Lab News auf Twitter (seit 2017)

November 01, 2020

As we enter a second (partial) lockdown tomorrow it is so good to know to have such talented, cooperative and resilient coworkers.

October 31, 2020

Looking forward to speaking at MIT Biology Colloquium Series on Tuesday Nov 03 at 4 pm EST. Hosted by postdocs. @MITBiology @anafiszbein

October 30, 2020

Science communicator and influencer @maithi_nk on basic science @Literaturherbst Göttingen tonight.

October 29, 2020

Solving the remdesivir mechanism was possible in a great collaboration with @HoebartnerLab @Uni_WUE. They synthesized RNA with remdesivir at defined positions. We used their RNA to trap the remdesivir-stalled state of the #SARSCoV2 polymerase by #cryoEM.

October 29, 2020

We show how the #COVID19 drug #remdesivir inhibits #coronavirus replication: Remdesivir stalls the viral polymerase by posing a translocation barrier, retaining the RNA 3'-end in the substrate-binding site, and hindering RNA proofreading. Preprint:

October 28, 2020

These events are now accessible with your "ON AIR" ticket: Ayelet Shachar: The shifting border (English) Jutta Allmendinger: Vertrauen (German) Jörg Hacker: Pandemien (German)

October 27, 2020

@mpi_bpc @maxplanckpress So great

October 26, 2020

@Karl_Lauterbach Danke für diese guten Worte. Eine schreckliche Nachricht und ein enormer Verlust auch für uns Göttinger.

October 24, 2020

@PlantEvolution I was also totally taken by it

October 23, 2020

Congratulations to Jutta Allmendinger for obtaining this year‘ science communications medal!

October 22, 2020

Two simple steps to join the literature festival events. Some in English. Starting tomorrow Friday 7 pm with Jutta Allmendinger @JA_Allmendinger

October 22, 2020

This year’s lab retreat took place at home and featured great talks by @5_Baldi, @dhnisz, @bulutkarslioglu, Markus Wahl and Jan-Philipp Juncker. Great variety from structure to condensates to cell transitions.

October 20, 2020

Our RNA polymerase II-U1 snRNP structure elucidates co-transcriptional splicing. It suggest a nascent RNA loop on the Pol II surface enables efficient splice site scanning. Fabulous work by Suyang Zhang in collaboration with the Lührmann lab. Manuscript:

October 17, 2020

Some thoughts on where our research field may be heading. From a discussion at the Keystone Meeting on Gene Regulation earlier this year.

October 17, 2020

She wants to encourage young people to become scientists: “It’s curiosity and passion!” - star photographer Herlinde Kölbl at the opening event of her exhibition ‘Fascination of science’ at Paulinerkirche Göttingen @Literaturherbst @mpi_bpc

October 16, 2020

@Helmholtz_HZI @helmholtz_de Toll, dass das HZI Emmanuelle Charpentier nach Deutschland geholt hatte!

October 16, 2020

@SchindelinL @KiskerLab @RVZ_Wuerzburg @Uni_WUE Really great!

October 16, 2020

@JA_Allmendinger Es freut mich, dass sie jetzt auf Twitter sind aber noch mehr, dass Sie uns bald in Göttingen zum Literaturherbst besuchen!

October 14, 2020

Save the date and keep fingers crossed that we can meet in person.

October 13, 2020

Looking forward to this workshop on the noncoding genome in Paris.

October 12, 2020

@patrick_pausch Yes. Absolutely. But most EM structures rely on fitting prior X-ray structures still.

October 09, 2020

Our review containing all RNA polymerase II structures is now freely available online:

October 07, 2020

Remembering the Paul-Ehrlich-Prize 2016 to Emmanuelle and Jennifer with former lab member Claus Kuhn as junior awardee. @doudna_lab

October 07, 2020

And here comes the next generation: a very warm welcome to our new group leader at the institute, Marieke Oudelaar! Her group will study genome organization and regulation. @MariekeOudelaar Website:

October 07, 2020

Many congratulations to our Max Planck colleague Emmanuelle Charpentier and Berkeley structural biologist Jennifer Doudna for the Nobel Prize 2020! So great! @doudna_lab @maxplanckpress

October 06, 2020

Many congratulations to our Max Planck colleague Reinhard Genzel for obtaining the Nobel Prize in physics. Fabulous!

October 02, 2020

Very excited to meet legendary photographer Herlinde Kölbl in Berlin tonight. Her recent project ‚fascinating science’ features 60 scientists from around the globe. @bbaw_de

October 01, 2020

Our new ‘Eigen Lounge’ is now ready for coffee and round table discussions. It commemorates the founder of our institute, Nobel laureate Manfred Eigen.

October 01, 2020

Hauke Hillen is starting as a tenure-track professor today at the University of Göttingen & UMG. Congratulations and all the best to the new lab! @hauke_hillen @uniGoettingen @mpi_bpc

September 29, 2020

@TheresiaBauer @unikonstanz @maxplanckpress @martinwikelski Das freut mich als gebürtigen Schwaben besonders! Ich erinnere mich an die interessanten Diskussionen zur Gründung dieses großartigen Instituts. Einzigartige Technologie @martinwikelski

September 23, 2020

Great opportunity for ambitious junior researchers! Please do not hesitate to contact your favorite Max Planck Institute for advice.

September 20, 2020

@AmyShaubMaddox The loneliness of the leader

September 16, 2020

The literature festival @Literaturherbst is starting soon. Looking forward to host (7 pm): Jutta Allmendinger (sociology), October 23 Jörg Hacker (pandemics), October 25 Ayelet Shachar (borders & migration), October 27 One online ticket for all events:

September 14, 2020

@AprilPawluk @MolecularCell @CellReports @CellPressNews Best of success! To best serve the community I recommend to take clear decisions.

September 13, 2020

@FuturiumD Viel Erfolg!

September 13, 2020

@SteffenKrach @ChariteBerlin Ja, ein großer Glücksfall für Berlin!

September 11, 2020

A 15-minute summary of the current state of our work on #SARSCoV2 polymerase and its inhibition by #remdesivir #COVID19

September 11, 2020

Save the date: #COVID19 #SARSCoV2 Cold Spring Harbor Asia Virtual Conference on Nov 2-4, 2020.

