Publikationen

Zeitschriftenartikel (281)

1.
Zeitschriftenartikel
Zhang, Z.; Kumar, V.; Dybkov, O.; Will, C. L.; Zhong, J.; Ludwig, S. E. J.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Structural insights into the cross-exon to cross-intron spliceosome switch. Nature (2024)
2.
Zeitschriftenartikel
Atkinson, R.; Georgiou, M.; Yang, C.; Szymanska, K.; Lahat, A.; Vasconcelos, E.J.R.; Ji, Y.; Moya Molina, M.; Collin, J.; Queen, R. et al.; Dorgau, B.; Watson, A.; Kurzawa-Akanbi, M.; Laws, R.; Saxena, A.; Shyan Beh, C.; Siachisumo, C.; Goertler, F.; Karwatka, M.; Davey, T.; Inglehearn, C.F.; McKibbin, M.; Lührmann, R.; Steel, D.H.; Elliott, D.J.; Armstrong, L.; Urlaub, H.; Ali, R.R.; Grellscheid, S.-N.; Johnson, C.A.; Mozaffari-Jovin, S.; Lako, M.: PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects. Nature Communications 15, 3138 (2024)
3.
Zeitschriftenartikel
Zhang, Z.; Kumar, V.; Dybkov, O.; Will, C. L.; Urlaub, H.; Stark, H.; Lührmann, R.: Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins. The EMBO Journal 43, S. 1065 - 1088 (2024)
4.
Zeitschriftenartikel
Kafian, H.; Mozaffari-Jovin, S.; Bagheri, M.; Shaegh, S. A. M.: Light-sheet fluorescent microscopy: fundamentals, developments and applications. Physica Scripta 98 (8), 082001 (2023)
5.
Zeitschriftenartikel
Thompson, H.L.; Shen, W.; Matus, R.; Kakkar, M.; Jones, C.; Dolan, D.; Grellscheid, S.; Yang, X.; Zhang, N.; Mozaffari-Jovin, S. et al.; Chen, C.; Zhang, X.; Topping, J.F.; Lindsey, K.: MERISTEM-DEFECTIVE regulates the balance between stemness and differentiation in the root meristem through RNA splicing control. Development 150 (7), dev201476 (2023)
6.
Zeitschriftenartikel
Dybkov, O.; Preußner, M.; El Ayoubi, L.; Feng, V.-Y.; Harnisch, C.; Merz, K.; Leupold, P.; Yudichev, P.; Agafonov, D. E.; Will, C. L. et al.; Girard, C.; Dienemann, C.; Urlaub, H.; Kastner, B.; Heyd, F.; Lührmann, R.: Regulation of 3′ splice site selection after step 1 of splicing by spliceosomal C* proteins. Science Advances 9 (9), eadf178 (2023)
7.
Zeitschriftenartikel
Georgiou, M.; Atkinson, R.; Mozaffari-Jovin, S.; Lako, M.: Progressive accumulation of cytoplasmic aggregates in PRPF31 retinal pigment epithelium cells interferes with cell survival. Clinical and Translational Discovery 2 (4), e89 (2022)
8.
Zeitschriftenartikel
Georgiou, M.; Yang, C.; Atkinson, R.; Pan, K.‐.; Buskin, A.; Molina, M. M.; Collin, J.; Al‐Aama, J.; Goertler, F.; Ludwig, S. E. J. et al.; Davey, T.; Lührmann, R.; Nagaraja‐Grellscheid, S.; Johnson, C. A.; Ali, R.; Armstrong, L.; Korolchuk, V.; Urlaub, H.; Mozaffari‐Jovin, S.; Lako, M.: Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient‐induced pluripotent stem cell‐derived retinal pigment epithelium cells. Clinical and Translational Medicine 12 (3), e759 (2022)
9.
Zeitschriftenartikel
Fianu, I.; Chen, Y.; Dienemann, C.; Dybkov, O.; Linden, A.; Urlaub, H.; Cramer, P.: Structural basis of Integrator-mediated transcription regulation. Science 374 (6569), S. 883 - 887 (2021)
10.
Zeitschriftenartikel
Gomkale, R.; Linden, A.; Neumann, P.; Schendzielorz, A. B.; Stoldt, S.; Dybkov, O.; Kilisch, M.; Schulz, C.; Cruz-Zaragoza, L. D.; Schwappach, B. et al.; Ficner, R.; Jakobs, S.; Urlaub, H.; Rehling, P.: Mapping protein interactions in the active TOM-TIM23 supercomplex. Nature Communications 12, 5715 (2021)
11.
Zeitschriftenartikel
Zhang, Z.; Rigo, N.; Dybkov, O.; Fourmann, J. B.; Will, C. L.; Kumar, V.; Urlaub, H.; Stark, H.; Lührmann, R.: Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature 596 (7871), S. 296 - 300 (2021)
12.
