Publikationen
Zeitschriftenartikel (273)
1.
Zeitschriftenartikel
Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient‐induced pluripotent stem cell‐derived retinal pigment epithelium cells. Clinical and Translational Medicine 12 (3), e759 (2022)
2.
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Structural basis of Integrator-mediated transcription regulation. Science 374 (6569), S. 883 - 887 (2021)
3.
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Mapping protein interactions in the active TOM-TIM23 supercomplex. Nature Communications 12, 5715 (2021)
4.
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Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature 596 (7871), S. 296 - 300 (2021)
5.
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SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes. Nucleic Acids Research 49 (10), S. 5845 - 5866 (2021)
6.
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Structure of a transcribing RNA polymerase II–U1 snRNP complex. Science 371 (6526), S. 305 - 309 (2021)
7.
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Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science 370 (6523), eabc3753 (2020)
8.
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OpenPepXL: An open-source tool for sensitive identification of cross-linked peptides in XL-MS. Molecular and Cellular Proteomics 19 (12), S. 2157 - 2167 (2020)
9.
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Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S. Science Signaling 13 (654), eaba8208 (2020)
10.
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Structural insights into the roles of metazoan-specific splicing factors in the human step 1 spliceosome. Molecular Cell 80 (1), S. 127 - 139.e6 (2020)
11.
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Molecular architecture of the human 17S U2 snRNP. Nature 583 (7815), S. 310 - 313 (2020)
12.
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Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. Molecular Cell 77 (6), S. 1322 - 1339.e11 (2020)
13.
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Kiyoshi Nagai (1949-2019). RNA 26 (2), S. vii - viii (2020)
14.
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Structural insights into nuclear pre-mRNA splicing in higher eukaryotes. Cold Spring Harbor Perspectives in Biology 11 (11), a032417 (2019)
15.
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Pathogenic abnormal splicing due to intronic deletions that induce biophysical space constraint for spliceosome assembly. American Journal of Human Genetics 105 (3), S. 573 - 587 (2019)
16.
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Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns. Nature Communications 10 (1), 3639 (2019)
17.
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Autoinhibition mechanism of the ubiquitin-conjugating enzyme UBE2S by autoubiquitination. Structure 27 (8), S. 1195 - 1210 (2019)
18.
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Multiple RNA-RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome. Nucleic Acids Research 46 (22), S. 12126 - 12138 (2018)
19.
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Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa. Nature Communications 9, 4234 (2018)
20.
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The Sm-core mediates the retention of partially-assembled spliceosomal snRNPs in Cajal bodies until their full maturation. Nucleic Acids Research 46 (7), S. 3774 - 3790 (2018)
21.
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Structural basis of splicing modulation by antitumor macrolide compounds. Molecular Cell 70 (2), S. 265 - 273 (2018)
22.
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Prp19/Pso4 is an autoinhibited ubiquitin ligase activated by stepwise assembly of three splicing factors. Molecular Cell 69 (6), S. 979 - 992 (2018)
23.
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Structure and conformational dynamics of the human spliceosomal Bact complex. Cell 172 (3), S. 454 - 464, e1-e5 (2018)
24.
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Yeast Prp2 liberates the 5' splice site and the branch site adenosine for catalysis of pre-mRNA splicing. RNA 23 (12), S. 1770 - 1779 (2017)
25.
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The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated Bact complex. Genes and Development 31 (23-24), S. 2416 - 2429 (2017)
26.
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Cryo-EM structure of a pre-catalytic human spliceosome primed for activation. Cell 170 (4), S. 701 - 713, e1 - e4 (2017)
27.
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Structural basis for λN-dependent processive transcription antitermination. Nature Microbiology 2 (7), 17062 (2017)
28.
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Regulation of Prp43-mediated disassembly of spliceosomes by its cofactors Ntr1 and Ntr2. Nucleic Acids Research 45 (7), S. 4068 - 4080 (2017)
29.
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Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation. eLife 6, e23533 (2017)
30.
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Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 542 (7641), S. 318 - 323 (2017)
31.
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Structural insights into the mechanism of the DEAH-box RNA helicase Prp43. eLife 6, e21510 (2017)
32.
