Lab News on Twitter (since 2017)

November 11, 2022

What a great evening. Thanks for coming, @JoeMillerJr!

November 10, 2022

Looking forward to the panel discussion on enlightenment & the future of democracy.

November 07, 2022

This is so great and so well deserved, congratulations to Dirk!

November 07, 2022

Important news: regulations to limit energy prizes in Germany will apply to scientific institutions! Many thanks to everyone who helped making this possible. @Leopoldina @BMBF_Bund

November 06, 2022

Really great video on exoplanets featuring Max Planck colleague @lkreidberg @mpi_astro

November 05, 2022

Although RNA exit path is wrong and many factors are missing, this movie gives a great impression of how RNA polymerase II copies genes to produce mRNA.

November 05, 2022

Looking forward to discuss PLANETARY HEALTH @Falling_Walls On Nov 8 at 4pm in Berlin. Register for free livestream:

November 04, 2022

Wonderful event with Antje Boetius @AWI_de on her life exploring the deep sea and addressing global challenges.

November 03, 2022

The place where gravitational wave physics started. Great opportunities for the future, incl. space detector LISA and synergy with quantum computing.

November 02, 2022

Many congratulations to @GargGaurika who passed her PhD defense, great manuscript on co-transcriptional pre-mRNA capping!

October 28, 2022

Here is the current lab! From January 1st coordinated by @lidschreiber with teams of project leaders @EOberbeckmann @c_dienemann and Kristina Zumer

October 27, 2022

17th Cramer lab retreat featuring @drosoigmm @SchurLab @jankosinski and Maria Sokolova.

October 25, 2022

Thanks to @LouisJeantetFDN for producing this video on our work: Featuring @Zhang_Suyang @MRC_LMB @isaac_fianu @HaiboWang36 @MariekeOudelaar @Stefan_W_Hell @mpi_nat and others.

October 25, 2022

At the interface to biology, the @MpiciPotsdam invents bioinspired materials and a sustainable future of chemistry.

October 25, 2022

It is one thing to hear about the fascinating nature of gravity but seeing a movie of two black holes merging is mind-blowing.

October 25, 2022

Insights into gene dose: mRNA and protein abundance scales allometrically with ploidy, i.e. tetraploid cells show only threefold increase in protein abundance. Glad we could contribute to this study by the Storchova lab.

October 24, 2022

Much looking forward to host Antje Boetius from Wegener Institute and @MarineMicrobio at Göttingen, join the live stream!

October 24, 2022

Plant science leads to fundamental biological insights and biotech applications. But it is also key to ensure food production and to obtain biomass for sustainable chemistry. Thanks for the warm welcome!

October 20, 2022

Looking forward to moderate the discussion!

October 18, 2022

Nice description of our lab's interdisciplinary research in the new issue of the Max Planck magazine. English version will follow.

October 17, 2022

Ulrich Nauber organized art exhibitions at our institute @mpi_nat for 20 years! Great outreach as science and art are close relatives.

October 16, 2022

Science enabled the development of tests, vaccines & drugs to fight SARS-CoV2. We must support science during the current crisis to be prepared for an unknown future.

October 16, 2022

Help needed: Anyone knows the artist „C. Seeberger“ who drew this beautiful portrait of Max Planck in 1934? Just obtained this ‚lost’ original artwork from a colleague.

October 15, 2022

@mkMellon I loved dreaming about densities and often figured out correct structural interpretations during sleep.

October 12, 2022

Spectacular talks by Sahin, Türeci and Kariko (on how mRNA vaccines became possible) were followed by a wonderful ceremony and dinner @LouisJeantetFDN in Geneva

October 09, 2022

Glad to live in a country that can attract and foster brilliant minds like Svante Pääbo.

October 08, 2022

„fund the best research despite the crisis“ - important interview on German radio @DLF with Max Planck colleagues Ute Frevert and @peterseeberger

October 05, 2022

Looking forward to give the Fred Richards Lecture at Yale today: "Transcription of the Genome" via @yalemed

October 03, 2022

Many, many congratulations to our @maxplanckpress colleague Svante Pääbo, on receiving this year‘s Nobel Prize in Physiology or Medicine! It is a great recognition of Svante‘s pioneering work and visionary leadership. Glad I could just visit @MPI_EVA_Leipzig, the place to be.

September 29, 2022

Some spontaneous thoughts on the science of the future, on our working culture and on the dialogue with the general public.

September 29, 2022

Some remarks on science communication and why we invite scientists to the upcoming literature festival at Goettingen. In German though.

September 28, 2022

So happy we were involved in this incredible work by Julia Mahamid‘s lab visualizing translation at atomic detail inside cells by cryo-ET.

September 23, 2022

Important message by the president of the German National Academy @Leopoldina today: high energy prizes will hurt research and endanger science. via @derspiegel

September 22, 2022

What an honor to speak af this symposium with @erin_schuman, Catt try ol Robinsson, Ugur Sahin, Özlem Türeci and Katalin Kariko.

September 22, 2022

Saying goodbye to @YingChen_P and @KokicGoran who both take positions. Many thanks for the great contributions and many congratulations! Hopefully this is not the last rooftop barbecue this year.

September 22, 2022

Many congratulations, Tony and @HymanLab!

September 22, 2022

First structural insights into how a NON-coding RNA promoter is recognized and opened by Pol II - without TFIIH but using the specialized factor SNAPc. Great work by @vasan06 in collaboration with @VanniniLab

September 22, 2022

Wonderful opportunities to develop the life sciences and for interactions with @LMU_Muenchen @LMU_Uniklinikum @BioM_Munich @GeneCenter_LMU

September 22, 2022

The new @MPIforBI studies the mystery of biological intelligence at two sites south of Munich, our life sciences campus in Martinsried and Seewiesen, where this beautiful lake and surroundings allow for animal observation in a natural habitat.

September 18, 2022

Learned more on where we stand with quantum computing at the amazing @MPI_Quantum. In the current hype it remains open which technology will prevail to ‚store’ qubits - but it is clear QC will be superior to traditional computing for several applications.

September 16, 2022

How do animals interact, move globally and behave collectively? A fascinating combination of biology, technology and computing unravels many secrets. @MPI_animalbehav hosts outstanding research group leaders with unconventional ideas!

September 16, 2022

Exciting to meet @zieglerphoto1 today @MPI_animalbehav, who obtained this year‘s World Press Photo Award for Nature, congratulations!

September 15, 2022

In direct neighborhood of @MPE_Garching, the MPI for Astrophysics focuses on theoretical work to understand the origins of the universe and the development of galaxies and stars.

September 15, 2022

How do they know the plasma inside the Tokamak fusion reactor is at 100 Mio degrees? They built this huge „thermometer“ @PlasmaphysikIPP. And they made the heat shield of tungsten, an important contribution to @iterorg

September 15, 2022

Movies of stars accelerated by black holes, maps of dark matter in the universe obtained with X-ray detectors in space, and chemistry on distant planets!

September 14, 2022

Looking forward to host Antje Boetius, Özlem Türeci and Ugur Sahin this year!

September 14, 2022

Founded by Einstein and reestablished by Heisenberg the MPI for Physics is world-leading in particle physics. The insitute was also instrumental in bringing to life the MPI for Astrophysics @PlasmaphysikIPP @MPE_Garching

September 09, 2022

Deeply impressed by the work @MaxAnthropology, aimed at understanding human cultures around the world. Researchers often spend a full year abroad. Also great outreach activities:

September 08, 2022

Facing questions by students on climate change and personalized medicine: it is one thing to develop technologies and therapies, but we also have to change the way we live.

September 08, 2022

Mathematics is often the key to enable breakthroughs in others disciplines, not only in biomedicine or physics, but increasingly also in the social sciences and beyond. This becomes obvious seeing the many interactions of @mpiMathSci with other institutes.

September 07, 2022

Where paleogenetics was developed and human history is lined out in an unprecedented way. @MPI_EVA_Leipzig

September 06, 2022

Astonishing encounters with our close relatives at the Wolfgang Köhler Center, the largest primate observation research center, hosting 50 animals. A collaborative project of @MPI_EVA_Leipzig & @Zoo_Leipzig.

September 05, 2022

What makes us human? Perception, language, learning and memory are focus areas at the MPI for human cognitive and brain sciences in Leipzig. Home of @MPS_cog.

September 05, 2022

What an honor to speak in a symposium with such distinguished colleagues

September 05, 2022

Thank you for hosting us and all the best for the future!

September 04, 2022

After visiting the first 15 institutes, it is clear many postdocs wish to have advice on alternative career paths. Please use offers by @maxplanckcareer and provide feedback. @MPGpostdocnet

September 02, 2022

Many congratulations, Tony!

September 02, 2022

Great to see how the 111-year old MPI for Medical Research develops, incl. the planned new building at the Neckar river in Heidelberg. For me, it will always be connected to the introduction of synchrotron radiation to structural biology by Ken Holmes.

September 01, 2022

The only place on our planet to do chemistry under the conditions of interstellar clouds: the MPI for Nuclear Physics next to @embl in Heidelberg. Colleagues here also study mysterious dark matter and other phenomena that are well beyond my understanding.

September 01, 2022

The workshops @mpi_astro build instruments for telescopes icl. @NASAWebb, allowing colleagues to study exoplanets and the birth of galaxies and planets. Touching fundamental questions of our existence.

August 31, 2022

So obvious here how science can help make the world a better place. Peace efforts in Sudan, constitutional advice for states in Latin America or global animal rights: so many important implications of the research carried out @MPILheidelberg - thank you for these insights!

August 27, 2022

Great to be back and meet several alumni who present stories from their labs!

August 27, 2022

The program for our Literature Festival #Literaturherbst is out, including Özlem Türeci and Ugur Sahin of BioNTech on November 02, presenting „Project Lightspeed“ - the story of how the first corona vaccine became possible.

August 26, 2022

@GiuCali_ @CSHL @sroka_martyna @CAMarshall480 @cshlmeetings What a wonderful colleague, it all started with crystallography and RNA

August 26, 2022

I learned, amongst other things, how analysis of a sample from 2300 water depth questions our current tree of life and understanding of eukaryote evolution. So much to be discovered in the ocean. Thank you for the stimulating discussion.

August 25, 2022

Located in Hamburg, @MPIPRIV has unique expertise in private law for numerous countries, competence centers for China and the islamic world, amongst others, and an impressive library that attracts ~1000 guest researchers each year.

August 24, 2022

What a privilege to be part of the first event held in the brand-new building @MPSDHamburg - the place to be for studying the structure and dynamics of matter on a large campus with strong partners @CFEL_Hamburg @unihh @desy @CssbHamburg @embl

August 24, 2022

Moving to visit the place where the foundations were laid to proof that global warming is a result of human activity, eventually leading to the Paris Agreement in 2015. Today continued outstanding research on climate modeling with big data, really critical for our future.

August 23, 2022

Impressed by @MPI_Muenster after meeting Dietmar Vestweber, @WickstromLab and @ralfhadams. Biomedical research including work on tissue morphogenesis and dynamics.

August 18, 2022

A glimpse of the future when visiting the MPI for Security and Privacy - topics range from cryptography to digital wellbeing. Strong local partner @ruhrunibochum

August 18, 2022

The @mpimoph not only conducts leading research in cellular, structural and chemical biology; it also enables large-scale robotic compound screens and lead discovery through COMAS and LDC.

August 17, 2022

Good-bye to @Zhang_Suyang & wishing her all the best for her lab @MRC_LMB - she solved the first transcription-splicing structure & will continue on this.

August 17, 2022

Very impressed by the MPI for Mathematics in the center of Bonn: 4 colleagues (of whom 2 obtained the Fields Medal) attract hundreds of guest scientists from around the globe each year.

August 12, 2022

@MPI_Metabolism not only does great science but also builds bridges to the hospital and creates strong synergy with the neighboring @MPIAGE

August 12, 2022

Thank you for hosting us! Great discussions on how to best support our group leaders.

August 11, 2022

Fascinating start of our tour of Max Planck Institutes in Bonn: Behavioral law and economics study how we judge and take decisions

July 25, 2022

Sharing the piece I wrote on the occasion of the 100th anniversary of Franklin‘s birth:

July 19, 2022

#Nucleosome passage by Pol II: H2A/H2B loss, backtracking and TFIIS-mediated reactivation. Finished in a transatlantic collaborationbetween @LucasFarnung @MoritzOchmann @GargGaurika @seyvos

July 15, 2022

Honored to witness today how Planck joins Gauss at the hall of fame ‚Walhalla‘ in Bavaria

July 14, 2022

Feels surreal to hold a copy of Galileo Galileis ‚Discorsi‘ from 1655 in hands. One of the treasures of @MPIWG.

