Publications of S. Mozaffari-Jovin
All genres
Journal Article (15)
Journal Article
15, 3138 (2024)
PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects. Nature Communications
Journal Article
98 (8), 082001 (2023)
Light-sheet fluorescent microscopy: fundamentals, developments and applications. Physica Scripta
Journal Article
150 (7), dev201476 (2023)
MERISTEM-DEFECTIVE regulates the balance between stemness and differentiation in the root meristem through RNA splicing control. Development
Journal Article
2 (4), e89 (2022)
Progressive accumulation of cytoplasmic aggregates in PRPF31 retinal pigment epithelium cells interferes with cell survival. Clinical and Translational Discovery
Journal Article
49 (10), pp. 5845 - 5866 (2021)
SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes. Nucleic Acids Research
Journal Article
69 (6), pp. 979 - 992 (2018)
Prp19/Pso4 is an autoinhibited ubiquitin ligase activated by stepwise assembly of three splicing factors. Molecular Cell
Journal Article
29 (24), pp. 2576 - 2587 (2015)
The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Genes and Development
Journal Article
4, e07320 (2015)
A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing. eLife
Journal Article
29 (1), pp. 94 - 107 (2015)
The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome. Genes and Development
Journal Article
11 (4), pp. 298 - 312 (2014)
Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans. RNA Biology
Journal Article
341 (6141), pp. 80 - 84 (2013)
Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8. Science
Journal Article
27 (5), pp. 525 - 540 (2013)
Structural basis for dual roles of Aar2p in U5 snRNP assembly. Genes and Development
Journal Article
26 (23), pp. 2422 - 2434 (2012)
The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes and Development
Journal Article
109 (43), pp. 17418 - 17423 (2012)
Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome. Proceedings of the National Academy of Sciences of the United States of America
Journal Article
35 (4), pp. 454 - 466 (2009)
Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase. Molecular Cell Conference Paper (2)
Conference Paper
60 (9), 3988, (2019)
The ciliopathy protein SANS (Usher syndrome 1G) regulates pre-mRNA splicing by facilitating the maturation of the spliceosomal tri-snRNP complex. Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Vancouver, Canada, April 28, 2019 - May 02, 2019. Investigative Ophthalmology and Visual Science
Conference Paper
59 (9), 1563, (2018)
Human iPSC-derived RPE and retinal organoids reveal impaired alternative splicing of genes involved in pre-mRNA splicing in PRPF31 autosomal dominant retinitis pigmentosa. Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Honululu, Haiti, April 29, 2018 - May 03, 2018. Investigative Ophthalmology and Visual Science Thesis - PhD (1)
Thesis - PhD
Mechanism of regulation of spliceosome activation by Brr2 and Prp8 and links to retinal disease. Dissertation, Georg-August-Universität, Göttingen (2013)