Zeitschriftenartikel
Yildirim, A.; Mozaffari-Jovin, S.; Wallisch, A. K.; Schäfer, J.; Ludwig, S. E. J.; Urlaub, H.; Lührmann, R.; Wolfrum, U.: SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes. Nucleic Acids Research 49 (10), S. 5845 - 5866 (2021)
13.
Zeitschriftenartikel
Zhang, S.; Aibara, S.; Vos, S. M.; Agafonov, D.; Lührmann, R.; Cramer, P.: Structure of a transcribing RNA polymerase II–U1 snRNP complex. Science 371 (6526), S. 305 - 309 (2021)
14.
Zeitschriftenartikel
Townsend, C.; Leelaram, M. N.; Agafonov, D. E.; Dybkov, O.; Will, C. L.; Bertram, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science 370 (6523), eabc3753 (2020)
15.
Zeitschriftenartikel
Netz, E.; Dijkstra, T. M. H.; Sachsenberg, T.; Zimmermann, L.; Walzer, M.; Monecke, T.; Ficner, R.; Dybkov, O.; Urlaub, H.; Kohlbacher, O.: OpenPepXL: An open-source tool for sensitive identification of cross-linked peptides in XL-MS. Molecular and Cellular Proteomics 19 (12), S. 2157 - 2167 (2020)
16.
Zeitschriftenartikel
Liess, A. K. L.; Kucerova, A.; Schweimer, K.; Schlesinger, D.; Dybkov, O.; Urlaub, H.; Mansfeld, J.; Lorenz, S.: Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S. Science Signaling 13 (654), eaba8208 (2020)
17.
Zeitschriftenartikel
Bertram, K.; El Ayoubi, L.; Dybkov, O.; Agafonov, D.; Will, C. L.; Hartmuth, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Structural insights into the roles of metazoan-specific splicing factors in the human step 1 spliceosome. Molecular Cell 80 (1), S. 127 - 139.e6 (2020)
18.
Zeitschriftenartikel
Zhang, Z.; Will, C. L.; Bertram, K.; Dybkov, O.; Hartmuth, K.; Agafonov, D. E.; Hofele, R. V.; Urlaub, H.; Kastner, B.; Lührmann, R. et al.; Stark, H.: Molecular architecture of the human 17S U2 snRNP. Nature 583 (7815), S. 310 - 313 (2020)
19.
Zeitschriftenartikel
Cossa, G.; Roeschert, I.; Prinz, F.; Baluapuri, A.; Silveira Vidal, R.; Schülein-Völk, C.; Chang, Y. C.; Ade, C. P.; Mastrobuoni, G.; Girard, C. et al.; Wortmann, L.; Walz, S.; Lührmann, R.; Kempa, S.; Kuster, B.; Wolf, E.; Mumberg, D.; Eilers, M.; Eilers, M.: Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. Molecular Cell 77 (6), S. 1322 - 1339.e11 (2020)
20.
Zeitschriftenartikel
Lührmann, R.: Kiyoshi Nagai (1949-2019). RNA 26 (2), S. vii - viii (2020)
21.
Zeitschriftenartikel
Kastner, B.; Will, C. L.; Stark, H.; Lührmann, R.: Structural insights into nuclear pre-mRNA splicing in higher eukaryotes. Cold Spring Harbor Perspectives in Biology 11 (11), a032417 (2019)
22.
Zeitschriftenartikel
Bryen, S. J.; Joshi, H.; Evesson, F. J.; Girard, C.; Ghaoui, R.; Waddell, L. B.; Testa, A. C.; Cummings, B.; Arbuckle, S.; Graf, N. et al.; Webster, R.; MacArthur, D. G.; Laing, N. G.; MR, D.; Lührmann, R.; Cooper, S. T.: Pathogenic abnormal splicing due to intronic deletions that induce biophysical space constraint for spliceosome assembly. American Journal of Human Genetics 105 (3), S. 573 - 587 (2019)
23.
Zeitschriftenartikel
Keiper, S. M.; Papasaikas, P.; Will, C. L.; Valcárcel, J.; Girard, C.; Lührmann, R.: Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns. Nature Communications 10 (1), 3639 (2019)
24.
Zeitschriftenartikel
Liess, A. K. L.; Kucerova, A.; Schweimer, K.; Yu, L.; Roumeliotis, T. I.; Diebold, M.; Dybkov, O.; Sotriffer, C.; Urlaub, H.; Choudhary, J. S. et al.; Mansfeld, J.; Lorenz, S.: Autoinhibition mechanism of the ubiquitin-conjugating enzyme UBE2S by autoubiquitination. Structure 27 (8), S. 1195 - 1210 (2019)
25.