July 06, 2022

Many congratulations @RehlingLab, newly elected member of @EMBO!

July 06, 2022

Thank you for the invitation, @BioM_Munich and congratulations on 25 years of the Munich Biotech Cluster.

July 01, 2022

Saying good-bye to @HaiboWang36 and wishing him all the best as a PI at @ZJU_China. Remembering his wonderful work on chromatin-associated factors:

July 01, 2022

So well deserved. @KokicGoran solved much of the mystery of TCR. All the best for the future!

June 27, 2022

Explaining gene transcription in German TV in 13 minutes…

June 23, 2022

Honored to serve science and society as next president of @maxplanckpress and looking forward to visit our 85 institutes and prepare for my term.

June 22, 2022

Very grateful to past and present lab members for their contributions. Wonderful to see many of them excel in their own labs.

June 20, 2022

What a memorable event, and so great to share with two close colleagues and friends.

June 17, 2022

Congratulations @msanderlab - and all the best to @MDC_Berlin

June 12, 2022

Looking forward to speak at the Aminoff Symposium in Stockholm on Tuesday. Programm:

June 05, 2022

Very impressed by the newly opened @ForumWissenGoe - a place teaching the scientific approach @uniGoettingen @thegoecampus

June 04, 2022

Honored to join the Berlin-Brandenburg Academy of Sciences and Humanities.

June 03, 2022

Many congratulations to Eusra Mohammad who just passed her PhD defense! Fine contributions to multiomics analyses of transcription-related CDKs.

June 02, 2022

Looking forward to discuss the future of biomedicine at Munich on July 5-6. @BioM_Munich

June 01, 2022

Thanks @plaschka_lab @AlexanderStark8 @IMPvienna for organizing a great day of exciting science.

May 27, 2022

Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells. Fine collaboration of @LeXiong @lidschreiber @taras_velychko @LCaizzi with Schöler lab. @eLife

May 26, 2022

Thanks for the warm (!) welcome and interesting science

May 25, 2022

Much looking forward to visit @IMPvienna, give the Birnstiel lecture and meet many colleagues incl. @plaschka_lab @AlexanderStark8

May 19, 2022

Finally big lab party again

May 17, 2022

Structures of nucleosome arrays suggest that H1 binding depends on length & trajectory of linker DNA. This can explain why arrays with short spacing are H1-depleted & suited for transcription. @mdombro_ @Sveta_Dodonova @c_dienemann Paper:

May 12, 2022

Looking forward to host Titia de Lange from @RockefellerUniv for our Bonhoeffer Award Lecture @mpi_nat next Tuesday.

May 11, 2022

So great to have @mleptin as president of @ERC_Research, congratulations!

May 10, 2022

mRNA vaccines became possible based on decades of basic research. Celebrating @Helmholtz_HIRI @Helmholtz_HZI with @JoergLab at Würzburg residence.

May 08, 2022

#Ukraine️ national colors east of #Göttingen campus.

May 08, 2022

„I come with a wish: foster diversity and understanding“ - Andreas Görgen (BKM) at the grand opening of the Göttingen Literaturhaus.

May 04, 2022

The talks given at the @Leopoldina #COVID symposium are now available online:

April 29, 2022

Thanks to colleagues in the DNA repair field for the invitation. In the future, @KokicGoran may be a frequent participant.

April 27, 2022

Huge Thank You to Steven Cusack and best of luck to Kristina Djinović-Carugo! EMBL Grenoble is close to my heart - great memories from PhD times.

April 26, 2022

Looking forward to host our new Federal Minister of Science @starkwatzinger @mpi_nat for a round table discussion on May 5.

April 22, 2022

Saying good-bye to @mdombro_ with a rooftop barbeque!

April 19, 2022

Here is the future!

April 07, 2022

Great honor to give this lecture in memory of our colleague Elisa Izaurralde.

April 03, 2022

Congratulations to @hauke_hillen for receiving the Engelhorn Research Award 2022 tonight in Munich!

April 02, 2022

Congratulations to former lab member Kayo Nozawa who just started her own lab at Tokyo Institute of Technology @NozawaL

March 29, 2022

Polymerase in action. Looking forward to the TV recording later tonight.

March 21, 2022

The talks of the cryo-EM workshop at Academia dei Lincei are now online. Keynote lecture starts at 3.01:

March 18, 2022

Looking forward to give the closing keynote at the cryo-EM workshop of the ACCADEMIA LINCEI today at 5.15 pm CET. Livestream:

March 18, 2022

Looking forward to close cooperation.

March 17, 2022

TT-seq measures synthesis and degradation of Alu retrotransposons. Glad we could contribute to this fine work of the Tresch lab.

March 16, 2022

Save the date: EMBL Conference Transcription and Chromatin, taking place August 27-30, 2022 in Heidelberg. So much looking forward to meet close colleagues in the field again. via @embl

March 07, 2022

@AsifaAkhtar1 Many congratulations, Asifa!

March 04, 2022

A famous alumnus of the University of #Odessa, #Ukraine, is George Gamow. He later worked at Göttingen and contributed to solving the genetic code.

February 26, 2022

‘A step to nowhere’: Russian scientist organizes protest of Ukraine war

February 21, 2022

Happy we could contribute to this new study from the lab of Jussi Taipale that uses massively parallel reporter assays to unravel sequence determinants for transcription activity and transcription factor function.

February 12, 2022

3 years ago I could visit this field station at the Beagle Channel near Ushuaia and understood a little better how traveling around Patagonia may have helped Darwin to come up with his revolutionary ideas. #DarwinDay

February 09, 2022

The lab of ⁦@ZStorchova⁩ shows that mRNA and protein abundance scales allometrically with cell ploidy. Glad we could contribute.

February 04, 2022

On the shoulders of giants: Ken Holmes started as a PhD student with Rosalind Franklin and later introduced synchrotron radiation to X-ray crystallography, what a step.

February 02, 2022

Movie by @KokicGoran shows how a protein complex (Pol II TCR complex) gets targeted by ubiquitination.

February 02, 2022

Great to see Roger still uses the initial ribbon model image of the core Pol II crystal structure from 2000 in his talks. Great memories.

February 01, 2022

„Anyone can identify Karikó in retrospect, given her persistence and her eventual discoveries. But what do we do right now to find the 2022 versions of Karikó…“ via @statnews

February 01, 2022

This one of the top Max Planck projects in this decade.

January 19, 2022

Congratulations to my colleagues @embl @emblebi on this ambitious and timely program! Best of luck!

January 19, 2022

Congratulations to the new life science factory that was just opened at Goettingen.

January 18, 2022

After two years of zoom I much look forward to meeting colleagues again and hope we can travel to this exciting meeting on DNA repair mechanisms.

January 15, 2022

Podcast on molecular evolution by Susanne Rostosky (German): Happy I could contribute with our old study (Lehmann et al. Nature 2007):

January 07, 2022

New interview on the latest on #SARS_CoV_2 #Covid_19 drugs #remdesivir #Molnupiravir #paxlovid (in German). Thanks to @gunnar_heine and colleagues.

January 05, 2022

The talk by Maja Göpel @beyond_ideology held on Nov 2, 2021 at #Literaturherbst is now available online (in German) at

January 01, 2022

It is an honor to serve as managing director of our new Max Planck Institute from today. I thank my colleagues for their trust and look forward to an exciting year.

December 17, 2021

Many congratulations Le Xiong for passing the PhD defense and all the best for the future!

December 16, 2021

Save the date: "Transcriptional regulation: Chromatin & RNA polymerase" Sept. 29–Oct. 2, 2022 in Snowbird, Utah.

December 09, 2021

So sad to say good-bye to Christina, Paulina, Felix, Sandra and Marc… but very happy they all found very good jobs. Many thanks indeed and all the best for the future!

December 01, 2021

Marco Dombrowski passed his defense today, many congratulations and all the best for the future!

November 30, 2021

This is so well-deserved, many congratulations!

November 27, 2021

#molnupiravir will not be a game changer in fighting #SARSCoV2 as its efficacy is low. Highlights need for developing new #antivirals targeting #coronavirus polymerase.

November 25, 2021

"Free, curiosity-driven basic research is the foundation of public research funding" - an important statement of the new German coalition #Koalitionsvertrag

November 13, 2021

Extremely sad. Terrible we lost such a wonderful and always supportive colleague @thegoecampus. My thoughts are with Ulf Diederichsen‘s family.

November 11, 2021

Great to see how Integrator embraces the paused transcription complex to engage with nascent RNA and trigger Pol II attenuation. Paper by @isaac_fianu et al. edited by @dijiang319 is out @ScienceMagazine:

November 09, 2021

One minute of standing ovations after an incredible talk by Özlem Türeci of BioNTech on how mRNA vaccines became possible @Falling_Walls

November 08, 2021

My recent keynote “Towards a mechanistic understanding of genome regulation” @MRC_LMB is online:

November 04, 2021

Much looking forward to discussing #SARS_CoV_2 replication and #COVID19 antivirals with @LoellChristiane and Christian Spahn at @Falling_Walls on November 8 in Berlin.

November 03, 2021

Lively discussion on economic and ecologic transformation yesterday night with Maja Göpel @beyond_ideology - science and society event @mpi_bpc and Literaturherbst Göttingen.

October 30, 2021

@lianafaye BioNTech?

October 27, 2021

Honored to join Ugur Sahin of BioNTech and Tzachi Pilpel @TPilpel @WeizmannScience for the Max Planck Forum on „#Covid19: From Vaccination to Medication“. Online on Nov 11, 2021 at 6.30 pm CET.

October 27, 2021

Very much looking forward to host Maja Göpel next week and discuss her vision of societal and economic transformation.

October 19, 2021

Our institute is hosting Tom Cech today for the Manfred Eigen Award Lecture: Cryo-EM of a telomeric complex and RNA as a regulator of epigenetic silencing

October 14, 2021

The paper by @KokicGoran et al. on DNA transcription-repair coupling is now available open access: Watch the conversion of the Pol II elongation complex EC* to a repair-competent EC-TCR containing CSB, CSA, DDB1 and UVSSA:

October 14, 2021

Looking forward to speak at #FallingWalls21 in Berlin November 7-9, 2021 to present our contribution to #ScienceBreakthroughs on #coronavirus #SARSCoV2 antivirals. Event information: Video abstract:

October 13, 2021

New article on the current discussion on the impact of #AlphaFold on structural biology (in German):

October 08, 2021

Congratulations to former lab member @ClausDKuhn for obtaining a professorship at University of Bayreuth!

October 07, 2021

So happy to have a REAL group retreat again! Many people have left and taken positions and many new ones have joined. Great opportunity to rethink our science.

October 06, 2021

Much looking forward to our lab retreat at Berlin starting tomorrow! Hosting as speakers rising stars @_taktas_ @MariekeOudelaar @luijsterburglab @KovtunOleksiy

October 06, 2021

Good summary by @Fischblog of the chances and risks of #molnupiravir treatment of #COVID19 patients (in German).

October 05, 2021

Congratulations, Seychelle!

October 05, 2021

Many congratulations and welcome to our new postdoc, Shen Han @s_Han7!

October 04, 2021

The program for our new seminar series is out! Looking forward to host @YuanHe_NWU @canardbruno @Beck_Laboratory @LabConti @RobKlose @AdelmanLab & Xaohua Shen @Tsinghua_Uni

October 04, 2021

The talks from the symposium at @StJude ("Bringing Chemistry to Medicine") are now available online:

October 01, 2021

Encouraging results for the antiviral #molnupiravir: oral treatment of #covid19 patients reduces risk of hospitalization by ~50%. We had previously described its molecular mechanism:

September 30, 2021

@NietoAngela @MichelaBertero @lorealspain @CSIC @UniversidadMH Many congratulations, Angela!

September 29, 2021

@hecklab @Pittcon @asmsnews @OmicsNL Many congratulations, Albert!

September 29, 2021

Looking forward to today‘s virtual Next Generation Biophysics Symposium @MRC_LMB @imperialcollege

September 24, 2021

Congratulations to our postdoc Suyang Zhang @Zhang_Suyang for obtaining a Group Leader position @MRC_LMB! All the best!

