Publikationen
Zeitschriftenartikel (273)
1.
Zeitschriftenartikel
12 (3), e759 (2022)
Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient‐induced pluripotent stem cell‐derived retinal pigment epithelium cells. Clinical and Translational Medicine 2.
Zeitschriftenartikel
374 (6569), S. 883 - 887 (2021)
Structural basis of Integrator-mediated transcription regulation. Science 3.
Zeitschriftenartikel
12, 5715 (2021)
Mapping protein interactions in the active TOM-TIM23 supercomplex. Nature Communications 4.
Zeitschriftenartikel
596 (7871), S. 296 - 300 (2021)
Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature 5.
Zeitschriftenartikel
49 (10), S. 5845 - 5866 (2021)
SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes. Nucleic Acids Research 6.
Zeitschriftenartikel
371 (6526), S. 305 - 309 (2021)
Structure of a transcribing RNA polymerase II–U1 snRNP complex. Science 7.
Zeitschriftenartikel
370 (6523), eabc3753 (2020)
Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science 8.
Zeitschriftenartikel
19 (12), S. 2157 - 2167 (2020)
OpenPepXL: An open-source tool for sensitive identification of cross-linked peptides in XL-MS. Molecular and Cellular Proteomics 9.
Zeitschriftenartikel
13 (654), eaba8208 (2020)
Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S. Science Signaling 10.
Zeitschriftenartikel
80 (1), S. 127 - 139.e6 (2020)
Structural insights into the roles of metazoan-specific splicing factors in the human step 1 spliceosome. Molecular Cell 11.
Zeitschriftenartikel
583 (7815), S. 310 - 313 (2020)
Molecular architecture of the human 17S U2 snRNP. Nature 12.
Zeitschriftenartikel
77 (6), S. 1322 - 1339.e11 (2020)
Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. Molecular Cell 13.
Zeitschriftenartikel
26 (2), S. vii - viii (2020)
Kiyoshi Nagai (1949-2019). RNA 14.
Zeitschriftenartikel
11 (11), a032417 (2019)
Structural insights into nuclear pre-mRNA splicing in higher eukaryotes. Cold Spring Harbor Perspectives in Biology 15.
Zeitschriftenartikel
105 (3), S. 573 - 587 (2019)
Pathogenic abnormal splicing due to intronic deletions that induce biophysical space constraint for spliceosome assembly. American Journal of Human Genetics 16.
Zeitschriftenartikel
10 (1), 3639 (2019)
Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns. Nature Communications 17.
Zeitschriftenartikel
27 (8), S. 1195 - 1210 (2019)
Autoinhibition mechanism of the ubiquitin-conjugating enzyme UBE2S by autoubiquitination. Structure 18.
Zeitschriftenartikel
46 (22), S. 12126 - 12138 (2018)
Multiple RNA-RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome. Nucleic Acids Research 19.
Zeitschriftenartikel
9, 4234 (2018)
Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa. Nature Communications 20.
Zeitschriftenartikel
46 (7), S. 3774 - 3790 (2018)
The Sm-core mediates the retention of partially-assembled spliceosomal snRNPs in Cajal bodies until their full maturation. Nucleic Acids Research 21.
Zeitschriftenartikel
70 (2), S. 265 - 273 (2018)
Structural basis of splicing modulation by antitumor macrolide compounds. Molecular Cell 22.
Zeitschriftenartikel
69 (6), S. 979 - 992 (2018)
Prp19/Pso4 is an autoinhibited ubiquitin ligase activated by stepwise assembly of three splicing factors. Molecular Cell 23.
Zeitschriftenartikel
172 (3), S. 454 - 464, e1-e5 (2018)
Structure and conformational dynamics of the human spliceosomal Bact complex. Cell 24.
Zeitschriftenartikel
23 (12), S. 1770 - 1779 (2017)
Yeast Prp2 liberates the 5' splice site and the branch site adenosine for catalysis of pre-mRNA splicing. RNA 25.
Zeitschriftenartikel
31 (23-24), S. 2416 - 2429 (2017)
The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated Bact complex. Genes and Development 26.
Zeitschriftenartikel
170 (4), S. 701 - 713, e1 - e4 (2017)
Cryo-EM structure of a pre-catalytic human spliceosome primed for activation. Cell 27.
Zeitschriftenartikel
2 (7), 17062 (2017)
Structural basis for λN-dependent processive transcription antitermination. Nature Microbiology 28.
Zeitschriftenartikel
45 (7), S. 4068 - 4080 (2017)
Regulation of Prp43-mediated disassembly of spliceosomes by its cofactors Ntr1 and Ntr2. Nucleic Acids Research 29.
Zeitschriftenartikel
6, e23533 (2017)
Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation. eLife 30.
Zeitschriftenartikel
542 (7641), S. 318 - 323 (2017)
Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 31.
Zeitschriftenartikel
6, e21510 (2017)
Structural insights into the mechanism of the DEAH-box RNA helicase Prp43. eLife 32.
