Publications of Kai Tittmann

Arbia, G.; Joly, M.; Nauton, L.; Leogrande, C.; Tittmann, K.; Charmantray, F.; Hecquet, L.: Enzymatic Upgrading of Biomass-Derived Aldoses to Rare Deoxy Ketoses Catalyzed by Transketolase Variants. ChemSusChem 18 (8), e202401834 (2025)

Mrozek, P.; Grunewald, S.; Treffon, K.; Poschmann, G.; Rabe von Pappenheim, F.; Tittmann, K.; Gatz, C.: Molecular basis for the enzymatic inactivity of class III glutaredoxin ROXY9 on standard glutathionylated substrates. Nature Communications 16, 589 (2025)

Lanza, L.; Rabe von Pappenheim, F.; Bjarnesen, D.; Leogrande, C.; Paul, A.; Krug, L.; Tittmann, K.; Müller, M.: Identification and Characterization of Thiamine Diphosphate‐Dependent Lyases with an Unusual CDG Motif. Angewandte Chemie International Edition 63 (34), e202404045 (2024)

Tamhankar, A.; Wensien, M.; Jannuzzi, S. A. V.; Chatterjee, S.; Lassalle-Kaiser, B.; Tittmann, K.; Debeer, S.: In Solution Identification of the Lysine–Cysteine Redox Switch with a NOS Bridge in Transaldolase by Sulfur K-Edge X-ray Absorption Spectroscopy. The Journal of Physical Chemistry Letters 15 (16), pp. 4263 - 4267 (2024)

Funk, L.-M.; Poschmann, G.; Rabe von Pappenheim, F.; Chari, A.; Stegmann, K. M.; Dickmanns, A.; Wensien, M.; Eulig, N.; Paknia, E.; Heyne, G. et al.; Penka, E.; Pearson, A. R.; Berndt, C.; Fritz, T.; Bazzi, S.; Uranga, J.; Mata, R. A.; Dobbelstein, M.; Hilgenfeld, R.; Curth, U.; Tittmann, K.: Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design. Nature Communications 15, 411 (2024)

Liu, Z.; Xiao, C.; Lin, S.; Tittmann, K.; Dai, S.: Multifaceted Role of the Substrate Phosphate Group in Transketolase Catalysis. ACS Catalysis 14 (1), pp. 355 - 365 (2024)

Uranga, J.; Rabe von Pappenheim, F.; Tittmann, K.; Mata, R. A.: Dynamic Protonation States Underlie Carbene Formation in ThDP-Dependent Enzymes: A Theoretical Study. The Journal of Physical Chemistry B 127, pp. 9423 - 9432 (2023)

Ye, J.; Bazzi, S.; Fritz, T.; Tittmann, K.; Mata, R. A.; Uranga, J.: Mechanisms of Cysteine-Lysine Covalent Linkage - The Role of Reactive Oxygen Species and Competition with Disulfide Bonds. Angewandte Chemie International Edition 62 (36), e202304163 (2023)

Hicks, K. G.; Cluntun, A. A.; Schubert, H. L.; Hackett, S. R.; Berg, J. A.; Leonard, P. G.; Ajalla Aleixo, M. A.; Zhou, Y.; Bott, A. J.; Salvatore, S. R. et al.; Chang, F.; Blevins, A.; Barta, P.; Tilley, S.; Leifer, A.; Guzman, A.; Arok, A.; Fogarty, S.; Winter, J. M.; Ahn, H.-C.; Allen, K. N.; Block, S.; Cardoso, I. A.; Ding, J.; Dreveny, I.; Gasper, W. C.; Ho, Q.; Matsuura, A.; Palladino, M. J.; Prajapati, S.; Sun, P.; Tittmann, K.; Tolan, D. R.; Unterlass, J.; Van Demark, A. P.; Vander Heiden, M. G.; Webb, B. A.; Yun, C.-H.; Zhao, P.; Wang, B.; Schopfer, F. J.; Hill, C. P.; Nonato, M. C.; Muller, F. L.; Cox, J. E.; Rutter, J.: Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase. Science 379, pp. 996 - 1003 (2023)

Prajapati, S.; Rabe von Pappenheim, F.; Tittmann, K.: Frontiers in the enzymology of thiamin diphosphate-dependent enzymes. Current Opinion in Structural Biology 76, 102441 (2022)

Rindfleisch, S.; Krull, M.; Uranga, J.; Schmidt, T.; Rabe von Pappenheim, F.; Kirck, L. L.; Balouri, A.; Schneider, T.; Chari, A.; Kluger, R. et al.; Bourenkov, G.; Diederichsen, U.; Mata, R. A.; Tittmann, K.: Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5′-monophosphate decarboxylase catalysis. Nature Catalysis 5, pp. 332 - 341 (2022)

Meyer, A.; Kehl, A.; Cui, C.; Reichardt, F. A. K.; Hecker, F.; Funk, L.-M.; Ghosh, M. K.; Pan, K. T.; Urlaub, H.; Tittmann, K. et al.; Stubbe, J.; Bennati, M.: 19F Electron-nuclear double resonance reveals interaction between redox-active tyrosines across the α/β interface of E. coli ribonucleotide reductase. Journal of the American Chemical Society 144, pp. 11270 - 11282 (2022)

Wensien, M.; Rabe von Pappenheim, F.; Funk, L. M.; Kloskowski, P.; Curth, U.; Diederichsen, U.; Uranga, J.; Ye, J.; Fang, P.; Pan, K. T. et al.; Urlaub, H.; Mata, R. A.; Sautner, V.; Tittmann, K.: A lysine–cysteine redox switch with an NOS bridge regulates enzyme function. Nature 593 (7859), pp. 460 - 464 (2021)

Rabe von Pappenheim, F.; Aldeghi, M.; Shome, B.; Begley, T.; de Groot, B. L.; Tittmann, K.: Structural basis for antibiotic action of the B1 antivitamin 2′-methoxy-thiamine. Nature Chemical Biology 16 (11), p. 1237-1245 (2020)

Singh, K.; Graf, B.; Linden, A.; Sautner, V.; Urlaub, H.; Tittmann, K.; Stark, H.; Chari, A.: Discovery of a regulatory subunit of the yeast fatty acid synthase. Cell 180 (6), pp. 1130 - 1143.e20 (2020)