September 17, 2021

Saying good-bye to @Sveta_Dodonova who starts her lab @embl in Heidelberg soon. Many thanks indeed & all the best for the future! We will miss you.

September 17, 2021

Pol II can form inactive dimers: the stalk of one Pol II copy binds the active centre cleft of the other Pol II copy, and vice versa. Maybe an inactive storage form of the enzyme? @shintoez @c_dienemann

September 15, 2021

@TriggerLoop The yeast work is highly appreciated and fits well but unfortunately we had to limit references due to length restrictions.

September 15, 2021

Transcription-coupled DNA repair: After a long journey, we can now see how CSA, CSB, UVSSA and CRL4 remodel the transcribing Pol II complex for ubiquitination and DNA repair. Masterpiece by @KokicGoran.

September 14, 2021

Very honored to receive the Aminoff Prize of the Royal Swedish Academy together with my close colleagues Elena Conti @MPI_Biochem and Seth Darst @RockefellerUniv. Grateful to many past and present coworkers @CramerLab, colleagues at @mpi_bpc and @maxplanckpress for all support.

September 14, 2021

Looking forward to this year's Literature Festival hosting Maja Göpel @beyond_ideology. You can get online tickets and practice your German - but there are also a limited number of seats available.

September 14, 2021

#Molnupiravir : coding for catastrophe - very informative news&views article by Liz Campbell on recent work from Götte lab, ⁦@HoebartnerLab⁩ and us in Nature Structural & Molecular Biology

September 10, 2021

So incredible: on his 80th birthday symposium, Ernst-Ludwig Winnacker explains his PhD work on the synthesis of vitamin B12! ⁦@GeneCenter_LMU⁩ ⁦

September 06, 2021

Structural basis of RNA processing by human mitochondrial RNase P now revealed by @BhattaArjun2p and @hauke_hillen. Glad we could contribute to their newly published paper:

August 30, 2021

So much looking forward to the Cold Spring Harbor Mechanisms of Eukaryotic Transcription virtual meeting starting tomorrow! #moet2021

August 24, 2021

@royalsociety @SjorsScheres So well deserved

August 24, 2021

The #coronavirus polymerase can dimerize via its nsp7 subunit when one nsp8 subunit is lost. We speculate the antiparallel dimer facilitates template switching during sub-genomic #SARSCoV2 RNA synthesis. Thanks to team #COVID19.

August 21, 2021

B12 was the first structure I saw in 3D when I was a student at the University of Bristol in 1992. I was so taken by its beauty that I moved to crystallography.

August 19, 2021

August 19, 2021

@OWitzig Nein, Medikamente werden nur ergänzend sein, bitte vor dem Herbst dringend impfen lassen.

August 19, 2021

Good summary of our recent studies of #molnupiravir (in German) via @BR24

August 17, 2021

This year’s Horizons meeting organized by our young scientist community is approaching: @HorizonsMolBio @mpi_bpc

August 16, 2021

Molecular mechanisms of #corona drug candidate #Molnupiravir Free access link to paper: Press release:

August 14, 2021

Free access link for AlphaFold2 and the future of structural biology

August 11, 2021

#molnupiravir is a #COVID19 drug candidate that targets #SARSCoV2 polymerase and causes #coronavirus mutagenesis. In collaboration with @HoebartnerLab we provide the mechanism of this phase III #antiviral:

August 10, 2021

#alphafold2 is based on @PDBeurope and is testimony to the power of open science. The marvelous resource provided by @DeepMind and @embl @emblebi is a seminal example of how transformative research may be done to the benefit of society.

August 02, 2021

Welcome to the lab, James!

July 30, 2021

@TheresiaBauer Danke, ein wichtiger Schritt!

July 29, 2021

@CeMM_News @georg_e_winter Congratulations, Martin!

July 28, 2021

July 28, 2021

Many congratulations, Ernst-Ludwig Winnacker, and thank you for all your great efforts to foster excellence in European science and to promote early scientific independence in Germany!

July 27, 2021

@DrReneHeller @MPSGoettingen Welcome to Goettingen

July 24, 2021

TBP binding to a nucleosome, assisted by TFIIA. Unexpected structures and their implications by @HaiboWang36 now online:

July 22, 2021

@TriggerLoop @ArndtLab Many thanks for writing this, Karen and Craig!

July 19, 2021

Looking forward to the Harden Conference "Machines on Genes" that takes place May 22-26, 2022.

July 16, 2021

Save the date: Sept 29-Oct 02, 2022 Transcriptional regulation: Chromatin and RNA polymerase II - ASBMB meeting in Snowbird, Utah

July 16, 2021

Finally! 1 1/2 years later we can again celebrate together in a local restaurant!

July 14, 2021

Super Elongation Complex binds RNA polymerase II lobe & protrusion to stimulate transcription allosterically. Comprehensive structure-function analysis by @YingChen_P et al.:

July 13, 2021

Please trust in science and get vaccinated! It works: Last winter old people were vaccinated in Germany and they were protected from #SARSCoV2 in spring (@rki_de & @DIEZEIT).

July 13, 2021

Many congratulations to @FKabinger who received a Boehringer Ingelheim Fellowship today!

July 13, 2021

Looking forward to give a lecture at @UniLeipzig today at 4 pm CEST:

July 07, 2021

Celebrating 50 years of the Protein Data Bank on 20-22 Oct 2021, register now:

July 06, 2021

Sara Martins @SaraMM_4 passed her PhD defense, many congratulations! Great presentation on how splicing influences transcription, her work with @LCaizzi:

July 02, 2021

Much looking forward to the virtual symposium „Bringing Chemistry to Medicine“ on July 22-23 at St. Jude.

June 29, 2021

@ewanbirney Unfortunately true

June 28, 2021

Multiomics shows that the pluripotency factor #Oct4 primarily controls enhancer activity and not accessibility. Fine collaboration of Le Xiong et al. with @Tolen13 in the lab of Hans Schöler @MPI_Muenster. Preprint:

June 24, 2021

On our YouTube channel you can now find recent lectures, special events and videos about our research.

June 22, 2021

@shengfui Warum wurde überhaupt gefragt?

June 20, 2021

We have to say good-bye to @LCaizzi, thanking her for pioneering work on the in vivo kinetics of pre-mRNA splicing and its coupling to transcription and wishing her all the best for continuing her career at Turin, Italy!

June 18, 2021

PAF and SPT6 stimulate human transcription elongation in distinct ways. Whereas PAF subunit RTF1 stimulates Pol II velocity, SPT6 stimulates Pol II passage through nucleosomes. Congratulations Kristina Zumer et al.!

June 15, 2021

It’s the year of the #PIC: Yeast Pol II pre-initiation complex at 2.9 Å resolution defines a unique mechanism of initial DNA opening. Tour-de-force by @S_Schilb with help from @shintoez & @c_dienemann. Download the paper here:

June 09, 2021

U.S. signs $1.2 bln deal for experimental #COVID19 drug #molnupiravir. We provide the molecular mechanism for free.

June 09, 2021

@PoulNissen @AarhusUni Many congratulations! So well deserved.

June 08, 2021

Many congratulations to Dr. Katalin Karikó for the 2022 Vilcek Prize for pioneering vaccine research - she modified RNA to suppress its immunogenicity and expand its life time:

June 08, 2021

Save the date: NEXT GENERATION BIOPHYSICS SYMPOSIUM 2021 Wednesday 29th September 2021 MRC Laboratory of Molecular Biology, Cambridge, UK

June 08, 2021

Looking forward to the annual molecular biology conference organized by PhD researchers at Göttingen.

June 06, 2021

The new public art gallery #kunsthaus göttingen has opened! First impressions here:

June 05, 2021

@ABaerbock Bitte setzen sie sich für die Widerspruchsregelung ein

June 03, 2021

Our high-resolution structures of human PIC and Mediator-PIC complexes are published. We define conformational changes underlying DNA opening and suggest how Mediator activates the TFIIH kinase CDK7.

May 28, 2021

Chromatin remodelers use 'rulers' to set nucleosome array spacing and phasing! Glad we could contribute to this interesting work by @EOberbeckmann @KorberLab

May 24, 2021

@OdedRechavi I recommend Magellan also, if you are interested here a short summary:

May 21, 2021

@crc_1064 Congratulations to my former colleagues in Munich!

May 21, 2021

Little is known about the biogenesis & nuclear import of RNA polymerases. We now report the structure of the import factor RPAP2 bound to Pol II. It shows RPAP2 must be displaced before transcription can start. Congratulations @isaac_fianu et al.!

May 19, 2021

@canardbruno @nathanpsmad @SFV_France @UnivOuverte @HuetSylvestre Je suis d‘accord, il ne faut pas répéter les erreurs du passé (SARS-COV1)

May 19, 2021

@YuanHe_NWU Congratulation Yuan, so well deserved!

May 18, 2021

So much looking forward to the Mechanisms of Eukaryotic Transcription Meeting on August 31 - September 3, 2022, very unfortunately only virtual. Thanks to great colleagues Mike Levine, Jane Mellor and @NogalesLab for organizing!

May 12, 2021

#COVID19 drug candidate #molnupiravir is incorporated by #SARSCoV2 polymerase into RNA and directs misincorporation of G or A when used as template. Structural basis of #antiviral-induced coronavirus mutagenesis. Great collaboration with @HoebartnerLab!

May 11, 2021

When U2 snRNP function is impaired, Pol II accumulates in the promoter proximal region and RNA synthesis activity ceases. It will be exciting to find out how cotranscriptional spliceosome assembly stimulates transcription.

May 10, 2021

Many congratulations to @Sveta_Dodonova who will start her new lab @embl in fall! We will miss her! See Svetlana‘s new website here: See her pioneering paper here:

May 09, 2021

50 years ago, Manfred Eigen founded our institute at Göttingen.

May 09, 2021

@pisaniferry Toujours pour l‘Europe

May 05, 2021

@neubadah Same here. Just for coronavirus papers it is different: Do everything at once.

May 03, 2021

In this paper we show with purified proteins that the Cdk8 module impairs Mediator binding to the PIC. Cdk8 kinase activity facilitates Mediator dissociation from the Cdk8 module and its binding to the PIC for transcription initiation. Led by @sarakosman.

April 28, 2021

Congratulations to Katja Lidschreiber who will take on the position of coordinator of the new coronavirus research network COFONI. We thank her for the great work and wish her all the best for the future!

April 27, 2021

@BJ_Greber Peer review may not be perfect but it is the best available system to ensure scientific quality. It generally works well. The occasional outliers confirm the rule. Attempts by some journals to make peer review more transparent can avoid issues. Review for journals you publish in.

April 27, 2021

Promoter opening goes along with detachment of TFIIH from the core PIC, predicted to stop DNA translocation and enable RNA chain initiation. Great work of @S_Schilb @shintoez @vasan06 @c_dienemann Free access: PIC: Mediator-PIC:

April 26, 2021

We present structures of (Mediator)-Pol II pre-initiation complexes at high resolution. Feels great to arrive at a detailed understanding, incl. conformational changes in TFIIH translocase XPB during DNA opening. PIC: Mediator-PIC:

April 24, 2021

Celebrating the 50th anniversary of the Protein Data Bank @buildmodels @PDBeurope with 1000 structures of #coronavirus #SARSCoV2:

April 19, 2021

The Warburg lecture on ‚RNA polymerases and the #COVID19 pandemic‘ is now available on the @GBM_eV website:

April 16, 2021

In contrast to #Remdesivir, #Molnupiravir is orally available. It now shows promise in #COVID19 outpatients. Such #antivirals targeting #coronavirus #SARS-CoV2 polymerase likely must be given early during infection. May become useful prophylactically.

April 12, 2021

We show how the chromatin remodeller Chd1 and the histone chaperone FACT help RNA polymerase II to pass through a nucleosome. Pol II transcribes into & partially unwraps the nucleosome, enabling Chd1 & FACT to bind. Congrats @LucasFarnung! Free download:

April 05, 2021

This study by @davidwtaylorjr and Kenneth Johnson is highly consistent with our study of the molecular mechanism of #remdesivir induced stalling of #coronavirus #SARSCoV2 polymerase due to a translocation barrier:

April 04, 2021

@judithmwhite When was this?