September 09, 2020

@KouMurayama @uni_tue @AvHStiftung Welcome

September 08, 2020

Now published: our method detecting newly synthesized RNA isoforms and monitoring isoform metabolism in cells (nano-ID). Great team effort coordinated by Björn Schwalb @birdumbrella. #nanopore @nanopore @NanoporePapers Paper:

September 07, 2020

@maithi_nk Many congratulations!

September 03, 2020

Many congratulations to our colleagues at the institute, Juliane and Stefan!

August 28, 2020

@KellyTHD_Nguyen This is so sad, Chris had organized a great party on the occasion of Kiyoshi’s 70th birthday last year which had to be canceled due to his illness...this is so sad.

August 27, 2020

@Pol2Runner Yes in the nucleosome

August 27, 2020

Half a year later: first real space Cramer lab group meeting with distancing.

August 26, 2020

Looking forward to this student-organized symposium on October 7-8, 2020. #Eureka2020

August 24, 2020

Join the 17th Horizons in Molecular Biology Conference on September 14-17, 2020! Great speaker line-up.

August 22, 2020

Here we review all ~200 available Pol II complex structures and summarize how these elucidated transcription initiation, promoter-proximal pausing and elongation, and the navigation of nucleosomes and DNA lesions.

August 20, 2020

Free download of the benchmark paper on Rosalind Franklin and the advent of molecular biology: #franklin100 #WomenInStem #DNA

August 19, 2020

Save the date: The 86th Harden Conference - Machines on Genes is rescheduled for 9-13 May 2021 and takes place in Alicante, Spain.

August 19, 2020

Registration is now open for our local coronavirus research webinar symposium on September 3, 2020:

August 17, 2020

Defining permissive epigenomes that enable cell reprogramming by various transcriptional regulators. Happy we could contribute to this study by the Schöler lab. #stemcells

August 06, 2020

The final version of our paper reporting the #SARSCoV2 polymerase-RNA structure is now available. A basis for investigating #coronavirus replication-blocking antivirals such as #Remdesivir.

August 02, 2020

Integrator is a genome-wide attenuator of non-productive transcription. Combining factor depletion, TT-seq and bioinformatics. Great collaboration with @torbenheick. Manuscript:

July 30, 2020

Now online: visualizing the central dogma inside cells! Glad we could contribute to this marvelous work on the expressome by the labs of Julia Mahamid and Juri Rappsilber @RappsilberLab @FJ_OReilly @Liang_Xue_ @DTegunov @JorgStulke @embl Paper:

July 30, 2020

Thanks to the editors at Cell for prioritizing this important historical topic. #Franklin100

July 30, 2020

@CWolberger Thank you for your great thread on this topic, Cynthia!

July 29, 2020

@g1_guillermo @cryoEM_Papers @MolecularCell @CRISPR_News @sofos112 @SQunxin @NNFCPR @UCPH_health Really great, many congratulations!

July 29, 2020

Rosalind Franklin provided the key data for deriving the double helix structure of DNA. She also pioneered studies of viruses and RNA. This benchmark essay celebrates the 100th anniversary of Franklin’s birth and the advent of molecular biology.

July 28, 2020

Join the seminars by Lucas Farnung and Hitoshi Kurumizaka tomorrow.

July 26, 2020

@CWolberger I agree; there will be a paper on this in Cell on Wednesday.

July 24, 2020

@giacomo_cavalli Thanks Giacomo; there will be a paper in Cell on her next week. Best

July 22, 2020

@TriggerLoop @researchsquare Maybe a biogenesis/assembly factor?

July 22, 2020

@afisch82 @TriggerLoop @JosefowiczLab @sjosefowicz Really great, many congratulations!

July 17, 2020

Patrick‘s overview seminar given at Dana Farber/Harvard Cancer Center is now available online:

July 14, 2020

Join Patrick’s talk online at Dana Farber/Harvard Cancer Center @df_hcc on Thursday at 12 noon Boston time.

July 03, 2020

Dimitry Tegunov‘s multiparticle cryo-EM refinement software ‚M’ is now available for download.

July 01, 2020

Very much looking forward to work with our new leadership! @AsifaAkhtar1

June 17, 2020

Evidence that CDK12 maintains an active transcription elongation complex by retaining the PAF complex. Happy we could collaborate with the lab of Shona Murphy.

June 16, 2020

@STOPlabPl Good luck!

June 16, 2020

Our new paper on the nucleosome-CHD4 chromatin remodeler structure is online. CHD4 is involved in gene repression and does not detach terminal DNA, in contrast to Chd1, which works in active transcription. We also map disease mutations. @LucasFarnung

June 16, 2020

Save the dates: program for our next seminar series is out. Much looking forward to host our colleagues @Beck_Laboratory, @HymanLab, @KukulskiWanda, Edward Lemke, Frank Uhlmann, @NVastenhouw & @tinekelenstra.

June 16, 2020

Like other enzymes, Pol II is regulated allosterically by proteins that influence active site structure & dynamics from a distance. First seen for the initiation factor TFIIB, now for the elongation factor RTF1. TFIIB: RTF1:

June 15, 2020

Pol II speed is enhanced by PAF subunit RTF1. Our new paper shows allosteric activation via the famous bridge helix. @seyvos @LucasFarnung Publication:

June 10, 2020

@billhansson @maxplanckpress Thank you so much for everything, Bill!

June 09, 2020

Isaac Fianu passed his PhD defense today, many congratulations!

June 08, 2020

CTCF-dependent genome topology is not strictly required for a functional cell-fate conversion but facilitates a rapid and efficient response to an external stimulus. Happy we could contribute to this important study of the Graf lab @CRGenomica.

June 06, 2020

@brodriguezsci Best to ask Dimitry...

June 06, 2020

"In agreement with a model of condensate-driven transcription initiation, large clusters of hypophosphorylated Pol II rapidly disassembled upon Mediator degradation." Happy we could contribute to this great collaboration with Martin Jaeger and Georg Winter.

June 06, 2020

Dimitry Tegunov's software 'M' enables multi-particle refinement and higher resolution in #cryoEM. Applied to tomography data from @Liang_Xue_ & Julia Mahamid @embl, M reveals ribosome-antibiotic complex at 3.7 Å in cells. @DTegunov @c_dienemann Preprint

May 26, 2020

We welcome our new colleague at the institute, Claus Ropers!

May 26, 2020

Welcome at our institute, Stefan!