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SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing. Nucleic Acids Research 45 (11), S. 6729 - 6745 (2017)
33.
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Molecular architecture of SF3b and structural consequences of its cancer-related mutations. Molecular Cell 64 (2), S. 307 - 319 (2016)
34.
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Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science 353 (6306), S. 1399 - 1405 (2016)
35.
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ATPγS stalls splicing after B complex formation but prior to spliceosome activation. RNA 22 (9), S. 1329 - 1337 (2016)
36.
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A protein map of the yeast activated spliceosome as obtained by electron microscopy. RNA 22 (9), S. 1427 - 1440 (2016)
37.
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U6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III. Scientific Reports 6, 31393 (2016)
38.
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A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity. Nature Communications 7, 11997 (2016)
39.
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The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction. eLife 5, e15564 (2016)
40.
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Molecular architecture of the human U4/U6.U5 tri-snRNP. Science 351 (6280), S. 1416 - 1420 (2016)
41.
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Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways. RNA Biology 13 (3), S. 320 - 330 (2016)
42.
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Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome. RNA 22 (2), S. 265 - 277 (2016)
43.
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Structural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryote Chaetomium thermophilum. Acta Crystallographica Section F 72 (2), S. 112 - 120 (2016)
44.
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Rational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing. Journal of Medicinal Chemistry 59 (22), S. 10190 - 10197 (2016)
45.
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The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Genes and Development 29 (24), S. 2576 - 2587 (2015)
46.
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Protein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex. EMBO Journal 34 (24), S. 3059 - 3073 (2015)
47.
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Dynamic contacts of U2, RES, Cwc25, Prp8 and Prp45 proteins with the Pre-mRNA branch-site and 3' splice site during catalytic activation and step 1 catalysis in yeast spliceosomes. PLoS Genetics 11 (9), e1005539 (2015)
48.
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Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5‘ splice site. RNA 21 (11), S. 1993 - 2005 (2015)
49.
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HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models. Journal of Clinical Investigation 125 (9), S. 3572 - 3584 (2015)
50.
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Snapshot: Spliceosome dynamics III. Cell 162 (3), S. 690 - 690.e1 (2015)
51.
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SnapShot: Spliceosome dynamics II. Cell 162 (2), S. 456 - 456.e1 (2015)
52.
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A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing. eLife 4, e07320 (2015)
53.
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SnapShot: Spliceosome dynamics I. Cell 161 (6), S. 1474 - 1474.e1 (2015)
54.
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The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes. Nature Structural and Molecular Biology 22 (2), S. 138 - 144 (2015)
55.
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The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome. Genes and Development 29 (1), S. 94 - 107 (2015)
56.
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Identification of small molecule inhibitors of pre-mRNA splicing. The Journal of Biological Chemistry 289 (50), S. 34683 - 34698 (2014)
57.
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Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells. Proceedings of the National Academy of Sciences of the United States of America 111 (44), S. 15622 - 15629 (2014)
58.
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Photo-cross-linking and high-resolution mass spectrometry for assignment of RNA-binding sites in RNA-binding proteins. Nature Methods 11 (10), S. 1064 - 1070 (2014)
59.
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Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex. Nature Structural and Molecular Biology 21 (10), S. 911 - 918 (2014)
60.
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Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28. Acta Crystallographica D 70 (6), S. 1622 - 1630 (2014)
61.
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Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans. RNA Biology 11 (4), S. 298 - 312 (2014)
62.
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Mass spectrometry–based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count. RNA 20 (3), S. 406 - 420 (2014)
63.
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Phosphorylation drives a dynamic switch in serine/arginine-rich proteins. Structure 21 (12), S. 2162 - 2174 (2013)
64.
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RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core. EMBO Journal 32 (21), S. 2804 - 2818 (2013)
65.
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The Prp19 complex directly functions in mitotic spindle assembly. PLoS One 8 (9), e74851 (2013)
66.
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Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8. Science 341 (6141), S. 80 - 84 (2013)
67.
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Molecular dissection of step 2 catalysis of yeast pre-mRNA splicing investigated in a purified system. RNA 19 (7), S. 902 - 915 (2013)
68.