April 01, 2021

@JTrittin @ramin_y @uniGoettingen @faznet @MpStephanWeil @CDUNds Göttingen spielt zudem in der Coronaforschung eine wichtige Rolle @ViolaPriesemann @snpoehlm @CramerLab

March 29, 2021

TT-seq combines short, non-perturbing 4SU labeling with RNA fragmentation to: -detect short-lived eRNA -estimate RNA synthesis & txn initiation rates -monitor txn responses -map putative enhancer landscapes -analyze enhancer cooperation Original method:

March 27, 2021

Enhancers may cooperate synergistically to determine cell fate. Synergistic enhancers are defined by eRNA synthesis, depend on cell-specific TFs and differ form occupancy-defined superenhancers. Great collaboration with Graf & Söding labs. Finally out:

March 24, 2021

The polymerase of #coronavirus #SARSCoV2 can adopt an alternative structure: an antiparallel dimer with only one nsp8 that may bind only one nsp13. We speculate the dimer facilitates template switching and synthesis of subgenomic viral #RNA. Manuscript:

March 23, 2021

Congratulations to Alexander Rotsch for obtaining one of the prestigious Boehringer Ingelheim Fellowships!

March 14, 2021

High conservation of the yeast (left) and human (right) Mediator-PIC assembly. TFIIH kinase also resides in similar location in yeast complex but was omitted due to mobility. Yeast: Human:

March 13, 2021

Following 20 years of work on Mediator we share our human Mediator-PIC structure. Mediator hook reaches the TFIIH kinase active center. Great team @vasan06 @S_Schilb @shintoez. Note related work by @YuanHe_NWU @TjianDarzacq. Submitted version of Jan 25:

March 08, 2021

Our new paper suggests that co-transcriptional spliceosome assembly triggers efficient release of paused RNA polymerase II for active transcription. Great contribution of first authors @LCaizzi and @SaraMM_4 to #womansday2021! Paper:

March 07, 2021

We began to collect our structural movies here. We will also upload more talks and other videos of interest. via @YouTube

March 04, 2021

Nuclear condensation of NELF: Summary of our collaborative paper with the Sawarkar lab. @rawatravans @MarcBoehning

March 02, 2021

How chemotherapy works: Great advances in understanding cisplatin since we described in 2007 how this anticancer drug initiates DNA repair.

March 02, 2021

Registration is now open for the IGBMC-FMI Graduate Student Symposium taking place online April 26-29, 2021. Program includes Cell Biology, Structural Biology, Neurobiology and Epigenetics. @IGBMC @FMIscience @eucor

February 28, 2021

Soon 750 million doses of #vaccine may be produced p.a. at the medieval town of Marburg where immunology pioneer Emil von Behring had used money from the 1901 Nobel Prize to fight diphtheria and tetanus.

February 28, 2021

BioNTech founders receive the Order of Merit of the Federal Republic of Germany, many congratulations!

February 26, 2021

Looking forward to speak about “RNA polymerases and #COVID19” at the award event @GBM_eV together with virologist @c_drosten from @ChariteBerlin on March 26. Registration:

February 24, 2021

@willida25 @CWolberger @WomenScienceRFS

February 24, 2021

Very grateful to @ERC_Research for funding that also facilitated our work on the #coronavirus polymerase. Thanks to @CORDIS_EU for highlighting our results obtained together with @HoebartnerLab on antiviral drug effectiveness and #Remdesivir:

February 24, 2021

Looking forward to speak tomorrow at the International Young Scientists Conference on Molecular and Cell Biology organized by young scientists in Warsaw @IIMCB_Poland. Program: Website:

February 23, 2021

After seven exciting years we have to say good-bye to @LucasFarnung. We thank him for all his great contributions @mpi_bpc and wish him all the best as starting assistant professor @HarvardCellBio @harvardmed.

February 22, 2021

Looking forward to speak at the Helmholtz Drug Discovery Conference 2021 that takes place on March 25-26. Free registration:

February 21, 2021

@alena_buyx Ein großartiger Erfolg, der auf Jahrzehnten von Forschung beruht.

February 20, 2021

TT‐seq maps thousands of eRNA-producing enhancers in human cancer cell lines, providing ~40,000 putative enhancer-promoter pairs, many at cancer‐associated genes.

February 18, 2021

Great Harnack Lecture by @francesarnold yesterday on enzyme evolution, referring also to the founder of our institute, Manfred Eigen. @mpi_bpc @maxplanckpress

February 16, 2021

From our work with the Sawarkar lab we propose that stress-induced NELF condensates are nuclear counterparts of cytosolic stress granules. These two condensates may drive the coordinated downregulation of transcription and translation in cells.

February 13, 2021

Deutsche Zusammenfassung unserer Studien zur #Coronavirus Replikation und deren (unvollständige) Inhibition durch das #COVID19 Medikament #Remdesivir

February 13, 2021

In 1988, Paul Sigler suggested the CTD binds transcription activators: Now we see that CTD shortening delays transcription activation... ...and this may be due to CTD-dependent Pol II clustering at genes:

February 09, 2021

Deadline approaching: apply now to join our PhD program for Genome Science @IMPRS_GS

February 08, 2021

Now online: Shortening the #CTD of Pol II impairs enhancer transcription and gene activation: This supports a model that CTD is important for Pol II recruitment to active genes by condensation: Grateful to @DarzacqClaire @XDarzacq

February 07, 2021

Wonderful documentary about the visit of star chansonnière Barbara at Göttingen in 1964 and its role in German-French reconciliation. Even if you do not speak German or French, you can feel the famous „Göttingen spirit“.

February 05, 2021

Nuclear condensation of transcription factor NELF drives downregulation of genes upon stress. Great collaboration of Marc Boehning @mpibpc with @rawatravans and Ritwick Sawarkar @mpi_ie @MRC_TU Now online:

February 04, 2021

Multi-particle #CryoEM refinement by @DTegunov applied to tomographic data from @Liang_Xue_ in Julia Mahamid's lab @embl enabled us to see an antibiotic bound to its ribosome target inside a bacterial cell. Great collaborative work now published:

February 02, 2021

Looking forward to start off the Non-coding Genome Course tomorrow at Institut Curie, Paris.

February 01, 2021

@PavelTomancak @CEITEC_Brno Great, many congratulations, Pavel!

February 01, 2021

Very grateful to obtain the Hector Science Award. Made possible by many highly dedicated coworkers and the support by mentors, colleagues and collaborators! @mpi_bpc @maxplanckpress @uniGoettingen @GeneCenter_LMU @LMU_Muenchen

January 28, 2021

Congratulations @DTegunov for passing the PhD defense! Outstanding thesis describing Warp and M software for #CryoEM data processing.

January 27, 2021

Welcome to Göttingen, Metin Tolan!

January 26, 2021

It is a great honor to receive the Jeantet Prize 2021. Very grateful to past & present coworkers for their contributions over the last two decades. Hoping we can soon get vaccinated and celebrate. @maxplanckpress @mpibpc @LouisJeantetFDN @uniGoettingen

January 19, 2021

Welcome to Göttingen, @SLorenzLab !

January 16, 2021

Great summary of our findings on the remdesivir mechanism by Prisca Straub from @BR24 @BR_Wissen (German).

January 15, 2021

Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters. Glad we could contribute to this work by @MYCGyvers

January 15, 2021

What does "co-transcriptional splicing" mean? Our model implies that spliceosome assembly is truly co-transcriptional, i.e. functionally dependent on active Pol II. The ensuing catalytic steps of splicing may be Pol II-independent, although they can occur on nascent RNA.

January 14, 2021

Pol II directly binds U1 snRNP: We propose a 'growing intron loop' model for co-transcriptional splicing. Great collaboration with R. Lührmann @mpi_bpc. Now online:

January 13, 2021

Here is the press release for our remdesivir paper, great collaboration with @HoebartnerLab:

January 12, 2021

#Remdesivir does NOT block #coronavirus polymerase. It imparis RNA translocation and causes an elongation barrier that is overcome at high substrate concentrations. Our paper presenting the mechanism of remdesivir action is now online: #SARSCoV2 #COVID19

January 06, 2021

@Alexis_Verger Cest frai

January 04, 2021

We stand on the shoulders of giants: 50 years ago, visionary scientists agreed to collect all macromolecular structures in a database, the PDB, which also set standards for structure quality and formed the basis of numerous innovations in biomedicine, chapeau!

January 01, 2021

Now published: Integrator is a genome-wide attenuator of non-productive transcription. Great collaboration with ⁦⁦@torbenheick⁩. Note conceptual similarity to yeast transcriptome surveillance by Nrd1:

December 31, 2020

As 2020 ends - many thanks to all coworkers, alumni, collaborators, colleagues and friends!

December 29, 2020

mRNA vaccine is an amazing success, based on basic molecular biology, incl.: -Discovery mRNA 1961 -Genetic code & translation -Codon optimization -Phage pol IVT -RNA modification & stability -Structure-based protein engineering 2017

December 16, 2020

Small-molecule inhibitors of human mitochondrial DNA transcription. Happy we could contribute to this great work by the labs of Claes Gustafsson & Nils-Göran Larsson! ⁦@mitopinionated⁩ ⁦@hauke_hillen⁩

December 11, 2020

Many congratulations to our colleague Asifa Akhtar for receiving the Leibniz Prize 2021!

December 10, 2020

Thanks to our secret santa @KJArmache for joining today‘s zoom Christmas party!

December 07, 2020

Congratulations to Ruth Ley for obtaining the Otto Bayer Award 2020! Congratulations to Julia Mahamid, Josep Cornella, Nikolai Franzmeier and Marinka Zitnik for obtaining the Early Excellence in Science Awards 2020! @CornellaLab @nfranzme @marinkazitnik

December 03, 2020

SAVE THE DATE: Dec 7-11, 2020 Online Workshop "Mechanisms of gene transcription and its regulation" - emphasis on mechanisms and covering transcription systems from viruses to human. Much looking forward to meet close colleagues! Program: @LandickLab

December 02, 2020

The talk by Ayelet Shachar on ‚Shifting borders in the time of #COVID19‘ is now online.

December 01, 2020

Our new manuscript sugggests how Chd1 and FACT mediate Pol II transcription through a nucleosome. Pol II partially unwraps DNA, activates Chd1 translocase and recruits FACT histone chaperone. Masterpiece by @LucasFarnung with M. Ochmann, M. Engeholm.

November 30, 2020

Today‘s nearly unbelievable breakthrough in structure prediction should help us obtain missing building blocks for large complexes. ‘It will change everything’: DeepMind’s AI makes gigantic leap in solving protein structures

November 22, 2020

@ABaerbock Wichtiger Schritt, sich der Gentechnik zu öffnen! Für Medizin, Ernährung und Umwelt.

November 20, 2020

Today we had to say good-bye to Anna (Ania) Sawicka who leaves to take a biotech job in Wroclaw and will be much missed. Stay tuned for Ania's forthcoming paper on the role of the CTD in transcription activation.

November 18, 2020

@AsifaAkhtar1 @nature Congratulations Asifa!

November 18, 2020

Looking forward to the CCP-EM symposium on the structural biology of #SARSCoV2 and methods development starting today. @ccp_em @EMDB_EMPIAR @wellcometrust

November 12, 2020

@carninci @ewanbirney Great opportunity! Best of success!

November 09, 2020

@AndreaMusacchi1 @YouTube Many congratulations again, Andrea!

November 09, 2020

@JoergLab I must admit that I was hopeful but also skeptical. Let’s hope for the best.

November 07, 2020

A good day for the global scientific community.

November 07, 2020

@LenaRogl @KamalaHarris So great

November 07, 2020

@mbeisen So great

November 07, 2020

@ewanbirney @jcbarret So great

November 07, 2020

@ArndtLab @jengoefried So great

November 06, 2020

@markschies @HumboldtUni @bbaw_de @ECChronoi @degruyter_TRS Mein Gefühl ist: wir sehen nur noch chronos und kairos wurde vergessen. Dabei werden wir uns später nur an kairos erinnern.

November 06, 2020

Welcome to the new members of our Genome Science graduate program! Including Aiturgan @zhnbkv_ and Florian @FKabinger in our laboratory.

November 05, 2020

This year's Genome Science lecture series starts tomorrow, Friday at 4.15 pm. @IMPRS_GS

November 01, 2020

As we enter a second (partial) lockdown tomorrow it is so good to know to have such talented, cooperative and resilient coworkers.

October 31, 2020

Looking forward to speaking at MIT Biology Colloquium Series on Tuesday Nov 03 at 4 pm EST. Hosted by postdocs. @MITBiology @anafiszbein

October 30, 2020

Science communicator and influencer @maithi_nk on basic science @Literaturherbst Göttingen tonight.