May 25, 2020

Happy to join and serve on the Scientific Advisory Board of the Gulbenkian Institute in Lisbon, Portugal.

May 21, 2020

Our paper describing the #coronavirus RNA polymerase structure is online. The nsp8 extensions contact RNA far away from the active site, apparently enabling processive replication of the very long #SARSCoV2 genome. Publication: PR:

May 18, 2020

After nearly two months in home office we carefully return to the lab. Here are 56 thoughts of the day that accumulated:

May 16, 2020

@IbrahimCisse_ @MIT_Physics @Cisse_lab Great many congratulations

May 15, 2020

Happy to share the original cryoEM data used to solve our #coronavirus #SARSCoV2 polymerase-RNA complex structure.

May 13, 2020

Explore #coronavirus replication in 3D. Our structural data for the RNA-dependent RNA polymerase of #SARSCoV2 in replication mode are now online: PDB: EMDB: Preprint: PR:

May 08, 2020

@Alexis_Verger @MED_COMPLEX Hey very nice overview! Is it really already two decades? Well yes we got older...

May 06, 2020

@lkreidberg Welcome and all the best! Patrick Cramer

April 30, 2020

Here is a simple animation of #coronavirus replication: NTPs enter from the right and are added to the growing RNA copy (red) of the #SARSCoV2 RNA genome (blue) by the viral polymerase. #COVID19 Preprint: Press release:

April 28, 2020

Watching #coronavirus replication! #SARSCoV2 polymerase-RNA structure: basis to study potential #COVID19 drug #Remdesivir Team @hauke_hillen @KokicGoran @LucasFarnung @c_dienemann @DTegunov @mpi_bpc @maxplanckpress Preprint PR

April 27, 2020

Very honored to be elected as a foreign member of the National Academy @theNASciences. Many thanks to my colleagues and friends in the US!

April 22, 2020

Our structures of nucleosome-bound Yamanaka factor Sox2 and Sox11 elucidate how pioneer factors invade chromatin for differentiation and development.

April 20, 2020

Many congratulations to Lucas Farnung who accepted an offer from @Harvard and will start his lab at Boston in January 2021!

April 18, 2020

@EsbinMeagan Many thanks indeed, really very kind of you! Please send my regards to Tij!

April 17, 2020

25 days in home office started with 25 thoughts of the day. Here they are:

April 17, 2020

@FMIscience @SchubelerLab Congratulations and best wishes, Dirk!

April 01, 2020

Increasing the sensitivity of crosslinking-mass spectrometry with a new peptide database. Glad we could contribute to this important technical development of the lab of Henning Urlaub. Publication:

March 31, 2020

We are supported again by an Advanced Grant of the European Research Council @ERC_Research. With these funds we will extend our research towards the mechanisms of chromatin transcription. Thanks to all coworkers who made this possible.

March 25, 2020

We start each day in home office with an encouraging philosophic quote in our Email inbox. Here is today's: “What does not engage our feelings does not long engage our thoughts either.” Lou Andreas-Salomé, Russian-German author 1861 St. Petersburg – 1937 Göttingen

March 23, 2020

First virtual Cramer lab meeting. Science continues mainly online. Take care of yourselves during these times.

March 11, 2020

Our structure of the SWI/SNF chromatin remodelling complex RSC is now published!

March 08, 2020

Great event this weekend @uniGoettingen @thegoecampus @ForumWissenGoe celebrating the international women's day #IWD2020 featuring Margot Kaessmann, Naima Diesner, Nivedita Mani, Jacqueline Amirfallah, Katrin Adt.

March 01, 2020

Chromatin remodelers contain ‘ruler’ elements that set nucleosome array spacing. Happy we could contribute to this collaboration between the labs of Philipp Korber, @hopfnerlab and @PetersonLab. Preprint:

March 01, 2020

The expressome structure we obtained in 2017 in vitro after stalling RNA polymerase (collaboration with Landick lab) is now shown to be adopted in vivo as an inactive state when transcription is blocked. Link to our 2017 in vitro expressome paper:

February 29, 2020

Visualizing the central dogma in cells! The labs of Julia Mahamid @embl and @RappsilberLab present the in situ structure of the transcribing-translating expressome. Glad we could contribute. @DTegunov @WimJHH @JorgStulke Preprint:

February 28, 2020

@FRobertLab @JeronimoCelia Absolutely great

February 27, 2020

Register for the "Gene transcription in yeast” Conference that takes place June 13-18, 2020 in Sant Feliu de Guixols, Spain:

February 26, 2020

Welcome to our new colleage Jochen Rink! @rinklab @mpi_bpc

February 26, 2020

Today we celebrated our recent successes with a lunch at a nearby village! Nice walk passing two medieval churches...

February 13, 2020

Save the date: @ASBMB Meeting on Transcriptional Regulation: Chromatin and RNA Polymerase II takes place Oct 1-5, 2020 in Snowbird, Utah.

February 10, 2020

It is an honor to accept the Otto Warburg Medal on behalf of past and present members of the laboratory. The Warburg Lecture will take place on April 3, 2020 during the GBM symposium on “The world of RNAs”

February 05, 2020

Shintaro Aibara obtained a Marie Curie Fellowship of the European Union, many congratulations!

January 28, 2020

The Hilldale Lecture given by Patrick at the University of Wisconsin in Madison last week is now available at YouTube: @UWBiochem

January 27, 2020

Around 450 participants at the joint Keystone meetings on Gene Regulation and Cancer Epigenetics! Follow us: #KSgene

January 22, 2020

Our structure of the chromatin-modifying coactivator SAGA elucidates early events before transcription pre-initiation complex formation. Note related work from the Schultz lab published back-to-back. @mpibpc @igbmc

January 14, 2020

Patrick Cramer will give the Weisbach Memorial Lecture @RockefellerUniv this Friday at 4 pm

January 06, 2020

Save the date for the key European transcription/chromatin conference of the year, taking place 29 August to 01 September in Heidelberg. And: Happy New Year from the Cramer lab!

January 04, 2020

@Lab_Journal Was sind die neuen Forschungsfelder in den Life Sciences, die in Deutschland zu wenig präsent sind?

December 19, 2019

Special Christmas reading on the efforts, rewards and drawbacks of exploration: 500 years after the first circumnavigation of the world...

December 18, 2019

This video explains our work - with a focus on cryo-electron microscopy (English subtitles). Thanks to the Schering Foundation for enabling this.

