Ausgewählte Publikationen

Eckermann, M, van der Meer, F, Cloetens P, Ruhwedel T, Möbius W, Stadelmann C, Salditt, T. (2021) Three-dimensional virtual histology of the cerebral cortex based on phase-contrast X-ray tomography.  Biomedical Optics Express 12(12):7582-7598. https://doi.org/10.1364/BOE.434885

Edgar JM, McGowan E, Chapple KJ, Möbius W, Lemgruber L, Insall RH, Nave KA, Boullerne A. Río-Hortega's drawings revisited with fluorescent protein defines a cytoplasm-filled channel system of CNS myelin. J Anat. 2021 Dec;239(6):1241-1255. doi: 10.1111/joa.13577. Epub 2021 Oct 28. PMID: 34713444 Review.

Spieth L, Berghoff SA, Stumpf SK, Winchenbach J, Michaelis T, Watanabe T, Gerndt N, Düking T, Hofer S, Ruhwedel T, Shaib AH, Willig K, Kronenberg K, Karst U, Frahm J, Rhee JS, Minguet S, Möbius W, Kruse N, von der Brelie C, Michels P, Stadelmann C, Hülper P, Saher G. Anesthesia triggers drug delivery to experimental glioma in mice by hijacking caveolar transport. Neurooncol Adv. 2021 Sep 20;3(1):vdab140.
doi: 10.1093/noajnl/vdab140. PMID: 34647026; PMCID: PMC8500692.

Thom T, Schmitz M, Fischer AL, Correia A, Correia S, Llorens F, Pique AV, Möbius W, Domingues R, Zafar S, Stoops E, Silva CJ, Fischer A, Outeiro TF, Zerr I. Cellular Prion Protein Mediates α-Synuclein Uptake, Localization, and Toxicity In Vitro and In Vivo. Mov Disord. 2021 Aug 27. doi: 10.1002/mds.28774. Epub ahead of print. PMID: 34448510.

Moyon S, Frawley R, Marechal D, Huang D, Marshall-Phelps KLH, Kegel L, Bøstrand SMK, Sadowski B, Jiang Y-H, Lyons DA, Möbius W and Casaccia P: TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice. Nat. Commun. 2021 Jun 7;12(1):3359. doi: 10.1038/s41467-021-23735-3

Siems SB, Jahn O, Hoodless LJ, Jung RB, Hesse D, Möbius W, Czopka T, Werner HB. Proteome Profile of Myelin in the Zebrafish Brain. Front Cell Dev Biol. 2021 Apr 8;9:640169. doi: 10.3389/fcell.2021.640169. eCollection 2021. PMID: 33898427

Stuendl A, Kraus T, Chatterjee M, Zapke B, Sadowski B, Moebius W, Hobert MA, Deuschle C, Brockmann K, Maetzler W, Mollenhauer B, Schneider A. α-Synuclein in Plasma-Derived Extracellular Vesicles Is a Potential Biomarker of Parkinson's Disease. Mov Disord, 18 May 2021. Vol. 36, No. 11, 2021. https://doi.org/10.1002/mds.28639

Möbius W, Hümmert S, Ruhwedel T, Kuzirian A, Gould R. (2021) New Species Can Broaden Myelin Research: Suitability of Little Skate, Leucoraja erinacea. Life (Basel). 2021 Feb 11;11(2):136. doi:10.3390/life11020136. PMID: 33670172 Free PMC article.

Popova B, Wang D, Pätz C, Akkermann D, Lázaro DF, Galka D, Kolog Gulko M, Bohnsack MT, Möbius W, Bohnsack KE, Outeiro TF, Braus GH. DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization. PLoS Genet. 2021 Mar 3;17(3):e1009407. doi: 10.1371/journal.pgen.1009407. eCollection 2021 Mar. PMID: 33657088 Free PMC article.