October 29, 2020

Solving the remdesivir mechanism was possible in a great collaboration with @HoebartnerLab @Uni_WUE. They synthesized RNA with remdesivir at defined positions. We used their RNA to trap the remdesivir-stalled state of the #SARSCoV2 polymerase by #cryoEM.

October 29, 2020

We show how the #COVID19 drug #remdesivir inhibits #coronavirus replication: Remdesivir stalls the viral polymerase by posing a translocation barrier, retaining the RNA 3'-end in the substrate-binding site, and hindering RNA proofreading. Preprint:

October 28, 2020

These events are now accessible with your "ON AIR" ticket: Ayelet Shachar: The shifting border (English) Jutta Allmendinger: Vertrauen (German) Jörg Hacker: Pandemien (German)

October 27, 2020

@mpi_bpc @maxplanckpress So great

October 26, 2020

@Karl_Lauterbach Danke für diese guten Worte. Eine schreckliche Nachricht und ein enormer Verlust auch für uns Göttinger.

October 24, 2020

@PlantEvolution I was also totally taken by it

October 23, 2020

Congratulations to Jutta Allmendinger for obtaining this year‘ science communications medal!

October 22, 2020

Two simple steps to join the literature festival events. Some in English. Starting tomorrow Friday 7 pm with Jutta Allmendinger @JA_Allmendinger

October 22, 2020

This year’s lab retreat took place at home and featured great talks by @5_Baldi, @dhnisz, @bulutkarslioglu, Markus Wahl and Jan-Philipp Juncker. Great variety from structure to condensates to cell transitions.

October 20, 2020

Our RNA polymerase II-U1 snRNP structure elucidates co-transcriptional splicing. It suggest a nascent RNA loop on the Pol II surface enables efficient splice site scanning. Fabulous work by Suyang Zhang in collaboration with the Lührmann lab. Manuscript:

October 17, 2020

Some thoughts on where our research field may be heading. From a discussion at the Keystone Meeting on Gene Regulation earlier this year.

October 17, 2020

She wants to encourage young people to become scientists: “It’s curiosity and passion!” - star photographer Herlinde Kölbl at the opening event of her exhibition ‘Fascination of science’ at Paulinerkirche Göttingen @Literaturherbst @mpi_bpc

October 16, 2020

@Helmholtz_HZI @helmholtz_de Toll, dass das HZI Emmanuelle Charpentier nach Deutschland geholt hatte!

October 16, 2020

@SchindelinL @KiskerLab @RVZ_Wuerzburg @Uni_WUE Really great!

October 16, 2020

@JA_Allmendinger Es freut mich, dass sie jetzt auf Twitter sind aber noch mehr, dass Sie uns bald in Göttingen zum Literaturherbst besuchen!

October 14, 2020

Save the date and keep fingers crossed that we can meet in person.

October 13, 2020

Looking forward to this workshop on the noncoding genome in Paris.

October 12, 2020

@patrick_pausch Yes. Absolutely. But most EM structures rely on fitting prior X-ray structures still.

October 09, 2020

Our review containing all RNA polymerase II structures is now freely available online:

October 07, 2020

Remembering the Paul-Ehrlich-Prize 2016 to Emmanuelle and Jennifer with former lab member Claus Kuhn as junior awardee. @doudna_lab

October 07, 2020

And here comes the next generation: a very warm welcome to our new group leader at the institute, Marieke Oudelaar! Her group will study genome organization and regulation. @MariekeOudelaar Website:

October 07, 2020

Many congratulations to our Max Planck colleague Emmanuelle Charpentier and Berkeley structural biologist Jennifer Doudna for the Nobel Prize 2020! So great! @doudna_lab @maxplanckpress

October 06, 2020

Many congratulations to our Max Planck colleague Reinhard Genzel for obtaining the Nobel Prize in physics. Fabulous!

October 02, 2020

Very excited to meet legendary photographer Herlinde Kölbl in Berlin tonight. Her recent project ‚fascinating science’ features 60 scientists from around the globe. @bbaw_de

October 01, 2020

Our new ‘Eigen Lounge’ is now ready for coffee and round table discussions. It commemorates the founder of our institute, Nobel laureate Manfred Eigen.

October 01, 2020

Hauke Hillen is starting as a tenure-track professor today at the University of Göttingen & UMG. Congratulations and all the best to the new lab! @hauke_hillen @uniGoettingen @mpi_bpc

September 29, 2020

@TheresiaBauer @unikonstanz @maxplanckpress @martinwikelski Das freut mich als gebürtigen Schwaben besonders! Ich erinnere mich an die interessanten Diskussionen zur Gründung dieses großartigen Instituts. Einzigartige Technologie @martinwikelski

September 23, 2020

Great opportunity for ambitious junior researchers! Please do not hesitate to contact your favorite Max Planck Institute for advice.

September 20, 2020

@AmyShaubMaddox The loneliness of the leader

September 16, 2020

The literature festival @Literaturherbst is starting soon. Looking forward to host (7 pm): Jutta Allmendinger (sociology), October 23 Jörg Hacker (pandemics), October 25 Ayelet Shachar (borders & migration), October 27 One online ticket for all events:

September 14, 2020

@AprilPawluk @MolecularCell @CellReports @CellPressNews Best of success! To best serve the community I recommend to take clear decisions.

September 13, 2020

@FuturiumD Viel Erfolg!

September 13, 2020

@SteffenKrach @ChariteBerlin Ja, ein großer Glücksfall für Berlin!

September 11, 2020

A 15-minute summary of the current state of our work on #SARSCoV2 polymerase and its inhibition by #remdesivir #COVID19

September 11, 2020

Save the date: #COVID19 #SARSCoV2 Cold Spring Harbor Asia Virtual Conference on Nov 2-4, 2020.

September 09, 2020

@KouMurayama @uni_tue @AvHStiftung Welcome

September 08, 2020

Now published: our method detecting newly synthesized RNA isoforms and monitoring isoform metabolism in cells (nano-ID). Great team effort coordinated by Björn Schwalb @birdumbrella. #nanopore @nanopore @NanoporePapers Paper:

September 07, 2020

@maithi_nk Many congratulations!

September 03, 2020

Many congratulations to our colleagues at the institute, Juliane and Stefan!

August 28, 2020

@KellyTHD_Nguyen This is so sad, Chris had organized a great party on the occasion of Kiyoshi’s 70th birthday last year which had to be canceled due to his illness...this is so sad.

August 27, 2020

@Pol2Runner Yes in the nucleosome

August 27, 2020

Half a year later: first real space Cramer lab group meeting with distancing.

August 26, 2020

Looking forward to this student-organized symposium on October 7-8, 2020. #Eureka2020

August 24, 2020

Join the 17th Horizons in Molecular Biology Conference on September 14-17, 2020! Great speaker line-up.

August 22, 2020

Here we review all ~200 available Pol II complex structures and summarize how these elucidated transcription initiation, promoter-proximal pausing and elongation, and the navigation of nucleosomes and DNA lesions.

August 20, 2020

Free download of the benchmark paper on Rosalind Franklin and the advent of molecular biology: #franklin100 #WomenInStem #DNA

August 19, 2020

Save the date: The 86th Harden Conference - Machines on Genes is rescheduled for 9-13 May 2021 and takes place in Alicante, Spain.

August 19, 2020

Registration is now open for our local coronavirus research webinar symposium on September 3, 2020:

August 17, 2020

Defining permissive epigenomes that enable cell reprogramming by various transcriptional regulators. Happy we could contribute to this study by the Schöler lab. #stemcells

August 06, 2020

The final version of our paper reporting the #SARSCoV2 polymerase-RNA structure is now available. A basis for investigating #coronavirus replication-blocking antivirals such as #Remdesivir.

August 02, 2020

Integrator is a genome-wide attenuator of non-productive transcription. Combining factor depletion, TT-seq and bioinformatics. Great collaboration with @torbenheick. Manuscript:

July 30, 2020

Now online: visualizing the central dogma inside cells! Glad we could contribute to this marvelous work on the expressome by the labs of Julia Mahamid and Juri Rappsilber @RappsilberLab @FJ_OReilly @Liang_Xue_ @DTegunov @JorgStulke @embl Paper:

July 30, 2020

Thanks to the editors at Cell for prioritizing this important historical topic. #Franklin100

July 30, 2020

@CWolberger Thank you for your great thread on this topic, Cynthia!

July 29, 2020

@g1_guillermo @cryoEM_Papers @MolecularCell @CRISPR_News @sofos112 @SQunxin @NNFCPR @UCPH_health Really great, many congratulations!

July 29, 2020

Rosalind Franklin provided the key data for deriving the double helix structure of DNA. She also pioneered studies of viruses and RNA. This benchmark essay celebrates the 100th anniversary of Franklin’s birth and the advent of molecular biology.

July 28, 2020

Join the seminars by Lucas Farnung and Hitoshi Kurumizaka tomorrow.

July 26, 2020

@CWolberger I agree; there will be a paper on this in Cell on Wednesday.

July 24, 2020

@giacomo_cavalli Thanks Giacomo; there will be a paper in Cell on her next week. Best

July 22, 2020

@TriggerLoop @researchsquare Maybe a biogenesis/assembly factor?

July 22, 2020

@afisch82 @TriggerLoop @JosefowiczLab @sjosefowicz Really great, many congratulations!

July 17, 2020

Patrick‘s overview seminar given at Dana Farber/Harvard Cancer Center is now available online:

July 14, 2020

Join Patrick’s talk online at Dana Farber/Harvard Cancer Center @df_hcc on Thursday at 12 noon Boston time.

July 03, 2020

Dimitry Tegunov‘s multiparticle cryo-EM refinement software ‚M’ is now available for download.

July 01, 2020

Very much looking forward to work with our new leadership! @AsifaAkhtar1

June 17, 2020

Evidence that CDK12 maintains an active transcription elongation complex by retaining the PAF complex. Happy we could collaborate with the lab of Shona Murphy.

June 16, 2020

@STOPlabPl Good luck!

June 16, 2020

Our new paper on the nucleosome-CHD4 chromatin remodeler structure is online. CHD4 is involved in gene repression and does not detach terminal DNA, in contrast to Chd1, which works in active transcription. We also map disease mutations. @LucasFarnung

June 16, 2020

Save the dates: program for our next seminar series is out. Much looking forward to host our colleagues @Beck_Laboratory, @HymanLab, @KukulskiWanda, Edward Lemke, Frank Uhlmann, @NVastenhouw & @tinekelenstra.

June 16, 2020

Like other enzymes, Pol II is regulated allosterically by proteins that influence active site structure & dynamics from a distance. First seen for the initiation factor TFIIB, now for the elongation factor RTF1. TFIIB: RTF1:

June 15, 2020

Pol II speed is enhanced by PAF subunit RTF1. Our new paper shows allosteric activation via the famous bridge helix. @seyvos @LucasFarnung Publication:

June 10, 2020

@billhansson @maxplanckpress Thank you so much for everything, Bill!

June 09, 2020

Isaac Fianu passed his PhD defense today, many congratulations!

June 08, 2020

CTCF-dependent genome topology is not strictly required for a functional cell-fate conversion but facilitates a rapid and efficient response to an external stimulus. Happy we could contribute to this important study of the Graf lab @CRGenomica.

June 06, 2020

@brodriguezsci Best to ask Dimitry...

June 06, 2020

"In agreement with a model of condensate-driven transcription initiation, large clusters of hypophosphorylated Pol II rapidly disassembled upon Mediator degradation." Happy we could contribute to this great collaboration with Martin Jaeger and Georg Winter.

June 06, 2020

Dimitry Tegunov's software 'M' enables multi-particle refinement and higher resolution in #cryoEM. Applied to tomography data from @Liang_Xue_ & Julia Mahamid @embl, M reveals ribosome-antibiotic complex at 3.7 Å in cells. @DTegunov @c_dienemann Preprint

May 26, 2020

We welcome our new colleague at the institute, Claus Ropers!

May 26, 2020

Welcome at our institute, Stefan!

May 25, 2020

Happy to join and serve on the Scientific Advisory Board of the Gulbenkian Institute in Lisbon, Portugal.

May 21, 2020

Our paper describing the #coronavirus RNA polymerase structure is online. The nsp8 extensions contact RNA far away from the active site, apparently enabling processive replication of the very long #SARSCoV2 genome. Publication: PR:

May 18, 2020

After nearly two months in home office we carefully return to the lab. Here are 56 thoughts of the day that accumulated:

May 16, 2020

@IbrahimCisse_ @MIT_Physics @Cisse_lab Great many congratulations

May 15, 2020

Happy to share the original cryoEM data used to solve our #coronavirus #SARSCoV2 polymerase-RNA complex structure.