December 17, 2019

Join the symposium to celebrate the 25th anniversary of the Eppendorf Award on June 25, 2020 in Heidelberg. Free registration:

December 12, 2019

First structures of viral multisubunit RNA polymerase: complete, core, transcribing, & capping complexes of Vaccinia show how such viruses make capped mRNA. Great collaboration with the lab of Utz Fischer in Würzburg! Free download:

December 09, 2019

Recognition of histone H3 trimethylated at K36 by a conserved reader domain: Our new paper reports the structure of the modified nucleosome-PWWP complex and multivalent binding to the methylated histone tail and both DNA gyres. @NatureSMB

December 08, 2019

Our colleague Reinhard Jahn startet as new president of the University of Göttingen. Hear his inauguration speech (in German):

December 06, 2019

Hosting Hans Schöler as our Christmas Speaker 2019!

November 29, 2019

Felix Wagner passed his PhD defense today, many congratulations! Cryo-EM structure of the SWI/SNF chromatin remodelling complex RSC bound to a nucleosome.

November 20, 2019

Marc Böhning passed his PhD defense, many congratulations! Pol II clustering driven by CTD phase separation. Great collaboration with @mz_science and @TjianDarzacq

November 05, 2019

Free download of the historic perspective on 50 years of eukaryotic transcription research. Summarizes major advances in the field and provides exemplary and key original references.

October 28, 2019

Congratulations to Edith Heard, Director General of EMBL, who received the Hansen Family Award today for her pioneering work in epigenetics. @Bayer @emblebi @embl @heard_lab

October 22, 2019

The first scientific travel report: discussing Georg Forster‘s ‚voyage around the world‘ from 1777 with historian Frank Vorpahl @ZDF @Literaturherbst @thegoecampus @ForumWissenGoe

October 20, 2019

Rewriting human history: Our Max Planck colleague Johannes Krause explains how DNA sequencing revolutionizes anthropology. „We are all migrants!“ Today at @Literaturherbst @mpi_bpc @thegoecampus

October 19, 2019

Amazing start of our public science talks at the literature festival 2019, from now on every evening for the next ten days.

October 15, 2019

Our structure of the SWI/SNF chromatin remodeling complex RSC bound to a nucleosome and exit DNA provides insights into formation of nucleosome-depleted, transcriptionally active promoters: Note forthcoming related work by @Nogaleslab and Yuan He's lab

October 14, 2019

Abstract deadline approaching for @KeystoneSymp meeting "Gene Regulation: From Mechanisms to Disease" in #Keystone. #KSgene

October 14, 2019

This month‘s issue of @Lab_Journal features a ‚journal club’ commentary on our work on how Pol II pausing influences transcription initiation.

October 13, 2019

Patrick will give lectures in Rotterdam, Utrecht, and Eindhoven on the next three days. Thanks to the Netherlands Society for Biochemistry and Molecular Biology for the invitation!

October 09, 2019

Sunny Liu defended her PhD thesis, many congratulations!

October 07, 2019

Now published: Real-time cryo-EM data pre-processing with Warp, by Dimitry @DTegunov. Warp corrects and denoises images, automatically picks particles, and generates output for RELION. @cryoEM_Papers #CryoEM Paper: Software:

October 04, 2019

Vasan Rengachari received a postdoctoral fellowship of the Engelhorn Foundation, many congratulations and best of success!

October 01, 2019

A growing global network! Cramer lab reunion with diverse talks by alumni, full of advice: “Stay excited”, “follow your dreams”, “bring empathy to the table!” Thank you for sharing your experiences. @KJArmache @VanniniLab

October 01, 2019

Congratulations to alumnus Alessandro Vannini, now Director of Structural Biology at Human Technopole in Milano!

September 30, 2019

Kiyoshi Nagai was a wonderful colleague, always interested in the latest science, always positive, and following an important long-term goal, which he achieved only recently; he will be sadly missed.

September 30, 2019

This year‘s lab retreat at Ringberg Castle starts off with a great talk by Julia Mahamid @embl

September 27, 2019

Many thanks to the Schering Foundation for organizing a great event in Berlin to celebrate the Ernst Schering Prize 2019. Thanks to all past and current members of the laboratory for their outstanding contributions that made this possible! @ScheringStiftg @mpi_bpc @thegoecampus

September 26, 2019

Today, Lucas Farnung received the Karl Lohmann Prize for his PhD research. He solved the first high-resolution structure of a complete chromatin remodeller, Chd1, bound to a nucleosome! @mpi_bpc @LucasFarnung @thegoecampus @goetageblatt

September 26, 2019

Thank you and all the best for the future! President of the University of Göttingen Ulrike Beisiegel is stepping down. @uniGoettingen @thegoecampus @mpi_bpc

September 20, 2019

Apply and join the Max Planck Society as a Research Group Leader, great start-up packages offered!

September 11, 2019

Exciting line-up of speakers at the EMBO|EMBL Symposium ‘Multiomics to Mechanism’. Follow us at #eesomics

September 02, 2019

The Schering Prize 2019 recognizes past and current members of our laboratory and their fabulous research! Thanks also to everyone who supported us. Video (German): Press release (English):

September 02, 2019

Reunion with alumni Karim-Jean Armache (NYU), Alan Cheung (UCL), Andreas Mayer (MPI Berlin) and Seychelle Vos (MIT) at Cold Spring Harbor during #MOET2019.

August 31, 2019

Many thanks to all participants for the great positive energy at the CSHL anniversary transcription meeting #MOET2019 and for all contributions! Please save the date for the next meeting: Aug 31-Sep 04, 2021!

August 28, 2019

Now online: this review summarizes the state of the eukaryotic transcription field and describes the dynamic interplay between nuclear condensates and Pol II complexes that together organize transcription. #moet2019

August 28, 2019

Magnificent opening lecture by Bob Roeder, founding father of the eukaryotic transcription field, summarizes five decades of frontier research. #moet2019

August 27, 2019

Celebrating 50 years of eukaryotic RNA polymerases at the Cold Spring Harbor meeting on Mechanisms of Eukaryotic Transcription, starting tonight. Follow us at #moet2019

August 22, 2019

Last chance to register for this year‘s Horizons conference, organized by PhD students at our institute, great speakers!