Zeitschriftenartikel
45 (11), S. 6729 - 6745 (2017)
SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing. Nucleic Acids Research 33.
Zeitschriftenartikel
64 (2), S. 307 - 319 (2016)
Molecular architecture of SF3b and structural consequences of its cancer-related mutations. Molecular Cell 34.
Zeitschriftenartikel
353 (6306), S. 1399 - 1405 (2016)
Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 35.
Zeitschriftenartikel
22 (9), S. 1329 - 1337 (2016)
ATPγS stalls splicing after B complex formation but prior to spliceosome activation. RNA 36.
Zeitschriftenartikel
22 (9), S. 1427 - 1440 (2016)
A protein map of the yeast activated spliceosome as obtained by electron microscopy. RNA 37.
Zeitschriftenartikel
6, 31393 (2016)
U6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III. Scientific Reports 38.
Zeitschriftenartikel
7, 11997 (2016)
A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity. Nature Communications 39.
Zeitschriftenartikel
5, e15564 (2016)
The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction. eLife 40.
Zeitschriftenartikel
351 (6280), S. 1416 - 1420 (2016)
Molecular architecture of the human U4/U6.U5 tri-snRNP. Science 41.
Zeitschriftenartikel
13 (3), S. 320 - 330 (2016)
Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways. RNA Biology 42.
Zeitschriftenartikel
22 (2), S. 265 - 277 (2016)
Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome. RNA 43.
Zeitschriftenartikel
72 (2), S. 112 - 120 (2016)
Structural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryote Chaetomium thermophilum. Acta Crystallographica Section F 44.
Zeitschriftenartikel
59 (22), S. 10190 - 10197 (2016)
Rational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing. Journal of Medicinal Chemistry 45.
Zeitschriftenartikel
29 (24), S. 2576 - 2587 (2015)
The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Genes and Development 46.
Zeitschriftenartikel
34 (24), S. 3059 - 3073 (2015)
Protein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex. EMBO Journal 47.
Zeitschriftenartikel
11 (9), e1005539 (2015)
Dynamic contacts of U2, RES, Cwc25, Prp8 and Prp45 proteins with the Pre-mRNA branch-site and 3' splice site during catalytic activation and step 1 catalysis in yeast spliceosomes. PLoS Genetics 48.
Zeitschriftenartikel
21 (11), S. 1993 - 2005 (2015)
Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5‘ splice site. RNA 49.
Zeitschriftenartikel
125 (9), S. 3572 - 3584 (2015)
HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models. Journal of Clinical Investigation 50.
Zeitschriftenartikel
162 (3), S. 690 - 690.e1 (2015)
Snapshot: Spliceosome dynamics III. Cell 51.
Zeitschriftenartikel
162 (2), S. 456 - 456.e1 (2015)
SnapShot: Spliceosome dynamics II. Cell 52.
Zeitschriftenartikel
4, e07320 (2015)
A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing. eLife 53.
Zeitschriftenartikel
161 (6), S. 1474 - 1474.e1 (2015)
SnapShot: Spliceosome dynamics I. Cell 54.
Zeitschriftenartikel
22 (2), S. 138 - 144 (2015)
The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes. Nature Structural and Molecular Biology 55.
Zeitschriftenartikel
29 (1), S. 94 - 107 (2015)
The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome. Genes and Development 56.
Zeitschriftenartikel
289 (50), S. 34683 - 34698 (2014)
Identification of small molecule inhibitors of pre-mRNA splicing. The Journal of Biological Chemistry 57.
Zeitschriftenartikel
111 (44), S. 15622 - 15629 (2014)
Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells. Proceedings of the National Academy of Sciences of the United States of America 58.
Zeitschriftenartikel
11 (10), S. 1064 - 1070 (2014)
Photo-cross-linking and high-resolution mass spectrometry for assignment of RNA-binding sites in RNA-binding proteins. Nature Methods 59.
Zeitschriftenartikel
21 (10), S. 911 - 918 (2014)
Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex. Nature Structural and Molecular Biology 60.
Zeitschriftenartikel
70 (6), S. 1622 - 1630 (2014)
Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28. Acta Crystallographica D 61.
Zeitschriftenartikel
11 (4), S. 298 - 312 (2014)
Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans. RNA Biology 62.
Zeitschriftenartikel
20 (3), S. 406 - 420 (2014)
Mass spectrometry–based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count. RNA 63.
Zeitschriftenartikel
21 (12), S. 2162 - 2174 (2013)
Phosphorylation drives a dynamic switch in serine/arginine-rich proteins. Structure 64.
Zeitschriftenartikel
32 (21), S. 2804 - 2818 (2013)
RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core. EMBO Journal 65.
Zeitschriftenartikel
8 (9), e74851 (2013)
The Prp19 complex directly functions in mitotic spindle assembly. PLoS One 66.
Zeitschriftenartikel
341 (6141), S. 80 - 84 (2013)
Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8. Science 67.
Zeitschriftenartikel
19 (7), S. 902 - 915 (2013)
Molecular dissection of step 2 catalysis of yeast pre-mRNA splicing investigated in a purified system. RNA 68.