Zeitschriftenartikel
Bao, P.; Boon, K. L.; Will, C. L.; Hartmuth, K.; Lührmann, R.: Multiple RNA-RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome. Nucleic Acids Research 46 (22), S. 12126 - 12138 (2018)
26.
Zeitschriftenartikel
Buskin, A.; Zhu, L.; Chichagova, V.; Basu, B.; Mozafarri Jovin, S.; Dolan, D.; Droop, A.; Collin, J.; Bronstein, R.; Mehrotra, S. et al.; Farkas, M.; Hilgen, G.; White, K.; Pan, K. T.; Treumann, A.; Hallam, D.; Bialas, K.; Chung, G.; Mellough, C.; Ding, Y.; Krasnogor, N.; Przyborski, S.; Zwolinski, S.; Al-Aama, J.; Alharthi, S.; Xu, Y.; Wheway, G.; Szymanska, K.; McKibbin, M.; Inglehearn, C. F.; Elliott, D. J.; Lindsay, S.; Ali, R. R.; Steel, D. H.; Armstrong, L.; Sernagor, E.; Urlaub, H.; Pierce, E.; Lührmann, R.; Grellscheid, S. N.; Johnson, C. A.; Lako, M.: Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa. Nature Communications 9, 4234 (2018)
27.
Zeitschriftenartikel
Roithová, A.; Klimešová, K.; Pánek, J.; Will, C. L.; Lührmann, R.; Stanek, D.; Girard, C.: The Sm-core mediates the retention of partially-assembled spliceosomal snRNPs in Cajal bodies until their full maturation. Nucleic Acids Research 46 (7), S. 3774 - 3790 (2018)
28.
Zeitschriftenartikel
Cretu, C.; Agrawal, A. A.; Cook, A.; Will, C. L.; Fekkes, P.; Smith, P. G.,.; Lührmann, R.; Larsen, N.; Buonamici, S.; Pena, V.: Structural basis of splicing modulation by antitumor macrolide compounds. Molecular Cell 70 (2), S. 265 - 273 (2018)
29.
Zeitschriftenartikel
Rocha de Moura, T.; Mozaffari-Jovin, S.; Szabo, C. Z. K.; Schmitzova, J.; Dybkov, O.; Cretu, C.; Kachala, M.; Svergun, D.; Urlaub, H.; Lührmann, R. et al.; Pena, V.: Prp19/Pso4 is an autoinhibited ubiquitin ligase activated by stepwise assembly of three splicing factors. Molecular Cell 69 (6), S. 979 - 992 (2018)
30.
Zeitschriftenartikel
Haselbach, D.; Komarov, I.; Agafonov, D. E.; Hartmuth, K.; Graf, B.; Dybkov, O.; Urlaub, H.; Kastner, B.; Lührmann, R.; Stark, H.: Structure and conformational dynamics of the human spliceosomal Bact complex. Cell 172 (3), S. 454 - 464, e1-e5 (2018)
31.
Zeitschriftenartikel
Bao, P.; Höbartner, C.; Hartmuth, K.; Lührmann, R.: Yeast Prp2 liberates the 5' splice site and the branch site adenosine for catalysis of pre-mRNA splicing. RNA 23 (12), S. 1770 - 1779 (2017)
32.
Zeitschriftenartikel
Bao, P.; Will, C. L.; Urlaub, H.; Boon, K. L.; Lührmann, R.: The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated Bact complex. Genes and Development 31 (23-24), S. 2416 - 2429 (2017)
33.
Zeitschriftenartikel
Bertram, K.; Agafonov, D. E.; Dybkov, O.; Haselbach, D.; Leelaram, M. N.; Will, C. L.; Urlaub, H.; Kastner, B.; Lührmann, R.; Stark, H.: Cryo-EM structure of a pre-catalytic human spliceosome primed for activation. Cell 170 (4), S. 701 - 713, e1 - e4 (2017)
34.
Zeitschriftenartikel
Said, N.; Krupp, F.; Anedchenko, E.; Santos, K. F.; Dybkov, O.; Huang, Y. H.; Lee, C. T.; Loll, B.; Behrmann, E.; Bürger, J. et al.; Mielke, T.; Loerke, J.; Urlaub, H.; Spahn, C. M. T.; Weber, G.; Wahl, M. C.: Structural basis for λN-dependent processive transcription antitermination. Nature Microbiology 2 (7), 17062 (2017)
35.
Zeitschriftenartikel
Fourmann, J. B.; Tauchert, M. J.; Ficner, R.; Fabrizio, P.; Lührmann, R.: Regulation of Prp43-mediated disassembly of spliceosomes by its cofactors Ntr1 and Ntr2. Nucleic Acids Research 45 (7), S. 4068 - 4080 (2017)
36.