August 20, 2019

The exciting program for this year's literature festival is out. Covering politics, fiction, society, science, history. Mainly in German. Tickets are sold out quickly... Popular science talks: Full program:

August 09, 2019

We show directly that transcription activation often involves a decrease in Pol II pause duration. Multiomics reveals this requires CDK9 and increases the productive initiation frequency. In contrast to promoters, enhancers are generally not pause-limited.

July 26, 2019

Saying thank you and good-bye to Seychelle Vos and wishing her all the best as Assistant Professor at MIT!

July 17, 2019

Our new paper with the Sandberg lab describes NASC-seq, which monitors RNA synthesis (rather than RNA levels) in single cells and can be used to follow differentiation events. Publication: Protocol:

July 16, 2019

Sara Osman passed her PhD defense today, many congratulations!

July 12, 2019

Katharina, Saskia and Goran formally graduated today, congratulations and all the best for the future!

July 08, 2019

We welcome our new colleague Ruben Fernandez Busnadiego, a master in cryo-electron tomography, at the Göttingen science campus! @uniGoettingen @thegoecampus @mpi_bpc

June 30, 2019

Our structure of the human TFIIH-XPA-DNA complex is published. The results explain how TFIIH switches from a transcription factor to a DNA repair factor, and represent the first step in a mechanistic analysis of nucleotide excision repair.

June 26, 2019

Today Sandra Schilbach received the Otto Hahn Medal for her great work on solving the structure of the Pol II pre-initiation complex with TFIIH and core Mediator. Great location in Hamburg. Congratulations!

June 25, 2019

Our structure of the human chromatin remodeller CHD4 in complex with the nucleosome deviates from the previous Chd1 structure, consistent with a role of this factor in gene repression rather than active transcription. Manuscript:

June 24, 2019

Our new seminar program is out. Looking forward to host again fine colleagues at Göttingen. Save the dates!

June 13, 2019

TT-seq is widely applicable to monitor RNA synthesis and enhancer dynamics in human cells. We now provide a detailed lab protocol and bioinformatic analysis pipeline: Experimental: Analysis:

June 12, 2019

@NogalesLab @EMBO Great many congratulations

June 07, 2019

Our paper on splicing kinetics is out. In a collaboration with the @gagneurlab we provide rates for 5‘ and 3‘ RNA cleavage in human cells.

June 01, 2019

Our structure of the super elongation complex (SEC) subunit AFF4 C-terminal homology domain reveals requirements for AFF homo- and heterodimerization in SEC formation. SEC functions in release of Pol II from promoter-proximal pausing. Manuscript:

May 28, 2019

Our new paper presents transcriptome maps of 30 general RNA degradation factors, revealing their occupancy and possibly functional relationships. Great collaboration with the lab of Johannes Soeding! Manuscript:

May 24, 2019

Many congratulations to our colleague Brenda Schulman who received the Jung Prize for Medicine yesterday in Hamburg!

May 07, 2019

Our high-resolution structure of human TFIIH with DNA & XPA represents an intermediate of DNA nucleotide excision repair (NER). Watch how the transcription factor (@NogalesLab) switches to repair mode, engaging DNA with both ATPases, XPB & XPD. Manuscript:

May 07, 2019

Many congratulations to our very successful postdoc Seychelle Vos who will open her lab at MIT this fall!

May 06, 2019

Congratulations to Katharina Hofmann and Saskia Gressel who both passed their PhD defense today! Great talks on functional genomics. All the best for the future!

April 27, 2019

@LugerLab @NatureSMB Really great many congratulations!

April 26, 2019

Our new paper elucidates human splicing kinetics. TT-seq and modeling reveal how splicing rates depend on Pol II elongation and RNA sequences. Great collaboration with Gagneur lab! @eLife @RNASociety @RNApreprints @RNA_seq @gagneurlab @LCaizzi @leonhard

April 10, 2019

Goran Kokic passed his PhD exam. Impressive work on TFIIH in DNA repair. Many congratulations!

April 08, 2019

We report a method to directly sequence newly synthesized, individual mRNA transcripts in human cells. Reveals metabolism of RNA splice variants/isoforms.

April 04, 2019

The new childcare facility at our institute just opened. Many thanks to all who helped!

March 27, 2019

MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation. Thanks to Elmar Wolf for the great collaboration.

March 26, 2019

Fine collaboration with the Anikin lab now resulted in our paper on posttranscriptional gene regulation in mitochondria:

March 26, 2019

Please RT: Cold Spring Harbor Meeting on Mechanisms of Eukaryotic Transcription takes place August 27-31, 2019. Celebrating 50 years of eukaryotic RNA polymerases!

March 26, 2019

Save the date: EMBO | EMBL Symposium: Multiomics to Mechanisms - Challenges in Data Integration, 11-13 September 2019 at Heidelberg.

March 11, 2019

Deadline approaching for applications to become a Group Leader in our Lise Meitner program for young female researchers!

March 05, 2019

We thank Randy Schekman for his outstanding service as first editor-in-chief of eLife and look forward to working with Michael Eisen to support the leading OA journal!

February 27, 2019

@UhlenhautLab Great, congratulations!

February 26, 2019

Congratulations to our friends at @BIMSB_MDC @MDC_Berlin on the opening of their beautiful new building in Berlin by chancellor Merkel today!

February 21, 2019

Save the date: conference on chromatin dynamics in Bad Nauheim near Frankfurt, September 9-11, 2019

February 21, 2019

Many congratulations to our close colleague Herbert Jäckle!

December 27, 2018

Great collaboration with the Heard lab. TT-seq monitors X chromosome gene inactivation. Glad we could contribute to this interesting multiomics temporal analysis. @heard_lab

December 22, 2018

Our structure of the transcribing RNA polymerase II-nucleosome complex is now published and available online

December 18, 2018

NASC-seq monitors gene activity in single cells by detecting new mRNA. Great collaboration with the Sandberg lab. Manuscript:

December 14, 2018

@Beck_Laboratory Great to have you as a colleague! All the best

December 14, 2018

Hosting Asifa Akhtar from @mpi_ie as our Christmas speaker

December 11, 2018

Suyang Zhang arrived from Cambridge @MRC_LMB and obtained an EMBO postdoctoral fellowship, many congratulations!

December 06, 2018

And another Leibnizprize for our colleague Ayelet Shachar at the neighboring Max Planck institute, many congratulations!