May 13, 2020

Explore #coronavirus replication in 3D. Our structural data for the RNA-dependent RNA polymerase of #SARSCoV2 in replication mode are now online: PDB: EMDB: Preprint: PR:

May 08, 2020

@Alexis_Verger @MED_COMPLEX Hey very nice overview! Is it really already two decades? Well yes we got older...

May 06, 2020

@lkreidberg Welcome and all the best! Patrick Cramer

April 30, 2020

Here is a simple animation of #coronavirus replication: NTPs enter from the right and are added to the growing RNA copy (red) of the #SARSCoV2 RNA genome (blue) by the viral polymerase. #COVID19 Preprint: Press release:

April 28, 2020

Watching #coronavirus replication! #SARSCoV2 polymerase-RNA structure: basis to study potential #COVID19 drug #Remdesivir Team @hauke_hillen @KokicGoran @LucasFarnung @c_dienemann @DTegunov @mpi_bpc @maxplanckpress Preprint PR

April 27, 2020

Very honored to be elected as a foreign member of the National Academy @theNASciences. Many thanks to my colleagues and friends in the US!

April 22, 2020

Our structures of nucleosome-bound Yamanaka factor Sox2 and Sox11 elucidate how pioneer factors invade chromatin for differentiation and development.

April 20, 2020

Many congratulations to Lucas Farnung who accepted an offer from @Harvard and will start his lab at Boston in January 2021!

April 18, 2020

@EsbinMeagan Many thanks indeed, really very kind of you! Please send my regards to Tij!

April 17, 2020

25 days in home office started with 25 thoughts of the day. Here they are:

April 17, 2020

@FMIscience @SchubelerLab Congratulations and best wishes, Dirk!

April 01, 2020

Increasing the sensitivity of crosslinking-mass spectrometry with a new peptide database. Glad we could contribute to this important technical development of the lab of Henning Urlaub. Publication:

March 31, 2020

We are supported again by an Advanced Grant of the European Research Council @ERC_Research. With these funds we will extend our research towards the mechanisms of chromatin transcription. Thanks to all coworkers who made this possible.

March 25, 2020

We start each day in home office with an encouraging philosophic quote in our Email inbox. Here is today's: “What does not engage our feelings does not long engage our thoughts either.” Lou Andreas-Salomé, Russian-German author 1861 St. Petersburg – 1937 Göttingen

March 23, 2020

First virtual Cramer lab meeting. Science continues mainly online. Take care of yourselves during these times.

March 11, 2020

Our structure of the SWI/SNF chromatin remodelling complex RSC is now published!

March 08, 2020

Great event this weekend @uniGoettingen @thegoecampus @ForumWissenGoe celebrating the international women's day #IWD2020 featuring Margot Kaessmann, Naima Diesner, Nivedita Mani, Jacqueline Amirfallah, Katrin Adt.

March 01, 2020

Chromatin remodelers contain ‘ruler’ elements that set nucleosome array spacing. Happy we could contribute to this collaboration between the labs of Philipp Korber, @hopfnerlab and @PetersonLab. Preprint:

March 01, 2020

The expressome structure we obtained in 2017 in vitro after stalling RNA polymerase (collaboration with Landick lab) is now shown to be adopted in vivo as an inactive state when transcription is blocked. Link to our 2017 in vitro expressome paper:

February 29, 2020

Visualizing the central dogma in cells! The labs of Julia Mahamid @embl and @RappsilberLab present the in situ structure of the transcribing-translating expressome. Glad we could contribute. @DTegunov @WimJHH @JorgStulke Preprint:

February 28, 2020

@FRobertLab @JeronimoCelia Absolutely great

February 27, 2020

Register for the "Gene transcription in yeast” Conference that takes place June 13-18, 2020 in Sant Feliu de Guixols, Spain:

February 26, 2020

Welcome to our new colleage Jochen Rink! @rinklab @mpi_bpc

February 26, 2020

Today we celebrated our recent successes with a lunch at a nearby village! Nice walk passing two medieval churches...

February 13, 2020

Save the date: @ASBMB Meeting on Transcriptional Regulation: Chromatin and RNA Polymerase II takes place Oct 1-5, 2020 in Snowbird, Utah.

February 10, 2020

It is an honor to accept the Otto Warburg Medal on behalf of past and present members of the laboratory. The Warburg Lecture will take place on April 3, 2020 during the GBM symposium on “The world of RNAs”

February 05, 2020

Shintaro Aibara obtained a Marie Curie Fellowship of the European Union, many congratulations!

January 28, 2020

The Hilldale Lecture given by Patrick at the University of Wisconsin in Madison last week is now available at YouTube: @UWBiochem

January 27, 2020

Around 450 participants at the joint Keystone meetings on Gene Regulation and Cancer Epigenetics! Follow us: #KSgene

January 22, 2020

Our structure of the chromatin-modifying coactivator SAGA elucidates early events before transcription pre-initiation complex formation. Note related work from the Schultz lab published back-to-back. @mpibpc @igbmc

January 14, 2020

Patrick Cramer will give the Weisbach Memorial Lecture @RockefellerUniv this Friday at 4 pm

January 06, 2020

Save the date for the key European transcription/chromatin conference of the year, taking place 29 August to 01 September in Heidelberg. And: Happy New Year from the Cramer lab!

January 04, 2020

@Lab_Journal Was sind die neuen Forschungsfelder in den Life Sciences, die in Deutschland zu wenig präsent sind?

December 19, 2019

Special Christmas reading on the efforts, rewards and drawbacks of exploration: 500 years after the first circumnavigation of the world...

December 18, 2019

This video explains our work - with a focus on cryo-electron microscopy (English subtitles). Thanks to the Schering Foundation for enabling this.

December 17, 2019

Join the symposium to celebrate the 25th anniversary of the Eppendorf Award on June 25, 2020 in Heidelberg. Free registration:

December 12, 2019

First structures of viral multisubunit RNA polymerase: complete, core, transcribing, & capping complexes of Vaccinia show how such viruses make capped mRNA. Great collaboration with the lab of Utz Fischer in Würzburg! Free download:

December 09, 2019

Recognition of histone H3 trimethylated at K36 by a conserved reader domain: Our new paper reports the structure of the modified nucleosome-PWWP complex and multivalent binding to the methylated histone tail and both DNA gyres. @NatureSMB

December 08, 2019

Our colleague Reinhard Jahn startet as new president of the University of Göttingen. Hear his inauguration speech (in German):

December 06, 2019

Hosting Hans Schöler as our Christmas Speaker 2019!

November 29, 2019

Felix Wagner passed his PhD defense today, many congratulations! Cryo-EM structure of the SWI/SNF chromatin remodelling complex RSC bound to a nucleosome.

November 20, 2019

Marc Böhning passed his PhD defense, many congratulations! Pol II clustering driven by CTD phase separation. Great collaboration with @mz_science and @TjianDarzacq

November 05, 2019

Free download of the historic perspective on 50 years of eukaryotic transcription research. Summarizes major advances in the field and provides exemplary and key original references.

October 28, 2019

Congratulations to Edith Heard, Director General of EMBL, who received the Hansen Family Award today for her pioneering work in epigenetics. @Bayer @emblebi @embl @heard_lab

October 22, 2019

The first scientific travel report: discussing Georg Forster‘s ‚voyage around the world‘ from 1777 with historian Frank Vorpahl @ZDF @Literaturherbst @thegoecampus @ForumWissenGoe

October 20, 2019

Rewriting human history: Our Max Planck colleague Johannes Krause explains how DNA sequencing revolutionizes anthropology. „We are all migrants!“ Today at @Literaturherbst @mpi_bpc @thegoecampus

October 19, 2019

Amazing start of our public science talks at the literature festival 2019, from now on every evening for the next ten days.

October 15, 2019

Our structure of the SWI/SNF chromatin remodeling complex RSC bound to a nucleosome and exit DNA provides insights into formation of nucleosome-depleted, transcriptionally active promoters: Note forthcoming related work by @Nogaleslab and Yuan He's lab

October 14, 2019

Abstract deadline approaching for @KeystoneSymp meeting "Gene Regulation: From Mechanisms to Disease" in #Keystone. #KSgene

October 14, 2019

This month‘s issue of @Lab_Journal features a ‚journal club’ commentary on our work on how Pol II pausing influences transcription initiation.

October 13, 2019

Patrick will give lectures in Rotterdam, Utrecht, and Eindhoven on the next three days. Thanks to the Netherlands Society for Biochemistry and Molecular Biology for the invitation!

October 09, 2019

Sunny Liu defended her PhD thesis, many congratulations!

October 07, 2019

Now published: Real-time cryo-EM data pre-processing with Warp, by Dimitry @DTegunov. Warp corrects and denoises images, automatically picks particles, and generates output for RELION. @cryoEM_Papers #CryoEM Paper: Software:

October 04, 2019

Vasan Rengachari received a postdoctoral fellowship of the Engelhorn Foundation, many congratulations and best of success!

October 01, 2019

A growing global network! Cramer lab reunion with diverse talks by alumni, full of advice: “Stay excited”, “follow your dreams”, “bring empathy to the table!” Thank you for sharing your experiences. @KJArmache @VanniniLab

October 01, 2019

Congratulations to alumnus Alessandro Vannini, now Director of Structural Biology at Human Technopole in Milano!

September 30, 2019

Kiyoshi Nagai was a wonderful colleague, always interested in the latest science, always positive, and following an important long-term goal, which he achieved only recently; he will be sadly missed.

September 30, 2019

This year‘s lab retreat at Ringberg Castle starts off with a great talk by Julia Mahamid @embl

September 27, 2019

Many thanks to the Schering Foundation for organizing a great event in Berlin to celebrate the Ernst Schering Prize 2019. Thanks to all past and current members of the laboratory for their outstanding contributions that made this possible! @ScheringStiftg @mpi_bpc @thegoecampus

September 26, 2019

Today, Lucas Farnung received the Karl Lohmann Prize for his PhD research. He solved the first high-resolution structure of a complete chromatin remodeller, Chd1, bound to a nucleosome! @mpi_bpc @LucasFarnung @thegoecampus @goetageblatt

September 26, 2019

Thank you and all the best for the future! President of the University of Göttingen Ulrike Beisiegel is stepping down. @uniGoettingen @thegoecampus @mpi_bpc

September 20, 2019

Apply and join the Max Planck Society as a Research Group Leader, great start-up packages offered!

September 11, 2019

Exciting line-up of speakers at the EMBO|EMBL Symposium ‘Multiomics to Mechanism’. Follow us at #eesomics

September 02, 2019

The Schering Prize 2019 recognizes past and current members of our laboratory and their fabulous research! Thanks also to everyone who supported us. Video (German): Press release (English):

September 02, 2019

Reunion with alumni Karim-Jean Armache (NYU), Alan Cheung (UCL), Andreas Mayer (MPI Berlin) and Seychelle Vos (MIT) at Cold Spring Harbor during #MOET2019.

August 31, 2019

Many thanks to all participants for the great positive energy at the CSHL anniversary transcription meeting #MOET2019 and for all contributions! Please save the date for the next meeting: Aug 31-Sep 04, 2021!

August 28, 2019

Now online: this review summarizes the state of the eukaryotic transcription field and describes the dynamic interplay between nuclear condensates and Pol II complexes that together organize transcription. #moet2019

August 28, 2019

Magnificent opening lecture by Bob Roeder, founding father of the eukaryotic transcription field, summarizes five decades of frontier research. #moet2019

August 27, 2019

Celebrating 50 years of eukaryotic RNA polymerases at the Cold Spring Harbor meeting on Mechanisms of Eukaryotic Transcription, starting tonight. Follow us at #moet2019

August 22, 2019

Last chance to register for this year‘s Horizons conference, organized by PhD students at our institute, great speakers!

August 20, 2019

The exciting program for this year's literature festival is out. Covering politics, fiction, society, science, history. Mainly in German. Tickets are sold out quickly... Popular science talks: Full program:

August 09, 2019

We show directly that transcription activation often involves a decrease in Pol II pause duration. Multiomics reveals this requires CDK9 and increases the productive initiation frequency. In contrast to promoters, enhancers are generally not pause-limited.

July 26, 2019

Saying thank you and good-bye to Seychelle Vos and wishing her all the best as Assistant Professor at MIT!

