Zeitschriftenartikel (280)
51.
Zeitschriftenartikel
29 (24), S. 2576 - 2587 (2015)
The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Genes and Development 52.
Zeitschriftenartikel
34 (24), S. 3059 - 3073 (2015)
Protein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex. EMBO Journal 53.
Zeitschriftenartikel
11 (9), e1005539 (2015)
Dynamic contacts of U2, RES, Cwc25, Prp8 and Prp45 proteins with the Pre-mRNA branch-site and 3' splice site during catalytic activation and step 1 catalysis in yeast spliceosomes. PLoS Genetics 54.
Zeitschriftenartikel
21 (11), S. 1993 - 2005 (2015)
Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5‘ splice site. RNA 55.
Zeitschriftenartikel
125 (9), S. 3572 - 3584 (2015)
HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models. Journal of Clinical Investigation 56.
Zeitschriftenartikel
162 (3), S. 690 - 690.e1 (2015)
Snapshot: Spliceosome dynamics III. Cell 57.
Zeitschriftenartikel
162 (2), S. 456 - 456.e1 (2015)
SnapShot: Spliceosome dynamics II. Cell 58.
Zeitschriftenartikel
4, e07320 (2015)
A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing. eLife 59.
Zeitschriftenartikel
161 (6), S. 1474 - 1474.e1 (2015)
SnapShot: Spliceosome dynamics I. Cell 60.
Zeitschriftenartikel
22 (2), S. 138 - 144 (2015)
The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes. Nature Structural and Molecular Biology 61.
Zeitschriftenartikel
29 (1), S. 94 - 107 (2015)
The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome. Genes and Development 62.
Zeitschriftenartikel
289 (50), S. 34683 - 34698 (2014)
Identification of small molecule inhibitors of pre-mRNA splicing. The Journal of Biological Chemistry 63.
Zeitschriftenartikel
111 (44), S. 15622 - 15629 (2014)
Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells. Proceedings of the National Academy of Sciences of the United States of America 64.
Zeitschriftenartikel
11 (10), S. 1064 - 1070 (2014)
Photo-cross-linking and high-resolution mass spectrometry for assignment of RNA-binding sites in RNA-binding proteins. Nature Methods 65.
Zeitschriftenartikel
21 (10), S. 911 - 918 (2014)
Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex. Nature Structural and Molecular Biology 66.
Zeitschriftenartikel
70 (6), S. 1622 - 1630 (2014)
Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28. Acta Crystallographica D 67.
Zeitschriftenartikel
11 (4), S. 298 - 312 (2014)
Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans. RNA Biology 68.
Zeitschriftenartikel
20 (3), S. 406 - 420 (2014)
Mass spectrometry–based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count. RNA 69.
Zeitschriftenartikel
21 (12), S. 2162 - 2174 (2013)
Phosphorylation drives a dynamic switch in serine/arginine-rich proteins. Structure 70.
Zeitschriftenartikel
32 (21), S. 2804 - 2818 (2013)
RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core. EMBO Journal 71.
Zeitschriftenartikel
8 (9), e74851 (2013)
The Prp19 complex directly functions in mitotic spindle assembly. PLoS One 72.
Zeitschriftenartikel
341 (6141), S. 80 - 84 (2013)
Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8. Science 73.
Zeitschriftenartikel
19 (7), S. 902 - 915 (2013)
Molecular dissection of step 2 catalysis of yeast pre-mRNA splicing investigated in a purified system. RNA 74.
Zeitschriftenartikel
27 (5), S. 525 - 540 (2013)
Structural basis for dual roles of Aar2p in U5 snRNP assembly. Genes and Development 75.
Zeitschriftenartikel
27 (4), S. 413 - 428 (2013)
Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system. Genes and Development 76.
Zeitschriftenartikel
26 (23), S. 2422 - 2434 (2012)
The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes and Development 77.
Zeitschriftenartikel
9 (11), S. 1311 - 1318 (2012)
Emerging views about the molecular structure of the spliceosomal catalytic center. RNA Biology 78.
Zeitschriftenartikel
109 (43), S. 17418 - 17423 (2012)
Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome. Proceedings of the National Academy of Sciences of the United States of America 79.
Zeitschriftenartikel
18 (9), S. 1605 - 1611 (2012)
Molecular architecture of Zinc chelating small molecules that inhibit spliceosome assembly at an early stage. RNA 80.
Zeitschriftenartikel
18 (9), S. 1656 - 1665 (2012)
Box H/ACA snoRNAs are preferred substrates for the trimethylguanosine synthase in the divergent unicellular eukaryote Trichomonas vaginalis. RNA 81.
Zeitschriftenartikel
3, 994 (2012)
Retention of posttranscriptional spliceosomes in nuclear speckles until splicing completion. Nature communications 82.
Zeitschriftenartikel
18 (7), S. 1347 - 1357 (2012)
Antisense-targeted immuno-EM localization of the pre-mRNA path in the spliceosomal C complex. RNA 83.
Zeitschriftenartikel
31 (6), S. 1591 - 1604 (2012)
Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. EMBO Journal 84.
Zeitschriftenartikel
13 (5), S. 640 - 644 (2012)
Psoromic acid derivatives: A new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay. ChemBioChem 85.
Zeitschriftenartikel
45 (4), S. 567 - 580 (2012)
Dynamic protein-protein interaction wiring of the human spliceosome. Molecular Cell 86.
Zeitschriftenartikel
18 (6), S. 1244 - 1256 (2012)
Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS. RNA 87.
Zeitschriftenartikel
31 (9), S. 2222 - 2234 (2012)
Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein. EMBO Journal 88.
Zeitschriftenartikel
17 (9), S. 1655 - 1663 (2011)
Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31. RNA 89.
Zeitschriftenartikel
31 (13), S. 2667 - 2682 (2011)
Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method. Molecular and Cellular Biology 90.
Zeitschriftenartikel
286 (12), S. 10126 - 10136 (2011)
Synthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNA. Journal of Biological Chemistry 91.
Zeitschriftenartikel
331 (6018), S. 760 - 764 (2011)
HSPC117 is the essential subunit of a human tRNA splicing ligase complex. Science 92.
Zeitschriftenartikel
40 (6), S. 927 - 938 (2010)
3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core. Molecular Cell 93.
Zeitschriftenartikel
16 (12), S. 2384 - 2403 (2010)
Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis. RNA 94.
Zeitschriftenartikel
18 (6), S. 667 - 676 (2010)
An approach for de novo structure determination of dynamic molecular assemblies by electron cryomicroscopy. Structure 95.
Zeitschriftenartikel
30 (9), S. 2105 - 2119 (2010)
Molecular architecture of the human Prp19/CDC5L complex. Molecular and Cellular Biology 96.
Zeitschriftenartikel
38 (16), S. 5581 - 5593 (2010)
Mapping the binding site of snurportin 1 on native U1 snRNP by cross-linking and mass spectrometry. Nucleic Acids Research 97.
Zeitschriftenartikel
38 (2), S. 223 - 235 (2010)
Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes. Molecular Cell 98.
Zeitschriftenartikel
5, e10013 (2010)
The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. PLoS ONE 99.
Zeitschriftenartikel
17 (4), S. 403 - 409 (2010)
Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis. Nature Structural and Molecular Biology 100.
Zeitschriftenartikel
37 (6), S. 821 - 833 (2010)
An ancient mechanism for splicing control: U11 snRNP as an activator of alternative splicing. Molecular Cell