December 06, 2018

Many congratulations to our colleague at the institute, Melina Schuh, for being awarded the Leibnizpreis, the highest distinction in Germany!

November 30, 2018

CPF and APT are required to form 3'-ends on coding and non-coding genes, respectively. Our paper resulting from a collaboration with @lapassmore is now online.

November 21, 2018

We mourn the passing of Aaron Klug, a giant of molecular biology, who reported the first structure of tRNA

November 21, 2018

Our new structure suggests that DNA opening during transcription initiation involves promoter DNA distortion and closure of the RNA polymerase II clamp

November 20, 2018

Congratulations to former lab member Alan Cheung on becoming an EMBO Young Investigator!

November 14, 2018

Save September 11-13, 2019, for the EMBO|EMBL symposium on ‚Multiomics to mechanism - challenges in data integration‘

November 08, 2018

Many congratulations to Laleh Haghverdi and Julijana Gjorgjieva for receiving the Engelhorn Research Prize 2018 in Computational Biology!

October 24, 2018

Join us for a symposium in honor of Dirk Eick on November 9 in Munich #transcription #cancer #epigenetics #chromatin

October 16, 2018

Full house also for the discussion with Manuela Lenzen who presented her book on artificial intelligence and machine learning in the beautiful Paulinerkirche @Literaturherbst @thegoecampus @mpi_bpc

October 15, 2018

Hosting Germany‘s top energy economist tonight, Claudia Kemfert. Discussing her latest book on how to switch fast to renewable energy and fight climate change. @CKemfert @Literaturherbst

October 11, 2018

Tom Steitz is well known for the work on ribosomes, but his lab also paved the way to an understanding of RNA polymerases with seminal papers in the 90s on phage enzymes. A real hero of molecular biology who will be sadly missed.

October 08, 2018

Our structure of the Pol II-nucleosome complex reveals a defined nucleosome orientation and provides the starting point for understanding the mechanisms of chromatin transcription:

October 07, 2018

Congratulations to Salma Sohrabi-Jahromi for her poster award at the EMBL conference and thanks to the Söding lab for the collaboration on mapping RNA degradation factors on the transcriptome

September 27, 2018

Our application with the University of Göttingen and the Medical Center UMG for a large national research cluster on Multiscale Bioimaging was funded, thanks to all who helped us!

September 25, 2018

Nucleosome-transcription factor interaction landscape mapped. Thanks to Fangjie Zhu and Jussi Taipale for the great collaboration!

September 21, 2018

Distinct multiprotein complexes form the 3'-ends of protein-coding and non-coding RNAs. Great collaboration with Lori Passmore's lab @lapassmore.

September 15, 2018

We contributed to an enjoyable science slam in the old city, featuring scientists from all five Max Planck institutes in Göttingen

September 13, 2018

Tomorrow we celebrate the foundation of the Max Planck Society in Göttingen 70 years ago. Join us for a sciene slam at the local pub:

September 12, 2018

Save the date for next year‘s Cold Spring Harbor Meeting on Mechanisms of Eukaryotic Transcription, August 27-September 01, 2019

September 06, 2018

Our new review on mitochondrial transcription includes the first molecular movie of the mitochondrial transcription cycle. Publication: Movie:

September 05, 2018

Save the date: GRC conference on mechanisms of microbial transcription takes place July 28 to August 2, 2019 in Maine

September 05, 2018

Investigate the switch from paused to activated transcription complex in 3D! Our new Pol II complex structures and density maps are available for download:

September 02, 2018

@ProfJohnsen Really? When? This is sad for us.

August 31, 2018

Registration for the Structural Dynamics VIB Conference in Bruxelles ends in one week

August 23, 2018

Thanks to our colleague Karen Adelman for summarizing our recent findings on Pol II pausing and release and putting them into context: News and Views:

August 22, 2018

Molecular basis of transcription regulation: our new papers elucidate promoter-proximal RNA polymerase II pausing and elongation activation by human DSIF, NELF, PAF, SPT6.

August 20, 2018

Our paper on RNA polymerase II clustering through CTD phase separation is now online. Thanks to the Zweckstetter and @XDarzacq labs for the great collaboration!

August 15, 2018

Congratulations to our Max Planck colleagues: Global animal tracking from space!

August 15, 2018

@animaltracking @Astro_Alex @AniMove @unikonstanz @maxplanckpress @icouzin @UWICER @MP_Innovation Congratulations on the great Tagesschau Beitrag!!

August 08, 2018

RNA velocity predicts the fate of single cells. Glad we could contribute to an exciting collaboration of the Linnarsson and Kharchenko labs @slinnarsson @KharchenkoLab

August 01, 2018

Many congratulations to Peter Scholze, our new colleage at the Max Planck Institute in Bonn, for obtaining the Fields Medal, the ‚Nobel Prize‘ in Mathematics

July 04, 2018

Council congratulates EMBL Barcelona for getting successfully started!

July 04, 2018

The Klenk Symposium on Epigenetics will take place October 4-6, 2018 in Cologne.

June 24, 2018

The scandinavian #cryoEM symposium will take place in Copenhagen October 8-9, 2018

June 22, 2018

Save May 20-22, 2019 for the DNA damage response mechanisms conference in Madrid

June 14, 2018

'Warp' software by Dmitry Tegunov closes the gap between the electron microscope and 3D density reconstruction. See our manuscript and user guide for automated real-time cryo-EM data pre-processing and particle picking #cryoEM #Warp

June 09, 2018

Vienna RNA biology meeting will take place October 17-19, see

June 07, 2018

Our next seminar series program is out, please save the dates and join.

June 07, 2018

Many congratulations to our colleague at the institute, Jens Frahm, on winning the European Inventor Award! Do not miss their incredible movies made with real time MRI!

June 04, 2018

@benoitbruneau @Gene_Regulation TT-Seq we think

May 25, 2018

Our new review provides a movie of RNA polymerase I transcription that can be used for teaching purposes

May 23, 2018

On the shoulders of giants: celebrating the ‚founding fathers’ of our field, Bob Roeder, Bill Rutter, and Pierre Chambon in Paris on the occasion of the 50th anniversary of the discovery of the eukaryotic RNA polymerases

May 16, 2018

Many congratulations to Melina and our neighbors!

May 16, 2018

@SchuhLab @EMBO Great! Many congratulations!