Zeitschriftenartikel
27 (5), S. 525 - 540 (2013)
Structural basis for dual roles of Aar2p in U5 snRNP assembly. Genes and Development 69.
Zeitschriftenartikel
27 (4), S. 413 - 428 (2013)
Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system. Genes and Development 70.
Zeitschriftenartikel
26 (23), S. 2422 - 2434 (2012)
The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes and Development 71.
Zeitschriftenartikel
9 (11), S. 1311 - 1318 (2012)
Emerging views about the molecular structure of the spliceosomal catalytic center. RNA Biology 72.
Zeitschriftenartikel
109 (43), S. 17418 - 17423 (2012)
Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome. Proceedings of the National Academy of Sciences of the United States of America 73.
Zeitschriftenartikel
18 (9), S. 1605 - 1611 (2012)
Molecular architecture of Zinc chelating small molecules that inhibit spliceosome assembly at an early stage. RNA 74.
Zeitschriftenartikel
18 (9), S. 1656 - 1665 (2012)
Box H/ACA snoRNAs are preferred substrates for the trimethylguanosine synthase in the divergent unicellular eukaryote Trichomonas vaginalis. RNA 75.
Zeitschriftenartikel
3, 994 (2012)
Retention of posttranscriptional spliceosomes in nuclear speckles until splicing completion. Nature communications 76.
Zeitschriftenartikel
18 (7), S. 1347 - 1357 (2012)
Antisense-targeted immuno-EM localization of the pre-mRNA path in the spliceosomal C complex. RNA 77.
Zeitschriftenartikel
31 (6), S. 1591 - 1604 (2012)
Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. EMBO Journal 78.
Zeitschriftenartikel
13 (5), S. 640 - 644 (2012)
Psoromic acid derivatives: A new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay. ChemBioChem 79.
Zeitschriftenartikel
45 (4), S. 567 - 580 (2012)
Dynamic protein-protein interaction wiring of the human spliceosome. Molecular Cell 80.
Zeitschriftenartikel
18 (6), S. 1244 - 1256 (2012)
Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS. RNA 81.
Zeitschriftenartikel
31 (9), S. 2222 - 2234 (2012)
Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein. EMBO Journal 82.
Zeitschriftenartikel
17 (9), S. 1655 - 1663 (2011)
Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31. RNA 83.
Zeitschriftenartikel
31 (13), S. 2667 - 2682 (2011)
Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method. Molecular and Cellular Biology 84.
Zeitschriftenartikel
286 (12), S. 10126 - 10136 (2011)
Synthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNA. Journal of Biological Chemistry 85.
Zeitschriftenartikel
331 (6018), S. 760 - 764 (2011)
HSPC117 is the essential subunit of a human tRNA splicing ligase complex. Science 86.
Zeitschriftenartikel
40 (6), S. 927 - 938 (2010)
3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core. Molecular Cell 87.
Zeitschriftenartikel
16 (12), S. 2384 - 2403 (2010)
Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis. RNA 88.
Zeitschriftenartikel
18 (6), S. 667 - 676 (2010)
An approach for de novo structure determination of dynamic molecular assemblies by electron cryomicroscopy. Structure 89.
Zeitschriftenartikel
30 (9), S. 2105 - 2119 (2010)
Molecular architecture of the human Prp19/CDC5L complex. Molecular and Cellular Biology 90.
Zeitschriftenartikel
38 (16), S. 5581 - 5593 (2010)
Mapping the binding site of snurportin 1 on native U1 snRNP by cross-linking and mass spectrometry. Nucleic Acids Research 91.
Zeitschriftenartikel
38 (2), S. 223 - 235 (2010)
Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes. Molecular Cell 92.
Zeitschriftenartikel
5, e10013 (2010)
The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. PLoS ONE 93.
Zeitschriftenartikel
17 (4), S. 403 - 409 (2010)
Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis. Nature Structural and Molecular Biology 94.
Zeitschriftenartikel
37 (6), S. 821 - 833 (2010)
An ancient mechanism for splicing control: U11 snRNP as an activator of alternative splicing. Molecular Cell 95.
Zeitschriftenartikel
17 (2), S. 216 - 222 (2010)
Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation. Nature Structural and Molecular Biology 96.
Zeitschriftenartikel
29, S. 749 - 760 (2010)
The intronic splicing code: Multiple factors involved in ATM pseudoexon definition. The EMBO Journal 97.
Zeitschriftenartikel
82 (7), S. 2784 - 2796 (2010)
Determination of protein stoichiometry within protein complexes using absolute quantification and multiple reaction monitoring. Analytical Chemistry 98.
Zeitschriftenartikel
29, S. 4172 - 4184 (2010)
Functional organization of the Sm core in the crystal structure of human U1 snRNP. EMBO Journal 99.
Zeitschriftenartikel
16 (12), S. 1237 - 1243 (2009)
Reconstitution of both steps of S. cerevisiae splicing with purified spliceosomal components. Nature Structural and Molecular Biology