Winkler A, Wrzos C, Haberl M, Weil MT, Gao M, Möbius W, Odoardi F, Thal DR, Chang M,Opdenakker G, Bennett JL, Nessler S, Stadelmann C. Blood-brain barrier resealing in neuromyelitis optica occurs independently of astrocyte regeneration. J Clin Invest. 2021 Mar 1;131(5):e141694. doi:10.1172/JCI141694. PMID: 33645550

Lohrberg M, Winkler A, Franz J, van der Meer F, Ruhwedel T, Sirmpilatze N, Dadarwal R, Handwerker R, Esser D, Wiegand K, Hagel C, Gocht A, König FB, Boretius S, Möbius W, Stadelmann C, Barrantes-Freer A. Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination. Acta Neuropathol Commun. 2020 Dec 24;8(1):224. doi: 10.1186/s40478-020-01105-2. PMID: 33357244 Free PMC article.

Frühbeis C, Kuo-Elsner WP, Müller C, Barth K, Peris L, Tenzer S, Möbius W, Werner HB, Nave KA, Fröhlich D, Krämer-Albers EM. Oligodendrocytes support axonal transport and maintenance via exosome secretion. PLoS Biol. 2020 Dec 22;18(12):e3000621. doi: 10.1371/journal.pbio.3000621. eCollection 2020 Dec. PMID: 33351792 Free PMC article.

Dagkonaki A, Avloniti M, Evangelidou M, Papazian I, Kanistras I, Tseveleki V, Lampros F, Tselios T, Androutsou M, Kilintireas K, Möbius W, Torp Jensen L, Matsoukas J, Lassmann H, Anagnostouli M, Probert L. (2020) Mannan-MOG35-55 reverses experimental autoimmune encephalomyelitis, by inducing a peripheral type 2 myeloid response, reducing CNS inflammation and preserving axons in spinal cord lesions. Frontiers Front Immunol. 2020 Nov 19;11:575451. doi: 10.3389/fimmu.2020.575451. eCollection 2020. PMID: 33329540 Free PMC article.

Trevisiol A, Kusch K, Steyer A, Gregor I, Nardis C, Winkler U, Köhler S, Restrepo A, Möbius W, Werner HB, Nave K-A and Hirrlinger J. (2020) Structural myelin defects are associated with low axonal ATP levels but rapid recovery from energy deprivation in a mouse model of spastic paraplegia. PLoS Biol. 2020 Nov 16;18(11):e3000943. doi: 10.1371/journal.pbio.3000943. eCollection 2020 Nov

Berghoff S, Spieth L, Sun T, Hosang L, Schlaphoff L, Depp C, Düking T, Winchenbach J, Neuber J, Ewers D, Scholz P, van der Meer F, Cantuti-Castelvetri L. Sasmita A, Meschkat M, Ruhwedel T, Möbius W, Sankowski R, Prinz M, Huitinga I, Sereda M, Odoardi F, Ischebeck T, Simons, Stadelmann-Nessler C, Edgar J, Nave K-A, Saher G. (2020) Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis. Nat Neurosci. 2021 Jan;24(1):47-60. doi: 10.1038/s41593-020-00757-6. Epub 2020 Dec 21. PMID: 3334971

Moore S, Meschkat M, Ruhwedel T, Trevisiol A, Tzvetanova ID, Battefeld A, Kusch K, Kole M, Strenzke N, Möbius W, de Hoz L, Nave K-A. (2020) A role of oligodendrocytes in information processing. Nature Comm. 2020 11: 5497

Vaes JEG, van Kammen CM, Dijkhuizen RM, van der Toorn A, Ruhwedel T,Möbius W, Benders MJNL, Nijboer CH. (2020) Intranasal mesenchymal stem cell therapy to boost myelination after Encephalopathy of Prematurity. Glia 2021 Mar;69(3):655-680. doi: 10.1002/glia.23919.

