Zeitschriftenartikel (282)
51.
Zeitschriftenartikel
Structural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryote Chaetomium thermophilum. Acta Crystallographica Section F 72 (2), S. 112 - 120 (2016)
52.
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Rational design of cyclic peptide inhibitors of U2AF homology motif (UHM) domains to modulate pre-mRNA splicing. Journal of Medicinal Chemistry 59 (22), S. 10190 - 10197 (2016)
53.
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The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Genes and Development 29 (24), S. 2576 - 2587 (2015)
54.
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Protein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex. EMBO Journal 34 (24), S. 3059 - 3073 (2015)
55.
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Dynamic contacts of U2, RES, Cwc25, Prp8 and Prp45 proteins with the Pre-mRNA branch-site and 3' splice site during catalytic activation and step 1 catalysis in yeast spliceosomes. PLoS Genetics 11 (9), e1005539 (2015)
56.
Zeitschriftenartikel
Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5‘ splice site. RNA 21 (11), S. 1993 - 2005 (2015)
57.
Zeitschriftenartikel
HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models. Journal of Clinical Investigation 125 (9), S. 3572 - 3584 (2015)
58.
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Snapshot: Spliceosome dynamics III. Cell 162 (3), S. 690 - 690.e1 (2015)
59.
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SnapShot: Spliceosome dynamics II. Cell 162 (2), S. 456 - 456.e1 (2015)
60.
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A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing. eLife 4, e07320 (2015)
61.
Zeitschriftenartikel
SnapShot: Spliceosome dynamics I. Cell 161 (6), S. 1474 - 1474.e1 (2015)
62.
Zeitschriftenartikel
The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes. Nature Structural and Molecular Biology 22 (2), S. 138 - 144 (2015)
63.
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The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome. Genes and Development 29 (1), S. 94 - 107 (2015)
64.
Zeitschriftenartikel
Identification of small molecule inhibitors of pre-mRNA splicing. The Journal of Biological Chemistry 289 (50), S. 34683 - 34698 (2014)
65.
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Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells. Proceedings of the National Academy of Sciences of the United States of America 111 (44), S. 15622 - 15629 (2014)
66.
Zeitschriftenartikel
Photo-cross-linking and high-resolution mass spectrometry for assignment of RNA-binding sites in RNA-binding proteins. Nature Methods 11 (10), S. 1064 - 1070 (2014)
67.
Zeitschriftenartikel
Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex. Nature Structural and Molecular Biology 21 (10), S. 911 - 918 (2014)
68.
Zeitschriftenartikel
Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28. Acta Crystallographica D 70 (6), S. 1622 - 1630 (2014)
69.
Zeitschriftenartikel
Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans. RNA Biology 11 (4), S. 298 - 312 (2014)
70.
Zeitschriftenartikel
Mass spectrometry–based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count. RNA 20 (3), S. 406 - 420 (2014)
71.
Zeitschriftenartikel
Phosphorylation drives a dynamic switch in serine/arginine-rich proteins. Structure 21 (12), S. 2162 - 2174 (2013)
72.
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RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core. EMBO Journal 32 (21), S. 2804 - 2818 (2013)
73.
Zeitschriftenartikel
The Prp19 complex directly functions in mitotic spindle assembly. PLoS One 8 (9), e74851 (2013)
74.
Zeitschriftenartikel
Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8. Science 341 (6141), S. 80 - 84 (2013)
75.
Zeitschriftenartikel
Molecular dissection of step 2 catalysis of yeast pre-mRNA splicing investigated in a purified system. RNA 19 (7), S. 902 - 915 (2013)
76.
Zeitschriftenartikel
Structural basis for dual roles of Aar2p in U5 snRNP assembly. Genes and Development 27 (5), S. 525 - 540 (2013)
77.
Zeitschriftenartikel
Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system. Genes and Development 27 (4), S. 413 - 428 (2013)
78.
Zeitschriftenartikel
The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes and Development 26 (23), S. 2422 - 2434 (2012)
79.
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Emerging views about the molecular structure of the spliceosomal catalytic center. RNA Biology 9 (11), S. 1311 - 1318 (2012)
80.
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Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome. Proceedings of the National Academy of Sciences of the United States of America 109 (43), S. 17418 - 17423 (2012)
81.
Zeitschriftenartikel
Molecular architecture of Zinc chelating small molecules that inhibit spliceosome assembly at an early stage. RNA 18 (9), S. 1605 - 1611 (2012)
82.
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Box H/ACA snoRNAs are preferred substrates for the trimethylguanosine synthase in the divergent unicellular eukaryote Trichomonas vaginalis. RNA 18 (9), S. 1656 - 1665 (2012)
83.
Zeitschriftenartikel
Retention of posttranscriptional spliceosomes in nuclear speckles until splicing completion. Nature communications 3, 994 (2012)
84.
Zeitschriftenartikel
Antisense-targeted immuno-EM localization of the pre-mRNA path in the spliceosomal C complex. RNA 18 (7), S. 1347 - 1357 (2012)
85.
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Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. EMBO Journal 31 (6), S. 1591 - 1604 (2012)
86.
Zeitschriftenartikel
Psoromic acid derivatives: A new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay. ChemBioChem 13 (5), S. 640 - 644 (2012)
87.
Zeitschriftenartikel
Dynamic protein-protein interaction wiring of the human spliceosome. Molecular Cell 45 (4), S. 567 - 580 (2012)
88.
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Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS. RNA 18 (6), S. 1244 - 1256 (2012)
89.
Zeitschriftenartikel
Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein. EMBO Journal 31 (9), S. 2222 - 2234 (2012)
90.
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Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31. RNA 17 (9), S. 1655 - 1663 (2011)
91.
Zeitschriftenartikel
Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method. Molecular and Cellular Biology 31 (13), S. 2667 - 2682 (2011)
92.
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Synthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNA. Journal of Biological Chemistry 286 (12), S. 10126 - 10136 (2011)
93.
Zeitschriftenartikel
HSPC117 is the essential subunit of a human tRNA splicing ligase complex. Science 331 (6018), S. 760 - 764 (2011)
94.
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3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core. Molecular Cell 40 (6), S. 927 - 938 (2010)
95.
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Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis. RNA 16 (12), S. 2384 - 2403 (2010)
96.
Zeitschriftenartikel
An approach for de novo structure determination of dynamic molecular assemblies by electron cryomicroscopy. Structure 18 (6), S. 667 - 676 (2010)
97.
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Molecular architecture of the human Prp19/CDC5L complex. Molecular and Cellular Biology 30 (9), S. 2105 - 2119 (2010)
98.
Zeitschriftenartikel
Mapping the binding site of snurportin 1 on native U1 snRNP by cross-linking and mass spectrometry. Nucleic Acids Research 38 (16), S. 5581 - 5593 (2010)
99.
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Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes. Molecular Cell 38 (2), S. 223 - 235 (2010)
100.
Zeitschriftenartikel
The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. PLoS ONE 5, e10013 (2010)