Zeitschriftenartikel
Sidarovich, A.; Will, C. L.; Anokhina, M. M.; Ceballos, J.; Sievers, S.; Agafonov, D. E.; Samatov, T.; Bao, P.; Kastner, B.; Urlaub, H. et al.; Waldmann, H.; Lührmann, R.: Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation. eLife 6, e23533 (2017)
37.
Zeitschriftenartikel
Bertram, K.; Agafonov, D. E.; Liu, W.; Dybkov, O.; Will, C. L.; Hartmuth, K.; Urlaub, H.; Kastner, B.; Stark, H.; Lührmann, R.: Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 542 (7641), S. 318 - 323 (2017)
38.
Zeitschriftenartikel
Tauchert, M. J.; Fourmann, J. B.; Lührmann, R.; Ficner, R.: Structural insights into the mechanism of the DEAH-box RNA helicase Prp43. eLife 6, e21510 (2017)
39.
Zeitschriftenartikel
Pozzi, B.; Bragado, L.; Will, C. L.; Mammi, P.; Risso, G.; Urlaub, H.; Lührmann, R.; Srebrow, A.: SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing. Nucleic Acids Research 45 (11), S. 6729 - 6745 (2017)
40.
Zeitschriftenartikel
Cretu, C.; Schmitzova, J.; Ponce-Salvatierra, A.; Dybkov, O.; De Laurentiis, E.; Sharma, K.; Will, C. L.; Urlaub, H.; Lührmann, R.; Pena, V.: Molecular architecture of SF3b and structural consequences of its cancer-related mutations. Molecular Cell 64 (2), S. 307 - 319 (2016)
41.
Zeitschriftenartikel
Rauhut, R.; Fabrizio, P.; Dybkov, O.; Hartmuth, K.; Pena, V.; Chari, A.; Kumar, V.; Lee, C. T.; Urlaub, H.; Kastner, B. et al.; Stark, H.; Lührmann, R.: Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 353 (6306), S. 1399 - 1405 (2016)
42.
Zeitschriftenartikel
Agafonov, D. E.; van Santen, M.; Kastner, B.; Dube, P.; Will, C. L.; Urlaub, H.; Lührmann, R.: ATPγS stalls splicing after B complex formation but prior to spliceosome activation. RNA 22 (9), S. 1329 - 1337 (2016)
43.
Zeitschriftenartikel
Sun, C.; Rigo, N.; Fabrizio, P.; Kastner, B.; Lührmann, R.: A protein map of the yeast activated spliceosome as obtained by electron microscopy. RNA 22 (9), S. 1427 - 1440 (2016)
44.
Zeitschriftenartikel
Singh, J.; Sikand, K.; Conrad, H.; Will, C. L.; Komar, A. A.; Shukla, G. C.: U6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III. Scientific Reports 6, 31393 (2016)
45.
Zeitschriftenartikel
Boesler, C.; Rigo, N.; Anokhina, M. M.; Tauchert, M. J.; Agafonov, D. E.; Kastner, B.; Urlaub, H.; Ficner, R.; Will, C. L.; Lührmann, R.: A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity. Nature Communications 7, 11997 (2016)
46.
Zeitschriftenartikel
Fourmann, J. B.; Dybkov, O.; Agafonov, D. E.; Tauchert, M. J.; Urlaub, H.; Ficner, R.; Fabrizio, P.; Lührmann, R.: The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction. eLife 5, e15564 (2016)
47.
Zeitschriftenartikel
Agafonov, D. E.; Kastner, B.; Dybkov, O.; Hofele, R. V.; Liu, W.; Urlaub, H.; Lührmann, R.; Stark, H.: Molecular architecture of the human U4/U6.U5 tri-snRNP. Science 351 (6280), S. 1416 - 1420 (2016)
48.
Zeitschriftenartikel
Heininger, A. U.; Hackert, P.; Andreou, A. Z.; Boon, K. L.; Memet, I.; Prior, M.; Clancy, A.; Schmidt, B.; Urlaub, H.; Schleiff, E. et al.; Sloan, K. E.; Deckers, M.; Lührmann, R.; Enderlein, J.; Klostermeier, D.; Rehling, P.; Bohnsack, M. T.: Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways. RNA Biology 13 (3), S. 320 - 330 (2016)
49.
Zeitschriftenartikel
Schütze, T.; Ulrich, A. K. C.; Apelt, L.; Will, C. L.; Bartlick, N.; Seeger, M.; Weber, G.; Lührmann, R.; Stelzl, U.; Wahl, M. C.: Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome. RNA 22 (2), S. 265 - 277 (2016)
50.
Zeitschriftenartikel
Tauchert, M. J.; Fourmann, J. B.; Christian, H.; Lührmann, R.; Ficner, R.: Structural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryote Chaetomium thermophilum. Acta Crystallographica Section F 72 (2), S. 112 - 120 (2016)
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