveolar epithelial cells. Biomacromolecules 77.
Journal Article
28, pp. 2283 - 2292 (2009)
Exon, intron and splice site locations in the spliceosomal B complex. EMBO Journal 78.
Journal Article
459 (7243), pp. 73 - 76 (2009)
Self-assembly of a nanoscale DNA box with a controllable lid. Nature 79.
Journal Article
28 (6), pp. 766 - 778 (2009)
Snapshots of the RNA editing machine in trypanosomes captured at different assembly stages in vivo. EMBO Journal 80.
Journal Article
323 (5920), pp. 1477 - 1481 (2009)
Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex. Science 81.
Journal Article
36 (4), pp. 593 - 608 (2009)
The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. Molecular Cell 82.
Journal Article
19, pp. 96 - 102 (2009)
Structural mapping of spliceosomes by electron microscopy. Current Opinion in Structural Biology 83.
Journal Article
37 (20), pp. 6831 - 6848 (2009)
DNA translocation activity of the multifunctional replication protein ORF904 from the archaeal plasmid pRN1. Nucleic Acids Research 84.
Journal Article
65 (7), pp. 659 - 671 (2009)
Parallel, distributed and GPU computing technologies in single-particle electron microscopy. Acta Crystallographica D 85.
Journal Article
14, pp. 2528 - 2537 (2008)
Structure of yeast U6 snRNPs: arrangement of Prp24p and the LSm complex as revealed by electron microscopy. RNA 86.
Journal Article
15 (11), pp. 1206 - 1212 (2008)
Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy. Nature Structural and Molecular Biology 87.
Journal Article
135 (3), pp. 497 - 509 (2008)
An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. Cell 88.
Journal Article
5 (1), pp. 53 - 55 (2008)
GraFix: sample preparation for single-particle electron cryomicroscopy. Nature Methods 89.
Journal Article
449 (7160), pp. 311 - 315 (2007)
Structural insight into filament formation by mammalian septins. Nature 90.
Journal Article
35 (15), e95 (2007)
Improved identification of enriched peptide–RNA cross-links from ribonucleoprotein particles (RNPs) by mass spectrometry. Nucleic Acids Research 91.
Journal Article
26 (6), pp. 1737 - 1748 (2007)
Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. The EMBO Journal 92.
Journal Article
14, pp. 318 - 324 (2007)
Spontaneous reverse movement of mRNA-bound tRNA through the ribosome. Nature Structural Molecular Biology 93.
Journal Article
24 (2), pp. 267 - 278 (2006)
Organization of Core Spliceosomal Components U5 snRNA Loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as Revealed by Electron Cryomicroscopy. Molecular Cell 94.
Journal Article
26 (14), pp. 5528 - 5543 (2006)
Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions. Molecular and Cellular Biology 95.
Journal Article
103 (5), pp. 1266 - 1271 (2006)
Crystal structure of a core spliceosomal protein interface. Proceedings of the National Academy of Sciences of the United States of America 96.
Journal Article
35, pp. 435 - 457 (2006)
Cryo-electron microscopy of spliceosomal components. Annual Review of Biophysics and Biomolecular Structure 97.
Journal Article
11 (12), pp. 1915 - 1930 (2005)
Complete MALDI-ToF MS analysis of cross-linked peptide-RNA oligonucleotides derived from nonlabeled UV-irradiated ribonucleoprotein particles. RNA 98.
Journal Article
17 (6), pp. 869 - 883 (2005)
Major conformational change in the complex SF3b upon integration into the spliceosomal U11/U12 di-snRNP as revealed by electron cryomicroscopy. Molecular Cell 99.
Journal Article
13, pp. 1695 - 1706 (2005)
Structure of the hepatitis C virus IRES bound to the human 80S ribosome: Remodeling of the HCV IRES. Structure