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Structural basis for dual roles of Aar2p in U5 snRNP assembly. Genes and Development 27 (5), S. 525 - 540 (2013)
69.
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Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system. Genes and Development 27 (4), S. 413 - 428 (2013)
70.
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The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes and Development 26 (23), S. 2422 - 2434 (2012)
71.
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Emerging views about the molecular structure of the spliceosomal catalytic center. RNA Biology 9 (11), S. 1311 - 1318 (2012)
72.
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Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome. Proceedings of the National Academy of Sciences of the United States of America 109 (43), S. 17418 - 17423 (2012)
73.
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Molecular architecture of Zinc chelating small molecules that inhibit spliceosome assembly at an early stage. RNA 18 (9), S. 1605 - 1611 (2012)
74.
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Box H/ACA snoRNAs are preferred substrates for the trimethylguanosine synthase in the divergent unicellular eukaryote Trichomonas vaginalis. RNA 18 (9), S. 1656 - 1665 (2012)
75.
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Retention of posttranscriptional spliceosomes in nuclear speckles until splicing completion. Nature communications 3, 994 (2012)
76.
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Antisense-targeted immuno-EM localization of the pre-mRNA path in the spliceosomal C complex. RNA 18 (7), S. 1347 - 1357 (2012)
77.
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Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. EMBO Journal 31 (6), S. 1591 - 1604 (2012)
78.
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Psoromic acid derivatives: A new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay. ChemBioChem 13 (5), S. 640 - 644 (2012)
79.
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Dynamic protein-protein interaction wiring of the human spliceosome. Molecular Cell 45 (4), S. 567 - 580 (2012)
80.
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Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS. RNA 18 (6), S. 1244 - 1256 (2012)
81.
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Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein. EMBO Journal 31 (9), S. 2222 - 2234 (2012)
82.
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Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31. RNA 17 (9), S. 1655 - 1663 (2011)
83.
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Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method. Molecular and Cellular Biology 31 (13), S. 2667 - 2682 (2011)
84.
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Synthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNA. Journal of Biological Chemistry 286 (12), S. 10126 - 10136 (2011)
85.
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HSPC117 is the essential subunit of a human tRNA splicing ligase complex. Science 331 (6018), S. 760 - 764 (2011)
86.
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3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core. Molecular Cell 40 (6), S. 927 - 938 (2010)
87.
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Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis. RNA 16 (12), S. 2384 - 2403 (2010)
88.
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An approach for de novo structure determination of dynamic molecular assemblies by electron cryomicroscopy. Structure 18 (6), S. 667 - 676 (2010)
89.
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Molecular architecture of the human Prp19/CDC5L complex. Molecular and Cellular Biology 30 (9), S. 2105 - 2119 (2010)
90.
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Mapping the binding site of snurportin 1 on native U1 snRNP by cross-linking and mass spectrometry. Nucleic Acids Research 38 (16), S. 5581 - 5593 (2010)
91.
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Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes. Molecular Cell 38 (2), S. 223 - 235 (2010)
92.
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The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. PLoS ONE 5, e10013 (2010)
93.
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Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis. Nature Structural and Molecular Biology 17 (4), S. 403 - 409 (2010)
94.
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An ancient mechanism for splicing control: U11 snRNP as an activator of alternative splicing. Molecular Cell 37 (6), S. 821 - 833 (2010)
95.
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Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation. Nature Structural and Molecular Biology 17 (2), S. 216 - 222 (2010)
96.
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The intronic splicing code: Multiple factors involved in ATM pseudoexon definition. The EMBO Journal 29, S. 749 - 760 (2010)
97.
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Determination of protein stoichiometry within protein complexes using absolute quantification and multiple reaction monitoring. Analytical Chemistry 82 (7), S. 2784 - 2796 (2010)
98.
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Functional organization of the Sm core in the crystal structure of human U1 snRNP. EMBO Journal 29, S. 4172 - 4184 (2010)
99.
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Reconstitution of both steps of S. cerevisiae splicing with purified spliceosomal components. Nature Structural and Molecular Biology 16 (12), S. 1237 - 1243 (2009)