July 17, 2019

Our new paper with the Sandberg lab describes NASC-seq, which monitors RNA synthesis (rather than RNA levels) in single cells and can be used to follow differentiation events. Publication: Protocol:

July 16, 2019

Sara Osman passed her PhD defense today, many congratulations!

July 12, 2019

Katharina, Saskia and Goran formally graduated today, congratulations and all the best for the future!

July 08, 2019

We welcome our new colleague Ruben Fernandez Busnadiego, a master in cryo-electron tomography, at the Göttingen science campus! @uniGoettingen @thegoecampus @mpi_bpc

June 30, 2019

Our structure of the human TFIIH-XPA-DNA complex is published. The results explain how TFIIH switches from a transcription factor to a DNA repair factor, and represent the first step in a mechanistic analysis of nucleotide excision repair.

June 26, 2019

Today Sandra Schilbach received the Otto Hahn Medal for her great work on solving the structure of the Pol II pre-initiation complex with TFIIH and core Mediator. Great location in Hamburg. Congratulations!

June 25, 2019

Our structure of the human chromatin remodeller CHD4 in complex with the nucleosome deviates from the previous Chd1 structure, consistent with a role of this factor in gene repression rather than active transcription. Manuscript:

June 24, 2019

Our new seminar program is out. Looking forward to host again fine colleagues at Göttingen. Save the dates!

June 13, 2019

TT-seq is widely applicable to monitor RNA synthesis and enhancer dynamics in human cells. We now provide a detailed lab protocol and bioinformatic analysis pipeline: Experimental: Analysis:

June 12, 2019

@NogalesLab @EMBO Great many congratulations

June 07, 2019

Our paper on splicing kinetics is out. In a collaboration with the @gagneurlab we provide rates for 5‘ and 3‘ RNA cleavage in human cells.

June 01, 2019

Our structure of the super elongation complex (SEC) subunit AFF4 C-terminal homology domain reveals requirements for AFF homo- and heterodimerization in SEC formation. SEC functions in release of Pol II from promoter-proximal pausing. Manuscript:

May 28, 2019

Our new paper presents transcriptome maps of 30 general RNA degradation factors, revealing their occupancy and possibly functional relationships. Great collaboration with the lab of Johannes Soeding! Manuscript:

May 24, 2019

Many congratulations to our colleague Brenda Schulman who received the Jung Prize for Medicine yesterday in Hamburg!

May 07, 2019

Our high-resolution structure of human TFIIH with DNA & XPA represents an intermediate of DNA nucleotide excision repair (NER). Watch how the transcription factor (@NogalesLab) switches to repair mode, engaging DNA with both ATPases, XPB & XPD. Manuscript:

May 07, 2019

Many congratulations to our very successful postdoc Seychelle Vos who will open her lab at MIT this fall!

May 06, 2019

Congratulations to Katharina Hofmann and Saskia Gressel who both passed their PhD defense today! Great talks on functional genomics. All the best for the future!

April 27, 2019

@LugerLab @NatureSMB Really great many congratulations!

April 26, 2019

Our new paper elucidates human splicing kinetics. TT-seq and modeling reveal how splicing rates depend on Pol II elongation and RNA sequences. Great collaboration with Gagneur lab! @eLife @RNASociety @RNApreprints @RNA_seq @gagneurlab @LCaizzi @leonhard

April 23, 2019

Save the date: Keystone meeting on "Gene Regulation: From Mechanisms to Disease" and a parallel meeting on Cancer Epigenetics take place January 26-30, 2020 in Keystone, Colorado. Please RT! Flyer: Information:

April 10, 2019

Goran Kokic passed his PhD exam. Impressive work on TFIIH in DNA repair. Many congratulations!

April 08, 2019

We report a method to directly sequence newly synthesized, individual mRNA transcripts in human cells. Reveals metabolism of RNA splice variants/isoforms.

April 04, 2019

The new childcare facility at our institute just opened. Many thanks to all who helped!

March 27, 2019

MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation. Thanks to Elmar Wolf for the great collaboration.

March 26, 2019

Fine collaboration with the Anikin lab now resulted in our paper on posttranscriptional gene regulation in mitochondria:

March 26, 2019

Please RT: Cold Spring Harbor Meeting on Mechanisms of Eukaryotic Transcription takes place August 27-31, 2019. Celebrating 50 years of eukaryotic RNA polymerases!

March 26, 2019

Save the date: EMBO | EMBL Symposium: Multiomics to Mechanisms - Challenges in Data Integration, 11-13 September 2019 at Heidelberg.

March 11, 2019

Deadline approaching for applications to become a Group Leader in our Lise Meitner program for young female researchers!

March 05, 2019

We thank Randy Schekman for his outstanding service as first editor-in-chief of eLife and look forward to working with Michael Eisen to support the leading OA journal!

February 27, 2019

@UhlenhautLab Great, congratulations!

February 26, 2019

Congratulations to our friends at @BIMSB_MDC @MDC_Berlin on the opening of their beautiful new building in Berlin by chancellor Merkel today!

February 21, 2019

Save the date: conference on chromatin dynamics in Bad Nauheim near Frankfurt, September 9-11, 2019

February 21, 2019

Many congratulations to our close colleague Herbert Jäckle!

December 27, 2018

Great collaboration with the Heard lab. TT-seq monitors X chromosome gene inactivation. Glad we could contribute to this interesting multiomics temporal analysis. @heard_lab

December 22, 2018

Our structure of the transcribing RNA polymerase II-nucleosome complex is now published and available online

December 18, 2018

NASC-seq monitors gene activity in single cells by detecting new mRNA. Great collaboration with the Sandberg lab. Manuscript:

December 14, 2018

@Beck_Laboratory Great to have you as a colleague! All the best

December 14, 2018

Hosting Asifa Akhtar from @mpi_ie as our Christmas speaker

December 11, 2018

Suyang Zhang arrived from Cambridge @MRC_LMB and obtained an EMBO postdoctoral fellowship, many congratulations!

December 06, 2018

And another Leibnizprize for our colleague Ayelet Shachar at the neighboring Max Planck institute, many congratulations!

December 06, 2018

Many congratulations to our colleague at the institute, Melina Schuh, for being awarded the Leibnizpreis, the highest distinction in Germany!

November 30, 2018

CPF and APT are required to form 3'-ends on coding and non-coding genes, respectively. Our paper resulting from a collaboration with @lapassmore is now online.

November 21, 2018

We mourn the passing of Aaron Klug, a giant of molecular biology, who reported the first structure of tRNA

November 21, 2018

Our new structure suggests that DNA opening during transcription initiation involves promoter DNA distortion and closure of the RNA polymerase II clamp

November 20, 2018

Congratulations to former lab member Alan Cheung on becoming an EMBO Young Investigator!

November 14, 2018

Save September 11-13, 2019, for the EMBO|EMBL symposium on ‚Multiomics to mechanism - challenges in data integration‘

November 08, 2018

Many congratulations to Laleh Haghverdi and Julijana Gjorgjieva for receiving the Engelhorn Research Prize 2018 in Computational Biology!

October 24, 2018

Join us for a symposium in honor of Dirk Eick on November 9 in Munich #transcription #cancer #epigenetics #chromatin

October 16, 2018

Full house also for the discussion with Manuela Lenzen who presented her book on artificial intelligence and machine learning in the beautiful Paulinerkirche @Literaturherbst @thegoecampus @mpi_bpc

October 15, 2018

Hosting Germany‘s top energy economist tonight, Claudia Kemfert. Discussing her latest book on how to switch fast to renewable energy and fight climate change. @CKemfert @Literaturherbst

October 11, 2018

Tom Steitz is well known for the work on ribosomes, but his lab also paved the way to an understanding of RNA polymerases with seminal papers in the 90s on phage enzymes. A real hero of molecular biology who will be sadly missed.

October 08, 2018

Our structure of the Pol II-nucleosome complex reveals a defined nucleosome orientation and provides the starting point for understanding the mechanisms of chromatin transcription:

October 07, 2018

Congratulations to Salma Sohrabi-Jahromi for her poster award at the EMBL conference and thanks to the Söding lab for the collaboration on mapping RNA degradation factors on the transcriptome

September 27, 2018

Our application with the University of Göttingen and the Medical Center UMG for a large national research cluster on Multiscale Bioimaging was funded, thanks to all who helped us!

September 25, 2018

Nucleosome-transcription factor interaction landscape mapped. Thanks to Fangjie Zhu and Jussi Taipale for the great collaboration!

September 21, 2018

Distinct multiprotein complexes form the 3'-ends of protein-coding and non-coding RNAs. Great collaboration with Lori Passmore's lab @lapassmore.

September 15, 2018

We contributed to an enjoyable science slam in the old city, featuring scientists from all five Max Planck institutes in Göttingen

September 13, 2018

Tomorrow we celebrate the foundation of the Max Planck Society in Göttingen 70 years ago. Join us for a sciene slam at the local pub:

September 12, 2018

Save the date for next year‘s Cold Spring Harbor Meeting on Mechanisms of Eukaryotic Transcription, August 27-September 01, 2019

September 06, 2018

Our new review on mitochondrial transcription includes the first molecular movie of the mitochondrial transcription cycle. Publication: Movie:

September 05, 2018

Save the date: GRC conference on mechanisms of microbial transcription takes place July 28 to August 2, 2019 in Maine

September 05, 2018

Investigate the switch from paused to activated transcription complex in 3D! Our new Pol II complex structures and density maps are available for download:

September 02, 2018

@ProfJohnsen Really? When? This is sad for us.

August 31, 2018

Registration for the Structural Dynamics VIB Conference in Bruxelles ends in one week

August 23, 2018

Thanks to our colleague Karen Adelman for summarizing our recent findings on Pol II pausing and release and putting them into context: News and Views:

August 22, 2018

Molecular basis of transcription regulation: our new papers elucidate promoter-proximal RNA polymerase II pausing and elongation activation by human DSIF, NELF, PAF, SPT6.

August 20, 2018

Our paper on RNA polymerase II clustering through CTD phase separation is now online. Thanks to the Zweckstetter and @XDarzacq labs for the great collaboration!

August 15, 2018

Congratulations to our Max Planck colleagues: Global animal tracking from space!

August 15, 2018

@animaltracking @Astro_Alex @AniMove @unikonstanz @maxplanckpress @icouzin @UWICER @MP_Innovation Congratulations on the great Tagesschau Beitrag!!

August 08, 2018

RNA velocity predicts the fate of single cells. Glad we could contribute to an exciting collaboration of the Linnarsson and Kharchenko labs @slinnarsson @KharchenkoLab

August 01, 2018

Many congratulations to Peter Scholze, our new colleage at the Max Planck Institute in Bonn, for obtaining the Fields Medal, the ‚Nobel Prize‘ in Mathematics

July 04, 2018

Council congratulates EMBL Barcelona for getting successfully started!

July 04, 2018

The Klenk Symposium on Epigenetics will take place October 4-6, 2018 in Cologne.

June 24, 2018

The scandinavian #cryoEM symposium will take place in Copenhagen October 8-9, 2018

June 22, 2018

Save May 20-22, 2019 for the DNA damage response mechanisms conference in Madrid

June 14, 2018

'Warp' software by Dmitry Tegunov closes the gap between the electron microscope and 3D density reconstruction. See our manuscript and user guide for automated real-time cryo-EM data pre-processing and particle picking #cryoEM #Warp

June 09, 2018

Vienna RNA biology meeting will take place October 17-19, see

June 07, 2018

Our next seminar series program is out, please save the dates and join.

June 07, 2018

Many congratulations to our colleague at the institute, Jens Frahm, on winning the European Inventor Award! Do not miss their incredible movies made with real time MRI!

June 04, 2018

@benoitbruneau @Gene_Regulation TT-Seq we think

May 25, 2018

Our new review provides a movie of RNA polymerase I transcription that can be used for teaching purposes

May 23, 2018

On the shoulders of giants: celebrating the ‚founding fathers’ of our field, Bob Roeder, Bill Rutter, and Pierre Chambon in Paris on the occasion of the 50th anniversary of the discovery of the eukaryotic RNA polymerases

May 16, 2018

Many congratulations to Melina and our neighbors!

May 16, 2018

@SchuhLab @EMBO Great! Many congratulations!