Eichel M, Gargareta V-I, d‘Este E, Fledrich R, Kungl T, Buscham T, Lüders L, Miracle C, Jung R, Distler U, Kusch K, Möbius W, Hülsmann S, Tenzer S, Nave K-A, and Werner HB. (2020) CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves Nat Commun.  2020 11:4514; https://doi.org/10.1038/s41467-020-18172-7

Jean P, Anttonen T, Michanski S, de Diego AMG, Steyer AM, Neef A, Oestreicher D,  Kroll J, Nardis C, Pangršič T, Möbius W, Ashmore J, Wichmann C, Moser T. Macromolecular and electrical coupling between inner hair cells in the rodent cochlea. Nat Commun. 2020 Jun 25;11(1):3208. doi: 10.1038/s41467-020-17003-z. PMID: 32587250

Zheng  X,   Zhang L, Kuang Y,  Venkataramani V,  Jin F,  Hein K, Zafeiriou MP, Lenz C, Moebius W,  Kilic E, Hermann DM, Weber MS, Urlaub H, Zimmermann W-H, Bähr M and Doeppner TR (2020) Extracellular Vesicles Derived from Neural Progenitor Cells––a Preclinical Evaluation for Stroke Treatment in Mice. Translational Stroke Research https://doi.org/10.1007/s12975-020-00814-z

Stephan T, Brüser C, Deckers M, Steyer A, Balzarotti F, Behr T, Heim G, Hübner W, Ilgen P, Lange F, Pape J, Stoldt S, Huser T, Hell S, Möbius W, Rehling P, Riedel D, and Jakobs S. MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation. EMBOJ 2020 Jul 15;39(14):e104105. doi: 10.15252/embj.2019104105. Epub 2020 Jun 22. PMID: 32567732

Marshall-Phelps KLH, Kegel L, Baraban M, Ruhwedel T, Almeida RG, Rubio-Brotons M, Klingseisen A, Benito-Kwiecinski SK, Early JJ, Bin JM, Suminaite D, Livesey MR, Möbius W, Poole RJ, Lyons DA. (2020) Neuronal activity disrupts myelinated axon integrity in the absence of NKCC1b.J Cell Biol 2020 Jul 6;219(7):e201909022. doi: 10.1083/jcb.201909022. PMID: 32364583

Tasche D, Weber M, Mrotzek J, Gerhard C, Wieneke S, Möbius W, Höfft O, Viöl W. In Situ Investigation of the Formation Kinematics of Plasma-Generated Silver Nanoparticles. Nanomaterials (Basel). 2020 Mar 19;10(3):555. doi: 10.3390/nano10030555. PMID: 32204519

Steyer AM, Ruhwedel T, Nardis C, Werner HB, Nave K-A, Möbius W (2020): Pathology of myelinated axons in the PLP-deficient mouse model of spastic paraplegia type 2 revealed by volume imaging using focused ion beam-scanning electron microscopy. J Struc Biol, 2020 May 1;210(2):107492. doi: 10.1016/j.jsb.2020.107492.

Cohen CCH, Popovic MA, Klooster J, Weil M-T, Möbius W, Nave K-A and Kole MHP (2020): Saltatory conduction in myelinated axons involves a periaxonal nanocircuit. Cell 2020 Jan 23;180(2):311-322.e15. doi: 10.1016/j.cell.2019.11.039. Epub 2019 Dec 26. PMID: 31883793

Djannatian M, Timmler S, Arends M, Luckner M, Weil M-T, Alexopoulos I, Snaidero N, Schmid B, Misgeld T, Möbius W, Schifferer M, Peles E, Simons M: Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS. (2019) Nat. Commun. Oct 22;10(1):4794. doi: 10.1038/s41467-019-12789-z

Steyer AM, Schertel SA, Nardis C, Möbius W (2019): FIB-SEM of mouse nervous tissue: Fast and slow sample preparation Methods in Cell Biology, Volume 152, pp.1-21, ISSN 0091-679X, https://doi.org/10.1016/bs.mcb.2019.03.009

Weil MT, Ruhwedel T, Meschkat M, Sadowski B, Möbius W (2019). Transmission Electron Microscopy of Oligodendrocytes and Myelin. Methods Mol Biol. 2019;1936:343-375. doi: 10.1007/978-1-4939-9072-6_20.

