Publications of Ashwin Chari
All genres
Journal Article (43)
2024
Journal Article
15 (1), 1147 (2024)
Protein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing. Nature Communications
Journal Article
15, 411 (2024)
Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design. Nature Communications 2023
Journal Article
52, pp. 391 - 411 (2023)
Prospects and Limitations of High-Resolution Single-Particle Cryo-Electron Microscopy. Annual Review of Biophysics
Journal Article
EIGER2 hybrid-photon-counting X-ray detectors for advanced synchrotron diffraction experiments. Journal of Synchrotron Radiation, pp. 723 - 738 (2023)
Journal Article
186 (23), e16, pp. 5054 - 5067 (2023)
Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell 2022
Journal Article
50 (9), pp. 5282 - 5298 (2022)
Conformational rearrangements upon start codon recognition in human 48S translation initiation complex. Nucleic Acids Research 2021
Journal Article
11, 1289 (2021)
Chromatography-free purification strategies for large biological macromolecular complexes involving fractionated PEG precipitation and density gradients. Life
Journal Article
11 (12), 1289 (2021)
Chromatography-free purification strategies for large biological macromolecular complexes involving fractionated PEG precipitation and density gradients. Life 2020
Journal Article
587 (7832), pp. 157 - 161 (2020)
Atomic-resolution protein structure determination by cryo-EM. Nature
Journal Article
6 (30), eaba3916 (2020)
Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution. Science Advances
Journal Article
180 (6), pp. 1130 - 1143.e20 (2020)
Discovery of a regulatory subunit of the yeast fatty acid synthase. Cell 2019
Journal Article
27 (7), pp. 1124 - 1136 (2019)
Structural and functional analyses of the human PDH complex suggest a "Division-of-Labor" mechanism by local E1 and E3 clusters. Structure 2018
Journal Article
17 (7), pp. 471 - 492 (2018)
Cryo-EM in drug discovery: Achievements, limitations and prospects. Nature Reviews Drug Discovery 2017
Journal Article
8, 15578 (2017)
Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs. Nature Communications 2016
Journal Article
353 (6306), pp. 1399 - 1405 (2016)
Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Science
Journal Article
16 (12), pp. 3103 - 3112 (2016)
The ribosome cooperates with the assembly chaperone pICln to initiate formation of snRNPs. Cell Reports
Journal Article
353 (6299), pp. 594 - 598 (2016)
The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science
Journal Article
65 (1), pp. 23 - 34 (2016)
Sample preparation of biological macromolecular assemblies for the determination of high-resolution structures by cryo-electron microscopy. Microscopy 2015
Journal Article
12 (9), pp. 859 - 865 (2015)
ProteoPlex: Stability optimization of macromolecular complexes by sparse-matrix screening of chemical space. Nature Methods
Journal Article
34 (14), pp. 1925 - 1941 (2015)
Reconstitution of the human U snRNP assembly machinery reveals stepwise Sm protein organization. EMBO Journal