May 10, 2018

@R_H_Ebright PDB took very long; we sent it to many colleagues by mail

May 09, 2018

Our structures of transcription initiation complexes with TFIIH and Mediator are now available for download:

May 08, 2018

The RNA polymerase II CTD phase separates in vitro and governs polymerase clustering in vivo. Thanks to the Zweckstetter and @XDarzacq laboratories for this collaboration. Read the manuscript at

May 08, 2018

Great student-organized molecular biology meeting at Göttingen in fall

May 01, 2018

We are deeply saddened by the untimely passing of our great colleague Elisa Izaurralde, RNA biochemist at MPI Tübingen.

April 28, 2018

Join us on May 9 at 1 pm for the talk of Kelly Nguyen who just published the marvelous structure of human telomerase #cryoEM #RNA

April 14, 2018

Marching for free and open science!

April 12, 2018

Join the 2nd March for Science in Göttingen on April 14!

April 11, 2018

Patrick Cramer presents Kjeldgaard lecture in Aarhus, Denmark

April 09, 2018

Christian Dienemann passed his PhD exam, many congratulations!

April 03, 2018

Save December 5-7 for this year's epigenetics meeting in Freiburg

March 28, 2018

Congratulations to Hauke Hillen for obtaining this year's PhD Award of the German Society for Biochemistry and Molecular Biology for elucidating mitochondrial transcription!

March 18, 2018

Our new cryo-EM structure shows why the mushroom toxin amanitin binds 3000-times better to mammalian RNA polymerase II than to the yeast enzyme

March 16, 2018

RNA polymerases 50 years on: save May 22 for the symposium in Paris

February 19, 2018

Sandra Schilbach passed her PhD exam, presenting the pre-initiation complex structure, many congratulations!

February 14, 2018

Congratulations to former lab member Clemens Plaschka who will start as a group leader at IMP Vienna soon!

February 06, 2018

@TheVillaLab Many thanks for organizing this interesting meeting!

January 26, 2018

Congratulations to former lab member Christoph Engel on winning the Early Excellence in Science Award of the Bayer Foundation

January 18, 2018

Congratulations to Vannini and Müller labs on the Pol III PIC structures!

January 17, 2018

Our Stockholm team moves into the new building ‘Neo’ at Karolinska Institute

January 16, 2018

Applications for PhD fellowships are invited by our new Max Planck Research School for Genome Science that brings together experimental and computational biologists

January 13, 2018

A good summary of our recent structure of the Chd1 chromatin remodeling factor bound to the nucleosome published in Nature Structural and Molecular Biology by Michaela Smolle

January 03, 2018

Congratulations to Youwei Xu who takes on an Assistant Professor position at Shanghai Tech University

December 29, 2017

Our paper with Jussi Taipale’s lab on the interaction landscape of transcription factors and the nucleosome is available

December 21, 2017

Goodbye to Kayo Nozawa who takes a Research Associate position at Waseda University in Tokyo.

December 19, 2017

Christoph Engel starts his research group at Regensburg University in January 2018, funded by the Emmy-Noether-Programme.

December 18, 2017

Haibo Wang received an EMBO postdoctoral fellowship, congratulations!

December 16, 2017

Xiaoguang Xue received an EMBO long-term fellowship, congratulations!

December 08, 2017

We host Julie Ahringer from Cambridge as our Christmas speaker

December 02, 2017

Good-bye to Carrie Bernecky and all the best to her lab at IST Austria!

November 30, 2017

Congratulations to the Max Delbrück Center in Berlin, it turns 25! #MDC25

November 16, 2017

Cell published our mechanism of transcription initiation in human mitochondria...

November 08, 2017

Our institute hosts Kim Nasmyth for a Bonhoeffer Award Lecture

November 07, 2017

Patrick Cramer gives the Weigle Lecture in Geneva, where early molecular biology was done

November 06, 2017

Congratulations to Lucas Farnung and Hauke Hillen for passing their PhD exams!

November 04, 2017

From now on, updates on our facebook page will be shared on twitter

November 04, 2017

@nature published our milestone structure of a 46-subunit transcription initiation complex with TFIIH and Mediator

November 04, 2017

From now on, our facebook page updates will be shared on twitter.

Lab News Archiv bis 2017



November 8

Our institute hosts Kim Nasmyth for a Bonhoeffer Award Lecture.

November 7

Patrick Cramer gives Weigle Lecture in Geneva, where early molecular biology was done.

November 6

Congratulations to Lucas Farnung and Hauke Hillen for passing their PhD exams!

November 4

From now on, updates will be shared on twitter.

November 1

Nature published our milestone structure of the 46-subunit, ~2 MDa transcription initiation complex with TFIIH and core Mediator. Link to article.

October 31

DNA alkylation stops transcription using a novel mechanism that we discovered in a collaboration with the Sturla lab. Link to article.

October 27

The program for the new Genome Science Lecture Series is out. View program.

October 25

At our 12th lab retreat we hosted seven external speakers in Hamburg and defined our strategy for 2018.

October 22

The Göttingen Max Planck Institutes host another great speaker at the Literature Festival, Patrick Kingsley (New York Times) who describes current migration to Europe.

October 12

Cell published our mechanism of replication-transcription switching in mitochondria that we elucidated in collaboration with the Temiakov laboratory. Link to article.

October 11

Nature published our nucleosome-Chd1 structure that suggests a model for DNA translocation by chromatin remodeling enzymes. Link to article.

October 10

Our new eLife paper shows that polymerase pausing controls transcription initiation. Link to article.

October 4

The Nobel Prize in Chemistry was awarded to Jacques Dubochet, Joachim Frank and Richard Henderson for the development of cryo-electron microscopy, congratulations! Link to press release.

September 29

Göttingen Research Campus advances in national competition for excellence clusters. Link to press release.

September 15

Our institute hosted Jennifer Doudna for a Bonhoeffer Award Lecture on CRISPR systems. Link to press release.

September 13

Congratulations to former lab member Alessandro Vannini who obtained tenure at ICR London! Link to press release.

September 12

Our structure of human DSIF bound to transcribing RNA polymerase II is out. Link to article.

August 23

Congratulations to Carrie Bernecky who obtained an Assistsant Professorship at IST Austria in Vienna! Link to press release.

August 16

Our 'expressome' appears in Miller spreads from 1970. Link to article.

August 2

Our team wins the institute's volleyball tournament.

June 28

Edith Heard selected as next Director-General of EMBL. Link to press release.