May 10, 2018

@R_H_Ebright PDB took very long; we sent it to many colleagues by mail

May 09, 2018

Our structures of transcription initiation complexes with TFIIH and Mediator are now available for download:

May 08, 2018

The RNA polymerase II CTD phase separates in vitro and governs polymerase clustering in vivo. Thanks to the Zweckstetter and @XDarzacq laboratories for this collaboration. Read the manuscript at

May 08, 2018

Great student-organized molecular biology meeting at Göttingen in fall

May 01, 2018

We are deeply saddened by the untimely passing of our great colleague Elisa Izaurralde, RNA biochemist at MPI Tübingen.

April 28, 2018

Join us on May 9 at 1 pm for the talk of Kelly Nguyen who just published the marvelous structure of human telomerase #cryoEM #RNA

April 14, 2018

Marching for free and open science!

April 12, 2018

Join the 2nd March for Science in Göttingen on April 14!

April 11, 2018

Patrick Cramer presents Kjeldgaard lecture in Aarhus, Denmark

April 09, 2018

Christian Dienemann passed his PhD exam, many congratulations!

April 03, 2018

Save December 5-7 for this year's epigenetics meeting in Freiburg

March 28, 2018

Congratulations to Hauke Hillen for obtaining this year's PhD Award of the German Society for Biochemistry and Molecular Biology for elucidating mitochondrial transcription!

March 18, 2018

Our new cryo-EM structure shows why the mushroom toxin amanitin binds 3000-times better to mammalian RNA polymerase II than to the yeast enzyme

March 16, 2018

RNA polymerases 50 years on: save May 22 for the symposium in Paris

February 19, 2018

Sandra Schilbach passed her PhD exam, presenting the pre-initiation complex structure, many congratulations!

February 14, 2018

Congratulations to former lab member Clemens Plaschka who will start as a group leader at IMP Vienna soon!

February 06, 2018

@TheVillaLab Many thanks for organizing this interesting meeting!

January 26, 2018

Congratulations to former lab member Christoph Engel on winning the Early Excellence in Science Award of the Bayer Foundation

January 18, 2018

Congratulations to Vannini and Müller labs on the Pol III PIC structures!

January 17, 2018

Our Stockholm team moves into the new building ‘Neo’ at Karolinska Institute

January 16, 2018

Applications for PhD fellowships are invited by our new Max Planck Research School for Genome Science that brings together experimental and computational biologists

January 13, 2018

A good summary of our recent structure of the Chd1 chromatin remodeling factor bound to the nucleosome published in Nature Structural and Molecular Biology by Michaela Smolle

January 03, 2018

Congratulations to Youwei Xu who takes on an Assistant Professor position at Shanghai Tech University

December 29, 2017

Our paper with Jussi Taipale’s lab on the interaction landscape of transcription factors and the nucleosome is available

December 21, 2017

Goodbye to Kayo Nozawa who takes a Research Associate position at Waseda University in Tokyo.

December 19, 2017

Christoph Engel starts his research group at Regensburg University in January 2018, funded by the Emmy-Noether-Programme.

December 18, 2017

Haibo Wang received an EMBO postdoctoral fellowship, congratulations!

December 16, 2017

Xiaoguang Xue received an EMBO long-term fellowship, congratulations!

December 08, 2017

We host Julie Ahringer from Cambridge as our Christmas speaker

December 02, 2017

Good-bye to Carrie Bernecky and all the best to her lab at IST Austria!

November 30, 2017

Congratulations to the Max Delbrück Center in Berlin, it turns 25! #MDC25

November 16, 2017

Cell published our mechanism of transcription initiation in human mitochondria...

November 08, 2017

Our institute hosts Kim Nasmyth for a Bonhoeffer Award Lecture

November 07, 2017

Patrick Cramer gives the Weigle Lecture in Geneva, where early molecular biology was done

November 06, 2017

Congratulations to Lucas Farnung and Hauke Hillen for passing their PhD exams!

November 04, 2017

From now on, updates on our facebook page will be shared on twitter

November 04, 2017

@nature published our milestone structure of a 46-subunit transcription initiation complex with TFIIH and Mediator

November 04, 2017

From now on, our facebook page updates will be shared on twitter.

Lab News Archive Until 2017



November 8

Our institute hosts Kim Nasmyth for a Bonhoeffer Award Lecture.

November 7

Patrick Cramer gives Weigle Lecture in Geneva, where early molecular biology was done.

November 6

Congratulations to Lucas Farnung and Hauke Hillen for passing their PhD exams!

November 4

From now on, updates will be shared on twitter.

November 1

Nature published our milestone structure of the 46-subunit, ~2 MDa transcription initiation complex with TFIIH and core Mediator. Link to article.

October 31

DNA alkylation stops transcription using a novel mechanism that we discovered in a collaboration with the Sturla lab. Link to article.

October 27

The program for the new Genome Science Lecture Series is out. View program.

October 25

At our 12th lab retreat we hosted seven external speakers in Hamburg and defined our strategy for 2018.

October 22

The Göttingen Max Planck Institutes host another great speaker at the Literature Festival, Patrick Kingsley (New York Times) who describes current migration to Europe.

October 12

Cell published our mechanism of replication-transcription switching in mitochondria that we elucidated in collaboration with the Temiakov laboratory. Link to article.

October 11

Nature published our nucleosome-Chd1 structure that suggests a model for DNA translocation by chromatin remodeling enzymes. Link to article.

October 10

Our new eLife paper shows that polymerase pausing controls transcription initiation. Link to article.

October 4

The Nobel Prize in Chemistry was awarded to Jacques Dubochet, Joachim Frank and Richard Henderson for the development of cryo-electron microscopy, congratulations! Link to press release.

September 29

Göttingen Research Campus advances in national competition for excellence clusters. Link to press release.

September 15

Our institute hosted Jennifer Doudna for a Bonhoeffer Award Lecture on CRISPR systems. Link to press release.

September 13

Congratulations to former lab member Alessandro Vannini who obtained tenure at ICR London! Link to press release.

September 12

Our structure of human DSIF bound to transcribing RNA polymerase II is out. Link to article.

August 23

Congratulations to Carrie Bernecky who obtained an Assistsant Professorship at IST Austria in Vienna! Link to press release.

August 16

Our 'expressome' appears in Miller spreads from 1970. Link to article.

August 2

Our team wins the institute's volleyball tournament.

June 28

Edith Heard selected as next Director-General of EMBL. Link to press release.

June 7

We now located the chromatin transcription factor Paf1 complex on one side of RNA polymerase II:

May 29

Sofia Battaglia, Carina Demel and Tobias Gubbey passed their PhD exams, congratulations and all the best for the future!

May 24

Our new paper uses several 'omics' techniques to reveal a critical role of nascent RNA in coordinating the transcription cycle:

May 12

JMB published our reflection on the history and future of molecular biology on the occasion of John Kendrew's 100th birthday:

May 3

Nature published our 15-subunit core Mediator structure that leads to an extended transcription initiation complex model:

April 26

Christoph Wigge and Dietmar Riedel organized a symposium to inaugurate the new Titan electron microscope. More information

April 25

Our latest review summarizes the current understanding of the conserved Pol II initiation complex structure:

April 22

We support the global March for Science.

April 18

Science published our work on the 'expressome' that visualizes the central dogma of molecular biology:

April 11

New EMBL site in Barcelona opened! More information.

April 3

We are co-organizing the Eukaryotic Transcription Meeting at Cold Spring Harbor this summer and the speaker list is out.

March 23

Cell just published our paper on Pol I initiation that suggests a basis for promoter recognition:

March 18

Our new paper defines the critical transition at the end of genes:

March 9

Our latest paper shows how to map enhancer landscapes with high temporal resolution:

March 6

The new IMPRS for Genome Science goes public:

February 16

Patrick Cramer joins the University of Göttingen as honorary professor.

February 13

Patrick Cramer joins the Editorial Advisory Board of Molecular Systems Biology.

February 1

Our coordinator for the new International Max Planck Research School for Genome Science, Henriette Irmer, started today, welcome!

January 25

Simon Neyer and Youwei Xu passed their PhD exams, congratulations!

January 20

10 years after the Nobel Prize: our general review is out at



December 8

We host Torben Heick-Jensen as our Christmas speaker.

December 8

Congratulations to our close colleagues Jörg Vogel and Karl-Peter Hopfner on being awarded the Leibniz Prize 2017, the most important science prize in Germany!

December 1

Svetlana Dodonova receives an EMBO long-term fellowship, many congratulations!

November 21

We received funding to set up a new International Max Planck Research School for Genome Science.

November 14

Merle Hantsche passes her PhD exam, many congratulations"

November 14

Our collaborative paper with the Frangakis lab is out at Nature:

October 24

Our 11th annual lab retreat in Berlin hosts 7 external speakers.

September 5

Congratulations to Margaux Michel on passing her PhD exam!

August 1

Patrick Cramer receives the Centenary Award of the British Biochemical Society. The award medal will be given at the 80th Harden Conference at Macclesfield, UK.

July 15

Felix Wagner receives Boehringer Ingelheim Fonds PhD Fellowship, congratulations!

June 15

Clemens Plaschka receives the Otto Hahn Medal in Saarbrücken.

Link to press release (in German).

June 3

Our paper on TT-Seq is out in Science, see the press release here.

May 11

Our paper on initiation complex structure (Plaschka, Hantsche et al.) is out at Nature!

May 2

Philipp Eser and Benedikt Zacher receive their PhD, congratulations!

April 15

Our lab will be funded again with an Advanced Investigator Grant of the European Research Council, ERC. We will receive a total of Euro 2.5 Mio during 2016-2021.
Link to Press Release (in German).

February 24

We co-organize a symposium on biological networks in Berlin.          

February 8

Congratulations to former lab member Claus Kuhn who will receive a prestigious award (Paul Ehrlich- und Ludwig Darmstaedter Nachwuchspreis) on March 14 in Frankfurt. The two other awardees are Emmanuelle Charpentier and Jennifer Doudna (Paul Ehrlich- und Ludwig Darmstaedter Preis).

January 20

Our paper on the first mammalian RNA polymerase structure (Carrie Bernecky et al.) is out at Nature.

January 1

Patrick Cramer takes up chair of EMBL council.

January 1

Patrick Cramer joins the Editorial Board of "Cell".



November 25-26

We co-organize workshop on the future of structural biology in Berlin. [more]

November 18

Clemens Plaschka receives prestigous "Kulturpreis Bayern" of the Bayernwerk AG.

November 17

Goran Kokic is awarded a Boehringer Ingelheim PhD Student Fellowship.

November 10

Paulina Seweryn is awarded a Humboldt Research Fellowship.

October 8

We're hosting the KFB lecture by Nick Proudfoot (University of Oxford).

September 30

Jürgen Niesser and David Pöllman receive their PhD, congratulations.

August 31

Patrick Cramer gives Sumner Lecture.

July 21

Wolfgang Mühlbacher receives his PhD, congratulations!

July 1

Anna Sawicka takes on EMBO Postdoctoral Fellowship.

June 1

Katja Fruehauf and Michael Lidschreiber start as first team members at our sattelite lab in Stockholm.

May 22

Christoph Engel receives prestigious ‘Promotionspreis’ of the German Society for Biochemistry and Molecular Biology (GBM).


Together with colleagues at the institute, we secure funding for a new Titan electron microscope with K2 and Falcon-III cameras, to be set up in 2016

March 19

Patrick Cramer receives Arthur Burkhardt Prize. (Click here for more information)

February 5

Our Nature article on the Pol II-Mediator core initiation complex by Clemens Plaschka et al. is published. (Click here to view the article)

January 21

The lab obtained additional funding within the SFB860 research network ‘Integrative Structural Biology of Dynamic Macromolecular Complexes’

January 1

Livia Caizzi takes on EMBO Postdoctoral Fellowship

January 1

Patrick Cramer starts as guest professor at Karolinska Institute in Stockholm:



December 5

Carlo Bäjen receives award for his PhD work by the Dr. Klaus Römer Foundation

November 20

Review on the occasion of the 100th birthday of crystallography published. (Click here to view the article)

October 1

Hauke Hillen takes on Boehringer Ingelheim PhD Student Fellowship.

July 1

Seychelle Vos takes on EMBO Postdoctoral Fellowship.

June 30

The lab obtains additional funding by the Lower Saxonian Ministry for Science and Culture (Niedersächsisches Ministerium für Wissenschaft und Kultur) to extend functional genomics efforts.

April 1

First group members from our Munich lab start at MPIbpc.

January 1

Patrick Cramer starts as director at the Max Planck Institute for Biophysical Chemistry

Go to Editor View