Steyer AM, Ruhwedel T, Möbius W. (2019) Biological Sample Preparation by High-pressure Freezing, Microwave-assisted Contrast Enhancement, and Minimal Resin Embedding for Volume Imaging. J Vis Exp. 2019 Mar 19;(145). doi: 10.3791/59156. PubMed PMID: 30958469.

Steyer AM, Schertel SA, Nardis C, Möbius W. FIB-SEM of mouse nervous tissue: Fast and slow sample preparation (2019). Methods in Cell Biology, Volume 152, pp.1-21, ISSN 0091-679X, https://doi.org/10.1016/bs.mcb.2019.03.009.

Möbius W, Posthuma G. (2018) Sugar and ice: Immunoelectron microscopy using cryosections according to the Tokuyasu method. Tissue Cell. 2019 Apr;57:90-102. doi: 10.1016/j.tice.2018.08.010. Epub 2018 Sep 3. Review. PubMed PMID: 30201442.

Stassart RM, Möbius W, Nave KA, Edgar JM. (2018) The Axon-Myelin Unit in Development and Degenerative Disease. Front Neurosci. 2018 Jul 11;12:467.

Weil M-T, Heibeck S, Töpperwien M, tom Dieck S, Ruhwedel T, Salditt T, Rodicio MC, Morgan JR, Nave K-A, Möbius W and Werner HB. (2018) Axonal Ensheathment in the Nervous System of Lamprey: Implications for the Evolution of Myelinating Glia. Journal of Neuroscience 18 July 2018, 38 (29) 6586-6596.

Weil, M-T, Ruhwedel, T, Möbius W, and Simons, M. (2017) Intracerebral injections and ultrastructural analysis of high-pressure frozen brain tissue. Curr. Protoc. Neurosci. 78:2.27.1-2.27.18. doi: 10.1002/cpns.22.

Weil M-T, Möbius W, Winkler A, Ruhwedel T, Wrzos C, Romanelli E, Bennett JL, Enz L, Goebels N, Nave KA, Kerschensteiner M, Schaeren-Wiemers N, Stadelmann C, Simons M (2016) Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases. Cell Rep. Jul 12;16(2): 314-22.

Möbius W, Nave KA, Werner HB (2016) Electron microscopy of myelin: Structure preservation by high-pressure freezing. Brain Res. 2016 Jun 15;1641(Pt A):92-100. doi: 10.1016/j.brainres.2016.02.027. Review. PubMed PMID: 26920467.

Möbius W (2016) Immunoelectron Microscopy: High-Resolution Immunocytochemistry. In: Ralph A Bradshaw and Philip D Stahl (Editors-in-Chief), Encyclopedia of Cell Biology, Vol 2, Waltham, MA: Academic Press, 2016, pp. 32-43.

Snaidero N, Möbius W, Czopka T, Hekking LH, Mathisen C, Verkleij D, Goebbels S, Edgar J, Merkler D, Lyons DA, Nave KA, Simons M: Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue. Cell 2014 Jan 16;156(1-2): 277-90.

Schertel A, Snaidero N, Han H-M, Ruhwedel T, Laue M, Grabenbauer G, Möbius W (2013): Cryo FIB-SEM: volume imaging of cellular ultrastructure in native frozen specimens. J Struc Biol 2013 Nov;184(2):355-60.

Möbius W, Cooper B, Kaufmann WA, Imig C, Ruhwedel T, Snaidero N, Saab AS, and Varoqueaux F (2010): Electron microscopy of the mouse central nervous system. Methods in Cell Biology Vol. 96:475-512.

Möbius, W (2009): Cryopreparation of biological specimens for immunoelectron microscopy. Invited review. Annals Anat. 191: 231-247.

Möbius W, Patzig J, Nave K-A, Werner H (2008): Review: Phylogeny of proteolipid proteins: divergence, constraints, and the evolution of novel functions in myelination and neuroprotection. Neuron Glia Biology 4 (2): 111-127.

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