June 7

We now located the chromatin transcription factor Paf1 complex on one side of RNA polymerase II:

May 29

Sofia Battaglia, Carina Demel and Tobias Gubbey passed their PhD exams, congratulations and all the best for the future!

May 24

Our new paper uses several 'omics' techniques to reveal a critical role of nascent RNA in coordinating the transcription cycle:

May 12

JMB published our reflection on the history and future of molecular biology on the occasion of John Kendrew's 100th birthday:

May 3

Nature published our 15-subunit core Mediator structure that leads to an extended transcription initiation complex model:

April 26

Christoph Wigge and Dietmar Riedel organized a symposium to inaugurate the new Titan electron microscope. More information

April 25

Our latest review summarizes the current understanding of the conserved Pol II initiation complex structure:

April 22

We support the global March for Science.

April 18

Science published our work on the 'expressome' that visualizes the central dogma of molecular biology:

April 11

New EMBL site in Barcelona opened! More information.

April 3

We are co-organizing the Eukaryotic Transcription Meeting at Cold Spring Harbor this summer and the speaker list is out.

March 23

Cell just published our paper on Pol I initiation that suggests a basis for promoter recognition:

March 18

Our new paper defines the critical transition at the end of genes:

March 9

Our latest paper shows how to map enhancer landscapes with high temporal resolution:

March 6

The new IMPRS for Genome Science goes public:

February 16

Patrick Cramer joins the University of Göttingen as honorary professor.

February 13

Patrick Cramer joins the Editorial Advisory Board of Molecular Systems Biology.

February 1

Our coordinator for the new International Max Planck Research School for Genome Science, Henriette Irmer, started today, welcome!

January 25

Simon Neyer and Youwei Xu passed their PhD exams, congratulations!

January 20

10 years after the Nobel Prize: our general review is out at



December 8

We host Torben Heick-Jensen as our Christmas speaker.

December 8

Congratulations to our close colleagues Jörg Vogel and Karl-Peter Hopfner on being awarded the Leibniz Prize 2017, the most important science prize in Germany!

December 1

Svetlana Dodonova receives an EMBO long-term fellowship, many congratulations!

November 21

We received funding to set up a new International Max Planck Research School for Genome Science.

November 14

Merle Hantsche passes her PhD exam, many congratulations"

November 14

Our collaborative paper with the Frangakis lab is out at Nature:

October 24

Our 11th annual lab retreat in Berlin hosts 7 external speakers.

September 5

Congratulations to Margaux Michel on passing her PhD exam!

August 1

Patrick Cramer receives the Centenary Award of the British Biochemical Society. The award medal will be given at the 80th Harden Conference at Macclesfield, UK.

July 15

Felix Wagner receives Boehringer Ingelheim Fonds PhD Fellowship, congratulations!

June 15

Clemens Plaschka receives the Otto Hahn Medal in Saarbrücken.

Link to press release (in German).

June 3

Our paper on TT-Seq is out in Science, see the press release here.

May 11

Our paper on initiation complex structure (Plaschka, Hantsche et al.) is out at Nature!

May 2

Philipp Eser and Benedikt Zacher receive their PhD, congratulations!

April 15

Our lab will be funded again with an Advanced Investigator Grant of the European Research Council, ERC. We will receive a total of Euro 2.5 Mio during 2016-2021.
Link to Press Release (in German).

February 24

We co-organize a symposium on biological networks in Berlin.          

February 8

Congratulations to former lab member Claus Kuhn who will receive a prestigious award (Paul Ehrlich- und Ludwig Darmstaedter Nachwuchspreis) on March 14 in Frankfurt. The two other awardees are Emmanuelle Charpentier and Jennifer Doudna (Paul Ehrlich- und Ludwig Darmstaedter Preis).

January 20

Our paper on the first mammalian RNA polymerase structure (Carrie Bernecky et al.) is out at Nature.

January 1

Patrick Cramer takes up chair of EMBL council.

January 1

Patrick Cramer joins the Editorial Board of "Cell".



November 25-26

We co-organize workshop on the future of structural biology in Berlin. [more]

November 18

Clemens Plaschka receives prestigous "Kulturpreis Bayern" of the Bayernwerk AG.

November 17

Goran Kokic is awarded a Boehringer Ingelheim PhD Student Fellowship.

November 10

Paulina Seweryn is awarded a Humboldt Research Fellowship.

October 8

We're hosting the KFB lecture by Nick Proudfoot (University of Oxford).

September 30

Jürgen Niesser and David Pöllman receive their PhD, congratulations.

August 31

Patrick Cramer gives Sumner Lecture.

July 21

Wolfgang Mühlbacher receives his PhD, congratulations!

July 1

Anna Sawicka takes on EMBO Postdoctoral Fellowship.

June 1

Katja Fruehauf and Michael Lidschreiber start as first team members at our sattelite lab in Stockholm.

May 22

Christoph Engel receives prestigious ‘Promotionspreis’ of the German Society for Biochemistry and Molecular Biology (GBM).


Together with colleagues at the institute, we secure funding for a new Titan electron microscope with K2 and Falcon-III cameras, to be set up in 2016

March 19

Patrick Cramer receives Arthur Burkhardt Prize. (Click here for more information)

February 5

Our Nature article on the Pol II-Mediator core initiation complex by Clemens Plaschka et al. is published. (Click here to view the article)

January 21

The lab obtained additional funding within the SFB860 research network ‘Integrative Structural Biology of Dynamic Macromolecular Complexes’

January 1

Livia Caizzi takes on EMBO Postdoctoral Fellowship

January 1

Patrick Cramer starts as guest professor at Karolinska Institute in Stockholm:



December 5

Carlo Bäjen receives award for his PhD work by the Dr. Klaus Römer Foundation

November 20

Review on the occasion of the 100th birthday of crystallography published. (Click here to view the article)

October 1

Hauke Hillen takes on Boehringer Ingelheim PhD Student Fellowship.

July 1

Seychelle Vos takes on EMBO Postdoctoral Fellowship.

June 30

The lab obtains additional funding by the Lower Saxonian Ministry for Science and Culture (Niedersächsisches Ministerium für Wissenschaft und Kultur) to extend functional genomics efforts.

April 1

First group members from our Munich lab start at MPIbpc.

January 1

Patrick Cramer starts as director at the Max Planck Institute for Biophysical Chemistry

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